scholarly journals A visual evaluation of oral plaque removal utilizing an adjunct enzyme pre-rinse in orthodontic subjects

2020 ◽  
Vol 90 (6) ◽  
pp. 844-850
Author(s):  
Jennifer Rose ◽  
Ahmed Ghoneima ◽  
Frank Lippert ◽  
Lisa Maxwell ◽  
George Eckert ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Repeated Measures ◽  
Orthodontic Appliances ◽  
Visual Evaluation ◽  
Double Blind ◽  
Plaque Score ◽  
Significance Level ◽  
Plaque Removal ◽  
Repeated Measures Analysis ◽  
Fixed Orthodontic Appliances

ABSTRACT Objective To determine if an adjunct proteolytic pre-rinse along with contemporary methods of dental cleaning may more effectively remove visual plaque in subjects with fixed orthodontic appliances. Materials and Methods Forty-three orthodontic subjects, ages 10 to 25, completed this single site, double-blind, crossover clinical trial. Subjects randomly received bromelain enzyme or a powdered-sugar placebo pre-rinse, followed by manual tooth brushing and use of a Waterpik. Subjects received the alternate pre-rinse during the subsequent visit. Baseline and residual plaque accumulation were recorded via disclosing tablet and digital photography. A single, blinded examiner scored visual plaque scores from randomized photographs. Treatment effects on composite plaque score were evaluated using repeated-measures analysis of variance. A 5% significance level was used for all tests. Results No significant differences in plaque scores were noted at baseline or post-rinse between the enzyme and placebo. The changes from baseline to post-rinse (P = .190), post-brushing (P = .764), and post-Waterpik (P = .882) were not significantly different between interventions. Significant reduction in plaque scores were observed in both arms of the study after brushing (P < .01) and waterjet use (P < .01). Neither age (P = .220) nor gender (P = .449) impacted plaque scores. Conclusions Use of a bromelain enzyme pre-rinse alone did not significantly enhance plaque removal. A significant reduction in retained plaque was observed with the application of brushing and or Waterpik.

Dental plaque removal and motivation of a manual toothbrush versus an interactive power toothbrush in young people with fixed orthodontic appliances: a single examiner-blind randomized controlled clinical trial

2021 ◽  
pp. 43828-43831
Keyword(s):  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Orthodontic Appliances ◽  
Auxiliary Result ◽  
Plaque Score ◽  
Plaque Removal ◽  
Fixed Orthodontic Appliances ◽  
Manual Toothbrush ◽  
Treatment Contrast ◽  
Mouth Wash

Introduction: The goal of this 2-arm equal preliminary clinical trial was to decide the plaque expulsion efficacy (primary result) and the motivation assessment (auxiliary result) looking at a manual versus an interactive power toothbrush in orthodontic patients. Methods: Sixty teenagers with fixed orthodontic appliances who reported to the Department of Periodontics for routine oral prophylaxis in the both arches were randomized in a 1:1 proportion parallel, randomized, examiner-blindcontrolled clinical preliminary. Qualification criteria included in any event 16 characteristic teeth, 1-6 "center consideration zones," plaque score of ≥1.75, no serious caries, gingivits and periodontitis, no dental prophylaxis, no smoking, no anti-microbials, and no chlorhexidine mouth wash. Subjects were to brush solo with either an interactive power toothbrush (Oral-B Professional Care 6000, D36/EB20) with Bluetooth innovation or a customary manual toothbrush (Oral-B Indicator 35 delicate). Center consideration regions were each brushed for 10 extra seconds like inter-proximal spaces. Plaque removal was surveyed with the utilization of the Turesky Modification of the Quigley-Hein Plaque Index (TMQHPI) to decide change from standard at 2 weeks followed by 6 weeks. Supervised brushing at screening and post-treatment visits recorded real brushing times. Subject-revealed motivational viewpoints were recorded at screening and week 6. Results: Fifty-nine subjects between 13-17 years finished the investigation. The interactive power toothbrush gave significantly (P\0.001) more noteworthy plaque decrease versus the manual toothbrush at 2 and 6 week as indicated by the entire mouth TMQHPI. The treatment contrast in balanced mean plaque change from standard was 0.777 (95% CI 0.614-0.940) at week 2 and 0.834 (0.686-0.981) at week 6. Mean decreases in the quantity of center consideration regions were likewise significantly more noteworthy (P \0.001) in the power brush bunch at weeks 2 and 6. Brushing times increased significantly at weeks 2 and 6 (P #0.013) versus standard baseline in the interactive powertoothbrush group only.Subject-revealed motivation was significantly increased in the interactive power tooth brush group at week 6 as opposed to screening (P #0.005). Conclusions: An interactive power toothbrush produced increased brushing times and significantly more prominent plaque removal versus a manual brush.

