Osseous Change Adjacent to Soft-Tissue Hemangiomas of the Extremities:Correlation with Lesion Size and Proximity to Bone

2003 ◽  
Vol 180 (6) ◽  
pp. 1695-1700 ◽  
Author(s):  
Justin Q. Ly ◽  
Timothy G. Sanders ◽  
John P. Mulloy ◽  
Gregory M. Soares ◽  
Douglas P. Beall ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Lesion Size ◽  
Osseous Change

scholarly journals Assessment of Referrals into the Soft Tissue Sarcoma Service: Evaluation of Imaging Early in the Pathway Process

Sarcoma ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Emma Rowbotham ◽  
Shaheel Bhuva ◽  
Harun Gupta ◽  
Philip Robinson
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Service Evaluation ◽  
Lesion Size ◽  
Imaging Diagnosis ◽  
Local Hospital ◽  
Patient Demographics ◽  
Tertiary Centre ◽  
Soft Tissue Masses ◽  
Malignant Lesions

Purpose. To prospectively evaluate regional referrals into a soft tissue sarcoma service from outside the tertiary centre with local hospital imaging.Materials and Methods. Consecutive referrals were prospectively assessed for: patient demographics, source, referral date, date received by Multidisciplinary Team (MDT), lesion size, local radiology, MDT radiology and final diagnoses. Radiology diagnosis was categorised benign, indeterminate or malignant by consensus. Delays were defined as >10 days.Results. 112 patients were included with high correlation between local and MDT radiology categrorisation and histology (P=0.54andP=0.49, resp.). There was only a trend for MDT radiology diagnosis to downgrade local imaging diagnosis (n=15,P>0.05). 48 cases (43%) had ultrasound and MRI at referral and 20 (18%) ultrasound only. 85% of cases were benign (lipoma most common), 15% malignant (sarcoma most common). Delay occurred in 34% of cases.Discussion. In comparison to previous series these results show a reduction in benign lesions, increased biopsy and malignancy rate for lesions referred to a tertiary centre when imaging is performed and reviewed by local radiologists.Advances in Knowledge. Imaging triage of soft tissue masses can decrease benign referral rates and increase the proportion of indeterminate and malignant lesions referred to specialist centres.

scholarly journals Apatinib with doxorubicin and ifosfamide as neoadjuvant therapy for high-risk soft tissue sarcomas: a retrospective cohort study

2021 ◽  
Author(s):  
Zhichao Tian ◽  
Jiaqiang Wang ◽  
Jinpo Yang ◽  
Peng Zhang ◽  
Xin Wang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Neoadjuvant Therapy ◽  
Objective Response ◽  
Soft Tissue Sarcomas ◽  
Disease Free Survival ◽  
Lesion Size ◽  
Target Lesion ◽  
Free Survival ◽  
Treatment Groups

Summary Background There is a need to establish an effective neoadjuvant therapy for soft tissue sarcomas (STSs). We previously showed that apatinib, administered in combination with doxorubicin-based chemotherapy, improves the efficacy of treatment. This study aimed to clarify the effectiveness and safety of apatinib combined with doxorubicin and ifosfamide (AI) neoadjuvant chemotherapy for STSs. Methods This retrospective study included patients with STS who received neoadjuvant therapy and surgery between January 2016 and January 2019. The patients were divided into two treatment groups: AI + apatinib group and AI group (doxorubicin + ifosfamide). Results The study included 74 patients (AI + apatinib: 26, AI: 48) with STS. There were significant between-group differences in objective response rates (53.85% vs. 29.17%, p = 0.047) and the average change in target lesion size from baseline (-40.46 ± 40.30 vs. -16.31 ± 34.32, p = 0.008). The R0 rate (84.62% vs. 68.75%; p = 0.170) and 2-year disease-free survival (73.08% vs. 62.50%, p = 0.343) were similar across groups. Finally, the rates of neoadjuvant therapy-related adverse effects and postoperative complications were similar in both groups (p > 0.05). Conclusion Apatinib plus doxorubicin and ifosfamide regimen is safe and effective as neoadjuvant therapy for patients with STS. However, the significantly improved preoperative ORR observed after neoadjuvant therapy did not translate into a significantly improved R0 rate and 2-year DFS. Prospective, well-powered studies are warranted to determine the long-term efficacy and optimal application of these protocols.

scholarly journals Intraosseous Ganglia: A Series of 17 Treated Cases

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Akio Sakamoto ◽  
Yoshinao Oda ◽  
Yukihide Iwamoto
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Clinical Information ◽  
Lesion Size ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Bone Lesions ◽  
Aged Patients ◽  
Plain Radiographs ◽  
Intraosseous Ganglion

