scholarly journals Acute Shortage Ventilator (Preprint)

2020 ◽  
Author(s):  
SLAC Stanford ◽  
Andrew Ames ◽  
Martin Breidenbach ◽  
Michael Bressack ◽  
Pieter A Breur ◽  
...  
Keyword(s):  
High Performance ◽  
Low Cost ◽  
Unit Cost ◽  
Artificial Lung ◽  
Control Mode ◽  
Short Term ◽  
Patient Circuit ◽  
Near Future ◽  
Volume Controlled ◽  
Pressure Controlled

UNSTRUCTURED We have implemented an Acute Shortage Ventilator (ASV) motivated by the COVID-19 pandemic and the possibility of severe ventilator shortages in the near future. The unit cost per ventilator is less than $400 US excluding the patient circuit parts. The ASV mechanically compresses a self-inflating bag resuscitator, uses a modified patient circuit, and is commanded by a microcontroller and an optional laptop. It operates in both Volume-Controlled Assist-Control mode and a Pressure-Controlled Assist-Control mode. It has been tested using an artificial lung against the EURS guidelines. The key design goals were to develop a simple device with high performance for short-term use, made primarily from common hospital parts and generally-available non-medical components, and at low cost and ease in manufacturing.

scholarly journals Acute Shortage Ventilator

2020 ◽  
Author(s):  
D. S. Akerib ◽  
A. Ames ◽  
M. Breidenbach ◽  
M. Bressack ◽  
P. A. Breur ◽  
...  
Keyword(s):  
High Performance ◽  
Low Cost ◽  
Unit Cost ◽  
Artificial Lung ◽  
Control Mode ◽  
Short Term ◽  
Patient Circuit ◽  
Near Future ◽  
Volume Controlled ◽  
Pressure Controlled

AbstractWe have implemented an “Acute Shortage Ventilator” (ASV) motivated by the COVID-19 pandemic and the possibility of severe ventilator shortages in the near future. The unit cost per ventilator is less than $400 US excluding the patient circuit parts. The ASV mechanically compresses a self-inflating bag resuscitator, uses a modified patient circuit, and is commanded by a microcontroller and an optional laptop. It operates in both Volume-Controlled Assist-Control mode and a Pressure-Controlled Assist-Control mode. It has been tested using an artificial lung against the EURS guidelines. The key design goals were to develop a simple device with high performance for short-term use, made primarily from common hospital parts and generally-available non-medical components, and at low cost and ease in manufacturing.

scholarly journals High Definition Map-Based Localization Using ADAS Environment Sensors for Application to Automated Driving Vehicles

2020 ◽  
Vol 10 (14) ◽  
pp. 4924
Author(s):  
Donghoon Shin ◽  
Kang-moon Park ◽  
Manbok Park
Keyword(s):  
High Performance ◽  
Low Cost ◽  
Autonomous Driving ◽  
Feature Representation ◽  
Map Matching ◽  
Localization Algorithm ◽  
Automated Driving ◽  
High Definition ◽  
Vehicle Position ◽  
Near Future

This paper presents high definition (HD) map-based localization using advanced driver assistance system (ADAS) environment sensors for application to automated driving vehicles. A variety of autonomous driving technologies are being developed using expensive and high-performance sensors, but limitations exist due to several practical issues. In respect of the application of autonomous driving cars in the near future, it is necessary to ensure autonomous driving performance by effectively utilizing sensors that are already installed for ADAS purposes. Additionally, the most common localization algorithm, which is usually used lane information only, has a highly unstable disadvantage in the absence of that information. Therefore, it is essential to ensure localization performance with other road features such as guardrails when there are no lane markings. In this study, we would like to propose a localization algorithm that could be implemented in the near future by using low-cost sensors and HD maps. The proposed localization algorithm consists of several sections: environment feature representation with low-cost sensors, digital map analysis and application, position correction based on map-matching, designated validation gates, and extended Kalman filter (EKF)-based localization filtering and fusion. Lane information is detected by monocular vision in front of the vehicle. A guardrail is perceived by radar by distinguishing low-speed object measurements and by accumulating several steps to extract wall features. These lane and guardrail information are able to correct the host vehicle position by using the iterative closest point (ICP) algorithm. The rigid transformation between the digital high definition map (HD map) and environment features is calculated through ICP matching. Each corrected vehicle position by map-matching is selected and merged based on EKF with double updating. The proposed algorithm was verified through simulation based on actual driving log data.

scholarly journals Effects of Magnetic Fields on the Properties of Water Treatedt by Reversed Osmosis

2019 ◽  
Author(s):  
Mahdi O. Karkush ◽  
Mahmoud D. Ahmed ◽  
Salim M. Al-Ani
Keyword(s):  
Electrical Properties ◽  
Magnetic Fields ◽  
Reverse Osmosis ◽  
High Performance ◽  
Tap Water ◽  
Low Cost ◽  
Negative Ions ◽  
Near Future ◽  
Magnetic Water ◽  
Properties Of Soil

