Involvement of Different Nerve Branches in Trigeminal Neuralgia on Right and Left Sides- A Retrospective Study

2021 ◽  
Vol 13 (1) ◽  
pp. 14-17
Author(s):  
Sunitha K. Caroline ◽  
Muthukrishnan Arvind ◽  
Ramesh R
Keyword(s):  
Retrospective Study ◽  
Trigeminal Neuralgia ◽  
Age Of Onset ◽  
Future Research ◽  
Nerve Branch ◽  
Systemic Factors ◽  
The Face ◽  
Orofacial Region ◽  
The Right ◽  
Clinical Records

One of the most common symptoms in the orofacial region is pain. Trigeminal neuralgia is characterized by pain affecting the trigeminal nerve and its related areas of distribution and is known to have significant impact on the quality of life. Misdiagnosis of trigeminal neuralgia has been reported by dentists in several previous studies in the literature. With this rationale, the aim of the present study is to determine the most commonly involved nerve branch and the side affected in trigeminal neuralgia patients. The present retrospective study involved 72 patients diagnosed with trigeminal neuralgia who reported from October 2013 to October 2014. Data regarding the age of onset, gender, side of involvement was analyzed from their clinical records. Out of the 72 patients, males were 42(58.3%) and females were 30(41.7%). In our study, a total of 56 % (i.e., 40) patients showed involvement on the right and 44% (i.e., 32) (i.e, 32) patients on the left side of the face. In this retrospective study, ophthalmic branch (V1) was affected only in 3 patients. Mandibular nerve (V3) alone was involved in 24 patients. Involvement of all the three divisions V1, V2 and V3 was seen in 16(22.3%) of patients. Clinical similarities of trigeminal neuralgia that have an impact on different populations were demonstrated in this study. Detailed history and proper identification of involved nerve branch play an important role in the diagnostic accuracy and treatment satisfaction. Most involved branch in our study was the mandibular (V3) branch and the most affected side was the right side. Correlation of systemic factors with trigeminal neuralgia can be attempted in future research.

scholarly journals A prospective study of 39 patients with trigeminal neuralgia treated with percutaneous balloon compression

2011 ◽  
Vol 69 (2a) ◽  
pp. 221-226 ◽  
Author(s):  
Wuilker Knoner Campos ◽  
Marcelo N. Linhares
Keyword(s):  
Trigeminal Neuralgia ◽  
Female Gender ◽  
Safe Procedure ◽  
Approval Ratings ◽  
Balloon Compression ◽  
Percutaneous Balloon ◽  
Percutaneous Balloon Compression ◽  
The Face ◽  
The Right ◽  
A Prospective Study

OBJECTIVE: Trigeminal neuralgia is the most common facial pain. It may be treated with percutaneous balloon compression (PBC), which is considered to be a safe and efficient procedure. The purpose of this study was to review our results with PBC and to assess the factors influencing the outcome. METHOD: A multivariate analysis was used to study 39 patients during a 50-month postoperative period. RESULTS: There was predominance of the female gender (54%), the right side of the face (84%) and V2V3 roots of trigeminal nerve (33%). The mean age was 62.3 years. No major complications or deaths occurred. Among all variables, postoperative hypoesthesia was the single prognostic factor capable of positively influencing the results (p=0.02). Most patients (80%) were pain-free after 50 months with a 90% satisfaction rate. CONCLUSION: PBC was a safe procedure with low morbidity, no mortality, high approval ratings, and was an important improving on patients' quality of life.

Asymmetric superior oblique split Z-tendon lengthening for face turn in bilateral asymmetric superior oblique overaction and exotropia

2020 ◽  
pp. 112067211989798
Author(s):  
Massimiliano Serafino ◽  
Matteo Scaramuzzi ◽  
Claudia Specchia ◽  
Francesco Bonsignore ◽  
Paolo Nucci
Keyword(s):  
Oblique Muscle ◽  
Intermittent Exotropia ◽  
Left Turn ◽  
Vertical Deviation ◽  
Tendon Lengthening ◽  
The Face ◽  
The Right ◽  
Clinical Records ◽  
Superior Oblique Muscle ◽  
Superior Oblique

Introduction: The aim was to evaluate the effectiveness of the procedure of the superior oblique split Z-tendon lengthening to collapse A pattern and treat face turn in a cohort of patients with both incomitant intermittent exotropia and a vertical deviation associated with a bilateral asymmetric superior oblique overaction. Methods: We retrospectively reviewed the clinical records of patients with facial turn associated with intermittent exotropia and bilateral asymmetric superior oblique overaction, who underwent superior oblique muscle split tendon lengthening and concurrent horizontal surgery between 2009 and 2017. Results: A total of eight patients met the inclusion criteria. The preoperative average face turn was 26.8° (range, 20°–5°), and it significantly improved to 5.4° (range, 2°–8°) ( p < 0.05). All the patients showed an improvement in the face turn with neutralization of the vertical deviation. The vertical deviation in the right gaze for the patient with a right turn and the left gaze in patients with left turn improved significantly (values of p < 0.05). Conclusion: The superior oblique split Z-tendon lengthening was an effective procedure to collapse the A pattern and the treatment of the face turn in a cohort of patients with both incomitant intermittent exotropia and a vertical deviation associated with a bilateral asymmetric superior oblique muscle overaction with less complications, and less varying results.

