scholarly journals Relationship Between Staphylococcus aureus Carriage and Surgical Site Infections Following Total Hip and Knee Arthroplasty in the South Asian Population: Protocol for a Prospective Cohort Study (Preprint)

2018 ◽  
Author(s):  
Syed H Mufarrih ◽  
Nada Q Qureshi ◽  
Anum Sadruddin ◽  
Pervaiz Hashmi ◽  
Syed Faisal Mahmood ◽  
...  

BACKGROUND Surgical site infections following total hip or knee arthroplasties have a reported rate of 0.49%-2.5% and can cause significant morbidity as well as tripling the cost of health care expenses. Both methicillin sensitive and methicillin resistant strains of Staphylococcus aureus surgical site infections have been established as a major risk factor for postoperative surgical site infections. S. aureus colonizes the nose, axillae, and perineal region in up to 20%-30% of individuals. Although the literature has reported a higher prevalence of methicillin resistant S. aureus in the South Asian population, routine preoperative screening and prophylaxis have not yet been implemented. OBJECTIVE The primary objective of our study is to identify the relationship between preoperative colonization status of S. aureus and incidence of postoperative surgical site infections in patients undergoing following total hip and knee arthroplasties. As part of the secondary objectives of this study, we will also investigate patient characteristics acting as risk factors for S. aureus colonization as well as the outcomes of total hip and knee arthroplasty patients which are affected by surgical site infections. METHODS This prospective cohort study will comprise of screening all patients older than 18 years of age admitted to the Aga Khan University Hospital for a primary total hip or knee arthroplasty for preoperative colonization with S. aureus. The patients will be followed postoperatively for up to one year following the surgery to assess the incidence of surgical site infections. The study duration will be 2 years (March 2018 to March 2020). For the purpose of screening, pooled swabs will be taken from the nose, axillae, and groin of each patient and inoculated in a brain heart infusion, followed by subculture onto mannitol salt agar and sheep blood agar. For methicillin resistant S. aureus identification, a cefoxitin disk screen will be done. Data will be analyzed using SPSS v23 and both univariate and multivariate regression analysis will be conducted. RESULTS Data collection for this study will commence at the Aga Khan University Hospital, Pakistan during March 2018. CONCLUSIONS This study will not only estimate the true burden caused by S. aureus in the population under study but will also help identify the patients at a high risk of surgical site infections so that appropriate interventions, including prophylaxis with antibiotics such as muciprocin ointment or linezolid, can be made. Given the differences in lifestyle, quality, and affordability of health care and the geographical variation in patterns of antibiotic resistance, this study will contribute significantly to providing incentive for routine screening and prophylaxis for S. aureus including methicillin resistant S. aureus colonization in the South Asian population. REGISTERED REPORT IDENTIFIER RR1-10.2196/10219

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Syed Hamza Mufarrih ◽  
Nada Qaisar Qureshi ◽  
Arif Ali ◽  
Azeem Tariq Malik ◽  
Huda Naim ◽  
...  

2013 ◽  
Vol 33 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Mohammad Shakhawat Hossain ◽  
Kypros Kypri ◽  
Bayzidur Rahman ◽  
Abul Hasnat Milton

2005 ◽  
Vol 33 (8) ◽  
pp. 455-462 ◽  
Author(s):  
Frank Huenger ◽  
Adriane Schmachtenberg ◽  
Helga Haefner ◽  
Dirk Zolldann ◽  
Katharina Nowicki ◽  
...  

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Maha Siddiqui

Introduction: South Asians have a higher death rate than any other population for cardiovascular disease (CVD) and high blood pressure (HBP). San Joaquin has a growing rate of South Asians immigrants who may be at risk for CVD. Objectives: Trainees conducted hypertension and CVD screenings at South Asians religious organizations to reduce the risk of CVD and spread awareness about the factors that lead to CVD and its implications in the South Asians population due to environmental racism in the most underserved county for health care, San Joaquin. Methods: I trained low-income minority high school students to conduct weekly blood pressure screenings and serve as a health technology coach by each student monitoring 2 hypertensive patients of 48 hypertensive or at risk hypertensive and low-income San Joaquin residents and constantly stressed, and at risk for CVD. CVD screenings were conducted at all San Joaquin gurdwaras and mosques to spread awareness about heart health and track hypertension in the South Asians community. Findings: -61.7% of the South Asian population of San Joaquin are at risk for CVD -3.3% of the South Asian population of San Joaquin are hypotensive -28.6% of the South Asian population of San Joaquin are Stage 1 hypertensive -29.7% of the South Asian population of San Joaquin are Stage 2 hypertensive -38.3% of the South Asian population of San Joaquin have normal blood pressure but consume red meat more than 4 times a month Direct Outcomes of Events: -Development of self-advocacy in the South Asian community. Community members became activists for their own heart health. -Increased participation of youth, in an otherwise adult dominant environment (i.e. the mosques and gurdwaras). -Increased awareness of CVD, hypertension, hypotension, and periodontal disease (PD) among the South Asian community. -Increased participation by youth and adults on activities such as games, challenges and information booths dispensing awareness on CVD and PD. -Increased interaction between community members of different religions, creed, and socioeconomic backgrounds. -Awareness, education among the South Asian community for better heart and oral health -Diagnoses and referrals of suspected cases of hypertension and CVD -Improved patient-provider trust -San Joaquin high school students trained for community outreach events and determined to address CVD. -Youth learned the value of empathy, multiculturalism, and service to disadvantaged communities through the program and volunteering.


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