Tracking Lower Urinary Tract Symptoms and Tamsulosin Side Effects Among Older Men using the PERSONAL app: Feasibility and Usability Study (Preprint)

2021 ◽  
Author(s):  
Austin W Lee ◽  
Stacey A Kenfield ◽  
Elizabeth Y Wang ◽  
Anthony Enriquez ◽  
Akinyemi Oni-Orisan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Lower Urinary Tract ◽  
Older Men ◽  
Mobile App ◽  
Urinary Tract Symptoms ◽  
Secondary Outcomes ◽  
Lower Urinary

BACKGROUND Continuous alpha 1a-blockade is first-line management for lower urinary tract symptoms (LUTS) amongst older men with suspected benign prostatic hyperplasia (BPH). Variable efficacy and safety for individual men necessitate a more personalized, data-driven approach to prescribing and deprescribing tamsulosin for LUTS in older men. OBJECTIVE We aimed to evaluate the feasibility and usability of using the PERSONAL (PlacEbo-controlled, Randomized, patient-Selected Outcomes, N-of-1 triALs) mobile app for tracking daily LUTS severity and medication side effects among older men receiving chronic tamsulosin therapy. METHODS We recruited patients from the University of California, San Francisco healthcare system to participate in a two-week pilot study. The primary objectives were to assess recruitment feasibility, study completion rates, frequency of symptom tracking, duration of tracking sessions, and app usability rankings measured using a follow-up survey. As secondary outcomes, we evaluated whether daily symptom tracking led to changes in LUTS severity, perceptions of tamsulosin, overall quality of life, and medication adherence between baseline and follow-up surveys as well as perceived app utility. RESULTS We enrolled 19 men within 23 days and 100% of participants completed the study. Each participant selected a unique combination of symptoms to track and recorded data in the PERSONAL app a median of 11 out of 14 days (79% daily completion rate). Median app session duration was 44 seconds (IQR: 33). On a scale of 1 (“Strongly Disagree”) to 5 (“Strongly Agree”), participants reported that the PERSONAL app was easy to use (mean=4.3, standard deviation [SD]=1.0), others could learn to use it quickly (mean=4.2, SD=0.9), and they felt confident using the app (mean=4.4, SD=0.8). LUTS severity, quality of life, and medication adherence remained unchanged after the 2-week study period. Fewer men were satisfied with tamsulosin after using the app (14/19 participants versus 17/19 participants at baseline), although perceived benefit from tamsulosin remained unchanged (95% at baseline and at follow-up). 58% of men agreed that the PERSONAL app can help people like them manage their urinary symptoms. CONCLUSIONS This pilot study demonstrated high feasibility and usability of the PERSONAL mobile app to track patient-selected urinary symptoms and tamsulosin side effects among older men taking tamsulosin for LUTS. We observed no adverse consequences of daily symptom monitoring on our secondary outcomes. This proof-of-concept study establishes a framework for future mobile app studies, such as digital N-of-1 trials, to collect comprehensive individual-level data for personalized LUTS management in older men.

scholarly journals To Compare the Efficacy of Tamsulosin, Solifenacin and Combination of Both in the Treatment of Double-J Stent Related Irritative Lower Urinary Tract Symptoms and Low Back Pain