Trigeminal Neuralgia

2018 ◽  
Author(s):  
Jumana T. Alshaikh ◽  
Shaan Sudhakaran ◽  
Helene Rubeiz
Keyword(s):  
Trigeminal Neuralgia ◽  
Age Of Onset ◽  
Neurovascular Compression ◽  
First Line ◽  
Risks And Benefits ◽  
Female Predominance ◽  
Structural Abnormalities ◽  
The Face ◽  
Physical Stimuli ◽  
Sixth Decade

Trigeminal neuralgia is characterized by severe, unilateral, paroxysmal stabbing pain affecting the face in the distribution of one of the divisions of the trigeminal nerve. The episodes of pain are brief and are triggered by innocuous physical stimuli. Typical age of onset is the sixth decade, with a female predominance. The most common cause is neurovascular compression. Other causes include multiple sclerosis and structural abnormalities in the cerebellopontine angle. The diagnosis is made clinically, but MRI can be useful in evaluation of the underlying etiology. First-line pharmacotherapy is carbamazepine or oxcarbazepine. If medical therapy fails, procedural interventions should be considered. From ablations to craniotomy, there is an array of procedural treatments available for trigeminal neuralgia. Patients should be educated on the risks and benefits of each procedure prior to pursuing treatment.

scholarly journals Atypical Trigeminal Neuralgia Secondary to Meningioma

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Premeshwar Niwant ◽  
Mukta Motwani ◽  
Sushil Naik
Keyword(s):  
Trigeminal Neuralgia ◽  
Cerebellopontine Angle ◽  
Unusual Case ◽  
Pressure Effect ◽  
Imaging Study ◽  
Moderate Pressure ◽  
Resonance Imaging ◽  
Nerve Branch ◽  
Axial Mass ◽  
The Face

Trigeminal neuralgia is a disorder of the fifth cranial nerve that causes episodes of intense, stabbing, electric shock-like pain that lasts from few seconds to few minutes in the areas of the face where the branches of the nerve are distributed. More than one nerve branch can be affected by the disorder. We report an unusual case of trigeminal neuralgia affecting right side of face presenting atypical features of neuralgia and not responding to the usual course of treatment. The magnetic resonance imaging study of brain revealed a large extra-axial mass involving right cerebellopontine angle region causing moderate pressure effect on trigeminal nerve and brain stem. The aim of this case report is to show a tumor of cerebellopontine angle, presenting clinically as atypical trigeminal neuralgia.

scholarly journals Prevalence of trigeminal neuralgia among dental patients - An institutional study

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 628-634
Author(s):  
Prashaanthi N ◽  
Santhosh Kumar M P ◽  
Shantha Sundari K K
Keyword(s):  
Trigeminal Neuralgia ◽  
The Elderly ◽  
Radiographic Examination ◽  
P Value ◽  
Age Group ◽  
Elderly Age ◽  
Dental Patients ◽  
Dental Hospital ◽  
The Face ◽  
The Right

Trigeminal neuralgia is a chronic condition which produces severe pain involving a part of the face. The aim of this study was to evaluate the prevalence of trigeminal neuralgia among dental patients visiting a dental institution. This retrospective study included patients who were diagnosed with trigeminal neuralgia from July 2019 to March 2020 in a dental hospital. The digital case records of all patients were retrieved and details were recorded, which included the clinical, radiographic examination and treatment undergone by the patients. Variables such as age, gender, site of involvement were also retrieved from the case records. Data were tabulated and statistically analysed using IBM SPSS version 23.0 and results obtained. P value < 0.05 was considered statistically significant. In the present study, out of 28 patients, males (53.6%) were more affected by trigeminal neuralgia than females (46.4%) with a higher prevalence on the right side (57.1%). Quadrant I (25%) and combination of quadrant II and quadrant III (25%) were most commonly involved by this condition. No statistically significant association was found between age and quadrant affected; gender and quadrant affected. (p>0.05). It can be concluded from our study that males were more affected with trigeminal neuralgia, the majority involving the right side of the face and seen commonly among the elderly age group. Dentists must be aware of the clinical features of trigeminal neuralgia for accurate diagnosis and early initiation of prompt treatment to avoid untoward complications.

scholarly journals Drug Therapy for Refractory Trigeminal Neuralgia- A Review

2021 ◽  
Vol 14 (02) ◽  
pp. 939-942
Author(s):  
Yogesh Chhaparwal ◽  
Mathangi Kumar ◽  
Shubha Chhaparwal
Keyword(s):  
Drug Therapy ◽  
Trigeminal Neuralgia ◽  
Electric Shock ◽  
Pain Control ◽  
Surgical Intervention ◽  
The Face ◽  
Orofacial Region ◽  
Line Of Therapy

Trigeminal neuralgia is the most common neuralgia affecting the orofacial region. The condition characterized by sudden, severe electric shock like pain on the face with pain free periods and is termed as refractory period.Management of this condition is achieved through various drug therapies and in some cases, surgical intervention may be required. Refractory trigeminal neuralgia is a condition that is non responsive to the traditional line of therapy. This poses a challenge to the clinicians to offer the patients alternate options for pain control in these patients. In this review, an attempt has been made to discuss the various drug therapies in the management of refractory trigeminal neuralgia.

