scholarly journals [ID 56084] EFEITOS DOS COGUMELOS AGARICUS BLAZEI E GANODERMA LUCIDUM SOBRE O DESENVOLVIMENTO EMBRIONÁRIO E GESTACIONAL DE RATAS WISTAR

2021 ◽  
Vol 25 (2) ◽  
Author(s):  
Camila Figueira Mendes ◽  
Erika Leão Ajala Caetano ◽  
Isabella Ferreira Camargo ◽  
Angela Faustino Jozala ◽  
Denise Grotto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Ganoderma Lucidum ◽  
Agaricus Blazei

Objetivo: Avaliar os efeitos sobre o desenvolvimento embrionário e gestacional em ratas prenhas expostas diariamente aos cogumelos Agaricus blazei e Ganoderma lucidum. Metodologia: Após a confirmação de prenhez (1º dia), os animais foram separados aleatoriamente em 5 grupos (n=6, cada): controle salina (Cs), A. blazei (Ab1-8, 1º - 8º dia), A. blazei (Ab9-19, 9º - 19º dia), G. lucidum (Gl1-8,1º - 8º dia) e G. lucidum   (Gl1-19, 9º - 19º dia). Os animais receberam diariamente, via gavagem, 1,5 mL de cada cogumelo (100 mg/kg de pó liofilizado dissolvido em solução salina). No 20º dia gestacional, as fêmeas foram eutanizadas para a coleta de sangue (análises bioquímicas e hematológicas); rins e placenta (análises histológicas); cornos uterinos (análises morfométricas e morfológicas dos fetos). Resultados: Efeitos deletérios no perfil reprodutivo e gestacional das ratas e alterações nos parâmetros hematológicos não foram observados, como também hepatotoxicidade ou nefrotoxicidade materna. No entanto, ocorreu uma redução plasmática de colesterol total e triglicérides. O G. lucidum aumentou as células produtoras de glicogênio na placenta no período anterior à implantação. Quanto à prole ocorreu uma diminuição significativa no peso dos fetos de ambos os grupos expostos aos cogumelos. Conclusão: A administração oral dos cogumelos Agaricus blazei e Ganoderma lucidum em ratas prenhas positivamente reduziu o colesterol total e triglicérides, revelando um efeito cardioprotetor. O uso desses cogumelos durante o período gestacional foi seguro, não tendo apresentado efeitos teratogênicos, levando a uma redução de peso da prole, que pode ser útil em ocorrências do diabetes mellitus gestacional.

scholarly journals Growing experiments with a medicinal mushroom Agaricus blazei (MURRILL)

2008 ◽  
Vol 14 (4) ◽  
Author(s):  
A. Geösel ◽  
J. Győrfi
Keyword(s):  
Medicinal Plants ◽  
Ganoderma Lucidum ◽  
Lentinula Edodes ◽  
Biological Efficiency ◽  
Viral Diseases ◽  
Medicinal Mushroom ◽  
Agaricus Blazei ◽  
Medicinal Products ◽  
Mushroom Compost ◽  
The Past

The demand of natural and medicinal products has been increased for the past years. These products are often made from herbal and medicinal plants, and recently the mushroom products are much called. Nearby some well known species (like Lentinula edodes or Ganoderma lucidum) some not respected biomedicines are available in Hungary. Agaricus blazei (Murrill) is a Basidiomycota fungus, with almond-like taste and nice texture. This medicinal mushroom proved to be useful in cancer therapy and against some bacterial and viral diseases. In our experiment we tested 8 Agaricus blazei strains on fermented mushroom compost. The yields, average mushroom size, productivity and biological efficiency of the species were measured. Our data demonstrate that it is possible to get fruit bodies less than 2 months, and strain "837", "2603" and "MaHe" are suggested for further experiments. These strains gave the highest yield and efficiency in the cultivation.

scholarly journals Efek Hipoglikemik dan Hepatoprotektif Fraksi Air Lingzhi (Ganoderma lucidum) pada Tikus Diabetes Mellitus

2022 ◽  
Vol 6 (2) ◽  
pp. 54-57
Author(s):  
Siti Maimunah ◽  
Dwiningsih Dwiningsih ◽  
Junaidi Khotib ◽  
Sukardiman Sukardiman
Keyword(s):  
Diabetes Mellitus ◽  
Ganoderma Lucidum

scholarly journals Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model

2019 ◽  
Vol Volume 15 ◽  
pp. 419-427 ◽  
Author(s):  
Teuku Heriansyah ◽  
Wiwit Nurwidyaningtyas ◽  
Djanggan Sargowo ◽  
Cholid Tri Tjahjono ◽  
Titin Andri Wihastuti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ganoderma Lucidum ◽  
Vascular Repair

scholarly journals Polysaccharide Peptide (PsP) Ganoderma lucidum: A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum]

2019 ◽  
Vol Volume 15 ◽  
pp. 517-518
Author(s):  
Teuku Heriansyah ◽  
Wiwit Nurwidyaningtyas ◽  
Djanggan Sargowo ◽  
Cholid Tri Tjahjono ◽  
Titin Andri Wihastuti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ganoderma Lucidum ◽  
Vascular Repair

Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Titin Andri Wihastuti ◽  
Reyhan Amiruddin ◽  
Fibe Yulinda Cesa ◽  
Amalia Istiqamah Alkaf ◽  
Meddy Setiawan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Rat Model ◽  
Ganoderma Lucidum ◽  
Vasa Vasorum ◽  
Diabetic Rat ◽  
Diabetic Rat Model

AbstractBackgroundType 2 diabetes mellitus (T2DM) is a major risk factor of atherosclerosis. Hyperglycemia in T2DM causes advanced formation of glycation end products (AGE) which leads to oxidative stress and chronic inflammation. Oxidative stress occurs due to increased levels of reactive oxygen species (ROS) such as H2O2. On the other hand, lipoprotein-associated phospholipase (Lp-PLA2) has pro-inflammatory effects, which cause instability of atherosclerosis plaques. This condition causes hypoxemic cells to stimulate HIFα induced vasa vasorum angiogenesis. This study aims to understand the potential of PSP as an anti-angiogenic agent through decreased levels of H2O2 and Lp-PLA2 leading to the decline of vasa vasorum angiogenesis in diabetic rat model. In addition, this study also measured the lipid profile of diabetic rat model in relation to vasa vasorum angiogenesis.MethodsTrue laboratory experiment with randomized post-test control of group design using 25 wistar rats (Rattus norvegicus) were divided into five groups; one normal group and four group with High Fat Diet (HFD) and low dose streptozotocin (30 mg/kgBW) injection sc, treated with placebo and three various doses of PSP 50, 150, 300 mg/kgBW.ResultsANOVA test (p < 0.05) shows that there is a significant influence of polysaccharide peptide (PSP) feeding on the decreased amount of vasa vasorum angiogenesis (p = 0.00), lipid profile (cholesterol total and triglyceride; p = 0.01, p = 0.001), and amount of H202 (p = 0.003). The amount of Lp-PLA2 declined to (p = 0.184). This result indicates that PSP prevents inflammation in atherosclerosis.ConclusionsPSP of Ganoderma lucidum is an anti-angiogenic agent in T2DM.

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