scholarly journals The effect of herpes viruses on antenatal programming of children's health

2019 ◽  
Vol 18 (3) ◽  
pp. 37-41
Author(s):  
L. A. Lityaevа ◽  
O. V. Kovaleva
Keyword(s):  
Pregnant Women ◽  
Herpes Virus ◽  
Cholesterol Metabolism ◽  
Risk Group ◽  
Bacterial Load ◽  
Gas Chromatography Mass Spectrometry ◽  
Herpes Viruses ◽  
Laboratory Observation ◽  
Quantitative Content ◽  
Herpès Virus

Objective: to assess the effect of viruses of herpes family in pregnant women on the health of children in the first half of their lives.A clinical and laboratory observation of 33 mother-child pairs was conducted. Of these, 25 women were from the risk group for intrauterine infection and 8 women were with a physiological course of pregnancy. The quantitative content of herpes virus markers was studied by their effect on cholesterol metabolism and symbiotic microbiota was studied by the quantitative content of long chain fatty acids and fatty aldehydes, phospholipids by gas chromatography-mass spectrometry in all women at 34-37 weeks of gestation and their infants.It was revealed that pregnant women of “risk group” increased the quantitative content of herpes virus markers with the prevalence of herpes simplex virus (HSV) 1,2 types and its associations with cytomegalovirus (CMV) and Epstein-Barr virus (EBV).A correlation was found between the degree of increase in markers of HSV, EBV, and CMV with that of the bacterial load of the intestine by conditionally pathogenic representatives and the deficiency of priority genera of the intestinal microbiota in mothers and the same indicators in their children.An increase in the quantitative content of herpes viruses, exceeding the norm by more than 2 times, is interconnected with the pathological course of pregnancy and the violation of the microecological status of pregnant women, which predicts the realization of somatic and infectious pathology in children in the first half of life.

Social and Medical Aspects of the Association HIV and Herpes Virus Infection in Pregnant Women

2016 ◽  
pp. 25-29
Author(s):  
Viacheslav Kaminsky ◽  
Tetiana Anoshina ◽  
Tetiana Kolomiychenko
Keyword(s):  
Virus Infection ◽  
Hiv Infection ◽  
Pregnant Women ◽  
High Frequency ◽  
Herpes Virus ◽  
Control Group ◽  
Herpes Viruses ◽  
Herpes Virus Infection ◽  
Women With Hiv ◽  
Herpès Virus

The objective: to evaluate the social and health aspects of the association of HIV and herpes infections (GVI) in pregnant women. Patients and methods. Clinical and statistical analysis of 1177 individual cards of pregnant women with HIV for 5 years. The control group consisted of 200 pregnant women with physiological pregnancy. Results. Analysis of individual cards of pregnant women with HIV found insufficient to TORCH-infection survey (74,7%). The frequency of herpes infections in HIV-infected patients was 42,3%. The most common laboratory revealed HSV1/2 – 41,9%, CMV – 22,4% and mixed infection (both HSV1/2 and CMV) – 28,1%, other types of AIT is quite rare. At 8,5% of pregnant women stated primary infection herpes viruses, 27,2% – the reactivation of infection. HIV infection is often associated with other infections: hepatitis, fungal infections, toxoplasmosis, papillomavirus infections, respiratory infections, infections of the genitourinary system. Fixed low social status of HIV-infected women with AIT, the presence of harmful habits, a high frequency of co-infections and low compliance to treatment, are additional factors of perinatal risk. History data indicate a high rate of abortions and missed abortion in women with HIV infection and GVI. Going the way of HIV infection with parenteral on sex strengthens the role of herpes virus infection as a cofactor transition from HIV to AIDS, and the development of perinatal complications. The current pregnancy burdened with 84,3% of women: high incidence of placental insufficiency (41,3%), the threat of miscarriage and preterm labor, fetal distress. Maternal mortality in 5 years was noted in 2 cases (0,1‰), both women were GVI, perinatal – in 12 cases, 8 (21,5‰) of them women with AIT. 12,1% of children were born in a state of severe asphyxia, malnutrition with 31,3%, from 3,8% of the children at the end of 1st day intrauterine diagnosed pneumonia. Conclusions. The high frequency of co-infection of HIV and herpes viruses, joining other infections and comorbidity in these women, their low social adaptation, and susceptibility to treatment, the negative impact of herpes infection in the course of HIV infection, the condition of women during pregnancy, the fetus and the newborn, which requires individual approach to the management of women based on established medical and social aspects of the problem.

scholarly journals Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns - A cross-sectional delivery survey in Central Gabon

2015 ◽  
Vol 39 ◽  
pp. 16-19 ◽  
Author(s):  
Mesküre Capan-Melser ◽  
Ghyslain Mombo-Ngoma ◽  
Daisy Akerey-Diop ◽  
Arti Basra ◽  
Rella Manego-Zoleko ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Herpes Virus ◽  
Human Herpes ◽  
Cross Sectional ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus

scholarly journals Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa

2010 ◽  
Vol 5 (1) ◽  
pp. 14 ◽  
Author(s):  
Babatyi I Malope-Kgokong ◽  
Patrick MacPhail ◽  
Georgina Mbisa ◽  
Edith Ratshikhopa ◽  
Mhairi Maskew ◽  
...  
Keyword(s):  
South Africa ◽  
Pregnant Women ◽  
Kaposi's Sarcoma ◽  
Herpes Virus ◽  
Kaposi’S Sarcoma ◽  
Herpès Virus