Transferrin-Conjugated Nanocarriers as Active-Targeted Drug Delivery Platforms for Cancer Therapy

2017 ◽  
Vol 23 (3) ◽  
pp. 454-466 ◽  
Author(s):  
Daniele R. Nogueira-Librelotto ◽  
Cristiane F. Codevilla ◽  
Ammad Farooqi ◽  
Clarice M. B. Rolim
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Therapeutic Benefit ◽  
Active Targeting ◽  
Future Research ◽  
Passive Targeting ◽  
The Right ◽  
Review Current ◽  
Target Effects

A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking advantage of the overexpression of transferrin receptors on the surface of tumor cells, transferrin-conjugated nanodevices have been designed, in hope that the biomarker grafting would help to maximize the therapeutic benefit and to minimize the side effects. Notably, active targeting nanoparticles have shown improved therapeutic performances in different tumor models as compared to their passive targeting counterparts. In this review, current development of nano-based devices conjugated with transferrin for active tumor-targeting drug delivery are highlighted and discussed. The main objective of this review is to provide a summary of the vast types of nanomaterials that have been used to deliver different chemotherapeutics into tumor cells, and to ultimately evaluate the progression on the strategies for cancer therapy in view of the future research.

scholarly journals The impact of regionalized trauma care on the distribution of severely injured patients in the Netherlands

2021 ◽  
Author(s):  
Suzan Dijkink ◽  
Erik W. van Zwet ◽  
Pieta Krijnen ◽  
Luke P. H. Leenen ◽  
Frank W. Bloemers ◽  
...  
Keyword(s):  
The Netherlands ◽  
Trauma Care ◽  
Trauma System ◽  
Future Research ◽  
Severely Injured ◽  
Trauma Centers ◽  
Severely Injured Patients ◽  
The Right ◽  
Injured Patients ◽  
The Impact

Abstract Background Twenty years ago, an inclusive trauma system was implemented in the Netherlands. The goal of this study was to evaluate the impact of structured trauma care on the concentration of severely injured patients over time. Methods All severely injured patients (Injury Severity Score [ISS] ≥ 16) documented in the Dutch Trauma Registry (DTR) in the calendar period 2008–2018 were included for analysis. We compared severely injured patients, with and without severe neurotrauma, directly brought to trauma centers (TC) and non-trauma centers (NTC). The proportion of patients being directly transported to a trauma center was determined, as was the total Abbreviated Injury Score (AIS), and ISS. Results The documented number of severely injured patients increased from 2350 in 2008 to 4694 in 2018. During this period, on average, 70% of these patients were directly admitted to a TC (range 63–74%). Patients without severe neurotrauma had a lower chance of being brought to a TC compared to those with severe neurotrauma. Patients directly presented to a TC were more severely injured, reflected by a higher total AIS and ISS, than those directly transported to a NTC. Conclusion Since the introduction of a well-organized trauma system in the Netherlands, trauma care has become progressively centralized, with more severely injured patients being directly presented to a TC. However, still 30% of these patients is initially brought to a NTC. Future research should focus on improving pre-hospital triage to facilitate swift transfer of the right patient to the right hospital.

scholarly journals Racial Disparities in Epigenetic Aging of the Right vs Left Colon

2020 ◽  
Author(s):  
Matthew Devall ◽  
Xiangqing Sun ◽  
Fangcheng Yuan ◽  
Gregory S Cooper ◽  
Joseph Willis ◽  
...  
Keyword(s):  
Dna Methylation ◽  
African Americans ◽  
Racial Differences ◽  
Age Of Onset ◽  
Left Colon ◽  
Right Colon ◽  
Normal Colon ◽  
Epigenetic Aging ◽  
Epigenetic Age Acceleration ◽  
The Right

Abstract There are well-documented racial differences in age-of-onset and laterality of colorectal cancer. Epigenetic age acceleration is postulated to be an underlying factor. However, comparative studies of side-specific colonic tissue epigenetic aging are lacking. Here, we performed DNA methylation analysis of matched right and left biopsies of normal colon from 128 individuals. Among African Americans (n = 88), the right colon showed accelerated epigenetic aging as compared to individual-matched left colon (1.51 years; 95% CI = 0.62 to 2.40 years; two-sided P = .001). In contrast, among European Americans (n = 40), the right colon shows remarkable age deceleration (1.93 years; 95% CI = 0.65 to 3.21 years; two-sided P = .004). Further, epigenome-wide analysis of DNA methylation identifies a unique pattern of hypermethylation in African American right colon. Our study is the first to report such race and side-specific differences in epigenetic aging of normal colon, providing novel insight into the observed younger age-of-onset and relative preponderance of right-side colon neoplasia in African Americans.

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