A CASE STUDY ON REDUCTION OF LUNG FUNCTIONS IN PATIENTS WITH DIABETES MELLITUS IN ANDHRA PRADESH, INDIA

Background and Objectives: The purpose of this study is to evaluate the pulmonary functions in patients with diabetes. Many studies additionally counsel that the respiratory organ as an organ in diabetes and glycemic exposure could also be an effort issue for reduced respiratory organ operate. Systemic inflammation, hypoxemia, oxidative stress, altered gas exchange, and changes in lung tissues were the major impacts on the respiratory system which were induced by hypoglycemia. Methods: Forty individual patients of both sexes were involved in the study and divided into two groups depending on their conditions. Group A consists of individuals without any complications or any disease conditions and group B consists of diabetic patients excluding smokers and divided into twenty to each group. Results: SPSS software was used for the analysis and spirometry was the device used to determine the pulmonary function. Values of Forced Expiratory Volume 1, Forced Vital Capacity, Forced Expiratory Flow, FEV% were only considered in the study and the study results conclude that diabetes shows its effect on the lungs in long term and leads to a decrease in lung function. Conclusion: It was concluded that that monitoring the Pulmonary function tests of the diabetic patients helps the individuals to avoid any complications further ahead and also it helps to ease the flow of the recovery and also prevent further more comorbidity that might arise in the future. Peer Review History: Received: 1 September 2021; Revised: 10 October; Accepted: 4 October, Available online: 15 November 2021 Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Kolawole Oyetunji Timothy, Department of Pharmacology and Therapeutics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. [email protected] Dr. Nuray Arı, Ankara University, Turkiye, [email protected] Rima Benatoui, Laboratory of Applied Neuroendocrinology, Department of Biology, Faculty of Science, Badji Mokhtar University Annaba, BP12 E L Hadjar–Algeria, [email protected] Similar Articles: CLINICAL COURSE AND DISEASE OUTCOME IN COVID-19 PATIENTS WITH DIABETES MELLITUS THE RELATIONSHIP BETWEEN DIABETES MELLITUS AND TUBERCULOSIS IN REVIEW OF PREVALENCE, DIAGNOSTICS AND PREVENTION

Download Full-text

Effect of Different Factors on Glycosylated Hemoglobin (HbA1c) Levels Among Diabetes Mellitus Patients

10.53350/pjmhs2115123513 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3513-3515

Author(s):

Bader Alsuwayt

Keyword(s):

Diabetes Mellitus ◽

Glycated Hemoglobin ◽

Glycosylated Hemoglobin ◽

Diabetic Patients ◽

Study Results ◽

Patients With Diabetes ◽

Insulin Use ◽

Low Rate ◽

Statin Use ◽

Hba1c Levels

Aim: To describe the rate of the controlled level of glycosylated hemoglobin (HbA1c) among diabetes mellitus patients in Dammam city, Kingdom of Saudi Arabia (KSA). To assess the association between the status of HbA1c and the different patient-related factors namely: insulin use, metformin, dyslipidemia, and statin use. Methods: This cross-sectional study was performed at Security Forces Hospital, Dammam, KSA, between November 2020 and February 2021. A sample of two hundred known diabetic patients who were regularly followed up at the outpatient department (OPD) was selected randomly for the current study. Results: A very low rate (24%) of controlled HbA1C levels in patients with diabetes (type 1 DM and type 2 DM), The data showed that 85 % of all participants in our study are T2DM patients, while only 15% are T1DM patients, Our data showed that patients with dyslipidemia, hypothyroidism, or hypertension have a high level of uncontrolled HbA1C levels. Surprisingly, both dyslipidemia and statin use were predictors of uncontrolled HbA1C, Unexpectedly, non-metformin use has a protective effect toward controlling HbA1C, While insulin use is a strong predictor of uncontrolled HbA1C (OD 5.20). Conclusion: A low rate of controlled glycated hemoglobin (HbA1c) level among patients with diabetes (T1DM and T2DM) in our sample urges the need for immediate intervention to investigate and improve the current findings. Further investigations are needed to fully explain the high rate of uncontrolled HbA1c among insulin, metformin and statins users. Keywords: Glycated hemoglobin, HbA1c, Diabetes mellitus, Statins, Metformin.

