scholarly journals POP4Teens: Results of a randomized controlled trial to evaluate the effectiveness of a web-based program to prevent adolescent prescription opioid misuse (Preprint)

2020 ◽  
Author(s):  
Lisa A. Marsch ◽  
Sarah K. Moore ◽  
Michael Grabinski ◽  
Sarah E. Bessen ◽  
Jacob Borodovsky ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Perceived Risk ◽  
Risk Perceptions ◽  
Controlled Trial ◽  
The United States ◽  
Prescription Opioid ◽  
Dissemination And Implementation ◽  
Opioid Use ◽  
Web Based ◽  
Randomized Controlled

BACKGROUND Prescription opioid use is not uncommon among adolescents in the United States. Despite recent declines from unprecedented peaks in adolescent prescription opioid (PO) use, there is seemingly paradoxical evidence that prescription opioid-related consequences (e.g., opioid use disorder and overdoses) are increasing. These trends and their possible consequences emphasize the importance of prevention efforts targeting PO misuse. To our knowledge, we have developed the first interactive, web-based program focused specifically on prevention of PO misuse among adolescents. OBJECTIVE Evaluate the effectiveness of a web-based program designed to prevent adolescent prescription opioid (PO) misuse, Pop4Teens (P4T) compared to an active control website, Just Think Twice (JTT) on impacting PO-related attitudes, knowledge, risk perception and intentions to use. METHODS We conducted an online, randomized controlled trial in 2018. A total of 406 adolescents (aged 12-17) were randomly assigned to P4T or JTT. The outcome variables were attitudes, knowledge, and risk perceptions associated with PO misuse, intentions to use POs, and program feedback. Data were collected at baseline, 1-, 3-, and 6-months. RESULTS Both programs produced significant and sustained improvements on intentions to use POs, increased perceived risk, impacted expectancies consistent with prevention, and improved PO refusal skills. P4T produced significantly greater increases in PO-related knowledge compared to JTT and was reportedly easier to use and more liked. Baseline scores for youth reporting past-year medical use of POs, friends who engage in non-medical use of prescription opioids, and/or poor mental health underscored their at-risk status compared to youth who were not in those groups. CONCLUSIONS P4T positively impacted all study variables consistent with preventing PO misuse among teens. P4Ts online nature simplifies dissemination and implementation of this novel tool designed to help meet the challenges of the evolving national opioid crisis. CLINICALTRIAL ClinicalTrials.gov NCT02737696; https://clinicaltrials.gov/ct2/show/NCT02737696?term=marsch&rank=6

scholarly journals Evaluating the Effectiveness of a Web-Based Program (POP4Teens) to Prevent Prescription Opioid Misuse Among Adolescents: Randomized Controlled Trial

10.2196/18487 ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e18487
Author(s):  
Lisa A Marsch ◽  
Sarah K Moore ◽  
Michael Grabinski ◽  
Sarah Y Bessen ◽  
Jacob Borodovsky ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Perceived Risk ◽  
Risk Perceptions ◽  
Controlled Trial ◽  
The United States ◽  
Prescription Opioid ◽  
Dissemination And Implementation ◽  
Opioid Use ◽  
Web Based ◽  
Randomized Controlled

Background Prescription opioid (PO) use is common among adolescents in the United States. Despite recent declines from unprecedented peaks in adolescent PO use (eg, in 2012-2013), there is seemingly paradoxical evidence that PO-related consequences (eg, opioid use disorder and overdoses) are increasing. These trends and their possible consequences emphasize the importance of prevention efforts targeting PO misuse. To our knowledge, we have developed the first interactive web-based program (POP4Teens [P4T]) focused specifically on the prevention of PO misuse among adolescents. Objective This study aimed to evaluate the effectiveness of P4T, a web-based program designed to prevent adolescent PO misuse, in comparison with JustThinkTwice (JTT), an active control website, on PO-related attitudes, knowledge, risk perception, and intentions to use. Methods We conducted a web-based randomized controlled trial in 2018. A total of 406 adolescents (aged 12-17 years) were randomly assigned to either P4T or JTT. The outcome variables were attitudes, knowledge, and risk perceptions associated with PO misuse, intentions to use POs, and program feedback. Data were collected at baseline and at 1, 3, and 6 months. Results Both programs resulted in significant and sustained improvements in intention to use POs, increased perceived risk, impacted expectancies consistent with prevention, and improved PO refusal skills. P4T produced significantly greater increases in PO-related knowledge than JTT did, and it was reportedly easier to use and more liked. Baseline scores for youth reporting past-year medical use of POs, friends who engage in nonmedical use of POs, and/or poor mental health underscored their at-risk status compared with youth from the other groups. Conclusions P4T positively impacted all study variables that are known to prevent PO misuse among teens. Moreover, its web-based nature simplifies the dissemination and implementation of this novel tool designed to help meet the challenges of the evolving national opioid crisis. Trial Registration ClinicalTrials.gov NCT02737696; https://clinicaltrials.gov/ct2/show/NCT02737696

