scholarly journals Modern approach to diagnosis and treatment of post-traumatic periorbital scarring

2021 ◽  
Vol 9 (2) ◽  
pp. 58-63
Author(s):  
O.V. Petrenko ◽  
N.V. Hryhorash
Keyword(s):  
Scar Tissue ◽  
Scar Formation ◽  
Diagnosis And Treatment ◽  
Optimal Timing ◽  
Modern Approach ◽  
Advantages And Disadvantages ◽  
Periorbital Region ◽  
Assessment And Treatment ◽  
Choice Of Treatment ◽  
Post Traumatic

Background. The treatment of cicatricial deformities of the periorbital region is one of the most difficult problems of ophthalmoplasty. The choice of treatment tactics depends on the correct assessment of the type of periorbital scarring, which further determines its effectiveness. Based on the analysis of literature sources, the causes of periorbital scarring are determined, and modern me­thods of their clinical assessment and treatment are presented. The purpose: to analyze the current state of the issues of pathogenesis, classification, diagnosis, and treatment of post-traumatic cicatricial deformities of the periorbital region. Materials and methods. The research was carried out using the search and information systems PubMed, eLibrary, Google Scholar, and library databases for the period 2012–2020. Results. It was found that the formation and type of scars depend on many internal and external factors. The most common classification divides the scars into normotrophic, atrophic, hypotrophic, which refer to superficial scars, as well as deep — hypertrophic, keloid, and mixed. Determining the stages of scar tissue formation is important for choosing a method of treating a patient and obtaining the most positive result. Various thoughts are given regar­ding the stages and timing of the wound healing and scar formation process. The main modern methods of assessing and diagnosing scars have been determined, their advantages and disadvantages have been analyzed. The modern approaches to the treatment of scars based on their type were analyzed. Conclusions. The results of the analysis of modern literary sources showed that the issue of the etiology and pathogenesis of pathological scars has not yet been finally resolved. There is no single approach to diagnosis and treatment of scars, the optimal timing of treatment initiation. A particular problem is the treatment of cicatricial deformities of the periorbital region, which is predetermined by its anatomical and functional complexity. All this makes the task of studying the features of the course of scar formation of this particular area and the development of individualized algorithms for their treatment urgent.

Modern approach to post-traumatic hepatic hematoma – US guided percutaneus drainage

2008 ◽  
Vol 29 (S 1) ◽  
Author(s):  
S Chiriac ◽  
D Claici ◽  
C Andrei ◽  
D Oneţ ◽  
C Banciu ◽  
...  
Keyword(s):  
Modern Approach ◽  
Hepatic Hematoma ◽  
Post Traumatic

Inflammatory disease of the womans reproductive system: modern trends in diagnosis and therapy (literature review)

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 35-41
Author(s):  
T Yu Pestrikova ◽  
I V Yurasov ◽  
E A Yurasova
Keyword(s):  
Genital Tract ◽  
Inflammatory Diseases ◽  
Diagnosis And Treatment ◽  
Long Term Results ◽  
Modern Approach ◽  
Pelvic Organs ◽  
Results Of Treatment ◽  
Number Of Patients ◽  
Diagnostic Approaches

Medical, social and economic relevance of inflammatory diseases of the woman's reproductive organs requires a very careful attitude to the diagnosis and treatment of this pathology. The number of patients with genital infections and inflammatory diseases of the pelvic organs can takes the first place in structure of gynecological morbidity, and is 60.4-65.0%, and this fact is not unique to Russia, but all over the world. Incidence rate of inflammatory diseases of the pelvic organs in the first decade of the twenty-first century is increased at 1.4 times in patients who are from 18 to 24 years old and at 1.8 times in patients aged 25-29 years. At the same time, the cost of diagnosis and treatment has increased, reaching 50-60% of the total cost of providing gynecological care for population. The inflammatory diseases of pelvic organs are a collective concept. It includes of various nosological forms. There are numerous contradictions in the views on diagnostic approaches and treatment tactics, the nature of screening and control over the long-term results of treatment, the etiological and pathogenetic significance of various microorganisms found in the genital tract in patients with inflammatory diseases of the pelvic organs. Currently, there are many opinions among specialists about diagnostic approaches and treatment tactics, the type of screening and monitoring the long-term results of treatment, the etiological and pathogenetic role of various microorganisms which can be found in the genital tract in patients with inflammatory diseases. This review presents the results of a modern approach to the diagnosis, management and rehabilitation of patients with inflammatory diseases of the pelvic organs.

