scholarly journals Influence of retrobulbar neuritis and papillitis on echographically measured optic nerve diameter

2010 ◽  
Vol 67 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Ivan Stefanovic ◽  
Milos Jovanovic ◽  
Bojana Dacic-Krnjaja ◽  
Dragan Veselinovic ◽  
Predrag Jovanovic
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Significant Negative Correlation ◽  
Optic Disk ◽  
Partial Loss ◽  
Retrobulbar Neuritis ◽  
Optic Nerve Diameter ◽  
Ophthalmologic Examination ◽  
Retrobulbar Optic Neuritis

Background/Aim. Retrobulbar (optic) neuritis is inflammation of the optic nerve that may cause a complete or partial loss of vision. This inflammation can affect a part of the nerve within the eyeball (neuropapillitis) or a part of the nerve behind the eyeball (retrobulbar neuritis). The aim of this study was to establish whether there is a correlation between the diameter of a retrobulbar part of the optic nerve and either visual acuity, prominence of the optic disk (papillitis), or nature of the neuritis (papillitis or retrobulbar). Methods. We tested 23 patients with retrobulbar neuritis and papillitis. In addition to a complete ophthalmologic examination, the diameter of retrobulbar region of the optic nerve was measured by the B-scan method. Following this, the 30-degree test was carried out. Results. We found an increased thickness of the retrobulbar region in 22 patients and different responses to the 30-degree test, as well as a statistically significant negative correlation between the thickness of retrobulbar part of the optic nerve and visual acuity. Conclusion. The retrobulbar part of the optic nerve is thicker in 94% of the patients with retrobulbar neuritis and in all the patients with papillitis. There is a correlation between the reduction of visual acuity and thickening of a retrobulbar part.

scholarly journals Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Piergiorgio Lochner ◽  
Roberto Cantello ◽  
Klaus Fassbender ◽  
Martin Lesmeister ◽  
Raffaele Nardone ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Axonal Injury ◽  
Optic Nerve Sheath Diameter ◽  
Healthy Controls ◽  
Longitudinal Assessment ◽  
Affected Side ◽  
Acute Optic Neuritis ◽  
Optic Nerve Diameter

Background and Objective. To investigate the relationship between optic nerve sheath diameter, optic nerve diameter, visual acuity and osteopontin, and neurofilament heavy chain in patients with acute optic neuritis. Patients and Methods. Sonographic and visual acuity assessment and biomarker measurements were executed in 23 patients with unilateral optic neuritis and in 19 sex- and age-matched healthy controls. Results. ONSD was thicker on the affected side at symptom onset (median 6.3 mm; interquartile range 6.0–6.5) than after 12 months (5.3 mm; 4.9–5.6; p<0.001) or than in controls (5.2 mm; 4.8–5.5; p<0.001). OND was significantly increased in the affected side (3.4 mm; 2.9–3.8) compared to healthy controls (2.7 mm; 2.5–2.9; p<0.001) and was thicker at baseline than after 12 months (2.8 mm; 2.7–3.0; p<0.01). Visual acuity improved significantly after 12 months (1.00; 0.90–1.00) compared to onset of symptoms (0.80; 0.40–1.00; p<0.001). OPN levels were significantly higher in patients at presentation (median 6.44 ng/ml; 2.05–10.06) compared to healthy controls (3.21 ng/ml, 1.34–4.34; p<0.03). Concentrations of NfH were significantly higher in patients than in controls. Conclusion. ONSD and OND are increased in the affected eye. OPN and NfH are elevated in patients, confirming the presence of any underlying inflammation and axonal injury.

Retrobulbar optic neuritis due to diseases of the posterior sinuses

1927 ◽  
Vol 23 (9) ◽  
pp. 973-973
Author(s):  
N. A. Khristianov
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Circulatory System ◽  
Nerve Lesions ◽  
Retrobulbar Optic Neuritis ◽  
Anatomical Connection

Close anatomical connection between the optic nerve and the posterior nasal appendages and the commonality of their circulatory system explain optic nerve lesions in purulent and catarrhal processes in the posterior sinuses. N.A. Khristianov describes a case of left-sided retrobulbar optic neuritis cured by opening the middle and posterior lattices of the same side, affected by chronic catarrh.

