scholarly journals On the occurrence of sonchuside A in Cicerbita alpina and its chemosystematic significance

2005 ◽  
Vol 70 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Christian Zidorn ◽  
Ritae Schwaha ◽  
Ernst Ellmerer ◽  
Hermann Stuppner
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Nmr Data ◽  
First Time ◽  
Cicerbita Alpina

The subaerial parts of Cicerbita alpina yielded the guaianolide 8-acetyl- 15?-D-glucopyranosyllactucin (1) and the germacranolide Sonchuside A (2). The sonchuside A is reported for the first time from the genus Cicerbita. 1H-NMR and 13C NMR data of compounds 1 and 2 measured in deuterodimethyl sulfoxide and deuteromethanol, respectively, are given and the chemosystematic implications of the occurrence of sonchuside A in C. alpina are discussed briefly.

scholarly journals Structure Elucidation of an Pentacyclic Triterpenoid and Phenolic from Steam Bark of Vitex Pubescens Vahl

2019 ◽  
Vol 1 (1) ◽  
pp. 68-74
Author(s):  
Lenny Anwar
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Betulinic Acid ◽  
Spectroscopic Data ◽  
Structure Elucidation ◽  
Stem Bark ◽  
Hydroxybenzoic Acid ◽  
Pentacyclic Triterpenoid ◽  
Reported Data ◽  
First Time

Pentacyclic triterpenoid, betulinic acid (1) and phenolic, p-hydroxybenzoic acid (2), had been isolated for the first time from the stem bark of Vitex pubescens Vahl. The structure of compounds 1 and 2 was determined based on the interpretation of spectroscopic data including UV, IR, NMR (1H-NMR, 13C-NMR, HMQC, HMBC, COSY) and MS, as well as by comparison with those reported data.

Isolation of Bioactive Compounds from Aspergillus terreus

2004 ◽  
Vol 59 (3) ◽  
pp. 324-328 ◽  
Author(s):  
Muhammad I. Choudhary ◽  
Syed G. Musharraf ◽  
Talat Mukhmoor ◽  
Farzana Shaheen ◽  
Shamsher Ali ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
13C Nmr ◽  
Culture Medium ◽  
Aspergillus Terreus ◽  
Ethyl Acetate Extract ◽  
Microsporum Canis ◽  
Spectroscopic Techniques ◽  
Significant Activity ◽  
Nmr Data ◽  
First Time

A new metabolite, 6-(4’-hydroxy-2’-methyl phenoxy)-(-)-(3R)-mellein (1) was isolated from the ethyl acetate extract of Aspergillus terreus culture medium along with three known isocoumarin derivatives, (-)-(3R)-6-methoxymellein (2), (-)-(3R)-6,7-dimethoxymellein (Kigelin) (3) and (3R, 4R)-6,7-dimethoxy-4-hydroxymellein (4). Metabolites 1 and 4 showed significant activity against human pathogenic dermatophytes, Microsporum canis and Trichophyton longifusus. Metabolite 1 also exhibited potent antioxidant activity. The structures of metabolites were characterized on the basis of spectroscopic techniques. 13C NMR data of metabolites 2 - 4 are also being reported for the first time

scholarly journals Comparative Metabolite Profiling of Wild and Cultivated Justicia procumbens L. Based on 1H-NMR Spectroscopy and HPLC-DAD Analysis

Plants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 860
Author(s):  
Hyunyong Lee ◽  
Jihyun Jeon ◽  
Joobyoung Yoon ◽  
Seung-Hwan Kim ◽  
Hyun Sik Choi ◽  
...  
Keyword(s):  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Raw Material ◽  
Cultivated Plants ◽  
Phase I Clinical Trials ◽  
Marker Compound ◽  
Nmr Data ◽  
Asthma Drug ◽  
Phytochemical Constituents ◽  
First Time