Download Full-text

EVALUATION OF ASSOCIATION BETWEEN AGE, GENDER,DURATION OF DIABETES MELLITUS AND HBA1C WITH THYROID PROFILE IN DIABETES MELLITUS PATIENTS

International Journal of Medical Science and Diagnosis Research ◽

10.32553/ijmsdr.v4i11.701 ◽

2020 ◽

Vol 4 (11) ◽

Author(s):

Bhaskar MK ◽

Sanjay Zachariah ◽

Annette Menezes

Keyword(s):

Diabetes Mellitus ◽

Diabetic Patients ◽

Thyroid Disorders ◽

Exclusion Criteria ◽

Duration Of Diabetes ◽

Study Results ◽

Patients With Diabetes ◽

And Gender ◽

Thyroid Profile ◽

Hypothyroid Patients

Background: Diabetes mellitus can be observed in any age group and gender. If it is not treated on time, it can lead to development of other disorders. The present study aims to evaluate the association of age, gender, duration of diabetes and HbA1C with thyroid profile in patients with diabetes mellitus. Materials and Methods: The study included 100 diabetic patients based on the inclusion and exclusion criteria. The study protocol was explained to each patient and informed consent was obtained. All the patients demographic and clinical data was recorded and analysed. SPSS (16.0) version used for analysis. Results: Patients between 41-50 years of age showed more of hypothyroid profile. Males are less prone to thyroid disorders compared to females. Patients with DM less than 10 years showed hypothyroid profile. Maximum hypothyroid patients showed HbA1C level less than 7%. Conclusion: The study results conclude that as age progresses, females are more prone to thyroid disorders compared to males. Keywords: Age, Diabetes Mellitus, Thyroid, Gender, HbA1C, Euthyroid

Download Full-text

Systemic Erythropoietin Concentration and its Correlation with Stage of Diabetic Retinopathy

10.21203/rs.2.12950/v1 ◽

2019 ◽

Author(s):

Sofija Davidović ◽

Babić Nikola ◽

Jovanović Sandra ◽

Barišić Sava ◽

Grković Desanka ◽

...

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Serum Concentration ◽

Proliferative Diabetic Retinopathy ◽

Elevated Serum ◽

Average Concentration ◽

Control Group ◽

Diabetic Patients ◽

Study Results ◽

Patients With Diabetes

Abstract Summary: Background: Erythropoietin (Epo) is one of systemic angiogenic factors, and its role in ocular angiogenesis and in diabetic retinopathy (DR) is not yet fully understood. Latest research data reveal possible correlation of higher EPO concentrations of erythropoietin in blood and in the eye, with more severe of stages of DR. The main aim of this work was to examine the possible influence of serum concentrations of erythropoietin on the development and stages of diabetic retinopathy in patients with diabetes mellitus type 2. Methods: The research involved 90 patients examined at University Eye Clinic in Clinical Center of Vojvodina in Novi Sad, Serbia. First group comprised of 60 patients with diabetes mellitus lasting 10 years or more, with diabetic retinopathy. Second, control group, consisted of 30 healthy individuals. In the first group of 60 diabetic patients, 30 of them had non-proliferative diabetic retinopathy (NPDR), and 30 had proliferative diabetic retinopathy (PDR). Laboratory EPO serum levels were determined, and they were correlated to the stage of DR. Concentration of EPO was assessed by ELISA method at the end of the study. Results: The highest average concentration of EPO in serum (9.95 mIU/ml) was determined in group of diabetics with PDR. The lowest average concentration of EPO in serum (6.90 mIU/ml) was found in control group. The average concentration of Epo in serum in group of diabetics with NPDR was 7.00 mIU/ml. EPO concentration in serum was elevated in group of PDR, and it was directly proportional to the level of clinical stadium of PDR, being significantly higher in moderate and severe subgroup of PDR comparing to control healthy subjects, NPDR and mild PDR (h=9.858, p=0.007). Conclusions: Significantly elevated serum concentration of EPO in advanced stages of DR, and positive correlation between EPO serum concentration and clinical stadium of PDR, suggest that erythropoietin presents one of the important growth factors from blood, which plays role in retinal ischemia and angiogenesis in diabetic retinopathy, especially in the proliferative stage of this disease. Keywords: diabetic retinopathy; erythropoietin; glycated hemoglobin; non-proliferative diabetic retinopathy; proliferative diabetic retinopathy.

Download Full-text

Study of pulmonary function test in newly diagnosed diabetes in a tertiary care teaching hospital, Kishanganj, Bihar

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol03-i08/04 ◽

2018 ◽

Vol 3 (08) ◽

Cited By ~ 1

Author(s):

Dr Ichchhit Bharat ◽

Dr Raghwendra Singh ◽

Dr Chandni Sehgal ◽

Dr. Sumit Sharma ◽

Dr. Anuj Kumar Saha ◽

...

