scholarly journals Adenomatoid Odontogenic Tumor – A Report of Two Cases with Histopathology Correlation

2011 ◽  
Vol 1 ◽  
pp. 64 ◽  
Author(s):  
Pavitra Baskaran ◽  
Satyaranjan Misra ◽  
M. Sathya Kumar ◽  
R. Mithra
Keyword(s):  
World Health Organisation ◽  
Young Female ◽  
Odontogenic Tumor ◽  
World Health ◽  
Adenomatoid Odontogenic Tumor ◽  
Odontogenic Epithelium ◽  
Odontogenic Origin ◽  
Progressive Growth ◽  
Current Article

Adenomatoid odontogenic tumor (AOT) is an uncommon, hamartomatous, benign, epithelial lesion of odontogenic origin that was first described by Driebaldt in 1907, as a pseudo-adenoameloblastoma. The current World Health Organisation (WHO) classification of odontogenic tumors defines AOT as being composed of the odontogenic epithelium in a variety of histoarchitectural patterns, embedded in mature connective tissue stroma, and characterized by slow, but progressive growth. The current article reports two cases with different presentations; first in a young female patient and the second in a middle-aged male patient. The importance of biopsy, which is the gold standard for diagnosis, and its use in planning of the treatment is discussed.

scholarly journals A RECENT UPDATE ON HISTOGENESIS OF ADENOMATOID ODONTOGENIC TUMOR: A REVIEW

2019 ◽  
pp. 55-62
Author(s):  
SAHANAZ P AHMED ◽  
NANDAKUMAR ARULMOZHI ◽  
RAMADAS RAMYA ◽  
KRISHNAKUMAR KARUNYA
Keyword(s):  
Odontogenic Tumor ◽  
Biological Behavior ◽  
Adenomatoid Odontogenic Tumor ◽  
Epithelial Tumor ◽  
Dental Lamina ◽  
Ultrastructural Studies ◽  
Root Sheath ◽  
Odontogenic Epithelium ◽  
Odontogenic Origin ◽  
Enamel Epithelium

Adenomatoid odontogenic tumor (AOT) is a relatively rare benign, epithelial tumor of odontogenic origin. There is varying class of thoughts contemplating this lesion to be a hamartoma or neoplastic growth of odontogenic epithelium. Controversy regarding the histogenesis of the lesion is plentiful in earlier literature. The recent advent of immunohistochemical and ultrastructural studies has aided in throwing light on the tissue of origin of this tumor. This review aims at understanding the evolving concepts of histogenesis of AOT to better understand the biological behavior of the lesion. The review of AOT was carried out using PubMed and Google Scholar databases and 39 articles from the year 2001 to 2016 which contributed to the histogenesis of AOT were included for review. Since the origin of the cystic lining is similar to a reduced enamel epithelium and not the dental lamina, we propose the former to be the progenitor of AOT. Furthermore, we consider extra-follicular, as well as peripheral AOTs, originate from the remnants of Hertwig’s epithelial root sheath (epithelial rests of Malassez), which complies with the common histology for all these variants.

scholarly journals A rare case of massif Adenomatoid Odontogenic Tumor in the anterior region of mandible: Mimicking as dentigerous cyst

2015 ◽  
Vol 27 (3) ◽  
Author(s):  
Aris Munandar ◽  
Endang Syamsudin ◽  
Melita Sylvyana ◽  
Kiki Akhmad Rizki
Keyword(s):  
Dentigerous Cyst ◽  
Final Diagnosis ◽  
Odontogenic Tumor ◽  
Radiographic Examination ◽  
Adenomatoid Odontogenic Tumor ◽  
Impacted Tooth ◽  
Unusual Site ◽  
Radiographic Features ◽  
Odontogenic Epithelium ◽  
Anterior Mandible

Background. Adenomatoid Odontogenic Tumor (AOT) is a rare tumor of epithelial origin. AOT appears in three clinico-topographic variants: follicular, extrafollicular and peripheral. The AOT was predominantly found in the upper jaw, and rarely found in mandible, especially at anterior mandible. AOT is a tumor of odontogenic epithelium having duct like structures, which may be partly cystic, and in some cases the solid lesion may be present only as masses in the wall of a large cyst. The surgical management of this lesion would be enucleation along with removal of associated impacted tooth. The prognosis for both of them is good and recurrences are very rare after complete removal of the lesion. Purpose. It is important to define final diagnose for AOT due to mimicking with DC in clinically and radiographically finding. Biopsy is still obviously necessary to the final diagnosis. Case. 15-year-old female patients reported with chief complain of swelling in anterior mandible. The swelling beginning 4 years ago, gradually progressed, with no history pain, discharge and patient is complaint about loss of sensation around anterior mandible. Aspiration revealed straw colored fluid thinking in the way of DC. The provisional diagnosis of DC was given due to clinical presentation and radiographic imaging. But the biopsy examination showed AOT due to duct-like epithelial cells was being found. Discussion. The case report illustrates characteristic clinical and radiographic features of follicular variant of AOT mimicking a DC at unusual site that is anterior mandible. AOT is thought to arise from odontogenic epithelium and associated with the impacted tooth. Rightfully AOT is a perfect imitator of DC radiographically as well as histopathologically. It usually clinically misdiagnosed as DC as both have a unilocular, well-defined radiolucency surrounding the crown of an impacted tooth. The mass was enucleated, involved teeth were extracted, and titanium plates are used to avoid pathologist fracture. The patient had uneventful postoperative recovery. Follow up of a year has not shown any evidence of recurrence. Conclusion. Follicular type of OAT could confuse us with DC if the support examination just only clinicaly finding and radiographic examination. This case could not be definitively diagnosed on clinical and radiographic features alone. Biopsy was obviously necessary to the final diagnosis.

