scholarly journals Our experiencies in treatment of squamous cell skin cancer of head and heck

2003 ◽  
Vol 50 (4) ◽  
pp. 85-89
Author(s):  
Predrag Kovacevic ◽  
Milan Visnjic ◽  
Aleksandar Visnjic

The incidence of squamous cell skin center is the second, after basocellular skin cancer. Surgical treatment is the first and most effective therapy for this tumor. The aim of study is to present experiences of Surgical clinic in Nis in treatment of squamous cell skin cancer in head and neck. During 10-year period (1990-2000) there were operated 346 patients with squamous cell skin cancer of head and neck. We performed wide surgical exsicion with clinical free margins of 5-10 mm, and more radical excision and reconstructions for advanced tumors. We registered postoperative complications in 14 (4,04%) patients. Early diagnose and adequate treatments of squamous cell skin cancer are preperiquisite for good postoperative results and low complication rate.

2021 ◽  
Vol 67 (1) ◽  
pp. 77-84
Author(s):  
Vladimir Masljakov ◽  
Dmitry Grebnev ◽  
Larisa Kim

The work is based on an analysis of the course of the disease in 185 patients with squamous cell skin cancer. The study program included studies in three major groups. The first included 74 (40%) patients who underwent combined treatment: an operation involving widespread excision of a tumor under intravenous anesthesia + photodynamic therapy (group 1). The second group was 111 (60%) patients with squamous cell carcinoma of the skin who received only operative treatment. To control and compare the obtained laboratory indicators, a second group was created, which included patients without established pathology. This group included 17 people who voluntarily agreed to conduct the study. The study traced the dynamics of changes in hemostasis scores and metalloproteinases in the two groups being compared. In the group of patients with squamous cell skin cancer, there was a statistically significant decrease in the metalloproteinase-1 inhibitor index, which led to an increase in all metalloproteinase-2, -7 and -9 indicators. Performing surgical treatment did not lead to correction of these indicators, both in the near and distant periods after treatment. The mechanism of influence of photodynamic therapy in squamous cell skin cancer can be characterized as follows: there is a decrease in the inhibitor of metalloproteinase-1, which leads to an increase in matrix metalloproteinases-2, -7 and -9 in the blood, as a result of damage to the endothelium of the vascular wall, which is confirmed by an increase in endothelin, this, in turn, led to the development of vasoconstriction and increased procoagulant activity The use of photodynamic therapy restores the index of metalloproteinase-1 inhibitor, this leads to the restoration of matrix metalloproteinases-2, -7 and -9 in the blood and the prevention of damage to the vascular wall. Comprehensive treatment of patients with squamous cell skin cancer in the initial stage of the disease should include photodynamic therapy with simultaneous intravenous blood irradiation, laser tumor training, and then surgical treatment, consisting in excision of the tumor with observance of oncological principles.


2019 ◽  
Vol 42 (7) ◽  
pp. 596-601 ◽  
Author(s):  
Aleksandr R. Bukatko ◽  
Parth B. Patel ◽  
Vindhya Kakarla ◽  
Matthew C. Simpson ◽  
Eric Adjei Boakye ◽  
...  

2019 ◽  
Vol 31 (3) ◽  
pp. 138-145 ◽  
Author(s):  
Alexandre Bozec ◽  
Dorian Culié ◽  
Gilles Poissonnet ◽  
Olivier Dassonville

1999 ◽  
Vol 3 (3) ◽  
pp. 120-122
Author(s):  
Robert Jackson

Background: The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. Objective: This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. Conclusion: Urbach showed that the areas of greatest sun exposure on his manikins corresponded with the location of 95% of squamous cell carcinoma and 66% of basal cell carcinoma. He also clearly showed the importance of scattered sky and reflected radiation.


2015 ◽  
Vol 66 (2) ◽  
pp. 98-105
Author(s):  
Xavier León Vintró ◽  
Maria T. Sánchez-Santos ◽  
Manel Mañós Pujol ◽  
Juan Jesús Herranz González-Botas ◽  
Francisco Esteban Ortega ◽  
...  

2017 ◽  
Vol 18 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Wan Cheol Ryu ◽  
In Chang Koh ◽  
Yong Hae Lee ◽  
Jong Hyun Cha ◽  
Sang Il Kim ◽  
...  

2016 ◽  
Vol 9 (2) ◽  
pp. 373-378 ◽  
Author(s):  
K.S. Schwab ◽  
A. Heine ◽  
T. Weimann ◽  
G. Kristiansen ◽  
P. Brossart

Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Considering the similar histological patterns of squamous cell cancer of the skin and squamous cell cancer of the head and neck, we assumed that nivolumab could also be effective in our patients with refractory metastatic squamous cell cancer of the skin. So far, there have been no clinical data on the therapeutic efficacy of nivolumab in squamous cell skin cancer. We here present a case of a patient with metastatic squamous cell skin cancer refractory to previous therapies, who showed a good response to nivolumab over a period of 5 months, but developed a serious hemolytic crisis under nivolumab treatment after eight applications.


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