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Function ◽

Pulmonary Function Tests ◽

Elastic Fibers ◽

Control Group ◽

Diabetic Patients ◽

Newly Diagnosed ◽

Duration Of Illness ◽

Diagnosed Diabetes ◽

Newly Diagnosed Diabetes

Background: Diabetes mellitus (DM) is accompanied by wide spread biochemical, morphological, and functional abnormalities which may precipitate certain complications that affect the neural, cardiovascular, renal systems, and also organs and tissues like skin, liver, collagen, and elastic fibers. This study was thus conducted to determine the pattern of pulmonary function abnormalities among patients with newly diagnosed diabetes mellitus (DM) at the outpatient clinic of M.GM Medical College. Materials & Methods: Pulmonary function tests (PFTs) were recorded in 50 diabetic patients and 50 normal healthy controls aged 30-60 years by using Helios 702 spirometer. The PFTs recorded were - FVC, FEV1, FEV1/FVC, FEF25, FEF50, FEF75, FEF25–75, and peak expiratory flow rate (PEFR). HbA1c of all the patients was estimated by ion exchange resin method. PFTs of diabetic patients and controls were compared by applying Student′s unpaired t test. Associations between FVC and FEV1 and HbA1c and duration of illness in diabetic patients were analyzed by applying Pearson′s coefficient. Results: Mean & SD value of fasting plasma glucose 149.2 ±75.6 for case and for control group the value was 92.8 ±17.6. For case group we found 66% (33) patients in restriction category and for control group the number was 7 (14%) and the found in statistically significant. We found 12 patients with mild, 25 patients with moderate and 13 patients with high severity. Conclusion: In the present study all the pulmonary parameters, that is, FVC, FEV1, PEF, FEF25-75, MVV and FEV1/ FVC were statistically significant. On correlating the FVC and FEV1 with duration of illness and HbA1c, we found that there was no significant correlation between them.

Download Full-text

Effect of diabetes mellitus on the Pulmonary Function Tests in Sudanese Diabetic Patients

10.29328/journal.jprr.1001007 ◽

2017 ◽

Vol 2 (1) ◽

pp. 004-010

Author(s):

Ali Ibrahim A

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Function ◽

Pulmonary Function Tests ◽

Diabetic Patients ◽

Function Tests

Download Full-text

Pulmonary function in children with type 1 diabetes mellitus

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2014-0147 ◽

2015 ◽

Vol 28 (1-2) ◽

Cited By ~ 6

Author(s):

María Martín-Frías ◽

Adelaida Lamas ◽

Emma Lara ◽

Milagros Alonso ◽

Purificación Ros ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Lung Function ◽

Pulmonary Function ◽

Type 1 Diabetes Mellitus ◽

Pulmonary Function Tests ◽

Pubertal Development ◽

Development Stage ◽

Forced Expiratory Volume

AbstractTo assess lung function in children and adolescents with type 1 diabetes mellitus (T1DM).We conducted a case-control study of 100 patients with T1DM [median age 13 (10.6–14.7), 44% men, 23% prepubertal, and all nonsmokers] and 77 controls. None had evidence of lung disease or any other comorbidity. We performed pulmonary function tests, including spirometry [forced vital capacity (FVC), forced expiratory volume in 1 s (FEVThe duration of diabetes was 6.2±3.8 years with a median HbAThe lung is functionally involved in children with T1DM. Pubertal development stage influences the evaluation of lung function.

Download Full-text

Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus

Journal of Diabetes Research ◽

10.1155/2017/6719239 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Triantafyllos Didangelos ◽

Konstantinos Tziomalos ◽

Charalambos Margaritidis ◽

Zisis Kontoninas ◽

Ioannis Stergiou ◽

...

