scholarly journals Angiotensin receptor blockers: do they protect against dementia and Alzheimer’s disease in the elderly?

Aging Health ◽  
2010 ◽  
Vol 6 (3) ◽  
pp. 285-287
Author(s):  
Tzvi Dwolatzky
Drugs & Aging ◽  
2013 ◽  
Vol 30 (6) ◽  
pp. 367-372 ◽  
Author(s):  
Hitomi Kurinami ◽  
Munehisa Shimamura ◽  
Naoyuki Sato ◽  
Hironori Nakagami ◽  
Ryuichi Morishita

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
K. E. Kramoh ◽  
E. Aké-Traboulsi ◽  
C. Konin ◽  
Y. N'goran ◽  
I. Coulibaly ◽  
...  

Background. Since the treatment of hypertension is beneficial for the elderly, we have undertaken this study that aims to evaluate the management of hypertension in elderly patient in Côte d'Ivoire.Methods. A retrospective study was conducted among 854 hypertensive elderly patients of Abidjan Cardiology Institute who were followed for a minimum of one year, between January 2000 and December 2009.Results. The patients mean age was years, and 59% were women. At the first presentation, it was mostly systolic-diastolic hypertension (51.8%) and isolated systolic hypertension (38.5%). Mean blood pressure was  mmHg for systolic,  mmHg for diastolic, and  mmHg for pulse pressure. Pulse pressure was ≥60 mmHg in 80.4%. According to the European Guidelines stratification of the cardiovascular risk-excess attributable to high blood pressure, 82.1% of the sample had a very high added risk. The pharmacological therapy was prescribed in 93.5%. More than 66% of patients were receiving ≥2 antihypertensive drugs including fixed-dose combination drugs. The most common agents used were diuretics (63.5%) followed by angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in 61.3%. The most common agents used for monotherapy were calcium antagonists. When ≥2 drugs were used, diuretics and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were the most common. Blood pressure control was achieved in 42.6%.Conclusion. The control of elderly hypertension can be effective in Sub-Saharan Africa. He required at least two antihypertensive drugs to meet the recommended blood pressure target.


2005 ◽  
Vol 6 (2_suppl) ◽  
pp. S11-S12
Author(s):  
Erland Erdmann

Chronic heart failure (CHF) is common among the elderly, who typically suffer from multiple co-morbidities.The clinician therefore needs to consider the possibility of interaction between drugs given to treat these underlying conditions and drugs given to treat CHF. Patients who remain symptomatic despite established CHF therapy derive important clinical benefits from the addition of an angiotensin receptor blocker (ARB), irrespective of age, sex, ethnicity and baseline heart failure, as recognised in the recent revision of the European Society of Cardiology guidelines for the treatment of CHF. Rationalisation of concomitant therapy in accordance with guideline recommendations can help to minimise the potential for adverse effects. This case report describes an elderly man with CHF and multiple co-morbidities who remained symptomatic despite established therapy.


2020 ◽  
Vol 6 (5) ◽  
pp. 1-7
Author(s):  
Chinonye A Maduagwuna ◽  

Study background: Chronic neuroinflammation is a common emerging hallmark of several neurodegenerative diseases. Alzheimer’s Disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions.


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