scholarly journals New Insights into Non-Invasive His Bundle Potential Detection on High Resolution Body Surface Recordings

2020 ◽  
Author(s):  
Nolwenn Tan ◽  
Romain Tixier ◽  
Josselin Duchateau ◽  
Laura Bear ◽  
Remi Dubois
Keyword(s):  
High Resolution ◽  
Body Surface ◽  
His Bundle ◽  
Non Invasive

scholarly journals Validation of non-invasive body-surface gastric mapping for detecting electrophysiological biomarkers by simultaneous high-resolution serosal mapping in a porcine model

2021 ◽  
Author(s):  
Stefan Calder ◽  
Leo K Cheng ◽  
Christopher Andrews ◽  
Niranchan Paskaranandavadivel ◽  
Stephen Waite ◽  
...  
Keyword(s):  
High Resolution ◽  
Slow Wave ◽  
Body Surface ◽  
Porcine Model ◽  
Slow Waves ◽  
Electrode Spacing ◽  
Non Invasive ◽  
Gastric Slow Waves ◽  
The Relationship ◽  
Gastric Mapping

Gastric disorders are increasingly prevalent, but reliable clinical tools to objectively assess gastric function are lacking. Body-surface gastric mapping (BSGM) is a non-invasive method for the detection of gastric electrophysiological biomarkers including slow wave direction, which have correlated with symptoms in patients with gastroparesis and functional dyspepsia. However, no studies have validated the relationship between gastric slow waves and body surface activation profiles. This study aimed to comprehensively evaluate the relationship between gastric slow waves and body-surface recordings. High-resolution electrode arrays were placed to simultaneously capture slow waves from the gastric serosa (32 x 6 electrodes at 4 mm resolution) and abdominal surface (8x8 at 20 mm inter-electrode spacing) in a porcine model. BSGM signals were extracted based on a combination of wavelet and phase information analyses. A total of 1185 individual cycles of slow waves assessed, out of which 897 (76%) were normal antegrade waves, occurring in 10/14 (71%) subjects studied. BSGM accurately detected the underlying slow wave in terms of frequency (r = 0.99, p = 0.43) as well as the direction of propagation (p = 0.41, F-measure: 0.92). In addition, the cycle-by-cycle match between BSGM and transitions of gastric slow waves in terms either or both temporal and spatial abnormalities was demonstrated. These results validate BSGM as a suitable method for non-invasively and accurately detecting gastric slow wave activation profiles from the body surface.

scholarly journals High resolution Physio-chemical Tissue Analysis: Towards Non-invasive In Vivo Biopsy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Guan Xu ◽  
Zhuo-xian Meng ◽  
Jian-die Lin ◽  
Cheri X. Deng ◽  
Paul L. Carson ◽  
...  
Keyword(s):  
High Resolution ◽  
Tissue Analysis ◽  
Non Invasive

Visualization of USPIO-Labeled Melt-Electrowritten Scaffolds by Non-Invasive Magnetic Resonance Imaging

2021 ◽  
Author(s):  
Kilian Maria Arthur Mueller ◽  
Geoffrey Topping ◽  
Sebastian Patrick Schwaminger ◽  
Younzhe Zou ◽  
Diana Marcela Rojas-González ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Tissue Engineering ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Digital Fabrication ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Forming Technology

Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in...

scholarly journals Ultrasound - first imaging modality in the detection of parathyroid adenomas

2008 ◽  
Vol 12 (3) ◽  
pp. 64 ◽  
Author(s):  
R Ahmed ◽  
N Khan ◽  
S Ellemdin ◽  
K Gayaparsad
Keyword(s):  
Nuclear Medicine ◽  
High Resolution ◽  
Gold Standard ◽  
Imaging Modality ◽  
Non Invasive ◽  
Highly Sensitive ◽  
Parathyroid Adenomas ◽  
Thyroid Adenomas ◽  
Invasive Method ◽  
Ultrasound Features

Abstract We present a series of 12 patients in whom the typical ultrasound features of parathyroid adenomas were accurately demonstrated. High resolution ultrasound [in experienced hands] is a highly sensitive accurate, safe and non invasive method of localizing parathyroid adenomas especially in patients with typically located glands and an absence of thyroid pathology. Our aim was to compare ultrasound with nuclear medicine as an imaging gold standard in patients with thyroid adenomas.

scholarly journals Diagnostic performance and utility of very high-resolution ultrasonography in diagnosing giant cell arteritis of the temporal artery

