A Review on Floating Multi-particulate Drug Delivery System

2021 ◽  
pp. 3987-3992
Author(s):  
Suraj B. Pund ◽  
Vishwas C. Bhagat ◽  
Madhuri T. Deshmukh ◽  
Deepak P. Kardile ◽  
Rajkumar V. Shete
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gastric Retention ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The objective of writing this review on Floating Drug Delivery Systems (FDDS) was to accumulate new work with a special focus on the primary floatation mechanism for gastric retention. Drug delivery systems are those that instantly float on contact with gastric fluids and present promising approaches to improve the bioavailability of drugs with absorption windows in the stomach or upper small intestine, imbalanced in the intestinal or colonic environment, and exhibit low solubility at high pH standards. It is a novel drug delivery system that takes full advantage of effectiveness and compliance. Physical problems such as short gastric residence time and unpredictable gastric emptying time were overcome with the use of floating dosage forms that provide the possibility of local and systemic effects. The floating drug delivery system allows prolonged and continuous entry of the drug into the upper part of the gastric retention pathway and increases the bioavailability of the medication characterized by a narrow absorption window. This review provides detailed information on the pharmaceutical basis of its Introduction, Advantages, Disadvantages, Factors Affecting Gastric Emptying, and Criteria for Suitable Drug Products for Floating Gastric-Retention, Classification of Floating Multiparticulate Drug Delivery System, and Characterization of Floating Multiparticulate Drug Delivery System. These systems are beneficial for various difficulties encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. This review article has attempted to announce to readers about the floating drug delivery system.

A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems

2021 ◽  
Vol 14 (1) ◽  
pp. 5257-5270
Author(s):  
Abhishek Kumar ◽  
Meenakshi Bharkatiya
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Floating Drug Delivery ◽  
Novel Drug ◽  
Floating Drug Delivery Systems ◽  
Gastro Retentive

Oral route has been the most convenient and accepted  route of drug delivery. Owing to tremendous curative  benefits of the oral controlled release dosage forms are  being preferred as the interesting topic in pharmaceutical  field to achieved improved therapeutics advantages.  Gastro retentive drug delivery system is novel drug  delivery systems which has an upper hand owing to its  ability of prolonged retaining ability in the stomach and  thereby increase gastric residence time of drugs and also  improves bioavailability of drugs. Concept of novel drug  delivery system arose to overcome the certain aspect  related to physicochemical properties of drug molecule  and the related formulations. In this context, various  gastro retentive drug delivery systems have been used to  improve the therapeutic efficacy of drugs that have a  narrow absorption window, are unstable at alkaline pH,  are soluble in acidic conditions, and are active locally in  the stomach. Concept of novel drug delivery system  arose to overcome the certain aspect related to  physicochemical properties of drug molecule and the  related formulations. Various approaches are currently  used including gastro retentive floating drug delivery  systems, swelling and expanding system, polymeric bio  adhesive systems, modified shape systems, high density  system and other delayed gastric emptying devices.  Moreover, future perspectives on this technology are  discussed to minimize the gastric emptying rate in both  the fasted and fed states. The present review briefly  addresses the physiology of the gastric emptying  process with respect to floating drug delivery systems.  The purpose of this review is to bring together the recent  literature with respect to the method of preparation, and  various parameters affecting the performance and  characterization of floating microspheres. Attempt has  been made to summarize important factors controlling  gastro retentive drug delivery systems. Overall, this  review may inform and guide formulation scientists in  designing the gastro retentive drug delivery system.

scholarly journals Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system

2021 ◽  
Vol 7 (1) ◽  
pp. 035-044
Author(s):  
Kajal D. Chaudhari ◽  
Minakshee G. Nimbalwar ◽  
Nikita S. Singhal ◽  
Wrushali A. Panchale ◽  
Jagdish V. Manwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Drug Delivery Systems ◽  
Gastro Retentive

Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.

scholarly journals A REVIEW: FLOATING DRUG DELIVERY SYSTEM AS A TOOL TO IMPROVE DISSOLUTION RATE IN GASTRIC

2020 ◽  
pp. 51-54
Author(s):  
IYAN SOPYAN ◽  
SRIWIDODO ◽  
RETNO WAHYUNINGRUM ◽  
NORISCA ALIZA P.
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Gastric Retention ◽  
Pharmaceutical Dosage Form ◽  
Physiological Variables ◽  
Floating Drug Delivery ◽  
Floating System ◽  
Floating Drug Delivery System

Floating drugs are an effective way to lift the absorption of the drug in the stomach. Drugs made drugs last longer in the stomach so that the solubility process will occur effectively in the stomach. This review-journal was created by extracting indexed journals with the floating drug as journal keywords of 40 journals. This assessment of a floating drug for a new drug delivery system (NDDS) is established to elucidate the floating drugs delivery system (FDDS) based on existing literature. The most recent progress of FDDS includes the formulation and physiological variables that could affect gastric retention and formulation are dealt with in detail. This review also summarizes some approaches to prepare a floating system, evaluation methods and characterization for FDDS pharmaceutical dosage form and also its classification.