Justicia procumbens L. is known across Korea, India, China, and Taiwan as a remedy against fever, cough, sore throat, and cirrhosis of ascites. J. procumbens provides the raw material for a candidate anti-asthma drug (DW2008S) currently completing phase I clinical trials sponsored by Dong Wha Pharmaceutical Company. HPLC-DAD was used to quantify phytochemical constituents of J. procumbens, and HPLC and 1H-NMR results were assessed by multivariate analysis. This is the first time a comparative study using HPLC-DAD and NMR fingerprints has been applied to identify chemical differences between wild and cultivated J. procumbens. The amount of justicidin B as the marker compound was higher in cultivated samples (0.80 ± 0.25 mg/g) than in wild ones (0.63 ± 0.30 mg/g). Orthogonal partial least squares discriminant analysis (OPLS-DA) from HPLC and NMR data revealed that there were clear differences between wild and cultivated types and identified five secondary metabolites, which could help distinguish between wild and cultivated plants. Among these five lignans, diphyllin showed the most potent discrimination between two types and was significantly detected higher in cultivated ones than in wild ones. A combination of 1H-NMR and HPLC-DAD analysis is effective for J. procumbens standardization and metabolomics studies.

scholarly journals A NEW PRENYLATED FLAVANONE FROM THE ARIAL PART OF Orthosiphon stamineus

2010 ◽  
Vol 8 (1) ◽  
pp. 101-103 ◽  
Author(s):  
M. Amzad Hossain ◽  
Atiqur Rahman ◽  
Sun Chul Kang
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Analytical Methods ◽  
Chloroform Extract ◽  
Orthosiphon Stamineus ◽  
First Time

Phytochemical investigations on the chloroform extract of the arial part of Orthosiphon stamineus resulted in isolation of one new prenylated compound 5,7-dimethoxy-3,4′-dihydroxy-3′,8-di-C-prenylflavanone together with four known flavonoids compounds, sinensetin, eupatorin, 5,6,7,4¢-tetramethoxyflavone and 3-hydroxy-5,6,7,4¢-tetramethoxyflavone. The structures were deduced on basis of different analytical methods such as UV, IR, 1H-NMR, 13C-NMR, DEPT, COSY, HMBQ and GC-MS. The prenylated compound is reported for the first time from this plant.   Keywords: Orthosiphon stamineus, prenylated flavanone, flavonoids

scholarly journals DIPRENYLATED XANTHONE FROM THE STEM BARK OF KANDIS GAJAH (Garcinia griffithii)

2010 ◽  
Vol 8 (1) ◽  
pp. 97-100
Author(s):  
Elfita Elfita ◽  
Supriyatna Supriyatna ◽  
Husen H. Bahti ◽  
Dachriyanus Dachriyanus
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Spectroscopic Data ◽  
Stem Bark ◽  
First Time

A diprenylated xanthone, 1,5-dihydroxy-3-methoxy-4,7-diprenylxanthone (1) had been isolated the first time from the dichloromethane extract of the stem bark of Garcinia griffithii, together with 1,7-dihydroxyxanthone (2) and polyisoprenylated benzophenone, guttiferone I (3). The structure of these compounds were determined on the basis of spectroscopic data including UV, IR,  1H NMR, 13C NMR, HMQC, HMBC and COSY.   Keywords: diprenylated xanthone, 1,5-dihydroxy-3-methoxy-4,7-diprenylxanthone, Garcinia griffithii

Two New Chalcone Glycoside Compounds from Viburnum lantana (Family Caprifoliaceae) and Antioxidant Activity of its Hydroalcoholic Extract

2019 ◽  
Vol 16 (2) ◽  
pp. 93-98
Author(s):  
Ali Shafaghat ◽  
Mohammad Shafaghatlonbar
Keyword(s):  
Antioxidant Activity ◽  
Ir Spectra ◽  
1H Nmr ◽  
13C Nmr ◽  
Natural Antioxidants ◽  
2D Nmr ◽  
Antioxidant Property ◽  
Hydroalcoholic Extract ◽  
First Time

In the present study, two novel chalcone glycosides, trans-3-ethoxy-4-O-(glucopyranoside) -2', 3', 4', 5', 6' -pentahydroxy chalcone (compound 1) and trans-3-methoxy-4-O-(glucopyranoside) -2', 3', 4', 5', 6' -pentahydroxy chalcone (compound 2) have been isolated from the leaves of Viburnum lantana L. The structures were elucidated by using 1H-NMR, 13C-NMR, 2D-NMR such as HMQC, HMBC and NOE experiments and UV-Vis, MS and IR spectra. The antioxidant property of hydroalcoholic extract was evaluated by DPPH style. The results revealed that the leave extract possesses significant antioxidant activity (IC50 = 52 µg/mL). This study indicates that hydroalcoholic extract of the leaves from this species is an important source of chalcone and flavonoid derivatives, as well as of useful natural antioxidants. These chalcone glycoside compounds were isolated for the first time from V. lantana leaves.

