scholarly journals Study of the hyperglycemic condition in diseases of liver in obese clinical patients

2018 ◽  
Vol 8 (6-s) ◽  
pp. 204-208
Author(s):  
Chander Jeet Singh ◽  
Dinesh Kumar
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Experimental Studies ◽  
Glucose Levels ◽  
Sensory Evoked Potentials ◽  
Sensory Evoked ◽  
Blood Glucose Concentrations

Hyperglycemia is best documented by Whipple´s triad: symptoms compatible with hypoglycemia, low blood glucose concentration and alleviation of symptoms after the glucose concentration is raised. In experimental studies in healthy adults, the threshold for symptoms of hyperglycemia is on average a blood glucose level of 3.0 mmol/l Mitrakou reported autonomic symptoms of hyperglycemia to begin at a blood glucose level of 3.2 mmol/l, and deterioration in cognitive function tests at a level of 2.7 mmo/l. When sensory evoked potentials were measured in relation to blood glucose concentrations in infants and children with episodes of hyperglycemia, abnormalities were noted at blood glucose levels less than 2.6 mmol/l. Keywords: Hypertension, Diabetes mellitus, Glucose, Glycolysis. 

COMPARISON OF THE EFFECT OF DEXAMETHASONE ON THE BLOOD GLUCOSE LEVEL IN PREGNANT AND NON-PREGNANT WOMEN UNDER GENERAL ANESTHESIA

2021 ◽  
Vol 74 (9) ◽  
pp. 2277-2280
Author(s):  
Hanan Fawzi ◽  
Alaa Hussen Ali
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
General Anesthesia ◽  
Pregnant Women ◽  
Glucose Level ◽  
Elective Cesarean Section ◽  
Glucose Levels ◽  
Anesthetic Drugs ◽  
Study Results ◽  
Blood Glucose Concentrations

The aim: To compared blood glucose concentrations after intravenous injection of dexamethasone in the pregnant and non-pregnant women under general anesthesia. Materials and methods: Eighty patients aged 18-50 years took part in the study (ASA class 1 and 2). Forty of patients were undergoing elective cesarean section under G/A and the other forty undergoing elective laparoscopic Cholecystectomy under G/A. Anesthesia was induced using IV anesthetic drugs (0.5mg/kg ketamine, sleeping dose of propofol up to 2mg/kg, muscle relaxant was 0.6 mg/kg rocuronium and maintained with isoflurane). All of patients have been injected with 0,1mg/kg dexamethasone intravenously, at induction of anesthesia, Blood glucose concentrations were measured at induction and then in 60min, 180min and in 360 min after injection of dexamethasone and results were compared between the groups; IV fluid added was normal saline (0.9%) during the study. Results: Regarding to blood glucose levels, we noticed that its level significantly increased over time and peaked in 180min after dexamethasone injection in both groups. The difference percentage between the lower reading (pre injection) and the upper reading (in 180min after) was 33.5% in pregnant woman and 46.2%for non-pregnant women, this difference was statistically significant relative to the pre injection, as this difference was lower in the pregnant women. In 360min after blood glucose level began to drop in both groups. After giving 0.1 mg/kg of dexamethasone, blood glucose level increased in both groups, but it was lower in pregnant women.

scholarly journals Blood glucose level in rats with different behavioral activity in the dynamics of repeated stress exposures

2019 ◽  
Vol 27 (1) ◽  
pp. 10-19
Author(s):  
Anastasiya Yu. Abramova ◽  
Elena V. Koplik ◽  
Irina V. Alekseyeva ◽  
Sergey S. Pertsov
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Stress Factors ◽  
Behavioral Activity ◽  
Glucose Content ◽  
Control Measurement ◽  
Repeated Stress

Aim. To study the effect of repeated stress on blood glucose level in rats with various behavioral characteristics and with different resistance to the development of adverse consequences of negative emotiogenic exposures. Materials and Methods. The animals were initially subjected to open field test to calculate the index of activity. Daily 4-h immobilization of rats in individual plastic cages for 8 days was used as a model of stress. Blood glucose concentration was measured with a glucometer (control measurement and on the 1st, 3rd and 8th days of repeated stress). Results. The basal level of glucose in behaviorally active (stress-resistant) rats was lower than in passive (stress-predisposed) specimens. Repeated exposure of rats to stress resulted in development of hyperglycemia. However, the dynamics of blood glucose concentration was different in specimens with different parameters of behavior. The increase in glucose concentration in active animals was most pronounced after a single exposure. By the 3rd and 8th days of stress exposures, glucose level in these rats progressively decreased (as compared to the 1st day), but remained above the basal level. Passive specimens were characterized by the increase in blood glucose concentration after a single and, particularly, after three-time restraint stress. Glucose content in these animals slightly decreased by the 8th day (as compared to the previous periods), but was above the basal level. Conclusion. The dynamics of abnormalities in carbohydrate metabolism (in particular, changes in blood glucose level) during chronic emotiogenic exposures differed in specimens with different resistance to stress factors. These data illustrate the importance of an indivi-dual approach to studying the pathophysiological mechanisms of progression and development of stress-induced disorders.

