scholarly journals Lupus nephritis: Update on aetiopathogenesis and controversies in classification

2014 ◽  
Vol 4 (8) ◽  
pp. 672-676 ◽  
Author(s):  
AD Pant
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Direct Binding ◽  
Circulating Immune Complex ◽  
Loss Of Tolerance ◽  
Renal Antigens ◽  
Chronic Autoimmune Disease

Systemic Lupus Erythematosus; a chronic autoimmune disease; is characterized by loss of tolerance against its own antigens and leads to production of autoantibodies and causes formation and deposition of immune complexes in different organs. Recent articles have been trying to unravel the mysteries of SLE. Different theories that have been proposed for the aetiopathogenesis of SLE are a)The circulating immune complex theory, b) The direct binding to endogenous renal antigens theory, and c) binding of antibody to antigens that were previously ‘planted’ into the kidney.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11596 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 672-676

scholarly journals Recent advances in the management of systemic lupus erythematosus

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 970 ◽  
Author(s):  
Savino Sciascia ◽  
Massimo Radin ◽  
Dario Roccatello ◽  
Giovanni Sanna ◽  
Maria Laura Bertolaccini
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Side Effects ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Therapeutic Strategies ◽  
Systemic Lupus ◽  
Systemic Involvement ◽  
Phase Ii And Iii ◽  
Chronic Autoimmune Disease

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease presenting highly heterogeneous clinical manifestations and multi-systemic involvement. Patients are susceptible to relapse­ and remission, thus making management challenging. Moreover, a considerable number of side effects may occur with conventional therapies; therefore, there is clearly a need for new therapeutic strategies. Since the pathogenesis of SLE is highly complex, it is far from being fully understood. However, greater understanding of the pathways and of the cellular and molecular mediators involved in SLE is being achieved. Emerging evidence has allowed the development of new biological therapeutic options targeting crucial molecular mediators involved in the pathogenesis of SLE. This literature review analyzes the availability of biological and target-directed treatments, phase II and III trials, and new therapies that are being developed for the treatment of SLE.

scholarly journals Vesiculobollous disease with Cutaneous Systemic Lupus Erythematosus Treated by Rituxima; a case report

2021 ◽  
Author(s):  
Wigdan Mohammed Niamat Alla ◽  
Burhan Mohamed Ali Ahmed ◽  
Mohammed Elmujtba Adam Essa ◽  
Atif Elhadi Abdalla Babker ◽  
Elnour Mohammed Elagib
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Chronic Autoimmune Disease

SLE is a chronic autoimmune disease characterized by multisystem inflammation, Vesiculobullous (VB) are different groups of oral disorders characterized by the formation of bullae. The aim of this report is to describe a case of a vesiculobullous disease in SLE.

scholarly journals Potentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor

2021 ◽  
pp. 1-5
Author(s):  
Tsz Ching Mok ◽  
Lok Ping Ng ◽  
Eva Tsz Fung Chui ◽  
Ho Yin Chung
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Neutrophil Apoptosis ◽  
Cytokine Storm ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Systemic Lupus ◽  
Stimulating Factor

Recombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious.

scholarly journals Correlation between physical markers and psychiatric health in a Portuguese systemic lupus erythematosus cohort: The role of suffering in chronic autoimmune disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195579 ◽  
Author(s):  
Margarida Figueiredo-Braga ◽  
Caleb Cornaby ◽  
Miguel Bernardes ◽  
Marta Figueiredo ◽  
Cristina Dos Santos Mesquita ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Chronic Autoimmune Disease

Negative Double Stranded DNA and Anti-Smith Antibodies in Lupus Nephritis

2012 ◽  
Vol 4 (2) ◽  
pp. 55-57
Author(s):  
Gagangeet Sandhu ◽  
Anip Bansal ◽  
Aditi Ranade ◽  
Ritu Aggarwal ◽  
Gopal Narayanswami ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Serological Screening ◽  
Double Stranded Dna ◽  
Dsdna Antibodies

