scholarly journals Current Approaches on Gastroretentive Drug Delivery systems

2020 ◽  
Vol 10 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Aniket Uttam Pund ◽  
Raosaheb Sopanrao Shendge ◽  
Ajinkya Kailas Pote
Keyword(s):  
Extended Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
The Novel ◽  
Novel Technologies ◽  
Novel Technology ◽  
The Many ◽  
Floating Systems ◽  
Acidic Region ◽  
Gastro Retentive

Over recent years, there have been many efforts to develop the absorption rate of medications and the therapeutic efficacy of oral dosage types. GRDDS for strengthen the pharmacological effects of drugs with a small uptake site, are unbalanced at pH greater than 7, are dissolved under acidic region, and are effective local region in the stomach. The gastro retentive systems that have the different evaluation parameter that according to the dosage forms. There are many criteria for the choosing of the drug used in the gastro-retardant systems as the drug should be sparingly stable, it should be compatible with the gastric region, and narrow absorption. In this review, we have summarized the information related to the various approaches for enhancing and prolonging of the dosage forms in the stomach for their extended-release of action. Also talking about the many natural and synthetic polymers is used in the formulation with their different grade and their ratio that affects on the release action. The many scientist and inventors have increased their interest in developing the novel dosage forms and they staying in the stomach for showing the prolonged period action. We have also discussed the novel technology are involved in the gastric retention many companies has been developed the polymer grades for using it in the formulation for showing the retention action. Keywords: Introduction, Approaches, Novel technologies, Polymer used in floating systems.

scholarly journals FDA Guidance for Industry 1 Extended Release Solid Oral Dosage forms: Development, Evaluation, and Application of In Vitro/In Vivo Correlations

1997 ◽  
Vol 4 (4) ◽  
pp. 23-32 ◽  
Author(s):  
Henry Malinowski ◽  
Patrick Marroum ◽  
Venkata Ramana Uppoor ◽  
William Gillespie ◽  
Hae-Young Ahn ◽  
...  
Keyword(s):  
Extended Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Fda Guidance ◽  
Solid Oral Dosage Forms ◽  
Development Evaluation ◽  
Oral Dosage Forms

Oral Fast Dissolving Film: The Avant-garde Avenue for oral Consignment Modus Operandi

2021 ◽  
pp. 2145-2152
Author(s):  
Aditya Singh ◽  
Vaseem A. Ansari ◽  
Md Faheem Haider ◽  
Farogh Ahsan ◽  
Tariq Mahmood ◽  
...  
Keyword(s):  
Dosage Forms ◽  
Sudden Onset ◽  
Review Article ◽  
Oral Dosage ◽  
The Novel ◽  
Promising Technique ◽  
Modus Operandi ◽  
Extrinsic Factors ◽  
Avant Garde ◽  
Oral Dosage Forms

The concept of oral fast dissolving film is a new weapon of treatment to the remarkable pharmaceutical field over conventional formulation to enhance pharmacological activity and treat intrinsic and extrinsic factors that prevent nausea and vomiting to dissolve rapidly in the tongue. The oral fast-dissolving film is just like an umbrella that protects immediately from the rain because easy to administer and sudden onset of drug action is possible as the film is taken through the oral, buccal and sublingual route. The design and development of a promising technique with increased demand for the novel dosage forms to gain more patient compliance is an oral fast dissolving film. This product therapy is one of the best scientific innovative aha moment of targeted formulation for the delivery of active ingredients that requires no water for administration. This review article overview the novel opportunities in the oral dosage forms, application, formulation consideration method of preparation, marketed product and patented technologies of oral fast dissolving films.

