Vesiculobollous disease with Cutaneous Systemic Lupus Erythematosus Treated by Rituxima; a case report

Case Report ◽

Autoimmune Disease ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

SLE is a chronic autoimmune disease characterized by multisystem inflammation, Vesiculobullous (VB) are different groups of oral disorders characterized by the formation of bullae. The aim of this report is to describe a case of a vesiculobullous disease in SLE.

Drug-Induced Gingival Overgrowth in an 8-Year-Old Girl: A Case Report

Avicenna Journal of Dental Research ◽

10.34172/ajdr.2021.21 ◽

2021 ◽

Vol 13 (3) ◽

pp. 109-112

Author(s):

Parviz Torkzaban ◽

Amir Talaie

Keyword(s):

Case Report ◽

Autoimmune Disease ◽

Lupus Erythematosus ◽

Immunological Tolerance ◽

Systemic Autoimmune Disease ◽

Channel Blockers ◽

Systemic Lupus ◽

Drug Induced ◽

Gingival Overgrowth

Systemic lupus erythematosus is a systemic autoimmune disease that involves multi organs. Genetic, endocrine, immunological, and environmental factors influence the loss of immunological tolerance against self-antigens leading to the formation of pathogenic autoantibodies that cause tissue damage through multiple mechanisms. The gingival overgrowth can be caused by three factors: noninflammatory, hyperplastic reaction to the medication; chronic inflammatory hyperplasia; or a combined enlargement due to chronic inflammation and drug-induced hyperplasia. Drug-Induced Gingival Overgrowth is associated with the use of three major classes of drugs, namely anticonvulsants, calcium channel blockers, and immunosuppressants. Due to recent indications for these drugs, their use continues to grow.

Recent advances in the management of systemic lupus erythematosus

F1000Research ◽

10.12688/f1000research.13941.1 ◽

2018 ◽

Vol 7 ◽

pp. 970 ◽

Cited By ~ 14

Author(s):

Savino Sciascia ◽

Massimo Radin ◽

Dario Roccatello ◽

Giovanni Sanna ◽

Maria Laura Bertolaccini

Keyword(s):

Side Effects ◽

Autoimmune Disease ◽

Lupus Erythematosus ◽

Clinical Manifestations ◽

Therapeutic Strategies ◽

Systemic Lupus ◽

Systemic Involvement ◽

Phase Ii And Iii ◽

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease presenting highly heterogeneous clinical manifestations and multi-systemic involvement. Patients are susceptible to relapse and remission, thus making management challenging. Moreover, a considerable number of side effects may occur with conventional therapies; therefore, there is clearly a need for new therapeutic strategies. Since the pathogenesis of SLE is highly complex, it is far from being fully understood. However, greater understanding of the pathways and of the cellular and molecular mediators involved in SLE is being achieved. Emerging evidence has allowed the development of new biological therapeutic options targeting crucial molecular mediators involved in the pathogenesis of SLE. This literature review analyzes the availability of biological and target-directed treatments, phase II and III trials, and new therapies that are being developed for the treatment of SLE.

Correlation between physical markers and psychiatric health in a Portuguese systemic lupus erythematosus cohort: The role of suffering in chronic autoimmune disease

PLoS ONE ◽

10.1371/journal.pone.0195579 ◽

2018 ◽

Vol 13 (4) ◽

pp. e0195579 ◽

Cited By ~ 4

Author(s):

Margarida Figueiredo-Braga ◽

Caleb Cornaby ◽

Miguel Bernardes ◽

Marta Figueiredo ◽

Cristina Dos Santos Mesquita ◽

...

Keyword(s):

Autoimmune Disease ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Overexpression of Cathepsin S Exacerbates Lupus Pathogenesis Through TLR7 and IFN-α in Transgenic Mice

10.21203/rs.3.rs-181707/v1 ◽

2021 ◽

Author(s):

Jinhee Lee ◽

Minjee Choi ◽

Soyoung Jang ◽

Mincheol Kang ◽

Su-Geun Lim ◽

...