Oleanane Glycosides from Eclipta prostrata

1970 ◽  
Vol 4 (2) ◽  
Author(s):  
Mohammad S Rahman ◽  
Rasheduzzaman Chowdhury ◽  
Chodhury M Hasan ◽  
Mohammad A Rashid
Keyword(s):  
Key Words ◽  
13C Nmr ◽  
Full Text ◽  
High Field ◽  
Stem Bark ◽  
Spectroscopic Studies ◽  
Hexane Extract ◽  
Nmr Data ◽  
Eclipta Prostrata ◽  
First Time

Two oleanane-type glycosides eclalbasaponin II (1) and eclalbasaponin I (2) along with the ubiquitous steroid, stigmasterol were isolated from an n-hexane extract of the stem bark of Eclipta prostrata. The structures of the isolated compounds were confirmed by extensive spectroscopic studies, notably high field NMR and MS. The 13C NMR data of the parent saponins 1 and 2 are reported here for the first time. Key words: Eclipta prostrata, Compositae, Oleanane glycoside, Eclalbasaponin I, Eclalbasaponin II. Dhaka Univ. J. Pharm. Sci. Vol.4(2) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Dihydroisocoumarins and Dihydroisoflavones from the Rhizomes of Dioscorea collettii with Cytotoxic Activity and Structural Revision of 2,2′-Oxybis(1,4-di-tert-butylbenzene)

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5381
Author(s):  
Songsong Jing ◽  
Zhuo Qu ◽  
Chengcheng Zhao ◽  
Xia Li ◽  
Long Guo ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
13C Nmr ◽  
The Other ◽  
Cytotoxic Activities ◽  
Spectroscopic Methods ◽  
1H And 13C Nmr ◽  
Structural Revision ◽  
Nmr Data ◽  
H460 Cell ◽  
First Time

The investigation of the constituents of the rhizomes of Dioscorea collettii afforded one new dihydroisocoumarin, named (−)-montroumarin (1a), along with five known compounds—montroumarin (1b), 1,1′-oxybis(2,4-di-tert-butylbenzene) (2), (3R)-3′-O-methylviolanone (3a), (3S)-3′-O-methylviolanone (3b), and (RS)-sativanone (4). Their structures were elucidated using extensive spectroscopic methods. To the best of our knowledge, compound 1a is a new enantiomer of compound 1b. The NMR data of compound 2 had been reported but its structure was erroneous. The structure of compound 2 was revised on the basis of a reinterpretation of its NMR data (1D and 2D) and the assignment of the 1H and 13C NMR data was given rightly for the first time. Compounds 3a–4, three dihydroisoflavones, were reported from the Dioscoreaceae family for the first time. The cytotoxic activities of all the compounds were tested against the NCI-H460 cell line. Two dihydroisocoumarins, compounds 1a and 1b, displayed moderate cytotoxic activities, while the other compounds showed no cytotoxicity.

scholarly journals Phytochemical studies on the aerial parts of Sarcococca hookeriana (Baillon) of Nepalese origin

1970 ◽  
Vol 21 ◽  
pp. 8-15
Author(s):  
Narayan P. Rai ◽  
Bimala Lama ◽  
Shiva P. Subedi ◽  
W. C. Taylor ◽  
M. D. Manandhar
Keyword(s):  
Spectral Analysis ◽  
Oleanolic Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Chemical Society ◽  
Chloroform Extract ◽  
Hmbc Spectrum ◽  
Aerial Parts ◽  
Phytochemical Studies ◽  
First Time

Two known pregnane type of alkaloids, axillaridine A and spiropachysine, and an unidentified pregane alkaloid along with oleanolic acid and stigmasteryl glucoside have been isolated from chloroform extract of the aerial parts of Sarcococca hookeriana. The structures of the alkaloids are established on the basis of spectral analysis of 1H-NMR, 13C-NMR, HMQC, COSY and HMBC spectrum. All compounds were isolated for the first time from S. hookeriana. So far, species of Sarcococca was not reported to contain spiropachysine which was initially reported as a novel alkaloid from Pachysandra terminalis SIEB. et ZUCC.(Buxaceae).DOI: 10.3126/jncs.v21i0.215Journal of Nepal Chemical Society Vol.21 2006 pp.8-15

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