scholarly journals Recent advances in the management of systemic lupus erythematosus

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 970 ◽  
Author(s):  
Savino Sciascia ◽  
Massimo Radin ◽  
Dario Roccatello ◽  
Giovanni Sanna ◽  
Maria Laura Bertolaccini
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Side Effects ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Therapeutic Strategies ◽  
Systemic Lupus ◽  
Systemic Involvement ◽  
Phase Ii And Iii ◽  
Chronic Autoimmune Disease

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease presenting highly heterogeneous clinical manifestations and multi-systemic involvement. Patients are susceptible to relapse­ and remission, thus making management challenging. Moreover, a considerable number of side effects may occur with conventional therapies; therefore, there is clearly a need for new therapeutic strategies. Since the pathogenesis of SLE is highly complex, it is far from being fully understood. However, greater understanding of the pathways and of the cellular and molecular mediators involved in SLE is being achieved. Emerging evidence has allowed the development of new biological therapeutic options targeting crucial molecular mediators involved in the pathogenesis of SLE. This literature review analyzes the availability of biological and target-directed treatments, phase II and III trials, and new therapies that are being developed for the treatment of SLE.

Systemic lupus erythematosus—clinical features and aetiopathogenesis

2013 ◽  
pp. 923-937
Author(s):  
Caroline Gordon
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Life Threatening ◽  
Symptoms And Signs

Systemic lupus erythematosus (SLE or lupus) is a multisystem, autoimmune disease associated with the formation of autoantibodies that form pathological immune complexes and activate a number of inflammatory pathways. The disease is characterized by remissions and relapses (flares) that can present with a variety of clinical manifestations. The symptoms and signs may range from mild features that can be treated easily to organ and even life threatening manifestations requiring potent immunosuppression. This chapter will review the epidemiology and pathology of lupus, then the clinical features including differential diagnosis and investigation of adult patients with SLE. Finally the classification, diagnosis, monitoring and outcome of lupus patients will be discussed.

scholarly journals Vesiculobollous disease with Cutaneous Systemic Lupus Erythematosus Treated by Rituxima; a case report

2021 ◽  
Author(s):  
Wigdan Mohammed Niamat Alla ◽  
Burhan Mohamed Ali Ahmed ◽  
Mohammed Elmujtba Adam Essa ◽  
Atif Elhadi Abdalla Babker ◽  
Elnour Mohammed Elagib
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Chronic Autoimmune Disease

SLE is a chronic autoimmune disease characterized by multisystem inflammation, Vesiculobullous (VB) are different groups of oral disorders characterized by the formation of bullae. The aim of this report is to describe a case of a vesiculobullous disease in SLE.

scholarly journals Correlation between physical markers and psychiatric health in a Portuguese systemic lupus erythematosus cohort: The role of suffering in chronic autoimmune disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195579 ◽  
Author(s):  
Margarida Figueiredo-Braga ◽  
Caleb Cornaby ◽  
Miguel Bernardes ◽  
Marta Figueiredo ◽  
Cristina Dos Santos Mesquita ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Chronic Autoimmune Disease

Systemic lupus erythematosus—clinical features and aetiopathogenesis

2013 ◽  
Author(s):  
Caroline Gordon
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Life Threatening ◽  
Symptoms And Signs

Systemic lupus erythematosus (SLE or lupus) is a multisystem, autoimmune disease associated with the formation of autoantibodies that form pathological immune complexes and activate a number of inflammatory pathways. The disease is characterized by remissions and relapses (flares) that can present with a variety of clinical manifestations. The symptoms and signs may range from mild features that can be treated easily to organ and even life threatening manifestations requiring potent immunosuppression. This chapter will review the epidemiology and pathology of lupus, then the clinical features including differential diagnosis and investigation of adult patients with SLE. Finally the classification, diagnosis, monitoring and outcome of lupus patients will be discussed.

scholarly journals Overexpression of Cathepsin S Exacerbates Lupus Pathogenesis Through TLR7 and IFN-α in Transgenic Mice

2021 ◽  
Author(s):  
Jinhee Lee ◽  
Minjee Choi ◽  
Soyoung Jang ◽  
Mincheol Kang ◽  
Su-Geun Lim ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Cathepsin S ◽  
Toll Like Receptor ◽  
Systemic Lupus ◽  
Autoimmune Reaction ◽  
Multiple Organs ◽  
Lupus Pathogenesis ◽  
Chronic Autoimmune Disease

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms.

scholarly journals Reversal of nzb/nzw disease with total lymphoid irradiation.

