Systemic lupus erythematosus in pregnancy: Case report

Systemic lupus erythematosus (SLE) is a chronic inflammatory connective tissue disease commonly diagnosed after the age of 20, mostly around the age of 30 years. It is more common in women than in men, especially during the fertile period. Women with SLE are at higher risk for spontaneous abortions, intrauterine fetal death, preeclampsia and eclampsia, preterm delivery and intrauterine growth retardation. This paper is a case report of a pregnant woman with SLE complicated with preeclampsia, but it also discusses follow-up of such pregnancies.

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Ayurvedic Management of Systemic Lupus Erythematosus Overlap Vasculitis vis a vis Vatarakta - A Case Report

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v3i5.13850 ◽

2018 ◽

Vol 3 (5) ◽

Author(s):

Dr. Gururaja D. ◽

Dr. Veeraj Hegde

Keyword(s):

Systemic Lupus Erythematosus ◽

Case Report ◽

Lupus Erythematosus ◽

Severe Pain ◽

Overlap Syndrome ◽

Burning Sensation ◽

Tinospora Cordifolia ◽

Systemic Lupus ◽

Multisystem Disease

Systemic Lupus erythematosus is the classic prototype of multisystem disease of autoimmune origin. SLE may be associated Vasculitis as an overlap syndrome. In this paper, a patient diagnosed as SLE with Vasculitis, which was managed successfully by Ayurveda treatment is discussed. A 39 year old female patient came to hospital with complaint of severe pain and burning sensation in both the legs for two months, associated with ulceration and gangrene of toes of both the legs for the last 15 days. She was diagnosed as SLE overlap vasculitis at a higher medical centre with relevant investigations and advised to go for amputation. As patient was not willing for surgery came to Ayurveda treatment. The condition was diagnosed as disease Vatarakta and treatment was planned accordingly. Treatment was planned by selecting suitable oral medicines, planning suitable Panchakarma procedures along with the ulcer management. Guduchi (Tinospora cordifolia) was the main drug which is used in Rasayana dosage. Patient responded well and we could able to save the limb. Patient was under follow up for more than a year without any complications and relapses.

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Hypocomplementemia Correlates with Intrauterine Growth Retardation in Systemic Lupus Erythematosus

American Journal of Reproductive Immunology ◽

10.1111/j.1600-0897.1999.tb00479.x ◽

1999 ◽

Vol 42 (3) ◽

pp. 153-159 ◽

Cited By ~ 14

Author(s):

Noriko Kobayashi ◽

Hideto Yamada ◽

Tatsuro Kishida ◽

Emi-Hirayama Kato ◽

Yasuhiko Ebina ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Growth Retardation ◽

Lupus Erythematosus ◽

Intrauterine Growth Retardation ◽

Systemic Lupus ◽

Intrauterine Growth

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Primary antiphospholipid syndrome progressing to systemic lupus erythematosus: a case report

Italian Journal of Medicine ◽

10.4081/itjm.2010.116 ◽

2013 ◽

pp. 116-121

Author(s):

Rocco Manganelli ◽

Salvatore Iannaccone ◽

Walter De Simone

Keyword(s):