2020 ◽  
Vol 23 (1) ◽  
pp. 48-51
Author(s):  
AHM Imrul Tareq ◽  
Md Sayedul Islam
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Lower Urinary Tract ◽  
Low Back ◽  
Double J Stent ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Background: Stent-associated symptoms can have a significant impact on patient quality of life. Hematuria, urgency, frequency, dysuria, and both bladder and flank pain are the most prevalent symptoms related to indwelling ureteral stents. Among them irritative lower urinary tract symptoms and low back pain are more frequent. Despite the stent related symptoms, because of its importance stent is being kept in situ with varieties of medication. Several alpha-adrenergic blocker and antimuscarinic drugs are used to relief these symptoms like Tamsulosin, Solifenacin, Alphazosin etc. Both Tamsulosin and Solifenacin are not costly as use daily single dose. So combination of Tamsulosin and Solifenacin may act as a reliever of stent related symptoms and also cost effective. Methods and materials: For this purpose, a total of 126 patients having unilateral double-J ureteral stent for 7 days with stent related irritative LUTS and low back pain were included in this study. This hospital based prospective randomized clinical trial was carried out in Urology department of Bangabandhu Sheikh Mujib Medical University, Dhaka, during January 2014 to June 2015, to compare the irritative IPSS, improvement of quality of life score component of IPSS ,the low back pain score for double-J ureteral stent using Tamsulosin, Solifenacin and combination of both (Tamsulosin and Solifenacin) Results: Regarding the irritative sub group of International Prostate Symptom Score (IPSS) was observed during 2nd and 4th weeks follow up IPSS was significantly (p<0.05) higher in solifenacin and Tamsulosin group with compared to Tamsulosin+Solifenacin group. During 4th weeks follow up the mean quality of life (QOL) score was significantly (p<0.05) higher in solifenacin group and Tamsulosin group with compared to Tamsulosin+Solifenacin group.During 2nd weeks and 4th weeks follow up visual Analogue Pain Scale (VAPS) was significantly (p<0.05) higher in solifenacin group followed by Tamsulosin group and Tamsulosin+Solifenacin group. Conclusion: Combined use of Tamsulosin and Solifenacin is more effective than use of single drug (either Tamsulosin or Solifenacin) in the treatment of ureteral double-J stent related irritative LUTS and low back pain. Bangladesh Journal of Urology, Vol. 23, No. 1, January 2020 p.48-51

1276: Lower Urinary Tract Symptoms: Local Ischemia Assessed by Sonographic Findings and Correlated to Impaired Quality of Life

2006 ◽  
Vol 175 (4S) ◽  
pp. 410-411
Author(s):  
Germar M. Pinggera ◽  
Michael Mitterberger ◽  
Leo Pallwein ◽  
Peter Rehder ◽  
Ferdinand Frauscher ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Local Ischemia ◽  
Urinary Tract Symptoms ◽  
Impaired Quality ◽  
Lower Urinary

scholarly journals Predictors of urogenital distress and impaired quality of life in adult Egyptians with lower urinary tract symptoms

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Isaac Samir Wasfy ◽  
Enayat Mohamed Soltan ◽  
Hassan A. Abdelwahab ◽  
Hend Mikhail Salama
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Emotional Health ◽  
Stress Symptoms ◽  
Urinary Tract Symptoms ◽  
Impaired Quality ◽  
Lower Urinary

Abstract Background This study aims to assess the severity of lower urinary tract symptoms, and to assess predictors of impaired quality of life among Egyptian adults complain of lower urinary tract symptoms. Methods An observational cross-sectional research was done using an online anonymous poll survey. The survey was implemented through sharing on different social media applications. The survey was posted from June 1, 2020, to June 10, 2020. The overall communities of the Egyptian adults who satisfied the incorporation rules and consented to take an interest in the research were incorporated using convenience and snowball collecting methods (188 adults). A semi-structured questionnaire on socio-demographic characteristics and Arabic Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) short forms were used. Results Approximately 220 Egyptian adults shared in the research but only 188 fulfilled inclusion and exclusion criteria. Approximately 92% of them had at least one symptom of lower urinary tract manifestations. Irritative symptoms presented in 65 (85.5%) of males and 102 (91.1%) of females. Stress symptoms presented in 44 (57.9%) of males and 63 (56.2%) of females with higher statistically significant mean of stress symptoms. Obstruction/discomfort symptoms presented in 51 (67.1%) of males, and 77 (68.8%) of females. Seeking help and duration of the urological problem were statistically significant independent positive predictors of UDI-6-total. The Irritative score, obstruction/discomfort score, and duration of the urological problem were statistically significant independent positive predictors of IIQ-7-total. Conclusions Urological problems are common and have an impact on the quality of life in various domains of physical activity, social relationships, travel, and emotional health.