1979 ◽  
Vol 150 (2) ◽  
pp. 371-378 ◽  
Author(s):  
B L Kotzin ◽  
S Strober
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Side Effects ◽  
Autoimmune Disease ◽  
Renal Disease ◽  
Lupus Erythematosus ◽  
Treated Group ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Total Lymphoid Irradiation ◽  
Dna Antibodies

NZB/NZW mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus (SLE). We demonstrated that total lymphoid irradiation (TLI) reversed well expressed disease in 6-mo-old NZB/NZW females with a prolongation in survival, decrease in proteinuria, and decrease in anti-DNA antibodies as compared to control animals. Few side effects were observed in the treated group. TLI also prolonged survival in animals with advanced renal disease. These findings suggest that TLI may have application to the treatment of human SLE.

scholarly journals Lupus nephritis: Update on aetiopathogenesis and controversies in classification

2014 ◽  
Vol 4 (8) ◽  
pp. 672-676 ◽  
Author(s):  
AD Pant
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Direct Binding ◽  
Circulating Immune Complex ◽  
Loss Of Tolerance ◽  
Renal Antigens ◽  
Chronic Autoimmune Disease

Systemic Lupus Erythematosus; a chronic autoimmune disease; is characterized by loss of tolerance against its own antigens and leads to production of autoantibodies and causes formation and deposition of immune complexes in different organs. Recent articles have been trying to unravel the mysteries of SLE. Different theories that have been proposed for the aetiopathogenesis of SLE are a)The circulating immune complex theory, b) The direct binding to endogenous renal antigens theory, and c) binding of antibody to antigens that were previously ‘planted’ into the kidney.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11596 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 672-676

scholarly journals ACUTE RESPIRATORY DISEASE AS THE DEBUT OF SYSTEMIC LUPUS ERYTHEMATOSUS

2015 ◽  
pp. 63-67
Author(s):  
A. Yu. Ischenko ◽  
E. Yu. Ilina ◽  
N. A. Bylova
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Respiratory Disease ◽  
Respiratory Infection ◽  
Lupus Erythematosus ◽  
Acute Respiratory Infection ◽  
Acute Respiratory Disease ◽  
Systemic Lupus ◽  
Chronic Autoimmune Disease ◽  
Clinical Cases

Systemic lupus erythematosus — a chronic autoimmune disease that is often associated with infectious processes. The paper presents two clinical cases of systemic lupus erythematosus , debuted with acute respiratory infection.

scholarly journals Modern considerations on the predisposing factors in the etiopathogenesis of systemic lupus erythematosus

2021 ◽  
Vol 68 (1) ◽  
pp. 22-30
Author(s):  
Ionica-Mariana Radulescu ◽  
◽  
Mihail Alecu ◽  
Laura Ion ◽  
Cosmin Moldovan ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Published Data ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Systemic Lupus ◽  
Trigger Factors

Lupus erythematosus is an autoimmune disease with severe skin involvement and/or multisystemic implications characterized by the development of autoantibodies and immune complexes that, in turn, cause inflammation, tissue damage and a variety of clinical manifestations. The etiopathogeny of lupus erythematosus is very complex and still incompletely discovered. The onset of this disease or the episodes of exacerbation involves various factors: genetic, immune, hormonal, environmental but many more are still under research. There is strong evidence to back up the theory of an autoimmune disease, even though the precise mechanism is yet to be discovered. Apart from a preexisting background predisposing to lupus, certain triggers are required to act in a synergic way to determine the onset of the clinical signs. Studies show that it is 10-15 times more common in women of childbearing age than men, with a higher incidence amongst Afro-American population compared to Caucasians. The aim of this article is to shed some light on the most important determining and trigger factors involved in systemic lupus erythematosus by reviewing the most recent published data.

scholarly journals Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinhee Lee ◽  
Soyoung Jang ◽  
Minjee Choi ◽  
Mincheol Kang ◽  
Su-Geun Lim ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Cathepsin S ◽  
Toll Like Receptor ◽  
Systemic Lupus ◽  
Autoimmune Reaction ◽  
Multiple Organs ◽  
Lupus Pathogenesis ◽  
Chronic Autoimmune Disease

AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms.

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