scholarly journals Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives

2007 ◽  
Vol 72 (2) ◽  
pp. 109-117 ◽  
Author(s):  
S.J. Vaghasia ◽  
V.H. Shah
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Activities ◽  
Microwave Assisted Synthesis ◽  
Mass Spectral Data ◽  
Pyrimidine Derivatives ◽  
Plate Method ◽  
Mass Spectral ◽  
Microwave Assisted ◽  
New Compounds

The synthesis of thiazolo[5,4-d]pyrimidines can be achieved from different 5- thiazolidinones, 2-butyl-1H-imidazole-5-carbaldehyde and thiourea using microwave irradiation within 5 min. The structures of the products were supported by FTIR, PMR and mass spectral data. The in vitro antimicrobial activity of the synthesized thiazolo[5,4-d]pyrimidines 1a-j, having substituents at the 1- and 3-positions, were determined by the cup-plate method against several standard strains chosen to define the spectrum and potency of the new compounds. The antimicrobial activities of the thiazolo[5,4-d]pyrimidines 1a-j are compared with those of known chosen standard drugs, viz. ampicillin, chloramphenicol, ciprofloxacin, norfloxacin and griseofulvin. .

scholarly journals Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity

2018 ◽  
Vol 83 (12) ◽  
pp. 1305-1313
Author(s):  
Dongamanti Ashok ◽  
Nalaparaju Nagaraju ◽  
Madderla Sarasija ◽  
Vijaya Lakshmi
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Pathogenic Bacteria ◽  
Microwave Assisted Synthesis ◽  
Good Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted ◽  
Bacteria And Fungi

A series of novel tetrazole scaffolds containing chalcones 4a?e and aurones 5a?e were synthesized under conventional and microwave irradiation conditions. All the newly synthesized compounds were characterized by IR, NMR and mass spectral data. Furthermore, the title compounds were screened in vitro for their antimicrobial activity against bacteria, such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli, as well as fungi, such as Aspergillus niger, A. flavus and Fusarium oxysporum. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.

scholarly journals Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity

2015 ◽  
Vol 80 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Dongamanti Ashok ◽  
Bommidi Lakshmi ◽  
Sidda Ravi ◽  
Arram Ganesh
Keyword(s):  
Antimicrobial Activity ◽  
Sodium Acetate ◽  
Pathogenic Bacteria ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Good Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted ◽  
Bacteria And Fungi

A series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized chalcones 3a-g and pyrazolines 4a-g have been established on the basis of IR, 1H & 13C NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial activity. Some of the compounds shown very good activity compared to standard drugs against all pathogenic bacteria and fungi.

scholarly journals Microwave assisted synthesis of 2-(2-(tetrazolo[1,5-a]quinolin-4-yl)-2,3-dihydro-1h-benzo[b][1,4]diazepin-4-yl) substituted phenols and evaluation of their antimicrobial activity

2016 ◽  
Vol 81 (8) ◽  
pp. 851-858 ◽  
Author(s):  
Dongamanti Ashok ◽  
Velagapuri Rao ◽  
Rangu Kavitha
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Irradiation ◽  
13C Nmr ◽  
Sodium Acetate ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Substituted Phenols ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted

A series of new benzodiazepines 4a-h have been synthesized by Michael addition of chalcones 3a-h with o-phenylenediamine (OPDA) in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized benzodiazepines 4a-h have been established on the basis of IR, 1H & 13C NMR and mass spectral data and tested for antimicrobial activity.

scholarly journals Synthesis of thiourea derivatives bearing the benzo[b]thiophene nucleus as potential antimicrobial agents

2005 ◽  
Vol 70 (6) ◽  
pp. 807-815 ◽  
Author(s):  
K.M. Thakar ◽  
D.J. Paghdar ◽  
P.T. Chovatia ◽  
H.S. Joshi
Keyword(s):  
Spectral Data ◽  
1H Nmr ◽  
Antimicrobial Agents ◽  
Antimicrobial Activities ◽  
Mass Spectral Data ◽  
Thiourea Derivatives ◽  
Mass Spectral ◽  
New Compounds

The synthesis of a group of thiohydantoins and thiobarbiturates derived from 2-N-arylthiopyridocarbonyl-3,5-dichlorobenzo[b]thiophene is described. The structures of the new compounds are supported by IR, 1H-NMR and mass spectral data. These compounds were tested in vitro for their antimicrobial activities.

scholarly journals Antimicrobial Activity of some Pyrimidine Derivatives in DMF and DMSO