Systemic Lupus Erythematosus ◽

Case Report ◽

Antiphospholipid Syndrome ◽

Lupus Erythematosus ◽

Primary Antiphospholipid Syndrome ◽

Systemic Lupus ◽

Anionic Phospholipids ◽

Serological Studies ◽

Homogeneous Pattern

Introduction: Primary antiphospholipid syndrome (APS) is a thrombophilic disease that should be suspected in the presence of thrombotic events associated with hematologic abnormalities such as thrombocytopenia and prolongation of the activated partial thromboplastin time. The diagnosis must be confirmed by the demonstration of autoantibodies directed against anionic phospholipids and/or phospholipid-binding proteins. The disease can cause arterial thrombosis in any vascular district, including those of the kidney and central nervous system. Case report: In 2006 a 29-year-old male presented with kidney and brain involvement that was attributed to primary APS. The clinical diagnosis was confirmed by the results of a renal biopsy, which excluded the presence of systemic lupus erythematosus (SLE). The patient remained stable through 32 months of follow-up and then developed a malar rash with deteriorating renal function, decreasing platelet count, and reduced complement levels. Serological studies revealed positivity for ANA (homogeneous pattern), dsDNA, ACA, and beta-2-glycoprotein-1 antibodies. The diagnosis was revised to APS secondary to SLE. Conclusions: A diagnosis of primary APS should not be considered permanent: progression to SLE can occur, in some cases years after the original diagnosis. This case highlights the importance of ongoing follow-up of patients diagnosed with primary APS to detect changes that herald the emergence of SLE.

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Systemic lupus erythematosus complicated with antipholipid syndrome, which diagnosed from intrauterine growth retardation.

Nihon Naika Gakkai Zasshi ◽

10.2169/naika.91.1313 ◽

2002 ◽

Vol 91 (4) ◽

pp. 1313-1316

Author(s):

Hirotaka Matsuoka ◽

Kiyoshi Matsui ◽

Kouji Tominaga ◽

Akinori Ida ◽

Kyouko Minagawa ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Growth Retardation ◽

Lupus Erythematosus ◽

Intrauterine Growth Retardation ◽

Systemic Lupus ◽

Intrauterine Growth

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Core Decompression and Biological Treatment in Osteonecrosis of the Hip due to Systemic Lupus Erythematosus, 8-year Follow-up: A Case Report

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.5798 ◽

2021 ◽

Vol 9 (C) ◽

pp. 74-79

Author(s):

Sholahuddin Rhatomy ◽

Ismail Hadisoebroto Dilogo

Keyword(s):

Systemic Lupus Erythematosus ◽

Case Report ◽

Femoral Head ◽

Lupus Erythematosus ◽

Biological Treatment ◽

Core Decompression ◽

Treatment Result ◽

Harris Hip Score ◽

Systemic Lupus

BACKGROUND: Osteonecrosis most commonly affects the femoral head, especially in middle-aged adults. It can be caused by trauma, chronic inflammation, or infection. It leads to collapse of the entire femoral head and culminates with total hip replacement. CASE REPORT: A 29-year-old female with systemic lupus erythematosus (SLE) had a chief complaint of bilateral hip pain. She was diagnosed with early osteonecrosis of the femoral head (FICAT stage II) using magnetic resonance imaging and core decompression surgery was performed using three small diameter (4 mm) drillings and added biological treatment. She was evaluated with a visual analog scale (VAS), Harris hip score (HHS), and plain radiography in the pre-operative stage and post-operative follow-up. RESULTS: Functional outcome at 8-year follow-up showed improvement with significantly decreased VAS (pre-operative: 5, post-operative: 0), significant improvement of HHS from 52.725 points (poor) pre-operative to 92.025 points (excellent) post-operative, and subsided femoral head lesion. CONCLUSIONS: Surgical decompression and biological treatment result in decreased intraosseous pressure and enhanced osteogenesis. It can restrict the SLE disease progression and limit the number of cell death.

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Sensorineural hearing loss in systemic lupus erythematosus: case report and literature review

The Journal of Laryngology & Otology ◽

10.1017/s0022215108001783 ◽

2008 ◽

Vol 122 (12) ◽

pp. 1371-1376 ◽

Cited By ~ 23

Author(s):

N A Khalidi ◽

R Rebello ◽

D D Robertson

Keyword(s):

