Paleomonsoon modeling within PMIP: Recent progress and future directions

AbstractOrexin peptides and their cognate receptors were discovered 14 years ago. They soon took a very central position in the regulation of sleep and wakefulness. Active studies have further elucidated these functions as well as the role of orexins in, for instance, appetite, metabolism, analgesia, addiction, and stress response. This review summarizes all the important fields but especially aims at focusing on novel findings and future directions.

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Bioengineering Approaches to Accelerate Clinical Translation of Stem Cell Therapies Treating Osteochondral Diseases

Stem Cells International ◽

10.1155/2020/8874742 ◽

2020 ◽

Vol 2020 ◽

pp. 1-13

Author(s):

Meng Wang ◽

Yixuan Luo ◽

Yin Yu ◽

Fei Chen

Keyword(s):

Mechanical Properties ◽

Stem Cell ◽

Recent Progress ◽

Osteochondral Defect ◽

Cell Phenotype ◽

Stem Cell Therapies ◽

Future Directions ◽

Cell Therapies ◽

Osteochondral Repair ◽

Therapeutic Properties

The osteochondral tissue is an interface between articular cartilage and bone. The diverse composition, mechanical properties, and cell phenotype in these two tissues pose a big challenge for the reconstruction of the defected interface. Due to the availability and inherent regenerative therapeutic properties, stem cells provide tremendous promise to repair osteochondral defect. This review is aimed at highlighting recent progress in utilizing bioengineering approaches to improve stem cell therapies for osteochondral diseases, which include microgel encapsulation, adhesive bioinks, and bioprinting to control the administration and distribution. We will also explore utilizing synthetic biology tools to control the differentiation fate and deliver therapeutic biomolecules to modulate the immune response. Finally, future directions and opportunities in the development of more potent and predictable stem cell therapies for osteochondral repair are discussed.

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Insulin - producing cells derived from stem cells: recent progress and future directions

Journal of Cellular and Molecular Medicine ◽

10.1111/j.1582-4934.2006.tb00531.x ◽

2006 ◽

Vol 10 (4) ◽

pp. 866-883 ◽

Cited By ~ 28

Author(s):

A. Santana ◽

R. Enseñat - Waser ◽

María Isabel Arribas ◽

J. A. Reig ◽

E. Roche

Keyword(s):

Stem Cells ◽

Recent Progress ◽

Future Directions ◽

Insulin Producing Cells

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Chapter 3 Small-Molecule Protein–Protein Interaction Inhibitors as Therapeutic Agents for Neurodegenerative Diseases: Recent Progress and Future Directions

Annual Reports in Medicinal Chemistry - Annual Reports in Medicinal Chemistry Volume 44 ◽

10.1016/s0065-7743(09)04403-0 ◽

2009 ◽

pp. 51-69 ◽

Cited By ~ 7

Author(s):

Simon N. Haydar ◽

Heedong Yun ◽

Roland G.W. Staal ◽

Warren D. Hirst

Keyword(s):

Neurodegenerative Diseases ◽

Small Molecule ◽

Protein Interaction ◽

Recent Progress ◽

Therapeutic Agents ◽

Future Directions ◽

Protein Protein Interaction

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Directed evolution approaches for optogenetic tool development

Biochemical Society Transactions ◽

10.1042/bst20210700 ◽

2021 ◽

Author(s):

Jaewan Jang ◽

G. Andrew Woolley

Keyword(s):

Directed Evolution ◽

Recent Progress ◽

Tool Development ◽

Future Directions ◽

Molecular Events

Photoswitchable proteins enable specific molecular events occurring in complex biological settings to be probed in a rapid and reversible fashion. Recent progress in the development of photoswitchable proteins as components of optogenetic tools has been greatly facilitated by directed evolution approaches in vitro, in bacteria, or in yeast. We review these developments and suggest future directions for this rapidly advancing field.

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Signal Transduction in Leaf Senescence: Progress and Perspective

Plants ◽

10.3390/plants8100405 ◽

2019 ◽

Vol 8 (10) ◽

pp. 405 ◽

Cited By ~ 3

Author(s):

Salman Ahmad ◽

Yongfeng Guo

Keyword(s):

Signal Transduction ◽

Leaf Senescence ◽

Recent Progress ◽

Crop Improvement ◽

Cellular Level ◽

Future Directions ◽

Nutrient Remobilization ◽

Potential Applications ◽

Leaf Tissues ◽

Inducing Factors

Leaf senescence is a degenerative process that is genetically controlled and involves nutrient remobilization prior to the death of leaf tissues. Age is a key developmental determinant of the process along with other senescence inducing factors. At the cellular level, different hormones, signaling molecules, and transcription factors contribute to the regulation of senescence. This review summarizes the recent progress in understanding the complexity of the senescence process with primary focuses on perception and transduction of senescence signals as well as downstream regulatory events. Future directions in this field and potential applications of related techniques in crop improvement will be discussed.

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