Effect Of Nhexane Extract Of Caryota No Seed On Markers Of Neurodegeneration And Fecundity In Drosophila Melanogaster

2020 ◽  
Vol 6 (5) ◽  
pp. 1-7
Author(s):  
Chinonye A Maduagwuna ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drosophila Melanogaster ◽  
Neurodegenerative Diseases ◽  
Cognitive Functions ◽  
The Elderly ◽  
Common Cause ◽  
Chronic Neuroinflammation

Study background: Chronic neuroinflammation is a common emerging hallmark of several neurodegenerative diseases. Alzheimer’s Disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions.

scholarly journals Oral infections and orofacial pain in Alzheimer's disease: case report and review

2010 ◽  
Vol 4 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Silvia Regina Dowgan T. de Siqueira ◽  
Thaís de Souza Rolim ◽  
Manoel Jacobsen Teixeira ◽  
Ricardo Nitrini ◽  
Renato Anghinah ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Facial Pain ◽  
Orofacial Pain ◽  
The Elderly ◽  
Secondary Headache ◽  
Behavioral Impairment ◽  
Common Cause ◽  
Oral Infections ◽  
Disease Case

Abstract Dental infections, frequent in the general population, are a common cause of inflammation with systemic impact, and are the most common cause of orofacial pain. Temporomandibular disorders are also frequent in the elderly and represent an important cause of secondary headache. Both inflammation and pain can also contribute to cognitive, functional and behavioral impairment of the elderly and aggravate symptoms of patients with Alzheimer's disease (AD). We report a case of a 74-year-old woman with AD and chronic facial pain who had a significant improvement in functional activities as well as in cognition and depressive symptoms after successful treatment of her facial pain. Patients with AD have higher compromise of oral health with infections and teeth loss. The investigation of orofacial pain should be performed in patients with AD, because of the associations reviewed and given the potential for improvement as highlighted by this case.

Impact of Exosomes Serving as a Tool for Nano-Science in Neurotherapeutics: Anti-Alzheimers

2021 ◽  
Vol 13 (SUP 1) ◽  
pp. 7-9
Author(s):  
Safiya Sultana T ◽  
Rupali D. Mitra ◽  
Jyotsna Gawai ◽  
Sudhanshu Singh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Cognitive Functions ◽  
Beta Amyloid ◽  
Nano Particles ◽  
Current Review ◽  
Nano Science

Alzheimer’s disease, being a chronic state progressive ND(neurodegenerative diseases), is characterised by abnormalities beta-amyloid and impaired cognitive functions resulting in dementia. Exosomes (Nano-particles) have developed as a promising mediators of NDs in which they carry toxic particles between cells and transfer them. Hence, current review focusesprimarily on the effects of exosomes in modulating mediators and promotingneuroprotection against NDs.

scholarly journals Dietary fats and the risk of incident Alzheimer disease (Arch. Neurol. — 2003. —Feb. — 60(2). — P. 194—200: англ.)

2003 ◽  
Vol XXXV (1-2) ◽  
pp. 79-79
Author(s):  
M. Morris ◽  
D. Evans ◽  
J. Bienias ◽  
C. Tangney ◽  
D. Bennett ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Alzheimer Disease ◽  
The Elderly ◽  
Dietary Fats ◽  
Progressive Dementia ◽  
Common Cause ◽  
Brain Degeneration ◽  
Older Populations

Alzheimer's disease, progressive brain degeneration, is the most common cause of progressive dementia in older populations. It has been shown that the characteristics of the diet of the elderly increase or decrease the risk of developing the disease.

scholarly journals Clinicotherapeutic Potential of Leptin in Alzheimer’s Disease and Parkinson’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Soumyabrata Munshi ◽  
Vineet Kumar Khemka ◽  
Kalpita Banerjee ◽  
Sasanka Chakrabarti
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Peptide Hormone ◽  
The Elderly ◽  
Clinical Associations ◽  
The Brain

Chronic neurodegenerative diseases are a group of devastating neurological disorders that result in significant morbidity and mortality in the elderly population worldwide. Recent researches have shown some interesting associations of the classical antiobesity hormone leptin with two most important neurodegenerative diseases—Alzheimer’s disease (AD) and Parkinson’s disease (PD). Although several clinical studies have found the procognitive and memory-enhancing role of this peptide hormone in leptin-deficient patients, surprisingly it has not been used in any clinical trials involving patients with developing or full-blown neurodegenerative conditions. This review article is an attempt to bring together the existing information about the clinical associations of leptin with AD and PD. It starts with the basic understanding of leptin action in the brain and its derangements in these diseases and eventually discusses the potential of this hormone as a neuroprotective agent in clinical scenario.

scholarly journals Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

2019 ◽  
Vol 20 (8) ◽  
pp. 1871 ◽  
Author(s):  
Samaila Musa Chiroma ◽  
Mohamad Taufik Hidayat Baharuldin ◽  
Che Norma Mat Taib ◽  
Zulkhairi Amom ◽  
Saravanan Jagadeesan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Functions ◽  
Neurodegenerative Disorder ◽  
Glycogen Synthase ◽  
Centella Asiatica ◽  
The Elderly ◽  
Aluminium Chloride ◽  
Gsk 3Β ◽  
First Time

