Secondary biphenotypic leukemia following Rosai-Dorfman-Disease A coincidence?
Keyword(s):
Rosai-Dorman-Disease is one subgroup of Non-Langerhans cell histiocytosis with massive lymphadenopathy. It is a generally a benign and self-limiting disease, but an association to hemato-lymphoid malignancies or immune diseases is suspected. We present the case of a 6-year old male patient with multifocal extranodal RDD developing a secondary biphenotypic, treatment-resistant leukemia during treatment. Hypothysing that RDD and the secondary leukemia could be based on the same malign clone or on a cancer predispostion syndrome, whole-exome-sequencing of a saliva sample and leukemic cells were performed. A common marker of cell lines of histiocytosis and leukemic blasts has not been found.
2010 ◽
Vol 134
(2)
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pp. 276-278
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2001 ◽
Vol 125
(10)
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pp. 1348-1350
1992 ◽
Vol 166
(2)
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pp. 291-295
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2020 ◽
Vol 11
(4)
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pp. 5187-5191
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