scholarly journals A randomized clinical trial to evaluate the plaque removal efficacy of an oscillating-rotating toothbrush versus a sonic toothbrush in orthodontic patients using digital imaging analysis of the anterior dentition

2018 ◽  
Vol 89 (3) ◽  
pp. 385-390 ◽  
Author(s):  
Christina Erbe ◽  
Collin Jacobs ◽  
Malgorzata Klukowska ◽  
Hans Timm ◽  
Julie Grender ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Orthodontic Appliances ◽  
Imaging Analysis ◽  
Plaque Score ◽  
Plaque Removal ◽  
Fixed Orthodontic Appliances ◽  
Adolescent Patients ◽  
Orthodontic Patients ◽  
Single Use ◽  
Electric Toothbrush

ABSTRACT Objective: To compare the plaque removal efficacy of an oscillating-rotating electric toothbrush with an orthodontic brush head versus a sonic toothbrush in adolescent patients with fixed orthodontic appliances. Materials and Methods: This was a randomized, examiner-blind, replicate single-use, two-treatment, four-period, crossover study with a washout period between visits of approximately 24 hours. Forty-four adolescent patients with fixed orthodontic appliances in both arches were randomized based on a computer-generated randomization schedule to one of four toothbrush treatment sequences. The primary outcome was plaque score change from baseline, measured using digital plaque imaging analysis. Results: Baseline plaque levels for both brush treatments were high, covering more than 50% of the tooth area. Effective plaque removal was observed with both brush treatments (P < .001); however, the reduction in plaque with the oscillating-rotating toothbrush was statistically significantly greater (P = .017) compared with the sonic toothbrush. Conclusions: The study provides evidence for more effective plaque-removing efficacy of the oscillating-rotating toothbrush versus the sonic toothbrush among orthodontic patients.

scholarly journals Randomized Double-blind Clinical Trial of Bleaching Products in Patients Wearing Orthodontic Devices

2016 ◽  
Vol 41 (4) ◽  
pp. 379-387 ◽  
Author(s):  
A Montenegro-Arana ◽  
LA Arana-Gordillo ◽  
D Farana ◽  
A Davila-Sanchez ◽  
E Jadad ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Statistical Difference ◽  
Orthodontic Appliances ◽  
Double Blind ◽  
Tooth Color ◽  
Anterior Teeth ◽  
Double Blind Clinical Trial ◽  
Number Of Patients ◽  
Fixed Orthodontic Appliances ◽  
Before And After

SUMMARY Objectives: This double-blind randomized clinical trial evaluated tooth sensitivity (TS) and the effectiveness (EF) of two types of bleaching agents (Trèswhite Ortho [TWO] and Trèswhite Supreme [TWS]) when used in patients wearing orthodontic appliances. Methods and Materials: Forty patients between the ages of 18 and 40 years were randomly stratified, with an equal allocation rate, into two groups (n=20), according to the bleaching agent applied. Tooth color of the six maxillary anterior teeth was measured before and after the treatment with a spectrophotometer. The TS was recorded on three scales before and during the bleaching treatment. Results: With regard to EF, a significant reduction was found (ranging from 7.3-9.6 and 5.3-9.5 Vita scale units for TWO and TWS, respectively, p<0.001); however, there was no statistical difference between the groups (p>0.63). The number of patients with sensitivity was 58.8% and 73.3% for TWO and TWS groups, respectively (p=0.53); however, with each of the three scales used, the intensity of sensitivity was low and there was no statistical difference between TWO and TWS (p>0.05). Conclusions: In spite of producing a side effect of low TS, the two bleaching treatments tested were effective for dental bleaching in patients with fixed orthodontic appliances.

Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial

Odontology ◽  
2019 ◽  
Vol 108 (3) ◽  
pp. 470-478 ◽  
Author(s):  
Cristina Leiva-Cala ◽  
Alejandro Ismael Lorenzo-Pouso ◽  
Belén Centenera-Centenera ◽  
Juan López-Palafox ◽  
Pilar Gándara-Vila ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Clinical Efficacy ◽  
Aloe Vera ◽  
Orthodontic Appliances ◽  
Double Blind ◽  
Aloe Vera Gel ◽  
Fixed Orthodontic Appliances ◽  
Chlorhexidine Gel

scholarly journals Supragingival plaque removal with and without dentifrice: a randomized controlled clinical trial

