Cellular Dynamics:

2011 ◽  
pp. 107-134
Keyword(s):  
Cellular Dynamics

Clonal trajectories and cellular dynamics of myeloid neoplasms with SF3B1 mutations

Leukemia ◽  
2021 ◽  
Author(s):  
Hassan Awada ◽  
Cassandra M. Kerr ◽  
Arda Durmaz ◽  
Vera Adema ◽  
Carmelo Gurnari ◽  
...  
Keyword(s):  
Cellular Dynamics ◽  
Myeloid Neoplasms

The anatomical sources of neointimal cells in the arteriovenous fistula

2021 ◽  
pp. 112972982110118
Author(s):  
Roberto I Vazquez-Padron ◽  
Laisel Martinez ◽  
Juan C Duque ◽  
Loay H Salman ◽  
Marwan Tabbara
Keyword(s):  
Arteriovenous Fistula ◽  
Intimal Hyperplasia ◽  
Current Knowledge ◽  
Cellular Dynamics ◽  
Relative Contribution ◽  
Effective Delivery ◽  
Transformation Processes

Neointimal cells are an elusive population with ambiguous origins, functions, and states of differentiation. Expansion of the venous intima in arteriovenous fistula (AVF) is one of the most prominent remodeling processes in the wall after access creation. However, most of the current knowledge about neointimal cells in AVFs comes from extrapolations from the arterial neointima in non-AVF systems. Understanding the origin of neointimal cells in fistulas may have important implications for the design and effective delivery of therapies aimed to decrease intimal hyperplasia (IH). In addition, a broader knowledge of cellular dynamics during postoperative remodeling of the AVF may help clarify other transformation processes in the wall that combined with IH determine the successful remodeling or failure of the access. In this review, we discuss the possible anatomical sources of neointimal cells in AVFs and their relative contribution to intimal expansion.

Cellular dynamics of the STAT3 transcription factor

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 127
Author(s):  
Velasco Cimica ◽  
Janaki Iyer ◽  
Nancy C. Reich
Keyword(s):  
Transcription Factor ◽  
Cellular Dynamics ◽  
Stat3 Transcription Factor

Spectral domain phase microscopy: a new tool for measuring cellular dynamics and cytoplasmic flow

2005 ◽  
Author(s):  
Emily J. McDowell ◽  
Michael A. Choma ◽  
Audrey K. Ellerbee ◽  
Joseph A. Izatt
Keyword(s):  
Spectral Domain ◽  
Cellular Dynamics ◽  
Phase Microscopy ◽  
Domain Phase

scholarly journals Cellular dynamics of EMT: lessons from live in vivo imaging of embryonic development

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jeffrey D. Amack
Keyword(s):  
Extracellular Matrix ◽  
Embryonic Development ◽  
In Vivo Imaging ◽  
Cytoskeletal Proteins ◽  
Cell Junctions ◽  
Model Organisms ◽  
Cellular Dynamics ◽  
Mesenchymal Transition ◽  
Cell Cell

AbstractEpithelial-mesenchymal transition (EMT) refers to a process in which epithelial cells lose apical-basal polarity and loosen cell–cell junctions to take on mesenchymal cell morphologies and invasive properties that facilitate migration through extracellular matrix. EMT—and the reverse mesenchymal-epithelial transition (MET)—are evolutionarily conserved processes that are used throughout embryonic development to drive tissue morphogenesis. During adult life, EMT is activated to close wounds after injury, but also can be used by cancers to promote metastasis. EMT is controlled by several mechanisms that depend on context. In response to cell–cell signaling and/or interactions with the local environment, cells undergoing EMT make rapid changes in kinase and adaptor proteins, adhesion and extracellular matrix molecules, and gene expression. Many of these changes modulate localization, activity, or expression of cytoskeletal proteins that mediate cell shape changes and cell motility. Since cellular changes during EMT are highly dynamic and context-dependent, it is ideal to analyze this process in situ in living organisms. Embryonic development of model organisms is amenable to live time-lapse microscopy, which provides an opportunity to watch EMT as it happens. Here, with a focus on functions of the actin cytoskeleton, I review recent examples of how live in vivo imaging of embryonic development has led to new insights into mechanisms of EMT. At the same time, I highlight specific developmental processes in model embryos—gastrulation in fly and mouse embryos, and neural crest cell development in zebrafish and frog embryos—that provide in vivo platforms for visualizing cellular dynamics during EMT. In addition, I introduce Kupffer’s vesicle in the zebrafish embryo as a new model system to investigate EMT and MET. I discuss how these systems have provided insights into the dynamics of adherens junction remodeling, planar cell polarity signaling, cadherin functions, and cytoskeletal organization during EMT, which are not only important for understanding development, but also cancer progression. These findings shed light on mechanisms of actin cytoskeletal dynamics during EMT, and feature live in vivo imaging strategies that can be exploited in future work to identify new mechanisms of EMT and MET.

scholarly journals Biliary atresia: cellular dynamics and immune dysregulation

2012 ◽  
Vol 21 (3) ◽  
pp. 192-200 ◽  
Author(s):  
Amy G. Feldman ◽  
Cara L. Mack
Keyword(s):  
Biliary Atresia ◽  
Immune Dysregulation ◽  
Cellular Dynamics
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