Human herpes virus type 8 seroprevalence in pregnant women in Geneva, Switzerland

2010 ◽  
Vol 24 (1) ◽  
pp. 183-185 ◽  
Author(s):  
B. Martinez de Tejada ◽  
Ingrid Steffen ◽  
Pablo Cantero ◽  
Klara M. Posfay-Barbe ◽  
Olivier Irion ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Virus Type ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type

Human herpes virus-8 infection among pregnant women and their children: Results from the sardinia-IDDM study 2

2001 ◽  
Vol 91 (5) ◽  
pp. 740-741 ◽  
Author(s):  
Diego Serraino ◽  
Mattia Locatelli ◽  
Marco Songini ◽  
Rocco Cirillo ◽  
Gian Franco Bottazzo ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus

scholarly journals Herpes-virus infection of pregnant women

1997 ◽  
Vol 46 (1) ◽  
pp. 69-73
Author(s):  
V. K. Yaroslavzki ◽  
V. A. Isakov ◽  
А. Е. Semenov
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Herpes Virus ◽  
Clinical Manifestations ◽  
Point Of View ◽  
Herpes Virus Infection ◽  
Herpès Virus

The modem items of information and the own point of view of the authors about clinical manifestations methods of diagnostics and treatment herpes-virus infection of pregnant women are represented in the lecture.

scholarly journals Salivary DNA loads for human herpes viruses 6 and 7 are correlated with disease phenotype in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome

2021 ◽  
Author(s):  
Ji-Sook Lee ◽  
Eliana M. Lacerda ◽  
Luis Nacul ◽  
Caroline C. Kingdon ◽  
Jasmin Norris ◽  
...  
Keyword(s):  
Large Scale ◽  
Herpes Virus ◽  
Chronic Fatigue ◽  
Healthy Controls ◽  
Herpes Viruses ◽  
Human Herpes ◽  
Fatigue Syndrome ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Viruses

AbstractMyalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is a complex chronic condition affecting multiple body systems, with unknown cause, unclear pathogenesis mechanisms, and fluctuating symptoms which may lead to severe debilitation. It is frequently reported to have been triggered by an infection, particularly with herpes virus family members; however, there are no clear differences in exposure to, or seroprevalence of, any herpes virus in people with ME/CFS and healthy individuals. Herpes viruses exist in lytic and latent forms, and it is possible that ME/CFS is associated with viral reactivation, which has not been detectable previously due to insensitive testing methods.Saliva samples were collected from 30 people living with ME/CFS at monthly intervals for six months and at times when they experienced symptom exacerbation, as well as from 14 healthy control individuals. The viral DNA load of the nine human herpes viruses was determined by digital droplet PCR. Symptoms were assessed by questionnaire at each time point.Human herpes virus (HHV) 6B, HHV-7, herpes simplex virus 1 and Epstein Barr virus were detectable within the saliva samples, with higher HHV-6B and HHV-7 viral loads detected in people with ME/CFS than in healthy controls. Participants with ME/CFS could be broadly separated into two groups: one group displayed fluctuating patterns of herpes viruses detectable across the six months while the second group displayed more stable viral presentation. In the first group, there was positive correlation between HHV-6B and HHV-7 viral load and severity of symptom scores, including pain, neurocognition and autonomic dysfunction.The results indicate that fluctuating viral load, related to herpesvirus reactivation state, may play a role in ME/CFS pathogenesis, or might be a consequence of dysregulated immune function. The sampling strategy and molecular tools developed permit large-scale epidemiological investigations.Contribution to the FieldThe cause of ME/CFS and the mechanisms underlying disease pathogenesis are not known, although symptoms are often triggered by infection. Human herpes virus (HHV) family members have been implicated, although there is no difference in the seroprevalence of any HHV in people with ME/CFS and healthy controls, showing there is similar prior infection rate. HHVs exist in either latent or active, lytic, phases in the human host, and it is possible that ME/CFS symptoms and their severity is related to HHV reactivation from a latent state. We have used droplet digital PCR, a sensitive and specific method, to measure the prevalence and DNA concentration of HHVs in the saliva of people with ME/CFS and controls, and analysed the correlation with disease over a six-month timecourse. We found that two HHVs, HHV-7 and HHV-6B, were elevated in saliva from people with ME/CFS, and that in people who were severely affected by ME/CFS, the concentration HHV DNA correlated with symptom severity over time in a subgroup of patients with fluctuating salivary HHV repertoire. Our study demonstrates the feasibility of measuring HHV concentration in readily acquired samples, enabling future large-scale studies aimed at testing the causal role of HHV reactivation in ME/CFS disease.

Sign in / Sign up

Export Citation Format

Share Document