scholarly journals DESIGN AND FABRICATION OF MEDICATED CHOCOLATE FORMULATION BY CHOCOLATE DRUG DELIVERY SYSTEM

2017 ◽  
pp. 128-133
Author(s):  
Reddy Sunil ◽  
K. Mounika ◽  
A. Venkatesham
Keyword(s):  
Drug Delivery ◽  
Cocoa Butter ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
Negative Symptoms ◽  
Chlorpheniramine Maleate ◽  
Endogenous Histamine ◽  
Total Fat

Objective: The objective of this study is to design and fabricate Chlorpheniramine Maleate chocolate formulation by chocolate drug delivery system. Chlorpheniramine Maleate binds to histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of negative symptoms brought on by histamine.Methods: Chocolate is a range of products derived from cocoa (cacao), mixed with fat (i.e., cocoa butter) and finely powdered sugar to produce a solid confectionery. The medicated chocolate formulation is widely used for pediatric administration and increases patient compliance. Chlorpheniramine Maleate chocolate formulation is prepared to improve patient compliance. Chocolates were formulated (F1-F3) with a total fat of 25-35 % (w/w) from cocoa liquor and cocoa butter with more than 34% total cocoa, composition as specified for dark chocolate, lecithin, sweetening agents.Results: The prepared chocolate formulations were evaluated for general appearance, drug content, In vitro drug release and DSC and FTIR, moisture content and blooming tests. F1 formulation releases complete drug within 60 min.Conclusion: The results indicate that the formulation has no drug excipient interactions and there was no degradation in drug, it is stable during chocolate formulation preparation. 

scholarly journals Applicability of Gum Karaya in the Preparation and in Vitro Evaluation of Losartan Potassium as Chronotherapeutic Drug Delivery System

2015 ◽  
Vol 7 (1-2) ◽  
pp. 65-74
Author(s):  
K. Latha ◽  
V. V. Srikanth ◽  
S. A. Sunil ◽  
N. R. Srinivasa ◽  
M. U. Uhumwangho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Losartan Potassium ◽  
In Vitro Dissolution ◽  
Burst Release ◽  
Gum Karaya

The objective of this investigation is to study the applicability of gum karaya, the natural gum for the preparation and in vitro evaluation of losartan potassium, as Chronotherapeutic Drug Delivery System (ChDDS). The compression-coated timed-release tablets (CCT) containing losartan potassium in the core tablet were prepared by dry coating technique with different ratios of gum karaya as the outer coat. The parameters investigated were tensile strength, friability, in vitro dissolution studies and drug concentration. The optimized formulation was further characterized by powder XRD and FTIR to investigate interactions and no interactions observed. The tensile strength and friability of all the CCT were between 1.06-1.23 MN/m2 and < 0.3% respectively.  All the CCT showed a clear lag time before a burst release of drug. However, the lag time of drug release increased as the amount of gum karaya in the outer layer increased. For instance, the lag time of LGK1, LGK2, LGK3, LGK4, LGK5, LGK6 and LGK7 were 16, 10.5, 5.5, 3, 2, 1.5 and 0.5 hrs respectively.  The drug content of all the CCT was >98%. Formulation LGK3 was taken as an optimized formulation which can be exploited to achieve ChDDS of losartan potassium for the treatment of hypertension. 

Excipient effects on in vitro cytotoxicity of a novel paclitaxel self‐emulsifying drug delivery system

2003 ◽  
Vol 92 (12) ◽  
pp. 2411-2418 ◽  
Author(s):  
Neslihan Gursoy ◽  
Jean‐Sebastien Garrigue ◽  
Alain Razafindratsita ◽  
Gregory Lambert ◽  
Simon Benita ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Cytotoxicity

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming
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