Thein vitro development of extended-release solid oral dosage forms

1985 ◽  
Vol 13 (5) ◽  
pp. 493-514 ◽  
Author(s):  
Lewis J. Leeson ◽  
Dennis Adair ◽  
James Clevenger ◽  
Nora Chiang
Keyword(s):  
Extended Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms ◽  
Vitro Development

scholarly journals Comparison of dissolution profile of extended-release oral dosage forms - two one-sided equivalence test

2013 ◽  
Vol 49 (2) ◽  
pp. 367-371 ◽  
Author(s):  
Felipe Rebello Lourenço ◽  
Daniela Dal Molim Ghisleni ◽  
Rosa Noriko Yamamoto ◽  
Terezinha de Jesus Andreoli Pinto
Keyword(s):  
Extended Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Dissolution Profile ◽  
Equivalence Test ◽  
Significance Level ◽  
Similarity Factor ◽  
Alternative Approach ◽  
Oral Dosage Forms ◽  
States Pharmacopeia

The aim of this work is to present the two one-sided test (TOST) as an alternative approach to compare dissolution profiles of extended-release dosage forms. The dissolution profiles of oxycodone extended-release tablets containing 10 mg, 20 mg and 40 mg (reference and generic) were evaluated according to the requirements described in United States Pharmacopeia. These dissolution profiles were compared using the conventional similarity factor (f2) and the proposed TOST as an equivalence test. TOST is a simple and alternative approach to compare dissolution profiles of extended-release dosage forms. It allows us to identify the time-point (or time-points) that did not show similarity. We concluded that the two one-sided test performed at a significance level of 5% and defined as D = 10 showed results comparable to those obtained by the conventional similarity factor (f2).

scholarly journals Recent Patents on Modified Release Oral Dosage Forms

2021 ◽  
Vol 11 (4-S) ◽  
pp. 195-211
Author(s):  
Atul Pund ◽  
Atishkumar Mundada ◽  
Manoj Magar ◽  
Abhijeet Kadam
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Extended Release ◽  
Dosage Forms ◽  
Delivery Systems ◽  
The Body ◽  
Oral Dosage ◽  
Modified Release ◽  
Delayed Release ◽  
Oral Dosage Forms

Background: Conventional oral dosage forms have limited bioavailability and frequent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. This results in poor patient compliance and fluctuations in the plasma drug levels, especially in the chronic diseases and disorders. Objective: To overcome such problems and to enhance the efficiency and bioavailability of the drug, modified drug delivery systems such as extended release delivery systems (controlled release; sustained release) and delayed release delivery systems are developed which can prolong the release and hence action of the drug in the body. Methods: Through this review, we throw the light on recent patents and patent applications on modified release systems pertaining to oral dosage forms.  The various free patent search databases were used to collect and analyze the information on modified release delivery systems. Results: Modified release systems such as extended release and delayed release delivery systems have been found to be of great significance due to their advantages over immediate release dosage forms. These systems are formulated using various approaches, different types of release controlling polymers such as natural, semisynthetic and synthetic polymers and found to avoid the limitations of conventional oral dosage forms. Conclusion: Modified drug release systems have potential especially, in case of the chronic diseases, mental health disorders and lifestyle diseases and disorders. These systems have unique commercial advantages which will sustain the interest of both the researchers and the pharmaceutical companies. Keywords: Modified release systems, extended release systems, controlled release systems, sustained release systems, delayed release systems, oral dosage forms, multilayer dosage form, multilayered tablets

scholarly journals How to Modify Drug Release in Paediatric Dosage Forms? Novel Technologies and Modern Approaches with Regard to Children’s Population

2019 ◽  
Vol 20 (13) ◽  
pp. 3200 ◽  
Author(s):  
Monika Trofimiuk ◽  
Katarzyna Wasilewska ◽  
Katarzyna Winnicka
Keyword(s):  
Drug Release ◽  
Paediatric Population ◽  
Drug Dosage ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Modified Release ◽  
Novel Technologies ◽  
Off Label ◽  
Pharmaceutical Technology ◽  
Oral Dosage Forms

In the pharmaceutical technology, paediatric population still presents the greatest challenge in terms of developing flexible and appropriate drug dosage forms. As for many medicines, there is a lack of paediatric dosage forms adequate for a child’s age; it is a prevailing practice to use off label formulations. Children need balanced and personalized treatment, patient-friendly preparations, as well as therapy that facilitates dosing and thus eliminates frequent drug administration, which can be ensured by modified release (MR) forms. MR formulations are commonly used in adult therapy, while rarely available for children. The aim of this article is to elucidate how to modify drug release in paediatric oral dosage forms, discuss the already accessible technologies and to introduce novel approaches of manufacturing with regard to paediatric population.

Sign in / Sign up

Export Citation Format

Share Document