Magnetic Resonance Imaging ◽

Systemic Lupus Erythematosus ◽

Hearing Loss ◽

Case Report ◽

Sensorineural Hearing Loss ◽

Lupus Erythematosus ◽

Sensorineural Hearing ◽

Resonance Imaging ◽

Systemic Lupus

AbstractObjectives:We present a case of systemic lupus erythematosus with symptomatic sensorineural hearing loss which was successfully treated with azathioprine, as assessed both clinically and radiologically. We also present a review of the relevant literature.Case report:A woman with systemic lupus erythematosus presented with sensorineural hearing loss, initially on the right and subsequently developing on the left over several months. An audiogram revealed profound neurosensory hearing loss bilaterally. The patient was treated with prednisone 60 mg daily and azathioprine 200 mg daily. An improvement on the left was noted on follow-up audiography as well as on magnetic resonance imaging of the internal auditory canals and surrounding structures.Conclusion:Sensorineural hearing loss has been described in autoimmune disorders but is rare. Aural symptoms have been described, with varying incidences (0–57.5 per cent), in systemic lupus erythematosus. However, symptomatic sensorineural hearing loss is rare in systemic lupus erythematosus. Prednisone appears essential when an immunological or vasculitic cause is found. The use of azathioprine should be considered, as well as follow-up with magnetic resonance imaging to detect improvement.

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Luaran Kehamilan Dengan Sistemik Lupus Eritematosus

Jurnal Ilmu Kedokteran ◽

10.26891/jik.v5i2.2011.63-70 ◽

2017 ◽

Vol 5 (2) ◽

pp. 63

Author(s):

Maya Savira

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antiphospholipid Antibodies ◽

Fetal Death ◽

Good Control ◽

Intrauterine Fetal Death ◽

Systemic Lupus ◽

Increased Risk ◽

Mother And Child ◽

Immune Complex Formation

Systemic lupus erythematosus often abbreviated to SLE or lupus, is a systemicautoimmune disease (or autoimmuneconnective tissue disease) that can affect any part ofthe body. As occurs in other autoimmune diseases, the immunesystem attacks the body’scells and tissue, resulting in inflammation and tissue damage. It is a type IIIhypersensitivityreaction caused by antibody-immune complex formation. Women with lupus are at risk for various complications ofpregnancy, and those with antiphospholipid antibodies may have an increased risk of miscarriage. Systemic lupuserythematosus increases the risk of spontaneous abortion, intrauterine fetal death, preeclampsia, intrauterine growthretardation, and preterm birth. The outcome for both mother and child is best when systemic lupus erythematosus hasbeen under good control for at least six months before pregnancy and when the kidney disease is in remission.

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Gestational outcomes in patients with neuropsychiatric systemic lupus erythematosus

Lupus ◽

10.1177/0961203317693929 ◽

2017 ◽

Vol 26 (5) ◽

pp. 537-542 ◽

Cited By ~ 3

Author(s):

G R de Jesus ◽

B C Rodrigues ◽

M I Lacerda ◽

F C dos Santos ◽

NR de Jesus ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Fetal Death ◽

Severe Form ◽

Intrauterine Fetal Death ◽

Early Complications ◽

Systemic Lupus ◽

Neuropsychiatric Disease ◽

Live Births ◽

Neuropsychiatric Systemic Lupus Erythematosus

This study analyzed maternal and fetal outcomes of pregnancies of neuropsychiatric systemic lupus erythematosus patients followed in a reference unit. This retrospective cohort study included 26 pregnancies of patients seen between 2011 and 2015 included with history and/or active neuropsychiatric systemic lupus erythematosus among 135 pregnancies. Three patients had active neuropsychiatric systemic lupus erythematosus at conception, but only one remained with neurological activity during gestation, characteristically related to the inadvertent suspension of medications. Twenty six percent of the newborns were small for gestational age and 40% of live births were premature, with no neonatal death or early complications of prematurity. Preeclampsia was diagnosed in nine pregnancies, with two cases of early severe form that resulted in intrauterine fetal death. Patients with neuropsychiatric systemic lupus erythematosus had more prematurity and preeclampsia compared to patients without neuropsychiatric disease. However, when concomitant lupus nephritis was excluded, the gestational results of neuropsychiatric systemic lupus erythematosus patients were more favorable.

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