scholarly journals Pregnancy and Healthy Childbirth in a 37 Year-Old Patient with Diverticular Disease

2020 ◽  
Vol 30 (5) ◽  
pp. 58-62
Author(s):  
P. S. Andreev ◽  
S. E. Katorkin ◽  
O. E. Davydova
Keyword(s):  
Abdominal Pain ◽  
Diverticular Disease ◽  
Clinical Case ◽  
Clinical Symptoms ◽  
Young Female ◽  
Foetal Development ◽  
Fibre Diet ◽  
Key Points ◽  
Uncomplicated Diverticular Disease ◽  
Specific Symptoms

Aim. To describe a clinical case of pregnancy and healthy labour in a young female patient with uncomplicated diverticular disease (DD).Key points. In recent years, DD is more frequently observed in younger patients. A 37-yo woman manifested the symptoms of periodic intense abdominal pain and constant abdominal discomfort. Colonic DD was diagnosed with irrigoscopy. A high-fibre diet, rifaximin-α at 400 mg twice a day for one week, once a month for six months, and topical anti-inflammatory therapy were prescribed. Clinical symptoms were eradicated upon the treatment. Unaware of pregnancy, the patient had another course of rifaximin-α at the second week of gestation, after which the therapy was stopped. Rifaximin-α, which has a poor intestinal absorption, did not affect the foetal development. A caesarean childbirth was healthy, the newborn was delivered on term with no complications (Apgar score 8).Conclusion. DD should be included in differential diagnosis for patients with non-specific symptoms (abdominal pain, bloating and discomfort), regardless of young age. No protocols are currently accepted for the DD management during gestation. In the clinical case reported, a patient having diverticular disease and a rifaximin-α therapy at an early term of gestation proceeded without complications for herself and the foetus.

scholarly journals Efficacy of a New Nutraceutical Formulation in Patients with Symptomatic Uncomplicated Diverticular Disease (SUDD): a Prospective Observational Study

2020 ◽  
Vol 28 ◽  
pp. 49-52
Author(s):  
Ferdinando D'Amico ◽  
Giulia Fiorini ◽  
Antonio Tursi ◽  
Ilaria Maria Saracino ◽  
Matteo Pavoni ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Adverse Events ◽  
Observational Study ◽  
Diverticular Disease ◽  
Prospective Observational Study ◽  
Remission Rate ◽  
Acute Diverticulitis ◽  
Symptom Relief ◽  
Bowel Habits ◽  
Uncomplicated Diverticular Disease

Background and Aim: Symptomatic uncomplicated diverticular disease (SUDD) is characterized by abdominal pain, bloating and altered bowel habits (constipation or diarrhea) attributed to diverticula in the absence of macroscopic mucosal alterations. There is no consensus about management of these patients. DIVER-100®, an association of natural active ingredients may be effective in the treatment of patients with SUDD. The aim was to evaluate the efficacy and safety of DIVER-100® in patients with SUDD. Methods: We conducted a prospective observational study to evaluate the efficacy of DIVER-100® in consecutive patients with SUDD, confirmed by radiology or endoscopy. All patients were treated with DIVER-100® 2 capsules/day 10 days per month, for 3 months. The primary endpoint was the clinical remission rate, defined as the reduction of abdominal pain and bloating, improvement of bowel habits and prevention of acute diverticulitis (AD). The secondary endpoint was the rate of adverse events. Results: One hundred and one patients were consecutively enrolled at the Internal Medicine and Gastroenterology Unit, Sant’Orsola Hospital, Bologna, Italy. DIVER-100® was effective in inducing remission of symptoms in 12 patients (11.9%) at 3 months and in 10 patients (9.9%) at 6 months. DIVER-100® significantly reduced abdominal pain and bloating in 45.5% and 57.4% of patients respectively (p <0.001) after 3 months. No episodes of AD and no adverse events related to DIVER--100® were recorded at month 6 in the study population. Conclusions: DIVER-100® is a safe and effective nutraceutical compound in obtaining remission and symptom relief in SUDD patients. Further randomized, placebo-controlled clinical trials are needed to confirm these preliminary data.

scholarly journals Prevalence and factors associated with different pathogens of acute diarrhea in adults in Beijing, China

2016 ◽  
Vol 10 (11) ◽  
pp. 1200-1207 ◽  
Author(s):  
Lei Jia ◽  
Changying Lin ◽  
Zhiyong Gao ◽  
Mei Qu ◽  
Junyong Yang ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Acute Diarrhea ◽  
Bacterial Infections ◽  
Laboratory Tests ◽  
Clinical Symptoms ◽  
Salmonella Spp ◽  
Detection Rates ◽  
Clinical Diagnoses ◽  
A Prospective Study ◽  
Specific Symptoms

