scholarly journals Promising Effects of Atorvastatin on Outcomes of Patients with Severe COVID-19, A Retrospective Cohort Study

2021 ◽  
Author(s):  
Mohmmad Haji Aghajani ◽  
Omid Moradi ◽  
Hamed Azhdari Tehrani ◽  
Hossein Amini ◽  
Elham Pourheidar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Mechanical Ventilation ◽  
Cohort Study ◽  
Coronary Artery ◽  
Hospital Mortality ◽  
Retrospective Cohort ◽  
Invasive Mechanical Ventilation ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Artery Disease

Purpose: Considering the anti-inflammatory effect of atorvastatin and the role of medical comorbidities such as hypertension and coronary artery disease on prognosis of the COVID-19 patients, we aimed to assess the effect of atorvastatin add-on therapy on mortality due to COVID-19. Methods: We conducted a retrospective cohort study, including patients who were hospitalized with confirmed diagnosis of severe COVID-19. Baseline characteristics and related clinical data of patients were recorded. Clinical outcomes consist of in hospital mortality, need for invasive mechanical ventilation and hospital length of stay. COX regression analysis models were used to assess the association of independent factors to outcomes. Results: Atorvastatin was administered for 421 out of 991 patients. The mean age was 61.640±17.003 years. Older age, higher prevalence of hypertension and coronary artery disease reported in patients who received atorvastatin. These patients had shorter hospital length of stay (P=0.001). Based on COX proportional hazard model, in hospital use of atorvastatin was associated to decrease in mortality (HR=0.679, P=0.005) and lower need for invasive mechanical ventilation (HR=0.602, P=0.014). Conclusions: Atorvastatin add-on therapy in patient with severe COVID-19 was associated with lower in hospital mortality and reduced the risk of need for invasive mechanical ventilation which support to continue the prescription of the medication.

Effect of hyperlipidemia in patients with a history of colon cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e15603-e15603
Author(s):  
Zahid Tarar ◽  
Muhammad Usman Zafar ◽  
Ghulam Ghous ◽  
Umer Farooq ◽  
Arjan Ahluwalia
Keyword(s):  
Coronary Artery Disease ◽  
Colon Cancer ◽  
Coronary Artery ◽  
Length Of Stay ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Inpatient Mortality ◽  
Peripheral Artery ◽  
History Of ◽  
Artery Disease

e15603 Background: The most common cancer of the digestive system is colorectal cancer. 5-year survival rate of early-stage colon cancer is > 90% whereas it is only 10% for patients with distant metastases. Recent studies have shown that lipids influence a tumor’s metastatic capabilities. High fat diet has also been linked with colon cancer. In this study, we try to understand the effect of hyperlipidemia in patients with a history of colon cancer. Methods: This is a retrospective study examining data from the National Inpatient Sample (NIS) Database of the year 2018. We identified patients with any history of Colon cancer using their specific ICD-10 codes. Additionally, we queried for ICD10 codes for hyperlipidemia. Primary outcome was inpatient mortality. Secondary outcome was hospital length of stay and total charge. Utilizing STATA MP 16.1 we performed multivariate logistic regression analysis. Various comorbidities including previous history of coronary artery disease, peripheral artery disease, stroke, smoking, diabetes, hypertension and chemotherapy were incorporated into the analysis. Additionally, hospital demographics were included in the analysis as well including race, hospital bed size teaching status, location, region, insurance and patient income. Data was considered statistically significant if p-value was < 0.05. Results: The total number of patients included in this study were 34,792. They were all adults age > 18 years. Approximately 49% were females. Mean age was 67 years and average hospital length of stay was 6.5 days. After running multivariable analysis for inpatient mortality, we noted that patients with hyperlipidemia had lower odds of mortality (Odds Ratio (OR) 0.64, 95% Confidence Intervals (CI) 0.56 – 0.73). Higher odds of mortality were seen in patients with coronary artery disease (OR 1.23, 95% CI 1.05 – 1.44). Among racial distributions, Blacks had higher odds of mortality when compared with White (OR 1.3, 95% CI 1.1 – 1.5). Hispanics had lower odds of inpatient mortality compared to Whites (OR 0.8, 95% CI 0.6 – 0.9). The odds of mortality were higher with increasing age (OR 1.025, 95% CI 1.02 – 1.031) and lower among females (0.82, 95% CI 0.73 – 0.91). Among secondary outcomes, hyperlipidemia did not affect the hospital length of stay or cost. Several factors increased the hospital length of stay which included any history of coronary artery disease, peripheral artery disease, or diabetes. In addition, patients admitted over the weekend had a higher length of stay. Conclusions: In this study, we find that hyperlipidemia is associated with lower mortality in patients with colon cancer. This could be possible because patients with hyperlipidemia are on statin therapy. This indirectly could point to a potential benefit of statins in colon cancer. Hyperlipidemia does not affect hospital length of stay or cost.

scholarly journals WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study

2021 ◽  
Author(s):  
Atsuhiko Kawabe ◽  
Takanori Yasu ◽  
Takeshi Morimoto ◽  
Akihiro Tokushige ◽  
Shin‐ichi Momomura ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Cohort Study ◽  
Coronary Artery ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Artery Disease ◽  
Wbc Count

scholarly journals Pre-operative echocardiography among patients with coronary artery disease in the United States Veterans Affairs healthcare system: A retrospective cohort study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Emily B. Levitan ◽  
Laura A. Graham ◽  
Javier A. Valle ◽  
Joshua S. Richman ◽  
Robert Hollis ◽  
...  
Keyword(s):  
United States ◽  
Coronary Artery Disease ◽  
Cohort Study ◽  
Coronary Artery ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
The United States ◽  
Veterans Affairs ◽  
System A ◽  
Artery Disease
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