Study of the hyperglycemic condition in diseases of liver in non-obese clinical patients

In Indonesia, it is estimated that there would be increasing in number of diabetes mellitus patients become 12 million cases in 2030. The expensive cost of conventional medications motivates people to find alternative medication. Bentonite is a natural clay which is a good absorbent and frequently called as healing clay for its potency in body detoxification. This study is an experimental research to prove bentonite which is a good absorbent and adsorbent in decreasing blood glucose concentration in diabetes mellitus. Subject of this research is 20 female Wistar rats which weigh 150–250 g. These subjects were divided into two groups: control group and bentonite group. Diabetes is induced by alloxan monohydrate 150mg/kg intraperitoneally, causing β cell necrosis in pancreas. Result of independent t-test showed that bentonite could significantly lower blood glucose levels with average value of 131.30 mg/dL (p=0.010). This concludes that bentonite canreduce blood glucose level in diabetic-induced rats.

Download Full-text

The Consequences of Prior Initiation of Breast Feeding on Blood Glucose Levels in Neonates Born In a Tertiary Care Hospital

Asian Journal of Clinical Pediatrics and Neonatology ◽

10.47009/ajcpn.2020.8.2.5 ◽

2020 ◽

Vol 8 (2) ◽

pp. 23-29

Author(s):

Rizwan-U- Zama ◽

Ayesha Siddiqa ◽

A.N. Thobbi ◽

Tehseen Sajid Mudhol ◽

R Shruthi

Keyword(s):

Blood Glucose ◽

Birth Weight ◽

Plasma Glucose ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

Mode Of Delivery ◽

Postnatal Life ◽

Care Hospital ◽

Glucose Levels ◽

Blood Glucose Levels

Background: Hypoglycemia is the most common event of failure of metabolic adjustments in the newborn. Changes in maternal and fetal monitoring techniques, administration of glucose-containing solutions during labor, delivery and early feeding in neonates significantly alter blood glucose concentrations during the first week of postnatal life. Subjects and Methods: A total of 90 healthy (60 born by FTND, 30 born by LSCS) term, AGA infants were longitudinally evaluated at birth, at one hour after feeds (post feed), and after 6 hours of life. Plasma glucose was estimated from Heel Prick capillary samples by glucometer method. The influence of mode of delivery, the interval between feeds, sex, birth weight, on blood glucose was analyzed. Results: The way of delivery did not affect the plasma glucose concentration in neonates. There was a substantial increase in blood glucose concentration after the first feed irrespective of their birth weight. It was found that female babies had a higher blood glucose concentration than male babies during our study period. All babies maintained normal blood glucose with the continuation of breastfeeding. Conclusion: Plasma glucose levels are satisfactorily maintained in healthy term infants without resort to pre-lacteal feeds and mode of delivery did not influence plasma glucose. There is no need to check blood glucose levels routinely in an asymptomatic, healthy, term, breastfed infants.

Download Full-text

Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels

Journal of Applied Physiology ◽

10.1152/jappl.2000.89.3.961 ◽

2000 ◽

Vol 89 (3) ◽

pp. 961-966 ◽

Cited By ~ 40

Author(s):

Samir Mitragotri ◽

Matthew Coleman ◽

Joseph Kost ◽

Robert Langer

Keyword(s):

Blood Glucose ◽

Glucose Concentration ◽

Interstitial Fluid ◽

Blood Glucose Concentration ◽

Potential Method ◽

Transport Processes ◽

Blood Capillaries ◽

Noninvasive Diagnostics ◽

Glucose Levels ◽

Blood Glucose Levels

Transdermal extraction of clinically relevant analytes offers a potentially noninvasive method of diagnostics. However, development of such a method is limited by the low permeability of skin. In this paper, we present a potential method for noninvasive diagnostics based on ultrasonic skin permeabilization and subsequent extraction of interstitial fluid (ISF) across the skin using vacuum. ISF extracted by this method was collected and analyzed for glucose and other analytes. Glucose concentration in the extracted fluid correlates well with blood glucose concentration over a range of 50–250 mg/dl. A mathematical model describing vacuum-induced transport of ISF through ultrasonically permeabilized skin is presented as well. The model accounts for convective, as well as diffusive, transport processes across blood capillaries, epidermis, and the stratum corneum. The overall predictions of the model compare favorably with the experimental observations.