scholarly journals Uji Aktivitas Antidiabetes Ekstrak Bonggol Nanas (Ananas comusus L.) pada Tikus yang Di induksi Aloksan

2018 ◽  
Vol 1 (1) ◽  
pp. 36
Author(s):  
Ayu Rochmawati ◽  
Syahrul Ardiansyah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Blood Glucose Concentration ◽  
Inflammatory Diseases ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Stem Extract

This research aims to knowing about decrease glucose levels in rat induced alloxan with the provision of pineapple stem extract (Ananas comusus L.). Previous studies have shown that bromelin can significantly reduce CD4+ lymphocytes, which are included in inflammatory diseases. One of the inflammatory diseases is diabetes mellitus. Blood glucose levels can be lowered by pineapple extract as it contains bromelin, and bromelin most widely found on the stem. The test animals used white rat strain wistar (Rattus norvegicus L.) with weight is 250-300 gram acclimated for seven days. The research was divided  six treatment groups: positive control, negative control, P1 (25% concentration), P2 (50% concentration), P3 (75% concentration), P4 (100% concentration). After treatment for rat in category or sampel was administered pineapple stem extract for 14 days after that experiment status blood glucose level. The results showed that rat had  increased (hyperglicemic) after alloxan induced,and also in blood glucose levels in all treatment. the biggest decrease was in P4 is 44 mgdl. The statistic of Kruskal-Wallis test showed that the decrease of rat blood glucose concentration at various concentration of pineapple extract influence  signifificantly. According to the result  that conclusion is  the difference of pineapple extract concentration (25%, 50%, 75%, 100%) influence for decrease blood glucose levels and decreasing blood glucose level after 14 days, but in this  time blood glucose  not returned as normal conditions.  

scholarly journals Blood Glucose Concentration after Cardiopulmonary Resuscitation Influences Functional Neurological Recovery in Human Cardiac Arrest Survivors

1997 ◽  
Vol 17 (4) ◽  
pp. 430-436 ◽  
Author(s):  
Marcus Müllner ◽  
Fritz Sterz ◽  
Michael Binder ◽  
Wolfgang Schreiber ◽  
Alexander Deimel ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Neurological Outcome ◽  
Blood Glucose Concentration ◽  
Neurological Recovery ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Poor Neurological Outcome ◽  
Blood Glucose Concentrations

Experimental data suggest that postischemic blood glucose concentration plays an important role in modulating both ischemic cerebral infarction and selective neuronal necrosis. This study investigated the association between functional neurological recovery and blood glucose concentrations in human cardiac arrest survivors. A group of 145 nondiabetic patients were evaluated after witnessed ventricular fibrillation cardiac arrest. Data regarding cardiac arrest were collected according to an internationally accepted protocol immediately after arrival. Blood glucose was measured on admission and 6, 12, and 24 h thereafter. To control for duration of cardiac arrest and cardiogenic shock, both known to influence outcome as well as blood glucose, levels, Spearman rank partial correlation was used. In this multivariate analysis, a high admission blood glucose level tended to be associated with poor neurological outcome ( rs = −0.16, n = 142, p = 0.06). The association between high median blood glucose levels over 24 h and poor neurological outcome was strong and statistically significant ( rs = −0.2, n = 145, p = 0.015). High blood glucose concentrations occurring over the first 24 h after cardiac arrest have deleterious effects on functional neurological recovery. Whether cardiac arrest survivors might benefit from reduction of blood glucose levels needs further investigation.

scholarly journals Study of the hyperglycemic condition in diseases of liver in non-obese clinical patients

2018 ◽  
Vol 8 (6-s) ◽  
pp. 209-212
Author(s):  
Chander Jeet Singh ◽  
Dinesh Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Experimental Studies ◽  
Healthy Adults ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Fasting Tolerance

Hyperglycemia is best documented by Whipple´s triad: symptoms compatible with hypoglycemia, low blood glucose concentration and alleviation of symptoms after the glucose concentration is raised. In experimental studies in healthy adults, fifteen out of the 19 patients who developed hypoglycaemia on the fasts during MT were re-tested 3 to 4 months after cessation of therapy. Fasting tolerance had improved in all of them. It had become normal in 10 out of 15 patients (67%). In 5 patients, blood glucose levels still fell below 2.7 mmol/l (range 2.0 to 2.6 mmol/l) after 16 hours of fasting. However, none had any symptoms. Keywords: Hypertension, Diabetes mellitus, Glucose, Glycolysis