scholarly journals Protocol for a Randomized Controlled Trial of a Web-Based HPV Vaccination Intervention for Young Gay, Bisexual, and Other Men Who Have Sex with Men (Preprint)

2019 ◽  
Author(s):  
Paul L. Reiter ◽  
Amy L. Gower ◽  
Dale E. Kiss ◽  
Molly A. Malone ◽  
Mira L. Katz ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Hpv Vaccine ◽  
Controlled Trial ◽  
Hpv Vaccination ◽  
Text Message ◽  
The United States ◽  
Hpv Infection ◽  
Web Based ◽  
Randomized Controlled ◽  
Sex With Men

BACKGROUND Gay, bisexual, and other men who have sex with men experience several disparities related to human papillomavirus (HPV) infection, including high incidence rates of anal cancer. HPV vaccine is currently recommended for young adults, yet HPV vaccine coverage is low among young gay, bisexual, and other men who have sex with men (YGBMSM). OBJECTIVE We describe the design and methods for a randomized controlled trial (RCT) to rigorously evaluate Outsmart HPV, a population-targeted, individually-tailored web-based HPV vaccination intervention for YGBMSM. The RCT is designed to determine the efficacy of the intervention, the mechanism by which the intervention has an effect (i.e., mediation), and whether efficacy varies by participant characteristics (i.e., moderation). METHODS Outsmart HPV was previously developed and pilot-tested. The current study is a three-arm prospective RCT that will enroll a projected 1995 YGBMSM who are ages 18-25, live in the United States, and have not received any doses of HPV vaccine. Participants will be recruited via paid advertisements on social media sites and randomized to receive either: (a) standard information online about HPV vaccine (control group); (b) Outsmart HPV content online with monthly unidirectional vaccination reminders sent via text message; or (c) Outsmart HPV content online with monthly interactive vaccination reminders sent via text message. Participants will complete online surveys at four time points during the study: baseline; immediately after engaging with online content; three months after randomization; and nine months after randomization. Primary outcomes will include both HPV vaccine initiation (i.e., receipt of one or more doses of HPV vaccine) and completion (receipt of all three doses recommended for this age range). We will examine constructs from the intervention’s theoretical framework as potential mediators, and we will examine demographic and health-related characteristics as potential moderators of intervention effects. RESULTS The Institutional Review Board at The Ohio State University has approved the study. Materials have been developed and finalized for all study groups. Recruitment for the RCT is scheduled to begin in Fall 2019. CONCLUSIONS If shown to be efficacious, Outsmart HPV has the potential to fill an important gap by promoting HPV vaccination among a population at increased risk of HPV infection and HPV-related disease. CLINICALTRIAL The trial is registered at ClinicalTrials.gov: NCT04032106 (available at: https://clinicaltrials.gov/ct2/show/NCT04032106).

scholarly journals Initial Impact of Tailored Web-Based Messages About Cigarette Smoke and Breast Cancer Risk on Boys’ and Girls’ Risk Perceptions and Information Seeking: Randomized Controlled Trial

2013 ◽  
Vol 2 (2) ◽  
pp. e53 ◽  
Author(s):  
Chris G Richardson ◽  
Laura L Struik ◽  
Kenneth C Johnson ◽  
Pamela A Ratner ◽  
Carolyn Gotay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cigarette Smoke ◽  
Information Seeking ◽  
Risk Perceptions ◽  
Controlled Trial ◽  
Web Based ◽  
Randomized Controlled

scholarly journals Effect of Web-Based Messages on Girls’ Knowledge and Risk Perceptions Related to Cigarette Smoke and Breast Cancer: 6-Month Follow-Up of a Randomized Controlled Trial