Background. Intraosseous ganglion is a cystic lesion that contains gelatinous material, most often occurs in middle-aged patients, and is regarded as similar to soft-tissue ganglion. The etiology is unknown, but association with degenerative joint disease has been considered.Materials and Methods. At a single institute, 17 patients (8 men, 9 women) with a mean age of 48.9 years (22–72 years) were surgically treated for an intraosseous ganglion. The lesions were located in 9 long bones (5 tibiae, 2 humeri, 1 ulna, and 1 femur); 4 flat bones (2 scapulae, 2 ilia); and 4 small bones (2 scaphoid, 1 metacarpal bone, and 1 talus). The diagnosis was confirmed based both on the gross intraoperative finding of intralesional gelatinous material and on histopathology.Results. All lesions occurred at the epiphysis or near the joint. The plain radiographs showed a lesion with marginal osteosclerosis. The average lesion size was 22.4 mm (range 6–40 mm). Among the 17 patients, 2 (12%) had osteoarthritis, 3 (18%) had pathological fracture, and 4 (24%) had extraskeletal extension.Discussion and Conclusion. The periosteum and cortex of bone represent physical barriers. Therefore, it seems much more likely that primary bone lesions will spread to the soft tissues. Intraosseous ganglion does not appear to be associated with either soft-tissue ganglion or with osteoarthritis. This clinical information and the appearance on plain radiographs, particularly the marginal osteosclerosis, are of differential diagnostic importance.

scholarly journals A Pilot Evaluation of Magnetic Resonance Imaging Characteristics Seen With Primary Soft Tissue Giant Cell Tumor in 2 patients

2019 ◽  
Author(s):  
Lina Zhang ◽  
Jianyun Kang ◽  
Kai Zhang ◽  
Ailian Liu ◽  
Huali Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lesion Size ◽  
Cell Tumor ◽  
Resonance Imaging ◽  
Adc Value ◽  
Dce Mri

Abstract Background Primary soft tissue giant cell tumor (GCT-ST) is a rare tumor with low malignant potential. Here we reported two cases of patients with soft tissue giant cell tumor in the limb, including their clinical and imaging findings (conventional Magnetic resonance imaging (MRI) and Diffusion weighted imaging (DWI)).Methods This retrospective study included two pathology-confirmed GCT-ST patients. Plain MRI, dynamic contrast enhancement MRI (DCE-MRI), and DWI were performed with a 3.0T whole-body MR scanner before surgery. The following characteristics of lesion were recorded: signal intensity on T 1 FSPGR and T 2 WI, morphology, maximum lesion size, time intensity curve (TIC) on DCE-MRI, and apparent diffusion coefficient (ADC) value from DWI.Results The maximum lesion size ranged from 4.0 cm to 6.0 cm. Signal intensities of all lesions were heterogeneous on T 1 FSPGR and T 2 WI. Nodular enhancements were observed for all lesions with either oval or irregular shapes on MRI. All lesion margins were blurred, and internal enhancements were heterogeneous on DCE-MRI. TIC appeared with a slow increase type. Lesions on DWI (b=500s/mm 2 ) were hyperintense with an higher mean ADC value of 2.19×10 −3 mm 2 /s compared to surrounding normal soft tissue (1.03×10 −3 mm 2 /s).Conclusions DWI may be a useful tool for differentiating benign soft tissue mass from giant cell-rich soft tissue neoplasms or malignant tumors.

scholarly journals Dealing with a soft tissue lesion that is scheduled for CT-guided biopsy and that has decreased in size on preprocedural planning CT

2020 ◽  
Vol 6 (1) ◽  
pp. 20190071
Author(s):  
Derya Yakar ◽  
Thomas C Kwee
Keyword(s):  
Soft Tissue ◽  
Benign Lesion ◽  
Clinical Situation ◽  
Lesion Size ◽  
Target Lesion ◽  
Size Reduction ◽  
Ct Guided ◽  
Guided Biopsy ◽  
Ct Guided Biopsy ◽  
Planning Ct

On planning CT before CT-guided biopsy, the target lesion may have decreased in size compared to previous imaging. Radiologists frequently face the dilemma of whether to biopsy these shrinking lesions or not. There is currently a lack of literature on how often such a situation is encountered in clinical practice, how it is dealt with, and if the perceived lesion size reduction always implies benignancy. This information would be valuable to develop evidence-based strategies for this specific clinical situation. We aimed to determine the frequency, radiologist’s management, and nature of lesions with size reduction on prebiopsy planning CT. In this retrospective study, we found that the incidence of lesions with size reduction on prebiopsy planning CT was 1.00% (11/1103). Biopsy was refrained from in most cases (9/11). Eight lesions proved to be benign, one malignant, one harboured both benign and malignant pathology, and one lesion remained of unclear nature. Soft tissue lesions with size reduction on prebiopsy planning CT are encountered infrequently and are usually not biopsied. Although most of these lesions are benign, lesion size reduction does not exclude malignancy. Therefore, clinical and imaging follow-up should be considered mandatory when biopsy is cancelled.

MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis

2008 ◽  
Vol 63 (4) ◽  
pp. 373-378 ◽  
Author(s):  
A. Datir ◽  
S.L.J. James ◽  
K. Ali ◽  
J. Lee ◽  
M. Ahmad ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Lesion Size ◽  
Soft Tissue Masses ◽  
The Relationship

scholarly journals The safety of primary surgical excision of small deep indeterminate musculoskeletal soft tissue masses

2021 ◽  
Vol 94 (1117) ◽  
pp. 20200713
Author(s):  
Michèle Calleja ◽  
Qasim Afzaal ◽  
Asif Saifuddin
Keyword(s):  
Soft Tissue ◽  
Residual Disease ◽  
Surgical Excision ◽  
Lesion Size ◽  
Safe Procedure ◽  
Deep Soft Tissue ◽  
Tissue Mass ◽  
Oncology Service ◽  
Soft Tissue Masses ◽  
Musculoskeletal Oncology

Objective: To determine the suitability of primary excision of small indeterminate deep soft tissue masses presenting to a tertiary musculoskeletal oncology service. Methods and materials: Review of all patients referred to a specialist musculoskeletal oncology service over a 20-month period with a deep indeterminate soft tissue mass by non-contrast MRI criteria that was recommended for primary surgical excision due to relatively small size (<30 mm). Data collected included age, gender, site and maximal size of the lesion, and final histological diagnosis for excised lesions. Results: 85 patients were included, mean lesion size being 12 mm (range 5–29 mm). Primary surgical resection had been undertaken in 69 cases (81.2%) by the conclusion of data collection, 36 males and 33 females with mean age of 45.6 years (range 11–80 years). Of these, 11 cases (15.9%) were non-neoplastic, 53 (76.8%) were benign, 1 (1.4%) was intermediate grade, while 4 (5.8%) were malignant including 3 synovial sarcomas. Two of these were treated with re-excision of the tumour bed showing no residual disease, with no evidence of local recurrence at a mean of 10.7 months post-excision. Conclusion: Primary surgical excision of small deep soft tissue masses that are indeterminate by non-contrast MRI criteria is considered a safe procedure when undertaken in a specialist musculoskeletal oncology service, with only 4 of 69 cases (5.8%) being malignant. Advances in knowledge: Small indeterminate deep soft tissue masses can safely be treated with primary excision in the setting of a specialist musculoskeletal oncology service.

scholarly journals A Pilot Evaluation of Magnetic Resonance Imaging Characteristics Seen With Primary Soft Tissue Giant Cell Tumor in 2 patients

2020 ◽  
Author(s):  
Lina Zhang ◽  
Jianyun Kang ◽  
Kai Zhang ◽  
Ailian Liu ◽  
Huali Wang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lesion Size ◽  
Cell Tumor ◽  
Resonance Imaging ◽  
Slow Increase ◽  
Adc Value ◽  
Dce Mri ◽  
Irregular Shapes

Abstract Background: Primary soft tissue giant cell tumor (GCT-ST) is a rare tumor with low malignant potential . Here we reported two cases of patients with soft tissue giant cell tumor in the limb, including their clinical and imaging findings (conventional Magnetic resonance imaging (MRI) and Diffusion-weighted imaging (DWI)). Methods: This retrospective study included two pathology-confirmed GCT-ST patients. Plain MRI, dynamic contrast enhancement MRI (DCE-MRI), and DWI were performed with a 3.0T whole-body MR scanner before surgery. The following characteristics of lesion were recorded: signal intensity on T 1 FSPGR and T 2 WI, morphology, maximum lesion size, time-intensity curve (TIC) on DCE-MRI, and apparent diffusion coefficient (ADC) value from DWI. Results: The maximum lesion size ranged from 4.0 cm to 6.0 cm. Signal intensities of all lesions were heterogeneous on T 1 FSPGR and T 2 WI. Nodular enhancements were observed for all lesions with either oval or irregular shapes on MRI. All lesion margins were blurred, and internal enhancements were heterogeneous on DCE-MRI. TIC appeared with a slow increase in type. Lesions on DWI (b=500s/mm 2 ) were hyperintense with a higher mean ADC value of 2.19×10 −3 mm 2 /s compared to surrounding normal soft tissue (1.03×10 −3 mm 2 /s). Conclusions: MRI features of these two GCT-STs include heterogeneous signal intensity within the lesion on T 2 WI and T 1 FSPGR, nodular enhancement with blurred margins, either oval or irregular shapes, and a slow increase enhancement of TIC on DCE-MRI. DWI may be a useful tool for differentiating benign soft tissue mass from giant cell-rich soft tissue neoplasms or malignant tumors. However, these findings need to be confirmed using a higher sample study.

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