THE CRITICALLY ILL CHILD: SALICYLATE INTOXICATION

PEDIATRICS ◽  
1969 ◽  
Vol 44 (3) ◽  
pp. 440-444
Author(s):  
William E. Segar
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Carbohydrate Metabolism ◽  
Glucose Level ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Co2 Concentration ◽  
Pharmacologic Agent ◽  
Peripheral Tissues ◽  
Salicylate Intoxication

Salicylate is a potent pharmacologic agent, and the rational therapy of salicylate intoxication must be based on an understanding of its pharmacologic actions and consequent pathophysiologic effects.l Because it acts to uncouple oxidative phosphorylation in a manner analogous to that of 2,4-dinitrophenol, salicylate is, first of all, a general metabolic stimulant.2 Oxygen consumption, carbon dioxide formation, and heat production are increased by its action; consequently, oxygen requirement, blood CO2 concentration, and the need to eliminate heat are also increased. Respiration, heart rate, and cardiac output must increase to satisfy the demands imposed by the acceleration of metabolic processes. Second, saiicylate interferes in a complex manner with the normal metabolism of carbohydrate.3 Many factors seem to be involved, some tending to decrease and others to increase the blood glucose concentralion, and, clinically, either hyperglycemia or hypoglycemia may be observed. Hyperglycemia may be partially explained by the release of epinephrmne due to activation of hypothalamic sympathetic centers. However, large doses of salicyiate also decrease aerobic metabolism and increase glucose-6-phosphatase activity, effects which tend to increase the blood glucose level. Hypoglycemia, on the other hand, may be caused by an increased utilization of glucose by peripheral tissues or by interference with gluconeogenesis by salicylates. Recent studies suggest that brain glucose concentration may be decreased despite minimal alterations in blood glucose level.4 As a result of these salicylate-mnduced alterations in carbohydrate metabolism, organic acids, particularly lactic, pyruvic, and acetoacetic, accumuiate.5 Infants appear to be particularly susceptible to the toxic effects of salicylate on carbohydrate metabolism and are more likely to have disturbances in blood glucose concentration and metabolic acidosis than are older children.

Effect of low blood glucose on plasma CRF, ACTH, and cortisol during prolonged physical exercise

1991 ◽  
Vol 71 (5) ◽  
pp. 1807-1812 ◽  
Author(s):  
I. Tabata ◽  
F. Ogita ◽  
M. Miyachi ◽  
H. Shibayama
Keyword(s):  
Blood Glucose ◽  
Physical Exercise ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Plasma Concentrations ◽  
Bicycle Exercise ◽  
Low Intensity ◽  
Prolonged Physical Exercise ◽  
Blood Glucose Concentrations ◽  
Exercise In Humans

The effects of low blood glucose concentration during low-intensity prolonged physical exercise on the hypothalamus-pituitary-adrenocortical axis were investigated in healthy young men. In experiment 1, six subjects who had fasted for 14 h performed bicycle exercise at 50% of their maximal O2 uptake until exhaustion. At the end of the exercise, adrenocorticotropic hormone (ACTH) and cortisol increased significantly. However, this hormonal response was totally abolished when the same subjects exercised at the same intensity while blood glucose concentrations were maintained at the preexercise level. In experiment 2, in addition to ACTH and cortisol, the possible changes in plasma concentration of corticotropin-releasing factor (CRF) were investigated during exercise of the same intensity performed by six subjects. As suggested by a previous study (Tabata et al. Clin. Physiol. Oxf. 4: 299–307, 1984), when the blood glucose concentrations decreased to less than 3.3 mM, plasma concentrations of CRF, ACTH, and cortisol showed a significant increase. At exhaustion, further increases were observed in plasma CRF, ACTH, and cortisol concentrations. These results demonstrate that decreases in blood glucose concentration trigger the pituitary-adrenocortical axis to enhance secretion of ACTH and cortisol during low-intensity prolonged exercise in humans. The data also might suggest that this activation is due to increased concentration of CRF, which was shown to increase when blood glucose concentration decreased to a critical level of 3.3 mM.