2014 ◽  
Vol 3 (3) ◽  
pp. e53 ◽  
Author(s):  
Jennifer Schwartz ◽  
Joan L Bottorff ◽  
Pamela A Ratner ◽  
Carolyn Gotay ◽  
Kenneth C Johnson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Cigarette Smoke ◽  
Risk Perceptions ◽  
Controlled Trial ◽  
Web Based ◽  
Randomized Controlled

The Use of Web-Based Support Groups versus Usual Quit-Smoking Care for Men and Women 21–59 Years Old: A Protocol for a Randomized Controlled Trial

2019 ◽  
Author(s):  
Cornelia Pechmann ◽  
Douglas Calder ◽  
Connor Phillips ◽  
Kevin Delucchi ◽  
Judith J. Prochaska
Keyword(s):  
Randomized Controlled Trial ◽  
Support Groups ◽  
Controlled Trial ◽  
Web Based ◽  
Men And Women ◽  
Randomized Controlled ◽  
Quit Smoking

Effectiveness of a web-based medication adherence tool with patient centered communication: Results of a clustered randomized controlled trial (Preprint)

2019 ◽  
Author(s):  
Jan van Lieshout ◽  
Joyca Lacroix ◽  
Aart van Halteren ◽  
Martina Teichert
Keyword(s):  
Randomized Controlled Trial ◽  
Medication Adherence ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Community Pharmacies ◽  
Web Based ◽  
Randomized Controlled ◽  
Tailored Interventions ◽  
Increased Risk

BACKGROUND Growing numbers of people use medication for chronic conditions; non-adherence is common, leading to poor disease control. A newly developed web-based tool to identify an increased risk for non-adherence with related potential individual barriers might facilitate tailored interventions and improve adherence. OBJECTIVE To assess the effectiveness of the newly developed tool to improve medication adherence. METHODS A cluster randomized controlled trial assessed the effectiveness of this adherence tool in patients initiating cardiovascular or oral blood glucose lowering medication. Participants were included in community pharmacies. They completed an online questionnaire comprising an assessments of their risk for medication non-adherence and subsequently of barriers to adherence. In pharmacies belonging to the intervention group, individual barriers displayed in a graphical profile on a tablet were discussed by pharmacists and patients at high non-adherence risk in face to face meetings and shared with their general practitioners and practice nurses. Tailored interventions were initiated by the healthcare providers. Barriers of control patients were not presented or discussed and these patients received usual care. The primary outcome was the difference in medication adherence at 8 months follow-up between patients with an increased non-adherence risk from intervention and control group, calculated from dispensing data. RESULTS Data from 492 participants in 15 community pharmacies were available for analyses (intervention 253, 7 pharmacies; control 239, 8 pharmacies). The intervention had no effect on medication adherence (-0.01; 95%CI -0.59 – 0.57; P= .96), neither in the post hoc per protocol analysis (0.19; 95%CI -0.50 – 0.89; P=.58). CONCLUSIONS This study showed no effectiveness of a risk stratification and tailored intervention addressing personal barriers for medication adherence. Various potential explanations for lack of effect were identified. These explanations relate for instance to high medication adherence in the control group, study power and fidelity. Process evaluation should elicit possible improvements and inform the redesign of intervention and implementation. CLINICALTRIAL The Netherlands National Trial Register: NTR5186. Date: May 18, 2015 (http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5186)

Effectiveness of a web-based acceptance and commitment therapy program for adolescent career preparation: A randomized controlled trial

2021 ◽  
Vol 127 ◽  
pp. 103578
Author(s):  
Noona Kiuru ◽  
Anne Puolakanaho ◽  
Päivi Lappalainen ◽  
Katariina Keinonen ◽  
Saija Mauno ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Acceptance And Commitment Therapy ◽  
Controlled Trial ◽  
Career Preparation ◽  
Web Based ◽  
Randomized Controlled ◽  
Therapy Program ◽  
Commitment Therapy ◽  
Acceptance And Commitment

Improved Cancer Coping from a Web‐based Intervention for Prostate Cancer Survivors: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Erin K. Tagai ◽  
Suzanne M. Miller ◽  
Shawna V. Hudson ◽  
Michael A. Diefenbach ◽  
Elizabeth Handorf ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomized Controlled Trial ◽  
Cancer Survivors ◽  
Controlled Trial ◽  
Web Based ◽  
Prostate Cancer Survivors ◽  
Randomized Controlled ◽  
Cancer Coping
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