scholarly journals A REVIEW: FLOATING DRUG DELIVERY SYSTEM AS A TOOL TO IMPROVE DISSOLUTION RATE IN GASTRIC

2020 ◽  
pp. 51-54
Author(s):  
IYAN SOPYAN ◽  
SRIWIDODO ◽  
RETNO WAHYUNINGRUM ◽  
NORISCA ALIZA P.
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Gastric Retention ◽  
Pharmaceutical Dosage Form ◽  
Physiological Variables ◽  
Floating Drug Delivery ◽  
Floating System ◽  
Floating Drug Delivery System

Floating drugs are an effective way to lift the absorption of the drug in the stomach. Drugs made drugs last longer in the stomach so that the solubility process will occur effectively in the stomach. This review-journal was created by extracting indexed journals with the floating drug as journal keywords of 40 journals. This assessment of a floating drug for a new drug delivery system (NDDS) is established to elucidate the floating drugs delivery system (FDDS) based on existing literature. The most recent progress of FDDS includes the formulation and physiological variables that could affect gastric retention and formulation are dealt with in detail. This review also summarizes some approaches to prepare a floating system, evaluation methods and characterization for FDDS pharmaceutical dosage form and also its classification.

scholarly journals A Comprehensive Review on Floating Drug Delivery System (FDDS)

2020 ◽  
Vol 10 (6) ◽  
pp. 174-182
Author(s):  
Aishwarya Rajendra Bhosale ◽  
Jitendra V Shinde ◽  
Rajashree S. Chavan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Special Focus ◽  
Gastric Emptying Rate ◽  
Principal Mechanism ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating System ◽  
Floating Drug Delivery System

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. Keywords: Floating drug delivery system, Absorption Window, Effervescent system, floating lag time.

scholarly journals A Novel of Floating Delivery System is a Tool to Enhance Absorption of Drug: A Review

2020 ◽  
Vol 2 (1) ◽  
pp. 27
Author(s):  
Iyan Sopyan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Gastric Retention ◽  
Pharmaceutical Dosage Form ◽  
Physiological Variables ◽  
New Drug ◽  
Floating Tablet ◽  
Low Solubility

This assessment of a floating drug for a novel of new drug delivery system (NDDS) is written to elucidate FDDS based on existing literature. The most recent progresses of FDDS include the formulation and physiological variables that could affect gastric retention and formulations are discussed in detail. This review also summarizes method assessments for FDDS pharmaceutical dosage form and its classification. FDDS. FDDS is made to increase the absorption of the drug that is expected to dissolve in the stomach so that the drug enters the intestine in a dissolved state and the fraction of the absorbed drug increases. FDDS approach is the best way to deal with drugs with low solubility in the digestive tract.Keywords : Floating Tablet, Evaluation, Gastric Retentive

A Review on Floating Multi-particulate Drug Delivery System

2021 ◽  
pp. 3987-3992
Author(s):  
Suraj B. Pund ◽  
Vishwas C. Bhagat ◽  
Madhuri T. Deshmukh ◽  
Deepak P. Kardile ◽  
Rajkumar V. Shete
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gastric Retention ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The objective of writing this review on Floating Drug Delivery Systems (FDDS) was to accumulate new work with a special focus on the primary floatation mechanism for gastric retention. Drug delivery systems are those that instantly float on contact with gastric fluids and present promising approaches to improve the bioavailability of drugs with absorption windows in the stomach or upper small intestine, imbalanced in the intestinal or colonic environment, and exhibit low solubility at high pH standards. It is a novel drug delivery system that takes full advantage of effectiveness and compliance. Physical problems such as short gastric residence time and unpredictable gastric emptying time were overcome with the use of floating dosage forms that provide the possibility of local and systemic effects. The floating drug delivery system allows prolonged and continuous entry of the drug into the upper part of the gastric retention pathway and increases the bioavailability of the medication characterized by a narrow absorption window. This review provides detailed information on the pharmaceutical basis of its Introduction, Advantages, Disadvantages, Factors Affecting Gastric Emptying, and Criteria for Suitable Drug Products for Floating Gastric-Retention, Classification of Floating Multiparticulate Drug Delivery System, and Characterization of Floating Multiparticulate Drug Delivery System. These systems are beneficial for various difficulties encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. This review article has attempted to announce to readers about the floating drug delivery system.