Investigation of malondialdehyde and some elements in young infertile males

2021 ◽  
pp. 5418-5422
Author(s):  
Khlowd Mohammed Jasem ◽  
Taha H. Alnasrawi ◽  
Haneen Haleem Shiblawi ◽  
Hameedah Hadi Abdul Wahid ◽  
Narjis Hadi Al-Saadi
Keyword(s):  
Trace Elements ◽  
Sperm Count ◽  
World Health Organisation ◽  
Toxic Chemicals ◽  
World Health ◽  
Psychosocial Effects ◽  
Radioactive Materials ◽  
The People ◽  
Zinc Levels

Infertility is an important medical issue that has serious medical and psychosocial effects on affected individuals. In 2003, the Iraqi community suffered from profanation acts because of conflicts in the country. Toxic chemicals and radioactive materials caused numerous injuries and deaths. The people who survived these horrific events eventually suffered either from cancer or infertility. The aim of this study was to determine the levels of malondialdehyde (MDA) and some trace elements in the seminal plasma of infertile males and determine their effects on sperm parameters. This study included 41 infertile males 18-40 years old. Levels of MDA, zinc, copper and magnesium were measured in their semen via spectrophotometry. According to the classification of the World Health Organisation, the patients were classified into three groups: normospermia, oligospermia and asthenspermia. Results showed significant differences in MDA and zinc levels among the three groups (p < 0.001). Moreover, results showed a mildly positive correlation between MDA levels and sperm count (r = 0.57). This study established that levels of MDA and some trace elements contribute to male infertility.

scholarly journals Extrafollicular Adenomatoid Odontogenic Tumor of the Mandible: Report of a Case

2009 ◽  
Vol 03 (01) ◽  
pp. 71-74 ◽  
Author(s):  
Nergiz Yilmaz ◽  
Aydan Acikgoz ◽  
Nukhet Celebi ◽  
A. Zeynep Zengin ◽  
Omer Gunhan
Keyword(s):  
Computer Tomography ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Odontogenic Tumor ◽  
Anterior Region ◽  
Adenomatoid Odontogenic Tumor ◽  
Fine Needle ◽  
Odontogenic Origin

ABSTRACTThe purpose of this study was to report an extrafollicular adenomatoid odontogenic tumor in the mandibular anterior region in a patient. A 15 year-old female with a painless swelling in the mandibular anterior region was referred to our clinic. Fine needle aspiration yielded no fluid. Periapical, panoramic and computer tomography scans showed circumscribed radiolucent area with fine calcifications. The lesion was totally enucleated and the teeth 31, 32 were removed. The rarity of adenomatoid odontogenic tumor may be associated with its slowly growing pattern and symptomless behavior. Therefore, it should be distinguished from more common lesions of odontogenic origin in routine dental examinations. (Eur J Dent 2009;3:71-74)

Imaging in low-grade glioma: a guide for neurologists

2017 ◽  
Vol 18 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Jennifer Larsen ◽  
Nigel Hoggard ◽  
Fiona M McKevitt
Keyword(s):  
Surgical Planning ◽  
World Health Organisation ◽  
Low Grade Glioma ◽  
World Health ◽  
Low Grade ◽  
The Central Nervous System ◽  
Contemporary Management

The management of low-grade glioma (LGG) is shifting as evidence has emergedthat refutes the previously commonplace imaging-based ‘watch and wait’ approach, in favour of early aggressive surgical resection. This coupled with the recent 2016 update to the World Health Organisation Classification of Tumours of the Central Nervous System is changing LGG imaging and management. Recently in Practical Neurology the contemporary management of low-grade glioma and the changes to this grading system were discussed in detail. 1 In this complementary article, we discuss the role of imaging in the diagnosis, surgical planning and post-treatment follow-up of LGG. We describe the principles of imaging these tumours and use several cases to highlight some difficult scenarios.

The perspective of German-speaking Countries for the Future work to Develop ICD-11

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
W. Gaebel
Keyword(s):  
Mental Disorders ◽  
Scientific Evidence ◽  
World Health Organisation ◽  
World Health ◽  
Additional Information ◽  
German Speaking ◽  
Icd 10 ◽  
Partnership Network ◽  
Future Work

In the course of the revision of the International Classification of Mental Disorders (currently 10th revision, hence ICD-10), an international scientific partnership network group was founded by the World Health Organisation (Chair: N. Sartorius, Geneva) in order to review the international scientific evidence of putative significance for the revision of ICD-10 in different language areas.In the course of this project we reviewed several areas of activity that may be of importance for the review process to develop ICD-11. First of all, general questions arise about how a psychiatric classification system should be organized. Will it still depend on classical psychopathological information with additional information from imaging, genetic and laboratory studies, and finally the patient history? An alternative approach is based on functional psychopathology be based on functional neural modules which represent functional activities of the human brain and their disturbances in mental disorders. Another area of debate is whether dimensions rather than categories shall lay a new foundation for the classification of mental disorders. A further issue arises when considering narrative elements of psychiatric history taking. In how far can or should such factors be integrated? All these questions are interwoven with the classical German contributions to psychiatric nosology by Kraepelin and Bleuler, which will be reassessed on the background of these current topics in revising ICD-10.

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