2015 ◽  
Vol 56 ◽  
pp. 131-141
Author(s):  
Shipra Baluja ◽  
Sumitra Chanda ◽  
Kajal Nandha
Keyword(s):  
Antimicrobial Activity ◽  
Dimethyl Sulfoxide ◽  
Spectral Data ◽  
Dimethyl Formamide ◽  
Mass Spectral Data ◽  
Pyrimidine Derivatives ◽  
Gram Negative ◽  
Mass Spectral ◽  
H Nmr

A series of pyrimidine derivatives have been synthesized and their structures were confirmed by IR, 1H NMR and mass spectral data. All these synthesized compounds were tested in vitro for their antimicrobial potential against Gram positive, Gram negative strains of bacteria as well as fungal strains in N, N-dimethyl formamide and dimethyl sulfoxide.

scholarly journals Synthesis and selective antitubercular and antimicrobial inhibitory activity of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole derivatives

2006 ◽  
Vol 71 (7) ◽  
pp. 713-720 ◽  
Author(s):  
P.T. Chovatia ◽  
J.D. Akabari ◽  
P.K. Kachhadia ◽  
P.D. Zalavadia ◽  
H.S. Joshi
Keyword(s):  
Hydrazine Hydrate ◽  
Antimycobacterial Activity ◽  
Antimicrobial Activities ◽  
Proteus Vulgaris ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Mycobacterium Tuberculosis H37rv ◽  
Aryl Ketones ◽  
New Compounds

The new compounds 1-aryl-3-{1-phenyl-3-[p (methylthio)phenyl]pyrazol-4-yl}-2-propen-1-ones 2a?l were prepared by the condensation of 1-phenyl-3-[p (methylthio)phenyl]-4-formylpyrazole 1 with different aryl ketones. Compounds 2a?l in reaction with hydrazine hydrate yielded 3-aryl-5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4 yl}-4,5-dihydro-(1H)-pyrazoles 3a?l and in the presence of hydrazine hydrate in glacial acetic acid gave 1-acetyl-3-aryl 5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4-yl}-4,5 dihydro-(1H)-pyrazoles 4a?l. These compounds were tested in vitro for their antitubercular and antimicrobial activities. The in vitro antimycobacterial activity of the newly synthesized compounds was investigated against Mycobacterium tuberculosis H37RV (ATCC 27294) in BACTEC 12B medium using the ALAMAR radiometric system. The antimicrobial in vitro activity was tested against Bacillus coccous, Bacillus subtilis Escherichia coli, Proteus vulgaris and antifungal activity against Aspergillus niger. The structures of the synthesized compounds were assigned on the basis of elemental analysis IR, 1H NMR and mass spectral data.

scholarly journals Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hanan A. Mohamed ◽  
Ehab Abdel-Latif ◽  
Bakr F. Abdel-Wahab ◽  
Ghada E. A. Awad
Keyword(s):  
Antimicrobial Activity ◽  
Minimum Inhibitory Concentration ◽  
Antimicrobial Agents ◽  
Inhibitory Concentration ◽  
Antimicrobial Activities ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
Test Organisms ◽  
New Compounds

A new series of 2-pyrazolin-1-ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N-thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested ones, compound 8c displayed excellent antimicrobial activity.

scholarly journals Green Synthetic Protocol for (E)-1-Aryl-3-(2-morpholinoquinolin- 3-yl)prop-2-en-1-ones and Their Antimicrobial Activity

2019 ◽  
Vol 31 (9) ◽  
pp. 1895-1898
Author(s):  
Relangi Siva Subrahmanyam ◽  
Venkateswara Rao Anna
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Mass Spectral Data ◽  
In Vitro Antimicrobial Activity ◽  
Mass Spectral ◽  
Fungal Organisms

We report here an easy, efficient and green synthetic protocol for the (E)-1-aryl-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones by the Claisen-Schmidt condensation of 2-morpholinoquinoline-3-carbaldehyde and different substituted acetophenones by using 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim)BF4. The compounds were characterized by using 1H NMR, 13C NMR and mass spectral data and screened there in vitro antimicrobial activity against different bacterial and fungal organisms.

scholarly journals Microwave Assisted Synthesis and Antimicrobial Activities of Some 2-Amino-4-aryl-3-cyano-6-(4’-hydroxy phenyl)-pyridines

2011 ◽  
Vol 8 (1) ◽  
pp. 119-122 ◽  
Author(s):  
Priya Gothwal ◽  
Gunwanti Malhotra ◽  
Y. K. Srivastava
Keyword(s):  
Antimicrobial Activity ◽  
Ammonium Acetate ◽  
Antimicrobial Activities ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

4’-Hydroxy chalcones were treated with malononitrile in the presence of ammonium acetate under solventless microwave assisted condition to get 2-amino-4-aryl-3-cyano-6-(4’-hydroxy phenyl)-pyridines. The prepared compounds were screened for their antimicrobial activity; some of them have exhibited promising antimicrobial activity.

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