scholarly journals Hypertension and the Kidney: Perspectives on the Relationship of Kidney Disease and Cardiovascular Disease

2009 ◽  
Vol 4 (12) ◽  
pp. 2045-2050 ◽  
Author(s):  
Matthew R. Weir
Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1348 ◽  
Author(s):  
Gunther Marsche ◽  
Gunnar H. Heine ◽  
Julia T. Stadler ◽  
Michael Holzer

In the general population, the ability of high-density lipoproteins (HDLs) to promote cholesterol efflux is a predictor of cardiovascular events, independently of HDL cholesterol levels. Although patients with chronic kidney disease (CKD) have a high burden of cardiovascular morbidity and mortality, neither serum levels of HDL cholesterol, nor cholesterol efflux capacity associate with cardiovascular events. Important for the following discussion on the role of HDL in CKD is the notion that traditional atherosclerotic cardiovascular risk factors only partially account for this increased incidence of cardiovascular disease in CKD. As a potential explanation, across the spectrum of cardiovascular disease, the relative contribution of atherosclerotic cardiovascular disease becomes less important with advanced CKD. Impaired renal function directly affects the metabolism, composition and functionality of HDL particles. HDLs themselves are a heterogeneous population of particles with distinct sizes and protein composition, all of them affecting the functionality of HDL. Therefore, a more specific approach investigating the functional and compositional features of HDL subclasses might be a valuable strategy to decipher the potential link between HDL, cardiovascular disease and CKD. This review summarizes the current understanding of the relationship of HDL composition, metabolism and function to their cardio-protective properties in CKD, with a focus on CKD-induced changes in the HDL proteome and reverse cholesterol transport capacity. We also will highlight the gaps in the current knowledge regarding important aspects of HDL biology.


Circulation ◽  
1997 ◽  
Vol 95 (6) ◽  
pp. 1347-1348 ◽  
Author(s):  
Russell P. Tracy ◽  
Paula B. Tracy

2020 ◽  
Vol 75 (11) ◽  
pp. 2286
Author(s):  
Jose Patricio Lopez ◽  
Patricio Lopez-Jaramillo ◽  
Paul A. Camacho ◽  
Darryl Leong ◽  
Sumathy Rangarajan ◽  
...  

Pharmateca ◽  
2021 ◽  
Vol 3_2021 ◽  
pp. 39-49
Author(s):  
O.D. Ostroumova Ostroumova ◽  
A.I. Kochetkov Kochetkov ◽  
E.E. Pavleeva Pavleeva ◽  
O.V. Golovina Golovina ◽  
N.A. Arablinsky Arablinsky ◽  
...  

2019 ◽  
Vol 91 (12) ◽  
pp. 75-83
Author(s):  
V V Fomin ◽  
T E Morosova ◽  
V V Tsurko

In recent years, the relationship of hyperuricemia and gout with a high risk of cardiovascular disease has been widely discussed. Therefore, it is important to systematically examine patients in order to diagnose comorbidities, among which cardiovascular disease and its complications occupy a leading place and consider mandatory treatment of patients with hyperuricemia and gout with high cardiovascular risk with lowering drugs, which fully reflects the provisions of the latest European recommendations for the management and treatment of patients with gout.


2019 ◽  
Vol 18 (3) ◽  
pp. 246-269
Author(s):  
Carlos Milton Guevara-Valtier ◽  
Ana Victoria Ramírez-Rodríguez ◽  
Velia Margarita Cárdenas-Villarreal ◽  
Tirso Duran-Badillo ◽  
Juana Mercedes Gutiérrez-Valverde ◽  
...  

