scholarly journals Some parameters of the oxidative stress in lens, humour aqueous and serum of patients with diabetes and age-related cataract

2003 ◽  
Vol 131 (3-4) ◽  
pp. 137-142 ◽  
Author(s):  
Lepsa Zoric
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Age Related ◽  
Lipid Oxidation Products ◽  
Patients With Diabetes

Contemporary hypothesis considers the oxidative stress as a crucial event in age-related processes in the body, as well as in the age-related cataract formation. The secondary aging factors accelerate ageing processes. One of them is diabetes. With the aim of investigation of the noninsulin-dependent diabetes (Type II) influence on cataract genesis here were analyzed contents of the lipid oxidation products (lipid peroxides - LP) and total sulfhydryle groups (TSH) in the lens? corticonuclear blocks and antioxidative capacity in their humour aqueous expressed as percent of induced malondyaldehyde (% iMDA) in 14 samples obtained from patients with cataract and diabetes mellitus type II (without diabetic complications) and compared to 66 samples of patients with cataract without diabetes, as well as some parameters of the oxidative stress in serums (content of vitamin C, acrobat - A dehydroascorbate - DA and their relation, vitamin E, glutathione - GSH peroxidase - P and catalase - Cat activity, content of malondyaldehyde - MDA and % iMDA) of 27 patients with age-related cataract and diabetes mellitus type II (without complications), and compared to the other 135 age-related cataract patients. Also were analyzed frequencies of the secondary senium diseases in a clinical group of 162 patients with cataract and sex and age matched 55 examined people without cataract, as a control group. Patients with diabetes and cataract have lower values of almost all investigated parameters of antioxidative defense in their serum and higher level of the lipid peroxidation products. Level of glutathione in their serums is significantly lower (p<0.05). Intensity of lipid peroxidation in corticonuclear lens blocks is higher in patients with diabetes, whereas their total sulfhydryle groups and % iMDA in humour aqueous shows lower antioxidant capacity in the same group, probably because of higher intensity of oxidative stress. Also, by investigation of frequencies of the secondary ageing diseases in patients with age-related cataract and age and sex matched control subjects, by a logistic regression was found high odds ratio (2.506) for diabetes. Results confirm hypothesis of the oxidative stress role in the age-related cataract genesis, and especially of patients with diabetes mellitus.

scholarly journals PECULIARITIES OF STATE OF PROTECTION AND AGGRESSION FACTORS IN PATIENTS WITH DIABETES MELLITUS TYPE II AND GASTROESOPHAGEAL REFLUX DISEASE

2020 ◽  
Vol 1 ◽  
pp. 27-34 ◽  
Author(s):  
Aleksey Oparin ◽  
Anton Kudriavtsev ◽  
Anatoliy Oparin
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Blood Flow Velocity ◽  
Reflux Disease ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Patients With Diabetes

Diabetes mellitus is one of the most serious problems of the clinical medicine. This is determined by the fact that it is followed by multisystemic affects, as well as complications on the side of other organs and systems, among which a special place is occupied by gastroesophageal reflux disease. As for the combination and mutual influence of diabetes mellitus and gastroesophageal reflux disease, this issue has not been studied yet, the data of modern literature are not complete and quite contradictory. The aim of the study: to investigate the state of the factors of aggression and protection of the oesophageal mucosa in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease without associated pathology. Method. There were two groups of patients under observation. The first group included 45 patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease (26 men and 19 women). The second group included 38 patients with gastroesophageal reflux disease without associated pathology – 20 men and 18 women. By sex, age, body weight, Helicobacter pylori infection, smoking and alcohol consumption, both groups were comparable. The surveillance program included determining the compensation ratio of carbohydrate metabolism and the state of the factor. The antioxidant protection factor was assessed by the level of catalase activity in the blood serum, as well as by the diameter of the celiac trunk and the blood flow velocity in it. Statistical processing of the obtained data was carried out with the aid of the program WINDOWS STATISTIKA 6.0. For all types of analysis, differences were considered statistically significant with p<0.05. Results. During the study, we found that in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease, as well as in patients with gastroesophageal reflux disease without associated pathology, the level of pH-metry was reduced, but with varying measures of confidence. At the same time, we found that patients with GERD without associated pathology had a decrease in the blood flow velocity in the celiac trunk. Concurrently, we ascertained that the decrease in the blood flow velocity in patients of both groups reduced the diameter of the celiac trunk. Conclusions. In patients with diabetes mellitus type II, concomitant gastroesophageal reflux disease has a subtle clinical presentation that is affected by a significant decline in mucosal sealing protection factors. In patients with GERD without associated pathology, typical clinical manifestations, accompanied by inflammation, acid regurgitation and dyspepsia, are more vivid.