Keyword(s):

Diabetes Mellitus ◽

Peripheral Neuropathy ◽

Enzyme Inhibitor ◽

Valsalva Maneuver ◽

Diabetic Patients ◽

Perception Threshold ◽

Long Term Outcome ◽

Patients With Diabetes ◽

Group A ◽

Group B

Aim. To evaluate the effect of quinapril on diabetic cardiovascular autonomic neuropathy (CAN) and peripheral neuropathy (DPN).Patients and Methods. Sixty-three consecutive patients with diabetes mellitus [43% males, 27 with type 1 DM, mean age 52 years (range 22–65)], definite DCAN [abnormal results in 2 cardiovascular autonomic reflex tests (CARTs)], and DPN were randomized to quinapril 20 mg/day (group A,n=31) or placebo (group B,n=32) for 2 years. Patients with hypertension or coronary heart disease were excluded. To detect DPN and DCAN, the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measurement of vibration perception threshold with biothesiometer (BIO), and CARTs [R-R variation during deep breathing [assessed by expiration/inspiration ratio (E/I), mean circular resultant (MCR), and standard deviation (SD)], Valsalva maneuver (Vals), 30 : 15 ratio, and orthostatic hypotension (OH)] were used.Results. In group A, E/I, MCR, and SD increased (pfor all comparisons < 0.05). Other indices (Vals, 30 : 15, OH, MNSIQ, MNSIE, and BIO) did not change. In group B, all CART indices deteriorated, except Vals, which did not change. MNSIQ, MNSIE, and BIO did not change.Conclusions.Treatment with quinapril improves DCAN (mainly parasympathetic dysfunction). Improved autonomic balance may improve the long-term outcome of diabetic patients.

Download Full-text

Serum Erythropoietin Concentration And Its Correlation With Stage Of Diabetic Retinopathy

10.21203/rs.2.12950/v2 ◽

2019 ◽

Author(s):

Sofija Davidović ◽

Babić Nikola ◽

Jovanović Sandra ◽

Barišić Sava ◽

Grković Desanka ◽

...

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Serum Concentration ◽

Proliferative Diabetic Retinopathy ◽

Elevated Serum ◽

Average Concentration ◽

Control Group ◽

Diabetic Patients ◽

Study Results ◽

Patients With Diabetes

Download Full-text

Laboratory Findings Associated with Pulmonary Tuberculosis in Diabetic Patients

Academia Journal of Medicine ◽

10.47008/ajm.2020.3.1.11 ◽

2020 ◽

Vol 3 (1) ◽

pp. 52-57

Author(s):

P.V.R. Leelamohan ◽

Kiran N

Keyword(s):

Diabetes Mellitus ◽

Pulmonary Tuberculosis ◽

Extrapulmonary Tuberculosis ◽

Age Groups ◽

Diabetic Patients ◽

Current Estimate ◽

Type 2 Diabetic Patients ◽

Laboratory Findings ◽

Study Results ◽

Patients With Diabetes

Background: An epidemic of diabetes is currently, both in developed and developing nations. The seriousness of the association of pulmonary tuberculosis and diabetes mellitus was first noted by the great Arab Physician Avicenna nearly 1000 years ago. The global figure of people with diabetes is projected to rise from the current estimate of 220 million to 300 million in 2025. Subjects and Methods: All type 2 diabetic patients reporting to MVJMC and RH will form the subjects for study. The study conducted over a period of 2 yrs. Adult patients with diabetes mellitus with pulmonary tuberculosis were included while Diabetic patients with extrapulmonary tuberculosis were excluded from the study. Results: LDL- 18% of the patients had an LDL value below 100. 40% of the patients had LDL value between 100 – 120. Only 42% of the patients had LDL values between 120-140. HDL: 22.0% of the patients had an HDL value below 30. 24% of the patients had HDL values between 30 – 40. Only 36.0% of the patients had HDL value between 40-50 and 18% of the patients had an HDL value between 50-60. Triglycerides: 56.0% of the patients had Triglycerides value below 150. 42% of the patients had Triglycerides value between 150 – 199. Only 2.0% of the patients had Triglycerides value between 200-499. Conclusion: Male preponderance of the disease was noted and Peak incidence of the disease was noted in the age groups of 31 – 40 and 41 – 50. The majority of our patients had poorly controlled blood sugars, suggesting that severe hyperglycemia is associated with the development of pulmonary tuberculosis and sputum positivity was more in patients aged ≤ 50 yrs. Early diagnosis and properly monitored treatment regimen is the only time tested answer to this problem.

Download Full-text

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120102 ◽

1985 ◽

Vol 43 ◽

pp. 682-683

Author(s):

Bruce R. Pachter

Keyword(s):

Diabetes Mellitus ◽

Peripheral Nerves ◽

Sudden Onset ◽

Extraocular Muscles ◽

Diabetic Patients ◽

Oculomotor Palsy ◽

Third Nerve Palsy ◽

Patients With Diabetes ◽

Intramuscular Nerve ◽

Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

Download Full-text