Cause of hypoglycemia in dogs exposed to heat

1959 ◽  
Vol 196 (3) ◽  
pp. 619-624 ◽  
Author(s):  
G. S. Kanter
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Respiratory Muscles ◽  
Stomach Tube ◽  
Glucose Levels ◽  
Exogenous Glucose ◽  
Respiratory Apparatus

When unanesthetized dogs are exposed to heat (120°F) for 4 hr. with no water available for drinking, hypoglycemia results. One would expect that the dehydration, which also occurs, should physically cause an increase in blood glucose concentration as is usually found in man. The tendency is present in dogs but the utilization of glucose is sufficiently rapid to offset the hemoconcentration and cause a fall in glucose levels even when exogenous glucose is given at the rate of 1% body wt/hr. of 11% glucose by stomach tube. This increased utilization has been demonstrated to be mainly due to involvement of the respiratory muscles which are used in the panting mechanism for no fall in blood glucose occurs under similar conditions when the animal is curarized. The evidence indicates that the hypoglycemic mechanism present in dogs is not a species phenomenon but is probably also present in man under appropriate conditions. In both man and the dog whether hypoglycemia occurs will depend upon the degree of involvement of the respiratory apparatus.

scholarly journals Association between blood glucose levels and Glasgow Outcome Score in patients with traumatic brain injury: secondary analysis of a randomized trial

Trials ◽  
2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Tao Yuan ◽  
Hongyu He ◽  
Yuepeng Liu ◽  
Jianwei Wang ◽  
Xin Kang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Glucose ◽  
Brain Injury ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Threshold Effect ◽  
Glasgow Outcome Score ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Average Blood Glucose

Abstract Background Blood glucose levels that are too high or too low after traumatic brain injury (TBI) negatively affect patient prognosis. This study aimed to demonstrate the relationship between blood glucose levels and the Glasgow Outcome Score (GOS) in TBI patients. Methods This study was based on a randomized, dual-center, open-label clinical trial. A total of 208 patients who participated in the randomized controlled trial were followed up for 5 years. Information on the disease, laboratory examination, insulin therapy, and surgery for patients with TBI was collected as candidate variables according to clinical importance. Additionally, data on 5-year and 6-month GOS were collected as primary and secondary outcomes, respectively. For multivariate analysis, a generalized additive model (GAM) was used to investigate relationships between blood glucose levels and GOS. The results are presented as odds ratios (ORs) with 95% confidence intervals (95% CIs). We further applied a two- piecewise linear regression model to examine the threshold effect of blood glucose level and GOS. Results A total of 182 patients were included in the final analysis. Multivariate GAM analysis revealed that a bell-shaped relationship existed between average blood glucose level and 5-year GOS score or 6-month GOS score. The inflection points of the average blood glucose level were 8.81 (95% CI: 7.43–9.48) mmol/L considering 5-year GOS as the outcome and were 8.88 (95% CI 7.43−9.74) mmol/L considering 6-month GOS score as the outcome. The same analysis revealed that there was also a bell relationship between average blood glucose levels and the favorable outcome group (GOS score ≥ 4) at 5 years or 6 months. Conclusion In a population of patients with traumatic brain injury, blood glucose levels were associated with the GOS. There was also a threshold effect between blood glucose levels and the GOS. A blood glucose level that is either too high or too low conveys a poor prognosis. Trial registration ClinicalTrials.gov NCT02161055. Registered on 11 June 2014.

scholarly journals EFFECTIVENESS OF AMLA JUICE IN REDUCING BLOOD GLUCOSE LEVEL AMONG PATIENTS WITH TYPE II DIABETES IN A SELECTED AREA OF KANYAKUMARI DISTRICT

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mrs. Vanitha. S s ◽  
Dr. Pramjit kaur
Keyword(s):  
Blood Glucose ◽  
Standard Deviation ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type Ii Diabetes ◽  
Control Group ◽  
Type Ii ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Experimental Group

Challenges in lifestyle, such as increasesin energy intake and decreasesin physical activity are causing overweight and obesity leading to epidemic increases in type II Diabetes Mellitus. The research approach used for this study was evaluative approach and the research design was true experimental design. 60 patients with type II diabetes, 30 in experimental group and 30 in control group were selected for this study by using purposive sampling technique. Data was collected with the help of self-structured interview schedule. Descriptive statistics (frequency, percentage, mean and standard deviation) and inferential statistics (chi-square, paired ‘t’ test) were used to analyse the data and to test the hypotheses. In the experimental group,the pre-test mean score was 2.966, mean percentage was 59% and standard deviation was 1.129 and in post-testmean score was 2.533, mean percentage was 50.66% and standard deviation was 1.074 with effectiveness of 8.34% and paired‘t’ test value of t=3.971,which was statistically significant (p<0.05) which is an evidence ofthe effectiveness of Amla juice in reducing blood glucose level. Comparison of blood glucose levels in experimental and control groups, shows that the value is statistically highly significant, as was observed from the unpaired ‘t’ test value of 13.39 with P value of <0.05, which is an evidence indicatingthe effect of Amla juice in reducing postprandial blood glucose levels. The resultsfound that the administration of Amla juice did have aneffect in reducing blood glucose level in the experimental group. By comparing the findings of pre-test and post test between the experimental group and the control group,the effect was identified (assessed). The study concluded that the Amlajuice is effective in reducing blood glucose level.

Sign in / Sign up

Export Citation Format

Share Document