scholarly journals Overview of subcutaneous immunoglobulin 16.5% in primary and secondary immunodeficiency diseases

Immunotherapy ◽  
2022 ◽  
Author(s):  
Roger H Kobayashi ◽  
Jiří Litzman ◽  
Syed Rizvi ◽  
Huub Kreuwel ◽  
Sonja Hoeller ◽  
...  
Keyword(s):  
Primary Immunodeficiency ◽  
Primary Immunodeficiency Disease ◽  
Patient Needs ◽  
Subcutaneous Immunoglobulin ◽  
Primary Immunodeficiency Diseases ◽  
Secondary Immunodeficiency ◽  
Specific Patient ◽  
Immunodeficiency Diseases ◽  
Key Characteristics ◽  
Immunodeficiency Disease

Most primary immunodeficiency diseases, and select secondary immunodeficiency diseases, are treated with immunoglobulin (IG) therapy, administered intravenously or subcutaneously (SCIG). The first instance of IG replacement for primary immunodeficiency disease was a 16.5% formulation administered subcutaneously in 1952. While most SCIG products are now a 10 or 20% concentration, this review will focus on SCIG 16.5% products with a historical overview of development, including the early pioneers who initiated and refined IG replacement therapy, as well as key characteristics, manufacturing and clinical studies. In determining an appropriate IG regimen, one must consider specific patient needs, characteristics and preferences. There are advantages to SCIG, such as stable serum immunoglobulin G levels, high tolerability and the flexibility of self-administered home treatment.

Current Applications of Flow Cytometry in the Diagnosis of Primary Immunodeficiency Diseases

2004 ◽  
Vol 128 (1) ◽  
pp. 23-31
Author(s):  
Orieji C. Illoh
Keyword(s):  
Flow Cytometry ◽  
Primary Immunodeficiency ◽  
Laboratory Tests ◽  
Data Extraction ◽  
Relevant Information ◽  
Primary Immunodeficiency Disease ◽  
Data Sources ◽  
Primary Immunodeficiency Diseases ◽  
Immunodeficiency Diseases ◽  
Immunodeficiency Disease

Abstract Context.—To review the applications of flow cytometry in the diagnosis and management of primary immunodeficiency disease. Data Sources.—Articles describing the use of flow cytometry in the diagnosis of several primary immunodeficiency diseases were obtained through the National Library of Medicine database. Study Selection.—Publications that described novel and known applications of flow cytometry in primary immunodeficiency disease were selected. Review articles were included. Articles describing the different immunodeficiency diseases and methods of diagnosis were also selected. Data Extraction.—Approximately 100 data sources were analyzed, and those with the most relevant information were selected. Data Synthesis.—The diagnosis of many primary immunodeficiency diseases requires the use of several laboratory tests. Flow cytometry has become an important part of the workup of individuals suspected to have such a disorder. Knowledge of the pathogenesis of many of these diseases continues to increase, hence we acquire a better understanding of the laboratory tests that may be helpful in diagnosis. Conclusions.—Flow cytometry is applicable in the initial workup and subsequent management of several primary immunodeficiency diseases. As our understanding of the pathogenesis and management of these diseases increases, the use of many of these assays may become routine in hospitals.

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