En este articulo se determinó la relación entre la Percepción del riesgo de enfermedad cardiovascular con el Nivel de uso de Tecnologías de la Información y Comunicación (TIC´s), así como el efecto explicativo del nivel de uso de las TIC´s y antecedentes para enfermedad cardiovascular en la Percepción del riesgo de enfermedad cardiovascular en adultos con obesidad. Este estudio es pertinente dado que la relación entre las variables propuestas, así como la relación de las TIC´s y otras variables sobre la percepción de riesgo de enfermedad cardiaca y cerebral aún no es del todo clara. Se realizó un estudio descriptivo-analítico realizado en una muestra de 260 adultos con obesidad. Se usaron los cuestionarios Percepción del Riesgo de enfermedad cardiovascular y Uso de TICS en pacientes atendidos en un centro de salud, se respetaron las normas éticas y se utilizó estadística descriptiva e inferencial. Se encontró relación entre la Percepción del riesgo de enfermedad cardiovascular y el uso de las TIC´s (rs =0,142, p=0,022). El Nivel de uso de TICS y antecedentes personales/familiares para el desarrollo de enfermedad cardiovascular fue un 14,3% en la percepción del riesgo de enfermedad cardiovascular. Se concluyó que la percepción del riesgo de enfermedad cardiovascular se relaciona con el Nivel de uso de Tecnologías de la información y comunicación en salud y es explicada en parte por el Nivel de uso de tecnologías de la información y comunicación y antecedentes de salud. Objective: This paper determined the relationship between the perception of risk of a cardiovascular disease with the level of use of Information and Communication Technology or ICT, as well as the explanatory effect of these ICTs and the history of cardiovascular disease in the perception of risk of cardiovascular disease in adults with obesity.Methods: This study is relevant since the relationship between the proposed variables, and the relationship of the ICTs and other variables about the risk perception of heart and brain disease is not very clear yet. An analytical-descriptive research was made on a sample of 260 obese adults. Questionnaires of risk perception of a cardiovascular disease and use of ICT in patients who receive care in a health center were used; ethical standards were observed and descriptive statistics and statistical inference were applied.Results: A relationship between risk perception of a cardiovascular disease and the use of ICTs was found (rs=0,142, p=0,022). The level of use of ICTs and personal/family history of disease for the development of a cardiovascular disease explain a 14,3% in the perception of risk of the disease.Conclusions: It was concluded that the perception of risk of cardiovascular disease was related to the level of use of Information and Communication Technologies regarding health, and it is partially explained by the level of use of the ICTs and health history.


2019 ◽  
Vol 13 (2) ◽  
pp. 1675-1678 ◽  
Author(s):  
Anandhara Indriani Khumaedi ◽  
Dyah Purnamasari ◽  
Ika Prasetya Wijaya ◽  
Yuniarti Soeroso

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
S. O. Oguntola ◽  
M. O. Hassan ◽  
R. Duarte ◽  
A. Vachiat ◽  
P. Manga ◽  
...  

Abstract Background Occurrence of cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) can be described as a “cruel alliance”, with CVD responsible for about half of all deaths among CKD patients. Chronic kidney disease patients are more likely to die from CVD than progress to end stage kidney disease (ESKD). Dyslipidaemia, a known traditional risk factor for CVD, is highly prevalent among CKD patients and with an even higher frequency among ESKD patients on dialytic therapies. Prolonged exposure of continuous ambulatory peritoneal dialysis (CAPD) patients to high glucose concentrations in CAPD fluid have been associated with increased risk of cardiovascular events. In this study, we investigated the relationship of atherosclerotic vascular disease (AsVD) to clinical and echocardiographic parameters among black South Africans with CKD (stage 3) and ESKD on CAPD and haemodialysis (HD). Methods This was a cross-sectional study of 40 adult (18–65 years) non-diabetic CKD patients (kidney disease outcome quality initiative [KDOQI] stage 3), 40 ESKD patients on CAPD, 40 ESKD patients on HD and 41 age and sex-matched healthy controls. An interviewer-administered questionnaire was used to obtain information on participants’ sociodemographic and cardiovascular risk factors. Anthropometric parameters were measured. Serum blood samples were analysed for creatinine, albumin and lipid profile; lipoprotein ratios, Framingham’s risk score and the 10-year risk of developing coronary heart disease (CHD) were calculated. Echocardiography was performed on all patients and carotid intima media thickness (CIMT) was measured in both right and left carotid arteries at 1 cm proximal to the carotid bulb. Spearman’s rank correlation and binary logistic regression were conducted to determine the relationship of AsVD to clinical and echocardiographic parameters. Results Atherosclerotic vascular disease was most prevalent among ESKD patients on CAPD (70%, n = 28/40). Chronic kidney disease and HD patients exhibited a similar prevalence (47.5%, n = 19/40), while the prevalence in controls was 17.1% (n = 7/41). Presence of AsVD was associated with significantly older age, higher waist hip ratio (WHR), left ventricular mass index (LVMI) and Framingham’s 10-year risk of developing CHD. Significant differences in clinical and echocardiographic parameters were observed when the study groups were compared. Age and LVH independently predicted AsVD. Conclusion Atherosclerotic vascular disease was more prevalent among CAPD patients compared to pre-dialysis CKD and HD patients. Among all lipoprotein ratios assessed, non-HDL-C showed the most consistent significant difference between the groups. Age (> 40 years) and presence of LVH were independent predictors of AsVD.


Sign in / Sign up

Export Citation Format

Share Document