EFFECT OF DIFFERENT STATINS IN ANIMAL MODEL OF ANXIETY IN WISTAR RATS

Objective: Pleiotropic mechanisms of statins have been explored in treating neurological disorders such as generalized anxiety disorder and depression. Hence, the aim of the present study is to evaluate the effect of different statins in animal model of anxiety in Wistar rats.Methods: Sixty rats were divided into five groups of 6 rats each for each model. Two models were used, elevated plus maze and open-field model. Grouping is as follows: Group 1 - normal control (0.9% saline), Group 2 - alprazolam 0.5 mg/kg, Group 3 - atorvastatin 10 mg/kg, Group 4 - rosuvastatin 10 mg/kg, and Group 5 - pitavastatin 10 mg/kg. All drugs were given orally for 30 days.Results: In open-field model and in elevated plus maze, alprazolam, atorvastatin, rosuvastatin, and pitavastatin in comparison with control showed significant antianxiety effect (p<0.01 and p<0.001), respectively.Conclusion: Hence, further clinical trials can be done to see the effect of various statins on generalized anxiety disorder in comparison with standard antianxiety drugs.

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Contextual conditioning in rats as an animal model for generalized anxiety disorder

Cognitive Affective & Behavioral Neuroscience ◽

10.3758/s13415-011-0021-6 ◽

2011 ◽

Vol 11 (2) ◽

pp. 228-244 ◽

Cited By ~ 31

Author(s):

Laura Luyten ◽

Debora Vansteenwegen ◽

Kris van Kuyck ◽

Loes Gabriëls ◽

Bart Nuttin

Keyword(s):

Animal Model ◽

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Generalized Anxiety ◽

Contextual Conditioning

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The Carioca High and Low Conditioned Freezing Lines: A New Animal Model of Generalized Anxiety Disorder

Anxiety Disorders ◽

10.5772/23598 ◽

2011 ◽

Cited By ~ 3

Author(s):

Vitor de Castro Gomes ◽

Carlos Eduardo Barroso Silva ◽

J. Landeira-Fernandez

Keyword(s):

Animal Model ◽

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Generalized Anxiety ◽

Conditioned Freezing

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Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder

Behavioural Brain Research ◽

10.1016/j.bbr.2014.01.012 ◽

2014 ◽

Vol 263 ◽

pp. 34-45 ◽

Cited By ~ 29

Author(s):

Gisele Pereira Dias ◽

Mário Cesar do Nascimento Bevilaqua ◽

Anna Claudia Domingos Silveira da Luz ◽

Renata Lopes Fleming ◽

Lítia Alves de Carvalho ◽

...

Keyword(s):

Animal Model ◽

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Fear Memory ◽

Generalized Anxiety

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Eugenol and Its Liposomal Based Nano-carrier Protects Against Anxiety Disorder in Mice.

10.21203/rs.3.rs-985817/v1 ◽

2021 ◽

Author(s):

fahad jibran siyal ◽

rehan ahmed siddiqui ◽

zahida memon ◽

zahra batool ◽

aneela Atta Ur Rahman ◽

...

Keyword(s):

Anxiety Disorder ◽

Anxiety Disorders ◽

Open Field ◽

Elevated Plus Maze ◽

Field Tests ◽

Life Time ◽

Dry Weight ◽

Elevated Plus Maze Test ◽

Behavioral Studies ◽

Plus Maze

Abstract Background: Anxiety can also be termed as excessive worry which last for at least more than six months and patients can have difficulty in controlling them. Anxiety is having 31% of life time prevalence and sad part is that the anxiety disorders are not treated and diagnosed well. 3.1% which is 6.8 Million peoples of America are having anxiety disorders. The main part of clove oil is eugenol along with caryophyllene. Eugenol is present at about 70 to 90 percentage and also it contains 15 percentage of total dry weight of bud. Methodology: Pre-clinical experimental study was conducted for 10-12 Months. Male BALB/c mice were purchased from ICCBS. Sample Size was 42 BALB/c mice and divided into 07 groups. Results: The animal model was developed and it was found that Eugenol and its liposomal based nano carrier protect anxiety disorders in mice with the help of behavioral tests such as Elevated plus maze and open field tests and was recorded as Mean and SD, frequency and percentages accordingly. Conclusion: Therefore with the help of behavioral studies i.e. open field test and elevated plus maze test, eugenol and its liposomal based nano particle protect anxiety disorder in the mice by increasing the entry time and stay of mice in open arms for longer duration in elevated maze plus test and in open field the anxiety was reduced after mice spent most of time in the center rather than periphery.

