474 INTRAUTERINE GROWTH RESTRICTION INCREASES INSULIN GROWTH FACTOR 1 PROMOTER MESSENGER RIBONUCLEIC ACID LEVELS IN THE BRAIN.

2006 ◽  
Vol 54 (1) ◽  
pp. S161.1-S161
Author(s):  
C. Humphrey ◽  
R. Langen ◽  
R. A. McKnight ◽  
C. W. Callaway ◽  
X. Yu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ribonucleic Acid ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Messenger Ribonucleic Acid ◽  
Intrauterine Growth ◽  
Insulin Growth Factor ◽  
The Brain

scholarly journals Placental Growth Factor for the Prediction of Adverse Outcomes in Patients with Suspected Preeclampsia or Intrauterine Growth Restriction

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50208 ◽  
Author(s):  
Jeanne Sibiude ◽  
Jean Guibourdenche ◽  
Marie-Danielle Dionne ◽  
Camille Le Ray ◽  
Olivia Anselem ◽  
...  
Keyword(s):  
Growth Factor ◽  
Intrauterine Growth Restriction ◽  
Placental Growth Factor ◽  
Adverse Outcomes ◽  
Growth Restriction ◽  
Intrauterine Growth

The brain development of infants with intrauterine growth restriction: role of glucocorticoids

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Ying-xue Ding ◽  
Hong Cui
Keyword(s):  
Endothelial Cells ◽  
Brain Injury ◽  
Intrauterine Growth Restriction ◽  
Growth And Development ◽  
Growth Restriction ◽  
Microvascular Endothelial Cells ◽  
Intrauterine Growth ◽  
Growth Restrictions ◽  
The Brain

Abstract Brain injury is a serious complication of intrauterine growth restriction (IUGR), but the exact mechanism remains unclear. While glucocorticoids (GCs) play an important role in intrauterine growth and development, GCs also have a damaging effect on microvascular endothelial cells. Moreover, intrauterine adverse environments lead to fetal growth restriction and the hypothalamus-pituitary-adrenal (HPA) axis resetting. In addition, chronic stress can cause a decrease in the number and volume of astrocytes in the hippocampus and glial cells play an important role in neuronal differentiation. Therefore, it is speculated that the effect of GCs on cerebral neurovascular units under chronic intrauterine stimulation is an important mechanism leading to brain injury in infants with growth restrictions.

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