scholarly journals FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT: A REVIEW

2021 ◽  
Vol 12 (1) ◽  
pp. 17-20
Author(s):  
Ankita Tripathi ◽  
Sapna Chaudhar ◽  
Khushboo Bhardwaj ◽  
Lalit Rana ◽  
Vivek Chauhan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gastric Retention ◽  
Principal Mechanism ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Systems

Floating drug delivery system was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single unit and multiple unit floating systems. In the recent decades, there have been numerous attempts to overcome the barrier like short gastric residence times and unpredictable gastric emptying times. This review also summarizes the in –vitro technique of evaluation, all the pre-formulation and post formulation evaluations criteria. These systems are useful to several problems encountered during the development of pharmaceutical dosage form. In this review, the technologies of formulation and mechanism of drug release, advantage, application in drug delivery of floating systems are discussed.

scholarly journals A summarized review about natural polymers role in floating drug delivery system and in-vivo evaluation studies

2017 ◽  
Vol 6 (4) ◽  
pp. 23-26 ◽  
Author(s):  
Muhammad Umar Javaid ◽  
Qurat Ul Ain ◽  
Umer Tahir ◽  
Safwan Shahid
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Natural Polymers ◽  
Ongoing Research ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The approach of eco-friendly and safe environmental materials for various industrial applications like medicine, agriculture and similar areas is growing rapidly. The advantages of biologically degradable and non-toxic materials like the natural polymers are evident by the mounting level of its use in pharmaceutical field particularly. The various natural polymers have been aiding the drug delivery systems for long time as the drug transporters with the objective of improving the efficacy and efficiency. The floating drug delivery systems are required to possess proper floating capability in gastric systems and use of natural polymers in such delivery systems has been very beneficial. The physical characteristics of natural polymers facilitate them to be brilliant drug carriers for such type of drug delivery systems.  The aim of this review is to provide the overview of role of natural polymers in floating drug delivery system, its characteristic effects, ongoing research and trend of future developments and applications in the field.Javaid et al., International Current Pharmaceutical Journal, March 2017, 6(4): 23-26http://www.icpjonline.com/documents/Vol6Issue4/01.pdf

scholarly journals A Comprehensive Review on Floating Drug Delivery System (FDDS)

2020 ◽  
Vol 10 (6) ◽  
pp. 174-182
Author(s):  
Aishwarya Rajendra Bhosale ◽  
Jitendra V Shinde ◽  
Rajashree S. Chavan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Special Focus ◽  
Gastric Emptying Rate ◽  
Principal Mechanism ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating System ◽  
Floating Drug Delivery System

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. Keywords: Floating drug delivery system, Absorption Window, Effervescent system, floating lag time.

SCOPE AND SIGNIFICANCE OF FLOATING DRUG DELIVERY SYSTEM

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (10) ◽  
pp. 5-12
Author(s):  
S. R. Pattan ◽  
◽  
N. P Wani ◽  
M. U Shelar ◽  
S. A. Nirmal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Delivery Systems ◽  
Oral Drug ◽  
Gastric Residence Time ◽  
Floating Drug Delivery ◽  
Technological Developments ◽  
Floating Drug Delivery System

In recent years there have been several scientific and technological advancements in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities,such as short gastric residence time (GRT) and unpredictable gastric emptying time (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems,polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

scholarly journals Floating drug delivery system- a review

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Sharma Anjali ◽  
Sharma Devkant
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gastric Retention ◽  
Residence Times ◽  
Principal Mechanism ◽  
Floating Drug Delivery ◽  
Floating Systems ◽  
Floating Drug Delivery Systems

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming various physiological problems such as short gastric residence times and unpredictable gastric emptying times. Several approaches are utilized in the prolongation of the gastric residence times, such as floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in-vitro techniques, in- vivo studies to evaluate the performance and application of floating systems, and applications of these systems.

scholarly journals OVERVIEW ON FLOATING DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (6) ◽  
pp. 65 ◽  
Author(s):  
Mirmeera Girish Niharika ◽  
Kannan Krishnamoorthy ◽  
Madhukar Akkala
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
In Vivo Studies ◽  
Gastric Retention ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Systems

The principal objective behind the writing of this article on the floating drug delivery system (FDDS) was to systematize the recent literature with the core process of floatation in acquiring gastric retention. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The novel methodologies in FDDS include approaches to design a single unit and multiple-unit floating systems, the physiological and formulation variability affecting gastric retention along with the use of recently invented and developed polymers. This review also focuses on various in vitro techniques and in vivo studies in view of performance and application of floating systems. Floating dosage forms can be delivered in conventional forms like tablets, capsules with the addition of suitable ingredients along with the gas generating agent. This review also throws light on different techniques used in developing floating dosage forms along with current and novel advancements.

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