scholarly journals The impact of adding solifenacin to tamsulosin therapy for treatment of storage lower urinary tract symptoms owing to benign prostatic hyperplasia

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Mohamed Elbadry ◽  
Ahmed Issam Ali ◽  
Eman Saleh ◽  
Amal Kamal ◽  
Ahmed H. Gabr
Keyword(s):  
Quality Of Life ◽  
Lower Urinary Tract ◽  
Group Versus ◽  
Prostatic Hyperplasia ◽  
Combination Group ◽  
Urinary Tract Symptoms ◽  
Bladder Symptoms ◽  
Group 1 ◽  
Lower Urinary

Abstract Background Benign prostatic hyperplasia (BPH) is a common problem in aging males which has a potential impact on patients’ health-related quality of life. In the present prospective study, we evaluated the effect of adding solifenacin to tamsulosin, compared to tamsulosin alone on overactive bladder symptoms scores (OABSS) and patients’ quality of life (QoL) in patients with filling lower urinary tract symptoms due to BPH. Methods Patients included in our study were randomly assigned into 2 groups: group 1 included patients with BPH who received tamsulosin alone and group 2 included patients with BPH who received a combination of tamsulosin and sofinacin. Treatment period was 12 weeks in both groups. Quality of life and overactive bladder symptoms score questionnaires were obtained and compared in both groups before and after treatment. Results No significant differences were found between both groups before treatment. At the end of treatment period, The QoL score for Group 1 patients was significantly greater than the other group (mean rank was 138.98 in tamsulosin group versus 62.02 in the combination group, P-value < 0.01). Similarly, OABSS for tamsulosin only group was significantly higher than combined treatment patients (mean rank was 145.03 in tamsulin group versus 55.98 in the combination group, P-value < 0.01). Conclusion Adding solifenacin to tamsulosin was associated with an improvement of QoL and OABSS in patients with irritative urinary symptoms due to BPH when compared with tamsulosin monotherapy.

scholarly journals Impact of surgical treatment of benign prostate hyperplasia on lower urinary tract symptoms and quality of life

2019 ◽  
Vol 76 (1) ◽  
pp. 30-35
Author(s):  
Uros Babic ◽  
Ivan Soldatovic ◽  
Ivan Vukovic ◽  
Svetomir Dragicevic ◽  
Dejan Djordjevic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Surgical Treatment ◽  
Operative Treatment ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Prostate Hyperplasia ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Background/Aim. Benign prostatic hyperplasia (BPH) is a pathological process, which is one of the most common causes of so-called lower urinary tract symptoms (LUTS). LUTS affect many aspects of daily activities and almost all domains of health-related quality of life (HRQoL). The objective of this study was to evaluate the effects of operative treatment of BPH using standard clinical diagnostic procedures and effects on LUTS using the symptom-score validated to Serbian language as well as implications on HRQoL. Methods. Seventy-four patients underwent surgical treatment for BPH. The study protocol included objective and subjective parameters of the following sets of variables measured before and after the surgery: voiding and incontinence symptoms were measured using the International Continence Society male Short Form (ICS male SF) questionnaire, HRQoL was measured using the SF-36 questionnaire along with standard clinical measurement of residual urine and urine flow. Results. After the surgery, all patients had decrease of voiding scores (13.5 ? 3.3 before and 1.5 ? 1.4 after surgery) and incontinence symptoms (5.7 ? 3.9 before and 0.6 ? 0.8 after surgery) in comparison to period before operative treatment. Significant improvements in all dimensions of HRQoL were noticed, particularly in emotional health. Although mental and physical total scores were significantly better than prior to the surgery, the level of improvement of voiding and incontinence scores were significantly correlated only with the level of improvement of mental score. Conclusion. After BPH surgery, patients are likely to have normal voiding symptoms, barely some involuntary control over urination and overll better HRQoL, particularly in emotional domain.

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