Evaluation of administration and use of antihypertensive drugs in severe preeclampsia patients at X General Hospital in Jakarta

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Abraham Simatupang ◽  
Ida Bagus Sutha Dwipajaya
Keyword(s):  
General Hospital ◽  
Antihypertensive Drugs ◽  
Monitoring And Evaluation ◽  
Severe Preeclampsia ◽  
Antihypertensive Drug Therapy ◽  
Close Monitoring ◽  
Further Training ◽  
Hypertension In Pregnancy ◽  
The Right ◽  
In Pregnancy

The high number of maternal mortality rate (MMR) is still a problem in Indonesia. Three ethyologies of maternal death are infection (12%), hypertension in pregnancy (25%) and bleeding (30%). Pre-eclampsia as a form of hypertension during pregnancy requires antihypertensive drug therapy. Rationality assessment for any kinds of pharmacotherapy is based on the right indication, the right medicine, the right patient, and the right dose. The main indication for antihypertensive medication in pregnancy is applied to the mother’s in preventing cerebrovascular disease. The aim of this study was to evaluate the characteristics, patterns and accuracy of the administration and use of antihypertensive drugs in patients with severe preeclampsia at X General Hospital in Jakarta in 2018. It was a non-experimental study with a descriptive and retrospective design using medical records. Administration and use of antihypertensive drugs in patients with severe preeclampsia at the X General Hospital in Jakarta showed 91.9% right indication, 86.72% right drug, 96.9% right patient and only 5.26% right dose with 4.0% accuracy of rational administration and use of drugs. In conclusion, the right dose in the management of patients with severe preeclampsia in X General Hospital in Jakarta is still low. Further training and close monitoring and evaluation on the rational use of antihypertension in severe preeclampsia is needed.

Effectiveness of Antihypertensive Drugs in the Treatment of Hypertension in Pregnancy

1990 ◽  
Vol 9 (3) ◽  
pp. 339-348 ◽  
Author(s):  
Liliana S. Voto ◽  
Carlos A. Quiroga ◽  
Alicia M. Lapidus ◽  
Patricia Catuzzi ◽  
Francisco Uranga Imaz ◽  
...  
Keyword(s):  
Antihypertensive Drugs ◽  
Hypertension In Pregnancy ◽  
Treatment Of Hypertension ◽  
In Pregnancy

scholarly journals Hipertensi pada Kehamilan

2019 ◽  
Vol 2 (2) ◽  
pp. 27
Author(s):  
Haidar Alatas
Keyword(s):  
Gestational Hypertension ◽  
Organ Damage ◽  
Antihypertensive Drug Therapy ◽  
Chronic Hypertension ◽  
First Line ◽  
Hypertension In Pregnancy ◽  
Increased Risk ◽  
Hypertensive Disorders In Pregnancy ◽  
In Pregnancy

Hipertensi pada kehamilan sering terjadi (6-10 %) dan meningkatkan risiko morbiditas dan mortalitas pada ibu, janin dan perinatal. Pre-eklampsia/eklampsia dan hipertensi berat pada kehamilan risikonya lebih besar. Hipertensi pada kehamilan dapat digolongkan menjadi pre-eklampsia/ eklampsia, hipertensi kronis pada kehamilan, hipertensi kronis disertai pre-eklampsia, dan hipertensi gestational. Pengobatan hipertensi pada kehamilan dengan menggunakan obat antihipertensi ternyata tidak mengurangi atau meningkatkan risiko kematian ibu, proteinuria, efek samping, operasi caesar, kematian neonatal, kelahiran prematur, atau bayi lahir kecil. Penelitian mengenai obat antihipertensi pada kehamilan masih sedikit. Obat yang direkomendasikan adalah labetalol, nifedipine dan methyldopa sebagai first line terapi. Penatalaksanaan hipertensi pada kehamilan memerlukan pendekatan multidisiplin dari dokter obsetri, internis, nefrologis dan anestesi. Hipertensi pada kehamilan memiliki tingkat kekambuhan yang tinggi pada kehamilan berikutnya. Hypertension complicates 6% to 10% of pregnancies and increases the risk of maternal, fetal and perinatal morbidity and mortality. Preeclampsia / eclampsia and severe hypertension in pregnancy are at greater risk. Four major hypertensive disorders in pregnancy have been described by the American College of Obstetricians and Gynecologists (ACOG): chronic hypertension; preeclampsia-eclampsia; chronic hypertension with superimposed preeclampsia; and gestational hypertension. The current review suggests that antihypertensive drug therapy does not reduce or increase the risk of maternal death, proteinuria, side effects, cesarean section, neonatal and birth death, preterm birth, or small for gestational age infants. The quality of evidence was low. Recommendations for treatment of hypertension in pregnancy are labetalol, nifedipine and methyldopa as first line drugs therapy. Although the obstetrician manages most cases of hypertension during pregnancy, the internist, cardiologist, or nephrologist may be consulted if hypertension precedes conception, if end organ damage is present, or when accelerated hypertension occurs. Women who have had preeclampsia are also at increased risk for hypertension in future pregnancies.

scholarly journals THE PERSONALIZED APPROACH TO ANTIHYPERTENSIVE THERAPY DURING PREGNANCY IN TERMS OF CLINICAL PHARMACOGENETICS