scholarly journals FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT: A REVIEW

2021 ◽  
Vol 12 (1) ◽  
pp. 17-20
Author(s):  
Ankita Tripathi ◽  
Sapna Chaudhar ◽  
Khushboo Bhardwaj ◽  
Lalit Rana ◽  
Vivek Chauhan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gastric Retention ◽  
Principal Mechanism ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Systems

Floating drug delivery system was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single unit and multiple unit floating systems. In the recent decades, there have been numerous attempts to overcome the barrier like short gastric residence times and unpredictable gastric emptying times. This review also summarizes the in –vitro technique of evaluation, all the pre-formulation and post formulation evaluations criteria. These systems are useful to several problems encountered during the development of pharmaceutical dosage form. In this review, the technologies of formulation and mechanism of drug release, advantage, application in drug delivery of floating systems are discussed.

scholarly journals OVERVIEW ON FLOATING DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (6) ◽  
pp. 65 ◽  
Author(s):  
Mirmeera Girish Niharika ◽  
Kannan Krishnamoorthy ◽  
Madhukar Akkala
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
In Vivo Studies ◽  
Gastric Retention ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Systems

The principal objective behind the writing of this article on the floating drug delivery system (FDDS) was to systematize the recent literature with the core process of floatation in acquiring gastric retention. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The novel methodologies in FDDS include approaches to design a single unit and multiple-unit floating systems, the physiological and formulation variability affecting gastric retention along with the use of recently invented and developed polymers. This review also focuses on various in vitro techniques and in vivo studies in view of performance and application of floating systems. Floating dosage forms can be delivered in conventional forms like tablets, capsules with the addition of suitable ingredients along with the gas generating agent. This review also throws light on different techniques used in developing floating dosage forms along with current and novel advancements.

scholarly journals FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT

2021 ◽  
Vol 12 (1) ◽  
pp. 33-39
Author(s):  
Ankita Tripathi ◽  
Suraj Neupane ◽  
Khushboo Bhardwaj ◽  
Shiva Mishra ◽  
Meenakshi Gupta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gastrointestinal Tract ◽  
Drug Delivery System ◽  
Residence Time ◽  
Delivery System ◽  
Dosage Form ◽  
In Vitro Release ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The purpose of the present work is to prolong the gastric residence time of Lornoxicam by developing gastric floating drug delivery system. Lornoxicam is non-steroidal anti-inflammatory drugs. Its short half life 2 to 3 hrs and maximal absorption of upper part of gastrointestinal tract. The residence time of the dosage form in the stomach depends upon various factors like pH, size of the dosage form, food intake, and biological factors which include age, body weight gender, posture, and diseased states Floating tablet prepared by melt granulation techniques, using bees wax as a binder and the other polymers include HPMC 50cPs,15cPs,5cPs and Sodium Alginate. The Prepared granules were then evaluated for Precompression Properties. The best batches were then tabulated, and Evaluation was carried out for the following parameters with in vitro release, buoyancy, Floating Lag timed. Batch F12 and F13 Showed best Floating time of 12hrs and Floating Lag time of 60 second.

A Review on Emerging Floating Drug Delivery System

2016 ◽  
Vol 6 (4) ◽  
Author(s):  
Christe Mary M ◽  
Sasikumar Swamiappan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stomach Contents ◽  
Gastric Fluid ◽  
Dosage Forms ◽  
Gastric Residence Time ◽  
Advantages And Disadvantages ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

Presently, various approaches have been exploited in the prolongation of gastric residence time which includes floating drug delivery system (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems and high density systems. Among various methods, floating drug delivery system is considered to be a predominant method. Gastric emptying of dosage forms is an extremely varying process and ability to extend and control the emptying time is a valuable resource for the dosage forms. This FDDS is having the ability to provides a solution for this purpose. The FDDS is a bulk density system lower than the gastric fluid, so that the rest will float on the stomach contents for a prolonged period of time and allowing the drug to release slowly at a desired rate from the system and intensifies the bio-availability of the drug having narrow absorption window. The main intension of writing this review on floating drug delivery system is to study the mechanism of flotation to acheive the gastric retention and to discuss briefly about the background of FDDS, advantages and disadvantages, application of FDDS and factors affecting the gastric retension time.

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