scholarly journals The long-term outcomes of early repolarization pattern and incidence of early repolarization syndrome in a population-based cohort study

2020 ◽  
Author(s):  
songkeat yodteerug ◽  
Prin Vathesatogkit ◽  
Pattara Rattanawong ◽  
Tachapong Ngarmukos ◽  
Sirin Apiyasawat ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Long Term Outcomes ◽  
Early Repolarization ◽  
Early Repolarization Syndrome

scholarly journals One-Year Outcomes with Once or Twice Daily Enoxaparin

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4968-4968
Author(s):  
Adi J. Klil-Drori ◽  
Sara Nazha ◽  
Marlene Gharib ◽  
Sylvie Perreault ◽  
Vicky Tagalakis
Keyword(s):  
Cohort Study ◽  
Major Bleeding ◽  
Research Funding ◽  
Population Based ◽  
Long Term Outcomes ◽  
Once Daily ◽  
Intention To Treat ◽  
One Year

Background: Enoxaparin given once daily (QD) for thrombotic disorders is less burdensome than twice-daily (BID) dosing. However, long-term outcomes when enoxaparin given as QD monotherapy are unknown. Methods: We did a population-based cohort study. New users of enoxaparin alone (2005-2014) were identified in the linked healthcare databases of Quebec, Canada, and followed up for up to one year. The number of dispensed syringes divided by prescription length determined QD or BID enoxaparin by intention to treat. Cumulative rates of major bleeding and re-treatment with anticoagulants at one year were compared between enoxaparin groups. Re-treatment was initiation of anticoagulation after at least 30 days of no dispensed anticoagulants. The duration of enoxaparin monotherapy was the sum of prescriptions until discontinuation. Results: The cohort included 504 patients; QD and BID enoxaparin users were 445 and 59, respectively. Mean (SD) age was 78.0 (6.6) years, 43.8% were males, and 61.9% had cancer. At 12 months, major bleeding occurred in 21 (4.7%) and 4 (6.8%) among QD and BID enoxaparin users, respectively (Figure 1A, P = 0.49). Re-treatment with anticoagulants occurred in 37 (9.6%) and 5 (9.4%) of QD and BID users, respectively (Figure 1B, P = 0.98). The duration of enoxaparin monotherapy was on average 13.9 (95% CI, 4.4-23.4, P = 0.005) days longer with QD vs BID use. Conclusions: Monotherapy with QD enoxaparin was common and longer than BID enoxaparin with no apparent differences in bleeding or re-treatment with anticoagulants. Figure 1 Disclosures Klil-Drori: Sanofi Canada: Research Funding. Nazha:Sanofi Canada: Employment. Gharib:Sanofi Canada: Employment. Perreault:Sanofi Canada: Research Funding. Tagalakis:Servier: Other: participated on ad boards; Bayer: Other: participated on ad boards; Pfizer: Other: participated on ad boards; Sanofi Aventis: Other: investigator initiated grant;participated on ad boards; BMS-Pfizer: Other: participated on ad boards.

scholarly journals Incidence, Risk Factors, and Outcomes of Neonatal Renal Vein Thrombosis in Ontario: Population-Based Cohort Study

Kidney360 ◽  
2020 ◽  
Vol 1 (7) ◽  
pp. 640-647 ◽  
Author(s):  
Allison C. Ouellette ◽  
Elizabeth K. Darling ◽  
Branavan Sivapathasundaram ◽  
Glenda Babe ◽  
Richard Perez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Renal Vein Thrombosis ◽  
Population Based ◽  
Long Term Outcomes ◽  
Vein Thrombosis ◽  
Increased Risk ◽  
Neonatal Renal Vein Thrombosis

BackgroundThere are limited data at a population level on the burden, risk factors, and long-term outcomes of neonatal renal vein thrombosis (nRVT). We conducted a population-based cohort study to understand the epidemiology and outcomes of nRVT over a 25-year period in Ontario.MethodsUsing linked administrative health databases, all hospitalized neonates ≤28 days born in Ontario between 1992 and 2016 with nRVT were identified. The primary outcome was to calculate the incidence of nRVT and trend over time in Ontario. We also determined the risk factors associated with nRVT as well as the risk of long-term outcomes after nRVT, including CKD, ESKD, all-cause mortality, and hypertension (HTN) compared with the healthy neonatal population without nRVT.ResultsThe annual incidence rate of nRVT was 2.6 per 100,000 live births (n=85). Presence of respiratory distress syndrome (OR, 8.01; 95% CI, 4.90 to 13.1), congenital heart disease (OR, 9.1; 95% CI, 5.05 to 16.4), central venous catheterization (OR, 3.9; 95% CI, 1.89 to 7.93), maternal preeclampsia (OR, 2.8; 95% CI, 1.6 to 4.79), and maternal diabetes (OR, 2.36; 95% CI, 1.36 to 4.07) conferred the highest risk for nRVT. Over a median follow-up of 15 years and after adjusting for confounders, neonates with nRVT versus the comparator cohort had a 15.5-fold risk of CKD, HTN, or death (n=49 [58%] versus n=90,050 [3%]; 95% CI, 11.7 to 20.6); 12.3-fold increased risk of CKD or death (n=39 [46%] versus n=32,016 [1%]; 95% CI, 8.9 to 16.8); and a 15.7-fold increased risk of HTN (n=33 [39%] versus n=64,458 [2%]; 95% CI, 11.1 to 21.1). None of the nRVT cohort developed ESKD. The median time to composite outcome of CKD, HTN, or death was 11.1 years.ConclusionsPatients with a history of nRVT remain at higher risk than the general population for long-term morbidity or mortality, indicating the need for long-term follow-up.

Long-term outcomes following self-poisoning in adolescents: a population-based cohort study

2015 ◽  
Vol 2 (6) ◽  
pp. 532-539 ◽  
Author(s):  
Yaron Finkelstein ◽  
Erin M Macdonald ◽  
Simon Hollands ◽  
Janine R Hutson ◽  
Marco L A Sivilotti ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Long Term Outcomes

scholarly journals Long term outcomes of transplantation using kidneys from expanded criteria donors: prospective, population based cohort study

BMJ ◽  
2015 ◽  
pp. h3557 ◽  
Author(s):  
Olivier Aubert ◽  
Nassim Kamar ◽  
Dewi Vernerey ◽  
Denis Viglietti ◽  
Frank Martinez ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Long Term Outcomes ◽  
Expanded Criteria ◽  
Expanded Criteria Donors

scholarly journals Intermediate and Long-term Outcomes of Survivors of Acute Kidney Injury Episodes: A Large Population-Based Cohort Study

2017 ◽  
Vol 69 (1) ◽  
pp. 18-28 ◽  
Author(s):  
Simon Sawhney ◽  
Angharad Marks ◽  
Nick Fluck ◽  
Adeera Levin ◽  
Gordon Prescott ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cohort Study ◽  
Large Population ◽  
Kidney Injury ◽  
Population Based ◽  
Long Term Outcomes
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