PREVALENCE OF DIABETIC NEUROPATHY IN PATIENTS WITH DIABETES MELLITUS TYPE II

2011 ◽  
Vol 22 ◽  
pp. S29
Author(s):  
Triada Exiara ◽  
Apostolos Konstantis ◽  
Maria Kouroupi ◽  
Anastasia Georgoulidou ◽  
Dimitra Papadopoulou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Patients With Diabetes

scholarly journals Protein spectrum of blood plasma in patients with diabetes mellitus type II

2018 ◽  
Vol 3 (2) ◽  
pp. 95-105
Author(s):  
V. Ionova ◽  
V. Lantsova ◽  
E. Tkach ◽  
R. Ziganshin ◽  
V. Shender ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Plasma ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Protein Spectrum ◽  
Patients With Diabetes

scholarly journals Analysis of the Efficacy of Cinnamon for Patients with Diabetes Mellitus Type II Based on Traditional Persian Medicine Syndrome Differentiation: A Randomized Controlled Trial

2020 ◽  
Vol 21 (7) ◽  
Author(s):  
Roghayeh Zare ◽  
Mesbah Shams ◽  
Mojtaba Heydari ◽  
Azadeh Najarzadeh ◽  
Mehdi Zarshenas
Keyword(s):  
Diabetes Mellitus ◽  
Controlled Trial ◽  
Diabetes Mellitus Type ◽  
Syndrome Differentiation ◽  
Diabetic Patients ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Persian Medicine ◽  
Patients With Diabetes ◽  
Traditional Persian Medicine

Background: Conflicting results have been obtained from the studies on the hypoglycemic effect of cinnamon in patients with diabetes mellitus type II (T2DM). Objectives: This research aimed at assessing the effect of applying the syndrome differentiation model based on traditional Persian medicine (TPM) to identify the patients who benefit more from cinnamon supplementation. Methods: This study was a randomized, triple-blind, placebo-controlled trial based on a parallel design. One hundred and forty eligible patients referring to the Diabetes Clinic of Yazd University of Medical Sciences, who were diagnosed with T2DM, were randomly divided into the cinnamon and placebo groups. Then, 500-mg capsules of cinnamon bark powder or placebo were administered to them twice a day for three months. All the participants completed a standard questionnaire for syndrome diagnosis in traditional Persian medicine (TPM). Fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), fasting insulin (FI), and insulin resistance (IR), calorie intake, and physical activity were measured before and after the interventions. The glycemic outcomes were analyzed according to the TPM syndrome. Results: There was no statistically significant difference between the patients’ demographic and clinical features in the two groups. Glycemic indices were improved in patients receiving cinnamon supplementation compared to placebo group (-13.1 ± 1.7, -1.7 ± 1.9, P < 0.001 for change in FPG and -0.27 ± 0.039 vs. 0.001 ± 0.019, P < 0.001 for change in HbA1C respectively). All the outcomes were more improved in the patients with wet syndrome compared to dry ones, which was compatible with Persian syndrome differentiation (P < 0.05). Conclusions: Diabetic patients with wet syndrome based on TPM benefit more form cinnamon supplementation.

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