The natural history of post-traumatic hypopituitarism: Implications for assessment and treatment

2005 ◽  
Vol 118 (12) ◽  
pp. 1416.e1-1416.e7 ◽  
Author(s):  
Amar Agha ◽  
Jack Phillips ◽  
Patrick O’Kelly ◽  
William Tormey ◽  
Christopher J. Thompson
Keyword(s):  
Natural History ◽  
Assessment And Treatment ◽  
History Of ◽  
Post Traumatic

scholarly journals Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway

2015 ◽  
Vol 37 (2) ◽  
pp. 666-676 ◽  
Author(s):  
Ting He ◽  
Xiaozhi Bai ◽  
Longlong Yang ◽  
Lei Fan ◽  
Yan Li ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Ex Vivo ◽  
Scar Tissue ◽  
Scar Formation ◽  
Jnk Pathway ◽  
Protein Levels ◽  
Mapk Inhibitors ◽  
Hypertrophic Scar Tissue ◽  
Loureirin B ◽  
Tgf Β1

Background/Aims: Our previous study confirmed that Loureirin B (LB) can inhibit hypertrophic scar formation. However, the mechanism of LB-mediated inhibition of scar formation is still unknown. Methods: Immunohistochemistry was used to detect expression of Col1, FN and TGF-β1 in skin and scar tissue. Fibroblasts were stimulated with TGF-β1 to mimic scar formation. LB or MAPK inhibitors were used to study the pathways involved in the process. Western blotting was used to evaluate the expression of p-JNK, p-ERK, p-p38, Col1 and FN. The contractile capacity of fibroblasts was evaluated using a gel contraction assay. Tissues were cultured ex vivo with LB to further investigate the participation of ERK and JNK in the LB-mediated inhibition of scar formation. Results: FN and Col1 were up regulated in hypertrophic scars. LB down regulated p-ERK and p-JNK in TGF-β1-stimulated fibroblasts, while levels of phosphorylated p38 did not change. The down regulation of p-ERK and p-JNK was associated with a reduction of Col1 and FN. Similarly, inhibition of ERK and JNK down regulated the expression of Col1 and FN in TGF-β1-stimulated fibroblasts. LB down regulated protein levels of p-ERK and p-JNK in cultured hypertrophic scar tissue ex vivo. Conclusions: This study suggests that LB can inhibit scar formation through the ERK/JNK pathway.

Reduction of post-traumatic neuroma and epineural scar formation in rat sciatic nerve by application of microcrystallic chitosan

Microsurgery ◽  
2011 ◽  
Vol 31 (8) ◽  
pp. 642-649 ◽  
Author(s):  
Wieslaw Marcol ◽  
Magdalena Larysz-Brysz ◽  
Magdalena Kucharska ◽  
Antoni Niekraszewicz ◽  
Wojciech Slusarczyk ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Scar Formation ◽  
Traumatic Neuroma ◽  
Rat Sciatic Nerve ◽  
Post Traumatic

scholarly journals Lipogranulomas of the mammary glands: diagnosis and treatment

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Natalia Cara ◽  
◽  
Veronica Svet ◽  
Ion Mereuta ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Mammary Gland ◽  
Inflammatory Process ◽  
Pathological Condition ◽  
Scar Tissue ◽  
Mammary Glands ◽  
Diagnosis And Treatment ◽  
Breast Lesions ◽  
Fat Necrosis

Steatonecrosis of the mammary gland is necrosis of its adipose tissue, followed by replacement with scar tissue. Lipogranuloma is known as a benign inflammatory process, necrosis of breast fat occurs due to iatrogenic breast trauma. Most often, fatty necrosis is seen in women with large breasts – in women with small breasts, it develops much less often. It is important to diagnose lipogranulomas because it can often mimic breast cancer. Fat necrosis of the breast is a common pathological condition, with a wide variety of presentations on mammography, ultrasound and MRI. The incidence of fatty necrosis of the breast is estimated at 0.6%, representing 2.75% of all breast lesions.

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