Introduction: Only a small proportion of patients with diarrhea are diagnosed with laboratory tests in China, and most are diagnosed based on clinical symptoms. Therefore, understanding the prevalence of different diarrheal pathogens and their specific symptoms is important. Methodology: Data from a prospective study in Beijing of acute diarrhea and the related pathogens were used to study the association between different pathogen groups and the infected patients’ characteristics. A total of 355 patients with acute diarrhea, clinically diagnosed with infectious or noninfectious diarrhea by general practitioners (GPs), were recruited from three districts. Results: Different species of diarrheal pathogens were detected in 133 (37.5%) patients. The most prevalent pathogen was calicivirus (42.9%), followed by rotavirus (30.1%), Vibrio parahaemolyticus (13.5%), and Salmonella spp. (10.5%). The detection rates in patients diagnosed with infectious or noninfectious diarrhea by GPs did not differ significantly (c2 = 0.026, p = 0.873). Abdominal pain correlated negatively with viral pathogens, whereas nausea, living in the suburbs, and winter infection correlated positively with viral infection. Abdominal pain and leukocytosis were positively associated with bacterial infections, whereas winter infection correlated negatively with them. Conclusion: In this study, we found that the detection rates in patients diagnosed with infectious or noninfectious diarrhea by GPs was the same. We also revealed the improper prescription of antibiotics by GPs based simply on clinical diagnoses. A further analysis of diagnostic accuracy and methods is required to assist GPs in improving their diagnoses when insufficient laboratory tests are available and budgets are limited.

scholarly journals Idiopathic recurrent pancreatitis in a young woman: unexpected clue

2020 ◽  
Vol 48 (3) ◽  
pp. 54-69
Author(s):  
N. B. Gubergrits ◽  
N. Ye. Monogarova ◽  
N. V. Byelyayeva ◽  
A. A. Zeynalova ◽  
P. G. Fomenko ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Abdominal Pain ◽  
Young Woman ◽  
Clinical Case ◽  
Clinical Symptoms ◽  
Pancreatic Insufficiency ◽  
Symptomatic Therapy ◽  
Recurrent Pancreatitis ◽  
Enzyme Preparations ◽  
Enzyme Replacement

The article presents a complex clinical case of idiopathic recurrent pancreatitis in a young woman, 23 years old. The main clinical manifestation of the disease was acute, intense, recurrent abdominal pain. Despite ongoing symptomatic therapy, the patient’s condition had been worsened, and the intensity of abdominal pain increased. Adequate dosage of the enzyme replacement therapy allowed increasing the duration of remission. Differential diagnosis, additional laboratory and instrumental studies allowed determining the cause of recurrent pancreatitis and confirming the diagnosis of cystic fibrosis with a primary lesion of the pancreas. A distinctive feature of this clinical case is the diagnosis of a hereditary cystic fibrosis disease in adulthood, the absence of clinical symptoms of lungs’ involvement in the pathological process, as well as the absence of underdevelopment, malnutrition. The diagnosis of cystic fibrosis is confirmed by German specialists; currently, the patient continues treatment in a German clinic. The article presents current data on idiopathic pancreatitis, discusses a diagnostic algorithm for identification of the cause of the disease. The etiology, pathogenetic mechanisms of cystic fibrosis occurrence are considered, the known types of CFTR gene mutations, causing the development of the disease, as well as the principles of replacement enzyme therapy in patients with cystic fibrosis are described. Evidence-based medicine data are presented, revealing the efficacy and safety of taking enzyme preparations in the correction of the exocrine pancreatic insufficiency.

scholarly journals Acute Abdomen in a 91-Year-Old Male due to Perforated Jejunal Diverticulitis

2020 ◽  
Vol 14 (3) ◽  
pp. 598-603
Author(s):  
Francesco Sammartino ◽  
Ivana Selvaggio ◽  
Gioacchino Maria Montalto ◽  
Carolina Pasecinic ◽  
Sirvjo Dhimolea ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Small Intestine ◽  
Abdominal Pain ◽  
Mortality Rate ◽  
Diverticular Disease ◽  
Acute Abdomen ◽  
The Elderly ◽  
Review Of The Literature ◽  
Key Points ◽  
Jejunal Diverticulitis

Non-Meckel small intestine diverticular disease is a rare and mostly asymptomatic condition. However, rare cases of acute and emergent complications bear a high mortality rate. We report a case of a 91-year-old male that presented with an acute abdomen due to perforated jejunal diverticulitis. A review of the literature and key points of the condition are depicted. Although jejunal diverticulosis is rare, it must be considered in the differential diagnosis, especially in the elderly with signs of ambiguous abdominal pain and peritonitis.

scholarly journals Clinical Progression and Phenotypic Characteristics of Non-compaction Cardiomyopathy in Monozygotic Twins

Doctor Ru ◽  
2021 ◽  
Vol 20 (4) ◽  
pp. 15-20
Author(s):  
K.S. Shulenin ◽  
◽  
D.V. Cherkashin ◽  
R.G. Makiev ◽  
V.N. Goryutskiy ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sudden Cardiac Death ◽  
Cardiac Failure ◽  
Cardiac Death ◽  
Clinical Case ◽  
Clinical Symptoms ◽  
Monozygotic Twins ◽  
Clinical Progression ◽  
Phenotypic Characteristics ◽  
Key Points

Objective of the Paper: To demonstrate the clinical features and phenotypic characteristics of non-compaction cardiomyopathy (NCCM) in monozygotic twins. Key Points. We describe a clinical case of two patients who are monozygotic twins, as well as clinical progression and results of clinical and instrumental tests. Both patients had signs of arrhythmia syndrome and less pronounced cardiac failure syndrome. Thromboembolic syndrome, a part of the traditional NCCM triad, was not observed. Conclusion. Marked genetic and phenotypic NCCM heterogeny, as well as issues associated with clinical symptoms and prognosis make genetic tests extremely essential, especially in family disease. Keywords: non-compaction cardiomyopathy, sudden cardiac death, monozygotic twins, cardiac failure, atrial fibrillation.

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