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. Centella asiatica (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions. This study aimed to evaluate the effectiveness of CA in preventing d-galactose/aluminium chloride (d-gal/AlCl3) induced AD-like pathologies and the underlying mechanisms of action were further investigated for the first time. Results showed that co-administration of CA to d-gal/AlCl3 induced AD-like rat models significantly increased the levels of protein phosphatase 2 (PP2A) and decreased the levels of glycogen synthase kinase-3 beta (GSK-3β). It was further observed that, CA increased the expression of mRNA of Bcl-2, while there was minimal effect on the expression of caspase 3 mRNA. The results also showed that, CA prevented morphological aberrations in the connus ammonis 3 (CA 3) sub-region of the rat’s hippocampus. The results clearly demonstrated for the first time that CA could alleviate d-gal/AlCl3 induced AD-like pathologies in rats via inhibition of hyperphosphorylated tau (P-tau) bio-synthetic proteins, anti-apoptosis and maintenance of cytoarchitecture.

scholarly journals Non-Alzheimer's disease-related memory impairment and dementia

2013 ◽  
Vol 15 (4) ◽  
pp. 465-473 ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Impairment ◽  
Clinical Symptoms ◽  
Memory Function ◽  
The Elderly ◽  
Memory Deficits ◽  
Common Cause ◽  
Underlying Causes ◽  
Therapeutic Possibilities

Although Alzheimer's disease (AD) is a common cause of memory impairment and dementia in the elderly disturbed memory function is a widespread subjective and/or objective symptom in a variety of medical conditions. The early detection and correct distinction of AD from non-AD memory impairment is critically important to detect possibly treatable and reversible underlying causes. In the context of clinical research, it is crucial to correctly distinguish between AD or non-AD memory impairment in order to build homogenous study populations for the assessment of new therapeutic possibilities. The distinction of AD from non-AD memory impairment may be difficult, especially in mildly affected patients, due to an overlap of clinical symptoms and biomarker alterations between AD and certain non-AD conditions. This review aims to describe recent aspects of the differential diagnosis of AD and non-AD related memory impairment and how these may be considered in the presence of memory deficits.

scholarly journals ЭТИЧЕСКИЕ ПРЕПЯТСТВИЯ ПРИМЕНЕНИЯ КУКЛОТЕРАПИИ ПРИ ДЕМЕНЦИИ И БОЛЕЗНИ АЛЬЦГЕЙМЕРА

2020 ◽  
Vol 51 (3) ◽  
pp. 108-119
Author(s):  
Severina D. Koldman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Older People ◽  
Cognitive Functions ◽  
Pharmacological Treatment ◽  
The Elderly ◽  
The Subject ◽  
Everyday Interaction

The article raises the question of the effectiveness and ethics of the method of doll therapy for older people suffering from a decrease in cognitive functions. The results of studies by sociologists and medical anthropologists, evidence of caring staff and relatives of people suffering from dementia and Alzheimer’s disease confirm that dolls make medication easier, improve mood and facilitate everyday interaction. The subject of discussion is the question of the ethics of the doll therapy in view of possible humiliation and dehumanization of older people. This study reveals the perception of doll therapy as a method of non-pharmacological treatment in caring for the elderly.

scholarly journals Ocular Manifestations of Alzheimer’s and Other Neurodegenerative Diseases: The Prospect of the Eye as a Tool for the Early Diagnosis of Alzheimer’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Pade Colligris ◽  
Maria Jesus Perez de Lara ◽  
Basilio Colligris ◽  
Jesus Pintor
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Ganglion Cells ◽  
The Elderly ◽  
Disease Diagnosis ◽  
Diagnostic Tools ◽  
Ocular Manifestations ◽  
Retinal Pathology ◽  
Nerve Fibre Layer

Dementia, including Alzheimer’s disease (AD), is a major disorder, leading to several ocular manifestations amongst the elderly population. These visual disorders may be due to retinal nerve degenerative changes, including nerve fibre layer thinning, degeneration of retinal ganglion cells, and changes to vascular parameters. There is no cure for Alzheimer’s, but medicines can slow down the development of many of the classic symptoms, such as loss of memory and communication skills, mood swings, and depression. The disease diagnosis is difficult, and it is only possible through PET scans of the brain, detecting evidence of the accumulation of amyloid and tau. PET is expensive and invasive, requiring the injection of radioactive tracers, which bind with these proteins and glow during scanning. Recently, scientists developed promising eye-scan techniques that may detect Alzheimer’s disease at its earliest stage, before major symptoms appear, leading to improved management of the disease symptoms. In this review, we are discussing the visual abnormalities of Alzheimer’s and other neurodegenerative diseases, focused on ocular functional-visual-structural biomarkers, retinal pathology, and potential novel diagnostic tools.

scholarly journals Molecular Aspects of Cellular Dysfunction in Alzheimer’s Disease: The Need for a Holistic View of the Early Pathogenesis

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1807
Author(s):  
Sara Merlo ◽  
Simona Federica Spampinato ◽  
Dmitry Lim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Economic Burden ◽  
Population Aging ◽  
The Elderly ◽  
Holistic View ◽  
Common Cause ◽  
Molecular Aspects ◽  
Cellular Dysfunction

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, a socio-economic burden destined to worsen with increased population aging [...]

scholarly journals Dementia with Lewy bodies

1997 ◽  
Vol 7 (2) ◽  
pp. 163-170 ◽  
Author(s):  
J Allardyce ◽  
IG McKeith
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
The Elderly ◽  
Common Cause ◽  
Autopsy Series ◽  
Cortical Lewy Bodies

Dementia with Lewy bodies (DLB) is being increasingly recognized as a common cause of progressive cognitive decline in the elderly, with hospital-based autopsy series demonstrating rates of between 7% and 25% of all cases of dementia, second only in frequency to Alzheimer's disease (AD). Although DLB has only recently been described, it is unlikely to be a newly occurring disease but one which has become identifiable as a result of advances in neuropathological techniques which make cortical Lewy bodies (LBs) easier to detect.

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