scholarly journals An overview of idiopathic optic neuritis in eastern Nepal

1970 ◽  
Vol 2 (1) ◽  
pp. 10-15
Author(s):  
H Das ◽  
Maria Gautam ◽  
P Lavaju
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Clinical Features ◽  
Steroid Therapy ◽  
Pulse Methylprednisolone ◽  
Pulse Steroid Therapy ◽  
Initial Visual Acuity ◽  
Pulse Methylprednisolone Therapy ◽  
Pulse Steroid

Background: Inflammation of the optic nerve is a common cause of visual loss due to optic nerve pathology. Objective: To report the clinical features, demographic pattern and response to pulse steroid therapy in patients with idiopathic optic neuritis in eastern Nepal. Materials and methods: The hospital data of patients with idiopathic optic neuritis admitted to the department of ophthalmology in a tertiary level center in eastern Nepal between Jan 2000 to Dec 2006 were retrospectively analyzed. The parameters studied were demographic pattern, clinical features, visual acuity and field defects. Results: Thirty-six patients (52 eyes) were found to have optic neuritis (papillits in 36 and retrobulbar optic neuritis in16 eyes). The male to female ratio was1.25:1. The mean age of the patients was 33.56±17.88 years (95 % CI=24.66 - 42.45). The most common modes of presentation were loss of visual acuity and color vision defect. One patient had features suggestive of multiple sclerosis. Vision improved in 42 eyes at discharge from the hospital. Response to pulse methylprednisolone therapy was good in most (42 eyes) of the cases except for the patients having initial visual acuity of no light perception. Conclusion: Response to pulse methylprednisolone therapy is good in patients with initial visual acuity of at least perception of light. Demographic and clinical features of our patients were different from those reported from the western world. Some similarity was observed between studies reported from the oriental countries. Keywords: optic neuritis; demographic pattern; pulse steroid therapy. DOI: 10.3126/nepjoph.v2i1.3698 Nep J Oph 2010;2(1):10-15

scholarly journals Isolated bilateral optic neuritis revealing a Lyme Disease : case report

2020 ◽  
Vol 7 (3) ◽  
pp. 145-149
Author(s):  
MIRAY LOUIS DE GONZAGUE
Keyword(s):  
Visual Acuity ◽  
Lyme Disease ◽  
Optic Neuritis ◽  
Anterior Segment ◽  
Central Nervous System Involvement ◽  
Optic Disk ◽  
Fundus Examination ◽  
Corrected Visual Acuity ◽  
Disease Case ◽  
Best Corrected Visual Acuity

Optic neuritis (ON) is an inflammation of the optic nerve and one of the most common manifestations of central nervous system involvement caused by various etiologies. Lyme optic neuritis  is a rare ocular manifestation of Lyme Disease. We report a case of a 13-year-old male patient, previously healthy, with decreased central visual acuity on his both eyes . On examination, best-corrected visual acuity on both eyes was 0,3 LogMar. Anterior segment biomicroscopy showed no inflammatory signs and the intraocular pressure was normal. A fundus examination performed under mydriasis revealed a swollen optic disk on both eyes confirmed by fluorescein angiography. The cerebrospinal fluid examination and Lyme Disease blood findings were positive. The diagnosis of Lyme disease-related optic neuritis was made. Treated with Ceftriaxone and Doxicycline, there was a vision recovery. We can state that isolated bilateral optic neuritis is uncommon and exceptional especially in children during Lyme disease.

scholarly journals MOG-related bilateral optic neuritis in a patient with cystic fibrosis

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Rachelle Abi Nahed ◽  
◽  
Georges Succarieh ◽  
Amine Al Soueidy ◽  
Patrick Baz ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Visual Acuity ◽  
Optic Neuritis ◽  
Optic Neuropathy ◽  
Complete Resolution ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Acute Onset ◽  
Optic Disk ◽  
High Dose

Optic neuropathy secondary to Cystic Fibrosis (CF) has been described as a manifestation of chloramphenicol toxicity. Inflammatory optic neuritis and Myelin Oligodendrocyte Glycoprotein (MOG)-related disorders have not been previously described in patients with CF. We report the case of a 19-year-old woman with cystic fibrosis who presented for sub-acute onset decreased visual acuity, dyschromatopsia, and optic disk swelling in both eyes, with near-complete resolution after a course of high-dose corticosteroids. MOG-IgG were positive in the serum. MOG-related optic neuritis can occur in CF and represent a diagnostic and long-term therapeutic challenge. Keywords: Optic neuritis; MOG; cystic fibrosis.