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Johnny K M Sundholm ◽  
Tom Pettersson ◽  
Anders Paetau ◽  
Anders Albäck ◽  
Taisto Sarkola
Keyword(s):  
High Resolution ◽  
Temporal Artery ◽  
Final Diagnosis ◽  
Thickness Measurement ◽  
Observer Agreement ◽  
Diagnostic Utility ◽  
Temporal Artery Biopsy ◽  
Glucocorticoid Treatment ◽  
Non Invasive ◽  
Very High

Abstract Objective Very-high resolution US (VHRU; 55 MHz) provides improved resolution and could provide non-invasive diagnostic information in GCA of the temporal artery. The objective of this study was to assess the diagnostic utility of VHRU-derived intima thickness (VHRU-IT) in comparison to high-resolution US halo-to-Doppler ratio (HRU-HDR) in patients referred for temporal artery biopsy. Methods VHRU and HRU of the temporal artery were performed before a biopsy procedure in 78 prospectively recruited consecutive patients who had received glucocorticoid treatment for a median of 8 days (interquartile range 0–13 days) before imaging. Based on the final diagnosis and biopsy findings, the study population was divided into the following four groups: non GCA (n = 40); clinical GCA with no inflammation on biopsy (n = 15); clinical GCA with inflammation limited to adventitia (n = 9); and clinical GCA with transmural inflammation (TMI; n = 11). Results Both VHRU and HRU were useful for identifying subjects with TMI, with VHRU outperforming HRU (area under curve: VHRU-IT 0.99, 95% CI 0.97, 1.00; HRU-HDR 0.74, 95% CI 0.52, 0.96; P=0.026). The diagnostic utility for diagnosing clinical GCA (negative biopsy) or inflammation limited to the adventitia was poor for both VHRU and HRU-HDR. From 5 days after initiation of glucocorticoid treatment, VHRU-IT was increased in eight of nine patients, whereas HRU-HDR was positive in three of seven patients. Both methods showed excellent inter-observer agreement (Cohen’s κ: VHRU-IT 0.873; HRU-HDR 0.811). Conclusion In suspected GCA, VHRU allows non-invasive real-time imaging of TMI manifestations of the temporal artery wall. VHRU-derived intimal thickness measurement seems to be more sensitive than the halo sign and HRU-HDR in detecting TMI in patients with prolonged glucocorticoid treatment.

scholarly journals Anterior high-resolution OCT in the diagnosis and management of corneal squamous hyperplasia mimicking a malignancy: a case report

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yi-Syun Shen ◽  
Joseph L. Hu ◽  
Chao-Chien Hu
Keyword(s):  
Case Report ◽  
High Resolution ◽  
Ocular Surface ◽  
Imaging Modality ◽  
Treatment Plan ◽  
Benign Lesion ◽  
Abrupt Transition ◽  
Diagnosis And Management ◽  
Non Invasive ◽  
Inferior Border

Abstract Background Anterior high-resolution optical coherence tomography (HR-OCT) is a novel non-invasive in vivo imaging modality that can assist in the diagnosis and management of various ophthalmic pathologies. The implementation of diagnosing ocular surface lesions has been explored in previous studies, successfully revealing specific signs in some ocular lesions. This case report aims to exhibit a case of corneal squamous hyperplasia diagnosed via anterior HR-OCT, prior to surgical intervention. Case presentation A 69 year-old male had blurred vision and foreign body sensation OD for several weeks. A rapidly-grown corneal mass was presented, showing an appearance of a grayish flesh-colored mass with elastic texture. Large vessels supplying the mass were also found. Anterior HR-OCT was performed, and the results suggested the lesion be benign hyperplasia. Superficial keratectomy was done, and the pathologic report showed mild-appearing epithelial squamous hyperplasia, which confirmed the analysis via anterior HR-OCT. Conclusion In the categorization by Nanji, et al. of corneal surface diseases using anterior OCT, the comparative epithelial thickness (normal range: 47—68 μm); inferior border obscuration of epithelium (normal or benign inferior border: no shadowing); reflectivity of epithelial layer (normal: not hyper-reflective); abrupt transition (normal: no horizontally abrupt transition); and sub-epithelium analysis vary between benign and malignant lesions (normal: demarcated anterior to Bowman’s layer), and the differences are systemically sorted. We applied all these characteristics to our patient as guidance, and the measurement results indicated the lesion be a benign lesion, which is consistent with the tissue pathology. Anterior HR-OCT is overall a non-invasive and timely method capable of assisting the diagnosis of ocular surface disease, predicting the qualities of a lesion, and determining the follow-up treatment plan.

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