Drugs Used During Pregnancy and Lactation

In time of pregnancy, drugs are often required to treat certain disorders. In general potential benefit outweighs known risks, drugs may be considered for treatment of disorders during pregnancy. All maternal drugs not cross the planceta to the fetus. Some drugs that cross the placenta may have a direct toxic effect or teratogenic effect . Understanding the risks of drugs use in pregnancy has lagged being the advances in other areas of pharmacotherapy. The adverse developmental effects of pharmaceutical products are recognized to include not only mal formation, but also growth restrictions, fetal death and functional defects in the newborn. Drug that does not cross placenta but still harm the fortus. 1979, FDA developed a system determining teratogenic risk of drugs based on animals& human studies. Divided drugs into 5 categories (A ,B, C, D, X). This article provide clinical therapeutic guidance relating drug use in pregnancy.

Human Milk: Benefits, Composition and Evolution

Breastfeeding provides all the energy that the child needs in the form of nutrients in the first months of life. The components cover the nutritional needs in all stages, including colostrum and final or mature milk. It must also be taken into account that the composition of milk varies from one woman to another, between both breasts, between feedings and in the different stages in the same mother. It can be said that variation is an active mechanism to perfectly adjust to the nutritional and immunological needs of each child. Components of breast milk can exert beneficial non-nutritional functions. Breast milk also has bioactive factors, which affect biological processes and, therefore, have an impact on health. In the nutrition of premature babies, parenteral nutrition is carried out first, which later becomes enteral through different strategies, such as early minimal enteral nutrition. Despite this, they still present postnatal growth restrictions, which is associated with adverse neurocognitive outcomes. Breast milk achieves multiple benefits in both preterm and term births. Digestion and absorption in the stomach and intestines follow circadian rhythms in mammals, and these rhythms are regulated by rhythmically expressed clock genes in the intestine, as well as by daily food intake.

Half-space Gaussian symmetrization: applications to semilinear elliptic problems

We consider a class of semilinear equations with an absorption nonlinear zero order term of power type, where elliptic condition is given in terms of Gauss measure. In the case of the superlinear equation we introduce a suitable definition of solutions in order to prove the existence and uniqueness of a solution in ℝ N without growth restrictions at infinity. A comparison result in terms of the half-space Gaussian symmetrized problem is also proved. As an application, we give some estimates in measure of the growth of the solution near the boundary of its support for sublinear equations. Finally we generalize our results to problems with a nonlinear zero order term not necessary of power type.

EXPOSURE TO TOXIC AGROCHEMICALS AND DEVELOPMENT OF CONGENITAL MALFORMATIONS: A SCOPING REVIEW

ABSTRACT Objective: to assess whether maternal and paternal exposure to toxic agrochemicals throughout life causes congenital malformations. Method: a scoping review was carried out on the PUBMED, CINAHL, EBSCO, MEDLINE, LILACS, SciELO, BDENF, Web of Science and ATHENA databases between August and September 2019 and updated in December 2020. A cohort and case control study were included, which addressed the effects of parents' exposure throughout their lives to toxic agrochemicals which caused congenital malformation outcomes. Results: the review covered 32 studies published between 2005 and 2020. The main malformations presented are related to the reproductive system, nervous system, musculoskeletal system, transverse limb deficiencies, digestive system and other malformations such as fetal growth restrictions, cleft palate and congenital heart disease. The most investigated toxic agrochemicals in the studies were the herbicides represented by atrazine. Conclusion: maternal and paternal exposure to toxic agrochemicals can be associated with greater chances of children being born with congenital malformations, especially those related to the male reproductive system.

Attractiveness of Constant States in Logistic-Type Keller–Segel Systems Involving Subquadratic Growth Restrictions

The chemotaxis-growth system(⋆)\left\{\begin{aligned} \displaystyle u_{t}&\displaystyle=D\Delta u-\chi\nabla\cdot(u\nabla v)+\rho u-\mu u^{\alpha},\\ \displaystyle v_{t}&\displaystyle=d\Delta v-\kappa v+\lambda u\end{aligned}\right.is considered under homogeneous Neumann boundary conditions in smoothly bounded domains \Omega\subset\mathbb{R}^{n}, n\geq 1. For any choice of \alpha>1, the literature provides a comprehensive result on global existence for widely arbitrary initial data within a suitably generalized solution concept, but the regularity properties of such solutions may be rather poor, as indicated by precedent results on the occurrence of finite-time blow-up in corresponding parabolic-elliptic simplifications. Based on the analysis of a certain eventual Lyapunov-type feature of (⋆), the present work shows that, whenever \alpha\geq 2-\frac{2}{n}, under an appropriate smallness assumption on 𝜒, any such solution at least asymptotically exhibits relaxation by approaching the nontrivial spatially homogeneous steady state \bigl{(}\bigl{(}\frac{\rho}{\mu}\bigr{)}^{\frac{1}{\alpha-1}},\frac{\lambda}{\kappa}\bigl{(}\frac{\rho}{\mu}\bigr{)}^{\frac{1}{\alpha-1}}\bigr{)} in the large time limit.

ACHIEVING PREGNANCY IN A CASE OF BICORNUATE UTERUS WITH ABSENT LEFT KIDNEY WITH HISTORY OF RESECTION OF LONGITUDINAL VAGINALSEPTUM: A CASE REPORT

The incidence of uterine malformations in general population is estimated to be about 3-5% and 5-10% in women with poor reproductive outcome. Fertility and evolution of pregnancy depends on the type of uterine anomaly. Many of them are asymptomatic but it is important to consider this diagnosis in vaginal septum ,hematocolpus ,recurrent miscarriages - early and late, preterm labours, malpresentations, intrauterine growth restrictions and menstrual disturbances like menorrhagia, dysmenorrhea. Septate and arcuate uterus represents approximately 75% of malformations while bicornuate, didelphys and unicornuate comprise the remaining 25%. Cases of pregnancy in a bicornuate uterus are still of sufficient interest and rarity to justify being reported. We report a case of bicornuate uterus with absent left kidney who presented as hematocolpos due to longitudinal vaginal septum in 2017.A diagnostic hysterolaproscopy with resection of septum was done patient again followed up with infertility in 2019. Patient then conceived on follicular monitoring and planned relation with luteal phase support.

Global bounded solution of the higher-dimensional forager–exploiter model with/without growth sources

This paper concerns with the global existence and boundedness of classical solution of the higher-dimensional forager–exploiter model with homogeneous Neumann boundary condition and nonnegative initial data. For cases where there are no forager and exploiter growth sources, it will be shown that if either the initial data and the production rate of nutrient are small or the taxis effects are small, then the classical solution exists globally and is bounded. For the case that only the forager has growth source, when [Formula: see text], it will be shown that if the taxis effect of exploiter is small then the classical solution exists globally and is bounded. For the case that both the forager and exploiter have growth restrictions, when [Formula: see text], we find a condition for the logistic degradation rates that ensures the global existence and boundedness of the classical solution.

Filippov solutions of vector Dirichlet problems

If in the right-hand sides of given differential equations occur discontinuities in the state variables, then the natural notion of a solution is the one in the sense of Filippov. In our paper, we will consider this type of solutions for vector Dirichlet problems. The obtained theorems deal with the existence and localization of Filippov solutions, under effective growth restrictions. Two illustrative examples are supplied.