Keyword(s):

Autoimmune Disease ◽

Lupus Erythematosus ◽

Cathepsin S ◽

Toll Like Receptor ◽

Systemic Lupus ◽

Autoimmune Reaction ◽

Multiple Organs ◽

Lupus Pathogenesis ◽

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms.

Lupus nephritis: Update on aetiopathogenesis and controversies in classification

Journal of Pathology of Nepal ◽

10.3126/jpn.v4i8.11596 ◽

2014 ◽

Vol 4 (8) ◽

pp. 672-676 ◽

Cited By ~ 1

Author(s):

AD Pant

Keyword(s):

Autoimmune Disease ◽

Lupus Nephritis ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Direct Binding ◽

Circulating Immune Complex ◽

Loss Of Tolerance ◽

Renal Antigens ◽

Systemic Lupus Erythematosus; a chronic autoimmune disease; is characterized by loss of tolerance against its own antigens and leads to production of autoantibodies and causes formation and deposition of immune complexes in different organs. Recent articles have been trying to unravel the mysteries of SLE. Different theories that have been proposed for the aetiopathogenesis of SLE are a)The circulating immune complex theory, b) The direct binding to endogenous renal antigens theory, and c) binding of antibody to antigens that were previously ‘planted’ into the kidney.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11596 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 672-676

ACUTE RESPIRATORY DISEASE AS THE DEBUT OF SYSTEMIC LUPUS ERYTHEMATOSUS

The Russian Archives of Internal Medicine ◽

10.20514/2226-6704-2015-0-6-63-67 ◽

2015 ◽

pp. 63-67

Author(s):

A. Yu. Ischenko ◽

E. Yu. Ilina ◽

N. A. Bylova

Keyword(s):

Autoimmune Disease ◽

Respiratory Disease ◽

Respiratory Infection ◽

Lupus Erythematosus ◽

Acute Respiratory Infection ◽

Acute Respiratory Disease ◽

Systemic Lupus ◽

Chronic Autoimmune Disease ◽

Clinical Cases

Systemic lupus erythematosus — a chronic autoimmune disease that is often associated with infectious processes. The paper presents two clinical cases of systemic lupus erythematosus , debuted with acute respiratory infection.

Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice

Scientific Reports ◽

10.1038/s41598-021-94855-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jinhee Lee ◽

Soyoung Jang ◽

Minjee Choi ◽

Mincheol Kang ◽

Su-Geun Lim ◽

...

Keyword(s):

Autoimmune Disease ◽

Lupus Erythematosus ◽

Cathepsin S ◽

Toll Like Receptor ◽

Systemic Lupus ◽

Autoimmune Reaction ◽

Multiple Organs ◽

Lupus Pathogenesis ◽

AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms.

Possible Case of Children Onset Systemic Lupus Erythematosus Triggered by Covid-19

10.21203/rs.3.rs-133376/v1 ◽

2020 ◽

Author(s):

Clémence Odile Bettiol ◽

Joseph Ntagerwa ◽

Axel De Greef ◽

David Tuerlinckx ◽

Yves Boutsen

Keyword(s):

Onset Systemic Lupus Erythematosus

Case Report ◽

Autoimmune Disease ◽

Lupus Erythematosus ◽

Disease Outbreaks ◽

Childhood Onset ◽

Systemic Lupus ◽

Immune Systems ◽

Initial Symptoms ◽

Abstract This case report will present the case of an 11 years old child diagnosed with childhood-onset systemic lupus erythematosus (cSLE) during the coronavirus Covid-19 pandemic. Her initial symptoms were compatible with a Covid-19 infection but repeated PCR on naso-pharyngeal swabs were negative. Two serological assays were carried out but only one showed doubtful IgG results.Considering that viral infection could be responsible for autoimmune disease outbreaks and with increasing evidences of SARS Cov 2 actions on human inflammatory and immune systems; we discuss here a potential cSLE diagnosis triggered by Covid-19 infection.