Download Full-text

Studies on Gymnemic Acids Nanoparticulate Formulations Against Diabetes Mellitus

International Journal of Biomedical and Clinical Engineering ◽

10.4018/ijbce.2012070101 ◽

2012 ◽

Vol 1 (2) ◽

pp. 1-12 ◽

Cited By ~ 4

Author(s):

R. Ravichandran

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Biochemical Parameters ◽

Blood Glucose Concentration ◽

Hypoglycemic Activity ◽

Solid Dosage Forms ◽

Gymnemic Acid ◽

Glucose Levels ◽

Solid Dosage ◽

Blood Glucose Levels

The solid dosage forms of Gymnemic acid nanoparticulate formulations developed earlier were tested for anti-diabetic activity and hypoglycemic activity. Glucose, insulin and various biochemical parameters were monitored from blood samples of rats to study the efficacy of these formulations. The nano-formulations exhibited significant anti-hyperglycemic activity and produced substantial hypoglycemia. Blood glucose levels (mg/dL) in glucose loaded hyperglycemic rats after dosing with Gymnemic acids nano-formulations were 79 to 98, as against 105 in the control after 3 hours. Hypoglycemic activity of Gymnemic acids nano-formulations ranged between 63 to 66 (Blood glucose concentration, mg/dL) as against 80 in the control. Biochemical parameters studied also supported the above observations. The study clearly shows that gymnemic acid nanoparticulate formulations developed may be a better therapeutic adjunctive option for diabetes mellitus in humans.

Download Full-text

Blood Glucose Concentration after Cardiopulmonary Resuscitation Influences Functional Neurological Recovery in Human Cardiac Arrest Survivors

Journal of Cerebral Blood Flow & Metabolism ◽

10.1097/00004647-199704000-00008 ◽

1997 ◽

Vol 17 (4) ◽

pp. 430-436 ◽

Cited By ~ 109

Author(s):

Marcus Müllner ◽

Fritz Sterz ◽

Michael Binder ◽

Wolfgang Schreiber ◽

Alexander Deimel ◽

...

Keyword(s):

Cardiac Arrest ◽

Blood Glucose ◽

Glucose Concentration ◽

Neurological Outcome ◽

Blood Glucose Concentration ◽

Neurological Recovery ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Poor Neurological Outcome ◽

Blood Glucose Concentrations

Experimental data suggest that postischemic blood glucose concentration plays an important role in modulating both ischemic cerebral infarction and selective neuronal necrosis. This study investigated the association between functional neurological recovery and blood glucose concentrations in human cardiac arrest survivors. A group of 145 nondiabetic patients were evaluated after witnessed ventricular fibrillation cardiac arrest. Data regarding cardiac arrest were collected according to an internationally accepted protocol immediately after arrival. Blood glucose was measured on admission and 6, 12, and 24 h thereafter. To control for duration of cardiac arrest and cardiogenic shock, both known to influence outcome as well as blood glucose, levels, Spearman rank partial correlation was used. In this multivariate analysis, a high admission blood glucose level tended to be associated with poor neurological outcome ( rs = −0.16, n = 142, p = 0.06). The association between high median blood glucose levels over 24 h and poor neurological outcome was strong and statistically significant ( rs = −0.2, n = 145, p = 0.015). High blood glucose concentrations occurring over the first 24 h after cardiac arrest have deleterious effects on functional neurological recovery. Whether cardiac arrest survivors might benefit from reduction of blood glucose levels needs further investigation.

Download Full-text

Studies on Gymnemic Acids Nanoparticulate Formulations against Diabetes Mellitus

Nanotechnology ◽

10.4018/978-1-4666-5125-8.ch058 ◽

2014 ◽

pp. 1276-1288

Author(s):

R. Ravichandran

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Biochemical Parameters ◽

Blood Glucose Concentration ◽

Dosage Forms ◽

Hypoglycemic Activity ◽

Gymnemic Acid ◽

Glucose Levels ◽

Solid Dosage ◽

Blood Glucose Levels

The solid dosage forms of Gymnemic acid nanoparticulate formulations developed earlier were tested for anti-diabetic activity and hypoglycemic activity. Glucose, insulin and various biochemical parameters were monitored from blood samples of rats to study the efficacy of these formulations. The nano-formulations exhibited significant anti-hyperglycemic activity and produced substantial hypoglycemia. Blood glucose levels (mg/dL) in glucose loaded hyperglycemic rats after dosing with Gymnemic acids nano-formulations were 79 to 98, as against 105 in the control after 3 hours. Hypoglycemic activity of Gymnemic acids nano-formulations ranged between 63 to 66 (Blood glucose concentration, mg/dL) as against 80 in the control. Biochemical parameters studied also supported the above observations. The study clearly shows that gymnemic acid nanoparticulate formulations developed may be a better therapeutic adjunctive option for diabetes mellitus in humans.