The current study focused on reviewing the rapid growing of using magnetic water in different fields of science and measure the influence of several intensities of magnetization on the chemical and electrical properties of tap water treated by reverse osmosis. The work includes circulation of water for 24 h. in magnetic fields of intensity 500, 1000, 1500, and 2000 G. The magnetization of water causes increasing some positive and negative ions in water such as (Mg, K, Na, Cl¯, Alkaline and SiO2) and decreasing some positive and negative ions (Ca and SO3). In the near future, the application of concepts of sustainability development in civil engineering have the to produce structures in harmony with these concepts through using of high-performance materials with less impacts on the environmental and have low cost. The main application of using magnetic water is improvement the geotechnical properties of soil through precipitation of calcite which increases the bond between soil particles and then strength of soil.

scholarly journals Fabrication of 6DOF Hexflex Positioner with Integrated Strain Sensing Using Non-Lithographically-Based Microfabrication

2020 ◽  
Author(s):  
Robert M. Panas ◽  
Martin Culpepper
Keyword(s):  
Capital Investment ◽  
High Performance ◽  
Dynamic Range ◽  
Low Cost ◽  
Unit Cost ◽  
Fabrication Process ◽  
Strain Sensing ◽  
Performance Limits ◽  
Average Unit ◽  
The Cost

Abstract A process flow is described for the low cost, flexible fabrication of metal MEMS with high performance integrated sensing. The process is capable of producing new designs in ≈ 1 week at an average unit cost of <$1k/device even at batch sizes of ≈ 1-10, with expected sensing performance limits of about 135dB over a 10khz sensor bandwidth. This is a ≈20x reduction in cost, ≈25x reduction in time, and potentially >30x increase in sensing dynamic range over comparable state-of-the-art compliant nanopositioners. The Non-Lithographically Based Microfabriction (NLBM) process is uniquely suited to create high performance nanopositioning architectures which are customizable to the positioning requirements of a range of nanoscale applications. These can significantly reduce the cost of nanomanufacturing research and development, as well as accelerate the development of new processes and the testing of fabrication process chains without excess capital investment. A 6-DOF flexural nanopositioner with integrated sensing for all 6-DOF was fabricated using the newly developed process chain. The fabrication process was measured to have ≈30µm alignment. Sensor arm, flexure, and trace widths of 150µm, 150µm and 800µm, respectively, were demonstrated. Process capabilities suggest lower bounds of 25 µm, 50µm and 100µm, respectively. Dynamic range sensing of 52dB was demonstrated for the nanopositioner over a 10kHz sensor bandwidth. Improvements are proposed to approach sensor performance of 132dB over a 10kHz sensor bandwidth.

Short-Term Effects of Pressure Controlled Versus Volume Controlled Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis

2021 ◽  
Vol 66 (10) ◽  
pp. 1593-1600
Author(s):  
Grazia Crescimanno ◽  
Francesca Greco ◽  
Manuela Bertini ◽  
Salvo Arrisicato ◽  
Oreste Marrone
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Noninvasive Ventilation ◽  
Short Term ◽  
Volume Controlled ◽  
Pressure Controlled ◽  
Lateral Sclerosis ◽  
Short Term Effects

Comparison of UV- and Derivative-Spectrophotometric and HPTLC UVDensitometric Methods for the Determination of Amrinone and Milrinone in Bulk Drugs

2020 ◽  
Vol 16 (3) ◽  
pp. 246-253
Author(s):  
Marcin Gackowski ◽  
Marcin Koba ◽  
Stefan Kruszewski
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Low Cost ◽  
Uv Spectra ◽  
Derivative Spectrophotometry ◽  
Therapeutic Monitoring ◽  
Bulk Drug ◽  
Layer Chromatography ◽  
Standard Solutions

Background: Spectrophotometry and thin layer chromatography have been commonly applied in pharmaceutical analysis for many years due to low cost, simplicity and short time of execution. Moreover, the latest modifications including automation of those methods have made them very effective and easy to perform, therefore, the new UV- and derivative spectrophotometry as well as high performance thin layer chromatography UV-densitometric (HPTLC) methods for the routine estimation of amrinone and milrinone in pharmaceutical formulation have been developed and compared in this work since European Pharmacopoeia 9.0 has yet incorporated in an analytical monograph a method for quantification of those compounds. Methods: For the first method the best conditions for quantification were achieved by measuring the lengths between two extrema (peak-to-peak amplitudes) 252 and 277 nm in UV spectra of standard solutions of amrinone and a signal at 288 nm of the first derivative spectra of standard solutions of milrinone. The linearity between D252-277 signal and concentration of amironone and 1D288 signal of milrinone in the same range of 5.0-25.0 μg ml/ml in DMSO:methanol (1:3 v/v) solutions presents the square correlation coefficient (r2) of 0,9997 and 0.9991, respectively. The second method was founded on HPTLC on silica plates, 1,4-dioxane:hexane (100:1.5) as a mobile phase and densitometric scanning at 252 nm for amrinone and at 271 nm for milrinone. Results: The assays were linear over the concentration range of 0,25-5.0 μg per spot (r2=0,9959) and 0,25-10.0 μg per spot (r2=0,9970) for amrinone and milrinone, respectively. The mean recoveries percentage were 99.81 and 100,34 for amrinone as well as 99,58 and 99.46 for milrinone, obtained with spectrophotometry and HPTLC, respectively. Conclusion: The comparison between two elaborated methods leads to the conclusion that UV and derivative spectrophotometry is more precise and gives better recovery, and that is why it should be applied for routine estimation of amrinone and milrinone in bulk drug, pharmaceutical forms and for therapeutic monitoring of the drug.

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