2018 ◽  
Vol 73 (3) ◽  
pp. 149-156 ◽  
Author(s):  
I. V. Ignatko ◽  
L. A. Strizhakov ◽  
V. S. Florova ◽  
A. L. Martirosova
Keyword(s):  
Drug Therapy ◽  
Additional Data ◽  
Antihypertensive Drugs ◽  
Placental Barrier ◽  
Medical Specialists ◽  
Liver Cytochrome ◽  
Personalized Approach ◽  
The Right ◽  
Selection Of ◽  
In Pregnancy

The right drug at the right dose administered to a patient in time is the goal which all medical specialists aim at when prescribing medicines to patients. Pregnancy is a condition when the principle of personalized pharmacotherapy is especially relevant. Due to the developing fetus and the occurring changes in the maternal organism, the selection of drug therapy during pregnancy is especially difficult for a clinician. This issue is tightly intertwined with clinical pharmacogenetics since the genetic code of a woman that determines the activity of the liver cytochrome, the fetus-placental barrier, and renal clearance contributes to the peculiarities of the drug metabolism during pregnancy. Additional data provides the opportunities to form therapeutic models and to determine the ways of personifying pharmacotherapy in pregnancy. The purpose of this review is to summarize the available data on the pharmacogenetics of antihypertensive drugs used during pregnancy.

scholarly journals Evaluasi Penggunaan Obat Antihipertensi pada Pasien Gagal Ginjal Kronik Rawat Inap di Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat

2020 ◽  
Vol 1 (2) ◽  
pp. 61
Author(s):  
Anna Pradiningsih ◽  
Baiq Leny Nopitasari ◽  
Nur Furqani ◽  
Esi Wahyuningsih
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Drug Use ◽  
General Hospital ◽  
Kidney Failure ◽  
Antihypertensive Drugs ◽  
Chronic Kidney Failure ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
The Right

ABSTRAKGagal ginjal kronik merupakan penurunan fungsi ginjal progresif yang  irreversible ketika ginjal tidak mampu mempertahankan keseimbangan metabolik. Gagal ginjal kronik di Rumah Sakit Umum Daerah Provinsi NTB memasuki daftar 10 penyakit terbanyak. Penelitian ini bertujuan untuk mengevaluasi penggunaan obat antihipertensi pada pasien gagal ginjal kronik rawat inap di Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat. Penelitian ini merupakan  penelitian observasional deskriptif dengan mengambil data secara cross sectional, sampel yang memenuhi kriteria inklusi sebanyak 43 orang. Evaluasi penggunaan obat dalam penelitian ini meliputi tepat pasien, tepat obat, tepat dosis, tepat indikasi dan tepat frekuensi. Hasil penelitian menunjukkan ketepatan penggunaan obat antihipertensi pada pasien gagal ginjal kronik yaitu 100% tepat pasien, 100% tepat obat, 100% tepat indikasi, 100% tepat dosis, 88,37% dan tepat frekuensi 27,91%.Kata kunci: Gagal ginjal kronik; Antihipertensi; Evaluasi penggunaan obat. ABSTRACTChronic kidney failure is a decrease in progressive kidney function which is irregular when the kidneys are unable to maintain metabolic balance. Chronic kidney failure at the NTB Provincial General Hospital enters the list of the 10 most diseases. This study aimed to evaluate the use of antihypertensive drugs in patients with chronic renal failure hospitalization at the Regional General Hospital of West Nusa Tenggara Province. The study was a descriptive observational study by taking cross sectional data, samples that met the inclusion criteria were 43 people. Evaluation of drug use in this study included the exact patient, the right medication, the right dose, the right indication and the right frequency. The results showed the accuracy of the use of antihypertensive drugs in patients with chronic renal failure, namely 100% right patients, 100% exact drugs, 100% exact indications, 100% exact dosages, 88.37% and exact frequency 27,91%.Keywords: Chronic Kidney Failure; Antihypertension; Evaluation of drug use.

scholarly journals Hypertension in pregnancy

2006 ◽  
Vol 12 (1) ◽  
pp. 7-15 ◽  
Author(s):  
E. I. Baranova
Keyword(s):  
Antihypertensive Drugs ◽  
Gestational Hypertension ◽  
Developed Countries ◽  
Third Trimester ◽  
Pregnancy Hypertension ◽  
The Third ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

In developed countries hypertension is observed in 6 - 15% of all pregnancies and occupies the second place in pregnancy morality rate after embolism. Hypertension can be dangerous not only for maternal but fetal deal h as well. Criteria for pregnancy hypertension are the same as general criteria ( ≥ 140 / ≥ 90 mm Hg). Hypertension in pregnancy is classified as following; preexisting hypertension, gestational hypertension, preeclampsia, mixed hypertension (preexisting and gestational). All antihypertensive drugs excluding methyldopa are contraindicated during the first and second trimesters, while several other drugs can be administrated during the third trimester.

The kidney and hypertension in pregnancy: Twenty exciting years

2001 ◽  
Vol 21 (2) ◽  
pp. 173-189 ◽  
Author(s):  
Marshall D. Lindheimer ◽  
John M. Davison ◽  
Adrian I. Katz
Keyword(s):  
Hypertension In Pregnancy ◽  
In Pregnancy
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