Malignant phyllodes tumor of the breast: case report, tumor characteristics, treatment approach

Due to the rarity of phyllodes breast tumors (particularly malignant tumors), a limited number of described cases and a lack of randomized studies, we currently do not have absolute guidelines for treating these types of tumors. The following article presents the case of a patient with a malignant phyllodes breast tumor, with numerous local recurrences after primary mastectomy and the effects of treatment. The course of the patient’s disease emphasizes the purposefulness and effectiveness of aggressive surgical treatment. In the article, the authors show that leaving even small abnormalities within the scar just to observation is not good practice; surgeons should try to remove all, even unclear, abnormalities.

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Bone metastasis from malignant phyllodes of the breast

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20194590 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4364

Author(s):

Daniel Oktavianus Dau ◽

I. Wayan Sudarsa

Keyword(s):

Case Report ◽

Bone Metastasis ◽

Breast Tumor ◽

Benign Tumor ◽

Phyllodes Tumor ◽

Breast Tumors ◽

Upper Arm ◽

Malignant Phyllodes Tumor ◽

Cystosarcoma Phyllodes ◽

The Right

Cystosarcoma phyllodes was described first in 1838 and originally was considered to be a benign tumor. It was not until 1931 that metastasis from a cystosarcoma phyllodes was reported. The incidence of cystosarcoma phyllodes is estimated to be 0.3% to 0.9% of all breast tumors. Sites most commonly affected by metastases are the lungs and bones. We present a case report 29-year old female patient presented with a voluminous breast mass at both of them which was completely resected. The right side presented of malignant phyllodes and the left side is borderline phyllodes. Six months later, both of her legs became paralyzed and accompanied by swelling over her right upper arm. Biopsy was performed, and the diagnosis was metastatic malignant phyllodes tumor. Histologic review of the breast tumor revealed stromal overgrowth.

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Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature

Breast Care ◽

10.1159/000448236 ◽

2016 ◽

Vol 11 (4) ◽

pp. 291-294 ◽

Cited By ~ 1

Author(s):

Canan Kelten ◽

Ceren Boyaci ◽

Cem Leblebici ◽

Kemal Behzatoglu ◽

Didem C. Trabulus ◽

...

Keyword(s):

Case Report ◽

Bone Cyst ◽

Clinical Breast Examination ◽

Phyllodes Tumor ◽

Breast Cancer Diagnosis ◽

Left Breast ◽

Malignant Phyllodes Tumor ◽

Her Family ◽

Simple Mastectomy ◽

Clinical Breast

Background: Malignant phyllodes tumors of the breast are rare biphasic neoplasms. Only few cases related to pregnancy have been reported. Case Report: A 37-year-old woman presented with swelling and pain in her left breast as well as hyperemia on the breast skin, 4 weeks after labor. In her family history, her aunt and maternal cousin had had a breast cancer diagnosis. Clinical evaluation of the patient was consistent with a breast abscess. Therefore, abscess drainage and biopsy from the cavity wall were performed. However, the biopsy was diagnosed as malignant phyllodes tumor. An evaluation by ultrasonography showed a well-defined hypoechoic mass with many cystic spaces covering the entire breast tissue. Therefore, a simple mastectomy was performed. Microscopic examination revealed a high-grade malignant phyllodes tumor. Additionally, bone cyst-like areas in the form of sponge-like blood-filled non-endothelialized spaces were observed. Conclusions: Since the breasts become larger due to the physiological changes during pregnancy, any underlying breast lesions may be obscured. Therefore, clinical breast examination in the first visit of pregnancy is important.

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Preoperative interventional artery embolization for the treatment of a giant malignant phyllodes tumor: A case report

Molecular and Clinical Oncology ◽

10.3892/mco.2021.2295 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Yue Tian ◽

Linlin Liu ◽

Liang Chen ◽

Shengdi Zhao ◽

Ruijun Su ◽

...

Keyword(s):

Case Report ◽

Phyllodes Tumor ◽

Artery Embolization ◽

Malignant Phyllodes Tumor

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Radiotherapy was Effective for Multiple Organ Metastases of a Malignant Phyllodes Tumor—A Case Report—

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ◽

10.3919/jjsa.79.2020 ◽

2018 ◽

Vol 79 (10) ◽

pp. 2020-2026

Author(s):

Tomohiro OSHINO ◽

Nobumoto TOMIOKA ◽

Kenichi WATANABE ◽

Masako SATO ◽

Mitsugu YAMAMOTO ◽

...

Keyword(s):

Case Report ◽

Phyllodes Tumor ◽

Multiple Organ ◽

Malignant Phyllodes Tumor

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Multifocal intra-parenchymal and sub-pectoral malignant phyllodes tumor in young female, rare and unusual presentation: A case report

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2020.05.014 ◽

2020 ◽

Vol 71 ◽

pp. 280-284

Author(s):

Mohammad Naser Athamnah ◽

Omar M. Abuelaish ◽

Nimah A. Rabai

Keyword(s):

Case Report ◽

Phyllodes Tumor ◽

Young Female ◽

Unusual Presentation ◽

Malignant Phyllodes Tumor

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Malignant phyllodes tumor in an 11-year-old girl with fatal clinical outcome. A case report

Breast Disease ◽

10.3233/bd-150193 ◽

2016 ◽

Vol 36 (1) ◽

pp. 61-64 ◽

Cited By ~ 3

Author(s):

Sidra Hassan ◽

Nasir Ud Din ◽

Naila Kayani

Keyword(s):

Case Report ◽

Clinical Outcome ◽

Phyllodes Tumor ◽

Malignant Phyllodes Tumor

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Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature

Case Reports in Oncological Medicine ◽

10.1155/2018/6491675 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

R. A. Amir ◽

Rola S. Rabah ◽

S. S. Sheikh

Keyword(s):

Case Report ◽

Breast Neoplasms ◽

Distant Metastasis ◽

Case Reports ◽

Phyllodes Tumor ◽

Pancreatic Metastasis ◽

Rare Tumor ◽

Review Of Literature ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors

Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term “cystosarcoma phyllodes” based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. However, seeing as up to 70% of phyllodes tumors are benign, “cystosarcoma” was removed, and the tumor is now recognized simply as phyllodes tumor. It is mainly seen in females between the ages of 35 and 55. Although most phyllodes tumors are benign, malignant cases do uncommonly occur, 22% of which have distant metastasis typically to the lungs and bones. Rarely, this tumor metastasizes to other locations. Herein, we report a case of malignant phyllodes tumor with metastasis to the pancreas. According to our knowledge, only 3 case reports of pancreatic metastasis from malignant phyllodes tumor have been reported in literature thus far. We aim to increase awareness among physicians of this rare metastasic potential of the uncommonly encountered malignant phyllodes tumor.

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