scholarly journals Visual Outcomes of Adding Erythropoietin to Methylprednisolone for Treatment of Retrobulbar Optic Neuritis

2019 ◽  
Author(s):  
Mostafa Soltan Sanjari ◽  
Farzad Pakdel ◽  
Fatemeh Moosavi ◽  
Niloofar Pirmarzdashti ◽  
Marzieh Nojomi ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Pilot Study ◽  
Optic Neuritis ◽  
Visual Outcome ◽  
Primary Outcome Measure ◽  
Recombinant Erythropoietin ◽  
Human Recombinant Erythropoietin ◽  
Retrobulbar Optic Neuritis ◽  
Group 2 ◽  
Group 1

Purpose: To compare the short-term visual function results and safety of erythropoietin as an add-on to the standard corticosteroid therapy in retrobulbar optic neuritis (RON). Methods: In this prospective pilot study, adult patients with isolated RON with less than 10 days of onset were enrolled. Patients were consecutively assigned to standard intravenous methylprednisolone treatment either in combination with intravenous erythropoietin (20,000 units/day for three days) (group-1) or alone (group-2). Primary outcome measure was best-corrected visual acuity (BCVA), which was assessed up to 120 days from the day the treatment was begun. Systemic evaluations were performed during and after treatment. Results: Sixty-two patients with RON (mean age = 26.6 ± 5.77 years; range = 18–40 years) were enrolled into the study (group-1, n = 35; group-2, n = 27). BCVA three months after the treatment was 0.19 ± 0.55 logMAR and 0.11 ± 0.32 logMAR in group-1 and group-2, respectively (95% CI: –0.61–0.16; P = 0.62). Change in BCVA after three months was 2.84 ± 3.49 logMAR in group-1 and 2.46 ± 1.40 logMAR in group-2 (95% CI: –0.93–1.91; P = 0.57). Pace of recovery was not significantly different between the groups. No complications were detected among patients. Conclusion: Intravenous erythropoietin as an add-on did not significantly improve the visual outcome in terms of visual acuity, visual field, and contrast sensitivity compared to traditional intravenous corticosteroid. This pilot study supports the safety profile of intravenous human recombinant erythropoietin, and it may help formulate future investigations with a larger sample size.

WED 143 Chronic relapsing inflammatory optic neuritis (CRION) in the neuroinflammatory clinic

2018 ◽  
Vol 89 (10) ◽  
pp. A16.4-A17
Author(s):  
Cousins Oliver ◽  
Khan Hina ◽  
Harikrishnan Sreedharan
Keyword(s):  
Multiple Sclerosis ◽  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Visual Loss ◽  
Correct Diagnosis ◽  
Corticosteroid Treatment ◽  
Oligoclonal Bands ◽  
Short Course

CRION is a rare cause of optic neuritis. It is usually bilateral, painful and associated with profound visual loss. Significant response to corticosteroid treatment is typical but relapse is common when treatment is withdrawn. We present 2 cases of possible CRION and discuss the diagnostic and management considerations.Case 1: 50-year-old woman presented with right optic neuritis which spontaneous recovered. A year later she had left painful visual loss which improved with a short course of corticosteroids. MRI neuroaxis revealed left optic nerve enhancement. Non-specific, faint unmatched OCBs were detected. AQP4-IgG was negative. Nine months later she had further visual loss in her left eye. Prednisolone and azathioprine were commenced.Case 2: 55-year-old woman with bilateral, painless visual acuity deterioration over two weeks. Investigations revealed negative anti-aquaporin 4 antibodies (AQP4-IgG), normal MRI of the neuroaxis, negative oligoclonal bands (OCBs) and visual evoked potentials showed bilateral delay. Serum ACE was slightly elevated. She was started on a tapering course of steroids and had significant visual acuity improvement.The diagnosis of CRION involves the exclusion of other causes of optic neuritis, particularly multiple sclerosis (MS), Neuromyelitis Optica (NMO) and sarcoidosis. Correct diagnosis is important as aggressive and long-term immunosuppression is required.

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