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Heterogeneity in the performance of outbred sprague-dawley rats in an elevated-plus maze test: A possible animal model for anxiety disorder

Life Sciences ◽

10.1016/0024-3205(96)00480-8 ◽

1996 ◽

Vol 59 (18) ◽

pp. 1499-1506 ◽

Cited By ~ 5

Author(s):

Amit Prasad ◽

Miyoshi Henry ◽

Chandan Prasad

Keyword(s):

Animal Model ◽

Anxiety Disorder ◽

Elevated Plus Maze ◽

Sprague Dawley ◽

Elevated Plus Maze Test ◽

Maze Test ◽

Sprague Dawley Rats ◽

Plus Maze

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The French Version of the Revised Child Anxiety and Depression Scale (RCADS) in a Nonclinical Sample

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000158 ◽

2015 ◽

Vol 74 (3) ◽

pp. 119-127 ◽

Cited By ~ 10

Author(s):

Martine Bouvard ◽

Anne Denis ◽

Jean-Luc Roulin

Keyword(s):

Factor Analysis ◽

Anxiety Disorder ◽

Confirmatory Factor Analysis ◽

Generalized Anxiety Disorder ◽

Child Anxiety ◽

Depression Scale ◽

Anxiety And Depression ◽

Generalized Anxiety ◽

French Version ◽

Confirmatory Factor

This article investigates the psychometric properties of the Revised Child Anxiety and Depression Scale (RCADS). A group of 704 adolescents completed the questionnaires in their classrooms. This study examines potential confirmatory factor analysis factor models of the RCADS as well as the relationships between the RCADS and the Screen for Child Anxiety Related Emotional Disorders-Revised (SCARED-R). A subsample of 595 adolescents also completed an anxiety questionnaire (Fear Survey Schedule for Children-Revised, FSSC-R) and a depression questionnaire (Center for Epidemiological Studies Depression Scale, CES-D). Confirmatory factor analysis of the RCADS suggests that the 6-factor model reasonably fits the data. All subscales were positively intercorrelated, with rs varying between .48 (generalized anxiety disorder-major depression disorder) and .65 (generalized anxiety disorder-social phobia/obsessive-compulsive disorder). The RCADS total score and all the RCADS scales were found to have good internal consistency (> .70). The correlations between the RCADS subscales and their SCARED-R counterparts are generally substantial. Convergent validity was found with the FSSC-R and the CES-D. The study included normal adolescents aged 10 to 19. Therefore, the findings cannot be extended to children under 10, nor to a clinical population. Altogether, the French version of the RCADS showed reasonable psychometric properties.

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Psychometric Properties of the Spontaneous and Deliberate Mind Wandering Scales

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000470 ◽

2019 ◽

Vol 35 (6) ◽

pp. 878-890 ◽

Cited By ~ 4

Author(s):

David Marcusson-Clavertz ◽

Oscar N. E. Kjell

Keyword(s):

Anxiety Disorder ◽

Psychometric Properties ◽

Generalized Anxiety Disorder ◽

Social Desirability ◽

Cognitive Task ◽

Experience Sampling ◽

Well Being ◽

Mind Wandering ◽

Generalized Anxiety ◽

Psychological Variables

Abstract. Thinking about task-unrelated matters (mind wandering) is related to cognition and well-being. However, the relations between mind wandering and other psychological variables may depend on whether the former commence spontaneously or deliberately. The current two studies investigated the psychometric properties of the Spontaneous and Deliberate Mind Wandering Scales (SDMWS; Carriere, Seli, & Smilek, 2013 ). Study 1 evaluated the stability of the scales over 2 weeks ( N = 284 at Time 1), whereas Study 2 ( N = 323) evaluated their relations to Generalized anxiety disorder symptoms, Openness, Social desirability, and experience-sampling reports of intentional and unintentional mind wandering during an online cognitive task. The results indicated that the SDMWS were better fitted with a two-factor than a one-factor solution, although the fit was improved with the exclusion of one item. The scales exhibited strong measurement invariance across gender and time, and moderately high test-retest reliability. Spontaneous mind wandering predicted Generalized anxiety disorder and experience-sampling reports of unintentional mind wandering, whereas Deliberate mind wandering predicted Openness and experience-sampling reports of intentional mind wandering. Furthermore, Spontaneous mind wandering showed a negative association with social desirability of weak-to-medium strength. In sum, the scales generally showed favorable psychometric properties.

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