Download Full-text

Effects of dietary manipulations and glucose infusion on glucagon response during exercise in rats

Journal of Applied Physiology ◽

10.1152/jappl.1997.83.1.148 ◽

1997 ◽

Vol 83 (1) ◽

pp. 148-152 ◽

Cited By ~ 5

Author(s):

Maurice Tadjoré ◽

Raynald Bergeron ◽

Martin Latour ◽

François Désy ◽

Claude Warren ◽

...

Keyword(s):

Blood Glucose ◽

Plasma Glucose ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

Glucose Infusion ◽

Glucose Response ◽

Glucose Levels ◽

Arterial Blood ◽

Blood Glucose Levels ◽

Exercise Period

Tadjoré, Maurice, Raynald Bergeron, Martin Latour, François Désy, Claude Warren, and Jean-Marc Lavoie.Effects of dietary manipulations and glucose infusion on glucagon response during exercise in rats. J. Appl. Physiol. 83(1): 148–152, 1997.—The purpose of the present investigation was to test the hypothesis that blood glucose concentration is not always related to glucagon response during exercise. Three groups of rats were submitted to a prolonged (3-h) swimming exercise. Two groups of rats had their normal food intake restricted by 50% the night before the experiment. One of these two groups of rats was intravenously infused with glucose throughout exercise to maintain euglycemia. The third group of rats swam while under normal dietary conditions. Plasma glucose, sampled in arterial blood, was reduced ( P < 0.05) at 75, 105, 150, and 170 min of exercise (from ∼130 to 110 mg/dl) in the food-restricted animals without glucose infusion, whereas a significant ( P < 0.05) increase was measured in the two other groups during exercise. A significant ( P < 0.01) difference in the mean integrated areas under the glucose-concentration curve was found only between the fed and the two food-restricted groups. Plasma insulin concentrations decreased ( P < 0.05) similarly in all groups during exercise, whereas plasma epinephrine and norepinephrine concentrations increased significantly ( P < 0.01) in all groups. Despite differences between groups in plasma glucose response during exercise, and despite the absence of any decrease in exercising blood glucose levels in at least two of the three groups, plasma glucagon responses were increased ( P < 0.05) similarly in all groups (from ∼250 to 550 pg/ml) at the end of the exercise period. The increase in glucagon was significant after 90 min of exercise in the food-restricted groups, with or without glucose infusion, but only after 140 min in the fed group. These results indicate that the glucagon response during exercise is not always linked to the decrease in plasma glucose.

Download Full-text

Study of the hyperglycemic condition in diseases of liver in obese clinical patients

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i6-s.2112 ◽

2018 ◽

Vol 8 (6-s) ◽

pp. 204-208

Author(s):

Chander Jeet Singh ◽

Dinesh Kumar

Keyword(s):

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

Experimental Studies ◽

Glucose Levels ◽

Sensory Evoked Potentials ◽

Sensory Evoked ◽

Blood Glucose Concentrations

Hyperglycemia is best documented by Whipple´s triad: symptoms compatible with hypoglycemia, low blood glucose concentration and alleviation of symptoms after the glucose concentration is raised. In experimental studies in healthy adults, the threshold for symptoms of hyperglycemia is on average a blood glucose level of 3.0 mmol/l Mitrakou reported autonomic symptoms of hyperglycemia to begin at a blood glucose level of 3.2 mmol/l, and deterioration in cognitive function tests at a level of 2.7 mmo/l. When sensory evoked potentials were measured in relation to blood glucose concentrations in infants and children with episodes of hyperglycemia, abnormalities were noted at blood glucose levels less than 2.6 mmol/l. Keywords: Hypertension, Diabetes mellitus, Glucose, Glycolysis.

Download Full-text

Efeitos dos Programas de Treinamento Aeróbio, de Força e Combinado na Glicose Sanguínea em Diabéticos do Tipo 2: uma Revisão Sistemática/ Effects of Aerobic, Strength and Combined Programs Training on Blood Glucose in Type 2 Diabetic: a Systematic Review.

REVISTA CIÊNCIAS EM SAÚDE ◽

10.21876/rcsfmit.v5i1.301 ◽

1970 ◽

Vol 5 (1) ◽

pp. 61-74 ◽

Cited By ~ 1

Author(s):

Alexandre de Souza E Silva ◽

Maria Paula Gonçalves Mota

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Blood Glucose ◽

Training Program ◽

Aerobic Training ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Pubmed Database

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

Download Full-text

Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

Clinical Phytoscience ◽

10.1186/s40816-019-0138-7 ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Musri Musman ◽

Mauli Zakia ◽

Ratu Fazlia Inda Rahmayani ◽

Erlidawati Erlidawati ◽

Safrida Safrida

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Body Weight ◽

Blood Glucose ◽

Phyllanthus Emblica ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

Download Full-text