Early NT-proBNP and MR-proANP associated with QoL 1 year after acutely decompensated heart failure: secondary analysis from the MOLITOR trial

Aim: Heart failure negatively impacts quality of life (QoL), which in turn contributes to an adverse long-term prognosis. We aimed at identifying biomarker trajectories after an episode of acutely decompensated heart failure (ADHF) that differ between patients showing average versus impaired QoL 1 year later, thus allowing to predict impaired QoL. Methods: Biomarkers were repeatedly measured throughout the year in 104 ADHF patients. QoL was assessed at discharge and 1 year after ADHF. Logistic regression and receiver operating characteristic analyses were used to identify predictors of impaired QoL while controlling psychosocial confounders. Results: MR-proANP predicted impaired physical and mental QoL. NT-proBNP measurements were important predictors for poor physical QoL. Conclusion: MR-proANP and NT-proBNP predict poor QoL after an epidode of ADHF. The trial is registered at http://clinicaltrials.gov as MOLITOR (IMpact of therapy optimisation On the Level of biomarkers in paTients with Acute and Decompensated ChrOnic HeaRt Failure) with unique identifier: NCT01501981.

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Residual congestion and long-term prognosis in acutely decompensated heart failure patients

Internal and Emergency Medicine ◽

10.1007/s11739-020-02326-y ◽

2020 ◽

Vol 15 (4) ◽

pp. 719-724

Author(s):

E. Ceriani ◽

G. Casazza ◽

J. Peta ◽

D. Torzillo ◽

S. Furlotti ◽

...

Keyword(s):

Heart Failure ◽

Decompensated Heart Failure ◽

Heart Failure Patients ◽

Acutely Decompensated Heart Failure ◽

Long Term Prognosis

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Minor Myocardial Damage Detected by Troponin T Is a Powerful Predictor of Long-Term Prognosis in Patients With Acute Decompensated Heart Failure

Yearbook of Cardiology ◽

10.1016/s0145-4145(07)70187-9 ◽

2006 ◽

Vol 2006 ◽

pp. 311-313

Author(s):

M.D. Cheitlin

Keyword(s):

Heart Failure ◽

Troponin T ◽

Acute Decompensated Heart Failure ◽

Myocardial Damage ◽

Decompensated Heart Failure ◽

Powerful Predictor ◽

Long Term Prognosis ◽

Minor Myocardial Damage

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Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults ≥60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction

Circulation Heart Failure ◽

10.1161/circheartfailure.118.005254 ◽

2018 ◽

Vol 11 (11) ◽

Cited By ~ 24

Author(s):

Haider J. Warraich ◽

Dalane W. Kitzman ◽

David J. Whellan ◽

Pamela W. Duncan ◽

Robert J. Mentz ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Ejection Fraction ◽

Physical Function ◽

Acute Decompensated Heart Failure ◽

Decompensated Heart Failure ◽

Reduced Ejection Fraction

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Long-term prognosis in Crohn's disease: factors that affect quality of life

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2006.02753.x ◽

2006 ◽

Vol 23 (3) ◽

pp. 377-385 ◽

Cited By ~ 51

Author(s):

C. CANAVAN ◽

K. R. ABRAMS ◽

B. HAWTHORNE ◽

D. DROSSMAN ◽

J. F. MAYBERRY

Keyword(s):

Quality Of Life ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Long Term Prognosis

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Association of Diabetes With Atrial Fibrillation Phenotype and Cardiac and Neurological Comorbidities: Insights From the Swiss‐AF Study

Journal of the American Heart Association ◽

10.1161/jaha.121.021800 ◽

2021 ◽

Author(s):

Arjola Bano ◽

Nicolas Rodondi ◽

Jürg H. Beer ◽

Giorgio Moschovitis ◽

Richard Kobza ◽

...

Keyword(s):

Quality Of Life ◽

Myocardial Infarction ◽

Heart Failure ◽

Atrial Fibrillation ◽

Cognitive Impairment ◽

Unique Identifier ◽

Cross Sectional ◽

Patients With Diabetes ◽

History Of

Background Diabetes is a major risk factor for atrial fibrillation (AF). However, it remains unclear whether individual AF phenotype and related comorbidities differ between patients who have AF with and without diabetes. This study investigated the association of diabetes with AF phenotype and cardiac and neurological comorbidities in patients with documented AF. Methods and Results Participants in the multicenter Swiss‐AF (Swiss Atrial Fibrillation) study with data on diabetes and AF phenotype were eligible. Primary outcomes were parameters of AF phenotype, including AF type, AF symptoms, and quality of life (assessed by the European Quality of Life‐5 Dimensions Questionnaire [EQ‐5D]). Secondary outcomes were cardiac (ie, history of hypertension, myocardial infarction, and heart failure) and neurological (ie, history of stroke and cognitive impairment) comorbidities. The cross‐sectional association of diabetes with these outcomes was assessed using logistic and linear regression, adjusted for age, sex, and cardiovascular risk factors. We included 2411 patients with AF (27.4% women; median age, 73.6 years). Diabetes was not associated with nonparoxysmal AF (odds ratio [OR], 1.01; 95% CI, 0.81–1.27). Patients with diabetes less often perceived AF symptoms (OR, 0.74; 95% CI, 0.59–0.92) but had worse quality of life (β=−4.54; 95% CI, −6.40 to −2.68) than those without diabetes. Patients with diabetes were more likely to have cardiac (hypertension [OR, 3.04; 95% CI, 2.19–4.22], myocardial infarction [OR, 1.55; 95% CI, 1.18–2.03], heart failure [OR, 1.99; 95% CI, 1.57–2.51]) and neurological (stroke [OR, 1.39, 95% CI, 1.03–1.87], cognitive impairment [OR, 1.75, 95% CI, 1.39–2.21]) comorbidities. Conclusions Patients who have AF with diabetes less often perceive AF symptoms but have worse quality of life and more cardiac and neurological comorbidities than those without diabetes. This raises the question of whether patients with diabetes should be systematically screened for silent AF. Registration URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02105844.

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