Isolation and first draft genome sequence of a linezolid-dependent Staphylococcus aureus clinical strain

2020 ◽  
Vol 15 (12) ◽  
pp. 1123-1129
Author(s):  
Víctor A. García-Angulo ◽  
Beatrice Herve ◽  
Joel Melo ◽  
Camila Sanhueza ◽  
Sebastián De la Fuente ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Aureus Strain ◽  
23S Rrna ◽  
Clinical Strain ◽  
Antibiotics Resistance ◽  
Type I ◽  
Linezolid Resistance

Background: Antibiotic-dependent pathogenic bacteria are sporadically isolated from patients that received prolonged antibiotic treatments. Evolution of antibiotics dependence and its clinical implications are scarcely studied. Materials & methods: A linezolid-dependent Staphylococcus aureus strain was isolated from a cystic fibrosis patient. A draft genome sequence was obtained and searched for known antibiotics resistance determinants and virulence factors. Results: The genome was assembled into 79 contigs for a total of 2.83 Mbp. This strain is a sequence type 5 methicillin-resistant Staphylococcus aureus with a type I SCC mec cassette also conserving the Panton–Valentine leukocidin. The G2576T substitution, conferring linezolid resistance, was harbored by all five copies of the 23S rRNA. Conclusion: The linezolid-dependent strain is related to a strain circulating in Latin America that acquired a mutation conferring linezolid resistance.

scholarly journals Draft Genome Sequence of a Staphylococcus aureus Strain Isolated from a Cow with Clinical Mastitis

2015 ◽  
Vol 3 (4) ◽  
Author(s):  
Paresh Sharma ◽  
D. Peddi Reddy ◽  
P. Anand Kumar ◽  
Ramya Gadicherla ◽  
Neena George ◽  
...  
Keyword(s):  
Public Health ◽  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Causative Agent ◽  
Draft Genome ◽  
Clinical Mastitis ◽  
Draft Genome Sequence ◽  
Aureus Strain ◽  
Potential Threat

We report here the draft genome of Staphylococcus aureus causing clinical mastitis in a cow from India. It is a major causative agent of mastitis and, further, livestock-associated strains are emerging as a potential threat to public health, thereby warranting studies to understand the genome of this deadly pathogen.

scholarly journals Genome Sequence of Staphylococcus aureus Strain HUK16, Isolated from Hexachlorocyclohexane-Contaminated Soil

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Cyrielle Gasc ◽  
Jean-Yves Richard ◽  
Pierre Peyret
Keyword(s):  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Contaminated Soil ◽  
Metabolic Pathways ◽  
Genetic Basis ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Aureus Strain

Staphylococcus aureus strain HUK16 has been isolated from hexachlorocyclohexane (HCH)-long-term contaminated soil. The genome of strain HUK16 was sequenced to understand the genetic basis of its adaptation to HCH and to find the potential metabolic pathways allowing it to degrade the pesticide. Here, we report the annotated draft genome sequence (~2.7 Mbp) of this strain.

scholarly journals Draft Genome Sequence of a Highly Virulent Rabbit Staphylococcus aureus Strain

2015 ◽  
Vol 3 (4) ◽  
Author(s):  
Zoltán Német ◽  
Ervin Albert ◽  
Tibor Nagy ◽  
Ferenc Olasz ◽  
Endre Barta ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Aureus Strain ◽  
Highly Virulent

scholarly journals Draft Genome Sequence of Methicillin-Resistant Staphylococcus aureus Strain AW7, Isolated from a Patient with Bacteremia

2019 ◽  
Vol 8 (40) ◽  
Author(s):  
David R. Cameron ◽  
Alban Ramette ◽  
Josef Prazak ◽  
José Entenza ◽  
Matthias Haenggi ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Draft Genome ◽  
Experimental Models ◽  
Draft Genome Sequence ◽  
Aureus Strain ◽  
Methicillin Resistant ◽  
Content Type ◽  
Mrsa Infection

Methicillin-resistant Staphylococcus aureus (MRSA) strain AW7 is a commonly used challenge strain in experimental models of MRSA infection. Here, we report its draft genome sequence.

scholarly journals Draft Genome Sequence of an Atypical Highly Virulent Rabbit Staphylococcus aureus Strain

2017 ◽  
Vol 5 (42) ◽  
Author(s):  
Zoltán Német ◽  
Ervin Albert ◽  
Tibor Nagy ◽  
Ferenc Olasz ◽  
Endre Barta ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Aureus Strain ◽  
Content Type ◽  
Highly Virulent

ABSTRACT Rabbit staphylococcosis is one of the most important diseases in industrial rabbit production. We report here the draft genome sequence of Staphylococcus aureus strain 380/11, an atypical highly virulent (aHV) rabbit Staphylococcus aureus strain.

scholarly journals Draft Genome Sequence of USA100 Methicillin-Resistant Staphylococcus aureus Strain 209

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Yingfeng Chen ◽  
Heidi A. Crosby ◽  
Wilhelm F. Oosthuysen ◽  
Daniel J. Diekema ◽  
Scott T. Kelley ◽  
...  
Keyword(s):  
Health Care ◽  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Draft Genome ◽  
Model Organism ◽  
Draft Genome Sequence ◽  
Aureus Strain ◽  
Type Ii ◽  
Methicillin Resistant

ABSTRACT USA100 strains are significant contributors to the overall burden of health care-associated methicillin-resistant Staphylococcus aureus (MRSA) infections. Strain 209 is a representative MRSA isolate that serves as a model organism for agr type II studies and USA100 virulence assessments. We present a draft genome sequence of this strain.

scholarly journals Draft Genome Sequence of Staphylococcus aureus Strain HD1410, Isolated from a Persistent Nasal Carrier

2018 ◽  
Vol 6 (19) ◽  
Author(s):  
Dennis Nurjadi ◽  
Sébastien Boutin ◽  
Alexander Dalpke ◽  
Klaus Heeg ◽  
Philipp Zanger
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Responses ◽  
Genome Sequence ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Aureus Strain ◽  
Content Type ◽  
Nasal Carrier ◽  
Persistent Carrier

ABSTRACT We report here the draft genome sequence of a Staphylococcus aureus strain isolated from the nares of an 18-year-old female healthy persistent-carrier individual, and it was used to investigate S. aureus -specific immune responses in colonized and noncolonized individuals.

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