Systemic lupus erythematosus (SLE) is an autoimmune disease in which auto-antibodies are generated against a variety of intracellular antigens. Anti-Smith (Sm) and anti-double stranded DNA (dsDNA) antibodies in particular are considered to be nephritogenic and their role and correlation with lupus nephritis (LN) has been well established. We present here a case in which the patient had diffuse proliferative full house severe LN, yet negative ds-DNA and anti-Sm antibodies. Although extremely rare, a few subsets of patients with drug-induced LN (hydralazine) have been described in the literature to have negative dsDNA and anti-Sm antibodies on serological screening. Our patient, however, had no evidence of drug induced LN. On further review, and similar to our case, we found only 6 additional well documented cases of non-drug induced severe LN with negative dsDNA antibodies.

scholarly journals Overexpression of Cathepsin S Exacerbates Lupus Pathogenesis Through TLR7 and IFN-α in Transgenic Mice

2021 ◽  
Author(s):  
Jinhee Lee ◽  
Minjee Choi ◽  
Soyoung Jang ◽  
Mincheol Kang ◽  
Su-Geun Lim ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Cathepsin S ◽  
Toll Like Receptor ◽  
Systemic Lupus ◽  
Autoimmune Reaction ◽  
Multiple Organs ◽  
Lupus Pathogenesis ◽  
Chronic Autoimmune Disease

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms.

scholarly journals Chemokines and Chemokine Receptors in the Development of Lupus Nephritis

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Xiaofeng Liao ◽  
Tharshikha Pirapakaran ◽  
Xin M. Luo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Nephritis ◽  
Chemokine Receptor ◽  
Lupus Erythematosus ◽  
Chemokine Receptors ◽  
Leukocyte Recruitment ◽  
Systemic Lupus ◽  
Receptor System ◽  
Multiple Organs

Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney is a critical step to promote LN progression, and the chemokine/chemokine receptor system is necessary for leukocyte recruitment. In this review, we summarize recent studies on the roles of chemokines and chemokine receptors in the development of LN and discuss the potential and hurdles of developing novel, chemokine-based drugs to treat LN.

scholarly journals Efficacy and Cytokine Modulating Effects of Tacrolimus in Systemic Lupus Erythematosus: A Review

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Kam Hon Yoon
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Nephritis ◽  
Cytotoxic T Lymphocytes ◽  
Lupus Erythematosus ◽  
Calcineurin Inhibitor ◽  
Systemic Autoimmune Disease ◽  
Systemic Lupus ◽  
Established Role ◽  
Multitarget Therapy

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with involvement of both B cells and cytotoxic T lymphocytes and several cytokines aberrations. Standard therapy for SLE has its limitations. Tacrolimus, a novel calcineurin inhibitor with potent immunosuppressive effects, has been shown in the recent years to be effective in SLE therapy. This paper serves to collate the experimental and clinical data on the efficacy of tacrolimus in the treatment of SLE and lupus nephritis. Tacrolimus as a key component of multitarget therapy in SLE is also discussed. The immunocytokine modulatory effects of tacrolimus are also reviewed with reference to SLE. It can be concluded that tacrolimus has an established role in the management of SLE.

scholarly journals ACUTE RESPIRATORY DISEASE AS THE DEBUT OF SYSTEMIC LUPUS ERYTHEMATOSUS

2015 ◽  
pp. 63-67
Author(s):  
A. Yu. Ischenko ◽  
E. Yu. Ilina ◽  
N. A. Bylova
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Respiratory Disease ◽  
Respiratory Infection ◽  
Lupus Erythematosus ◽  
Acute Respiratory Infection ◽  
Acute Respiratory Disease ◽  
Systemic Lupus ◽  
Chronic Autoimmune Disease ◽  
Clinical Cases

Systemic lupus erythematosus — a chronic autoimmune disease that is often associated with infectious processes. The paper presents two clinical cases of systemic lupus erythematosus , debuted with acute respiratory infection.

scholarly journals Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinhee Lee ◽  
Soyoung Jang ◽  
Minjee Choi ◽  
Mincheol Kang ◽  
Su-Geun Lim ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Cathepsin S ◽  
Toll Like Receptor ◽  
Systemic Lupus ◽  
Autoimmune Reaction ◽  
Multiple Organs ◽  
Lupus Pathogenesis ◽  
Chronic Autoimmune Disease

AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms.

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