2012 ◽  
Vol 23 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Fabricio B. Zanatta ◽  
Raquel P. Antoniazzi ◽  
Tatiana M. P. Pinto ◽  
Cassiano K. Rösing
Keyword(s):  
Clinical Trial ◽  
Test Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Separate Analysis ◽  
Randomized Controlled Clinical Trial ◽  
Significance Level ◽  
Plaque Removal ◽  
Randomized Controlled ◽  
Removal Capacity

The aim of this study was to compare the efficacy of dental plaque removal by brushing with and without conventional dentifrice. Twenty-four students aged 17 to 28 years participated in this randomized controlled clinical trial. Quadrants 1-3 or 2-4 were randomly allocated to the test group (brushing without dentifrice) or control group (brushing with dentifrice). After 72 h of cessation of oral hygiene, Quigley & Hein (Turesky) plaque index was assessed before and after brushing by a calibrated and blind examiner. Overtime and intergroup comparisons were performed by Student's paired sample t-test at 5% significance level. The results showed that both groups after toothbrushing presented statistically significant reductions in plaque, with no differences between them (from 3.06 ± 0.54 to 1.27 ± 0.26 versus from 3.07 ± 0.52 to 1.31 ± 0.23). A separate analysis of the buccal and lingual aspects also showed no significant differences between groups. It may be concluded that the use of a conventional dentifrice during toothbrushing does not seem to enhance plaque removal capacity.

scholarly journals Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Doubleblind Cross-over Clinical Trial

2015 ◽  
Vol 16 (4) ◽  
pp. 291-298 ◽  
Author(s):  
Roghayeh Ghorbanzadeh ◽  
Babak Pourakbari
Keyword(s):  
Clinical Trial ◽  
Silver Nanoparticles ◽  
Biofilm Formation ◽  
Orthodontic Appliances ◽  
Bacterial Cells ◽  
Streptococcus Sobrinus ◽  
Double Blind ◽  
Biofilm Inhibition ◽  
Cariogenic Bacteria

ABSTRACT Aim Polymethyl-methacrylate (PMMA) is commonly used primarily for baseplates of orthodontic appliances (BOA). The activities of cariogenic bacteria in biofilm on these surfaces may contribute to dental caries, gingival inflammation and periodontal disease. The PMMA incorporated with nanoparticles of silver (NanoAg-I-PMMA) and NanoAg in situ in PMMA (NanoAg-IS-PMMA) have been shown to control the growth of cariogenic bacteria, but clinical trial of anti-cariogenic application of these novel materials in orthodontics has not been evaluated. The main aim of the study is to compare the clinical effectiveness of using NanoAg-IS-PMMA and NanoAg-I-PMMA for construction of new BOA in inhibiting the planktonic growth and biofilm formation of the cariogenic bacteria. Materials and methods Twenty four patients with a median age of 12.6 years (7-15) harboring Streptococcus mutans, Streptococcus sobrinus and Lactobacillus acidophilus as well as Lactobacillus casei participated in the randomized, doubleblind, cross-over study. The experimental BOA, NanoAg-ISBOA and NanoAg-I-BOA, contained 0.5% w/w NanoAg while the control BOA was standard PMMA. Antibacterial effect of NanoAg-IS-BOA and NanoAg-I-BOA was assessed against test cariogenic bacteria by planktonic and biofilm bacterial cells growth inhibition. Results The average levels of test cariogenic bacteria in saliva decreased about 2 to 70 fold (30.9-98.4%) compared to baseline depending on the microorganism type and test BOA. Biofilm inhibition analysis demonstrated that NanoAg-I-BOA and NanoAg-IS-BOA inhibited the biofilm of all test bacteria by 20.1 to 79.9% compared to BOA. NanoAg-IS-BOA had a strong anti-biofilm effect against S. mutans, S. sobrinus and L. casei. However, NanoAg-I-BOA showed only slight antibiofilm effects on test bacteria. Most notably, at all period of the clinical trial, NanoAg-IS-BOA showed a higher antibacterial activity than NanoAg-I-BOA. Conclusion Based on the novel data that presented here, the NanoAg-IS-BOA had strong antimicrobial activity in the planktonic phase and subsequent biofilm formation of the cariogenic bacteria. Clinical significance Wearing of NanoAg-IS-BOA has the potential to minimize dental plaque formation and caries during orthodontic treatment. How to cite this article Ghorbanzadeh R, Pourakbari B, Bahador A. Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Double-blind Cross-over Clinical Trial. J Contemp Dent Pract 2015;16(4):291-298.

Effect of an early mobilisation programme on pain intensity after laparoscopic surgery: a randomised clinical trial

2020 ◽  
pp. bmjspcare-2020-002618
Author(s):  
Azam Dehghani ◽  
Ali Hajibagheri ◽  
Ismail Azizi-Fini ◽  
Fatemeh Atoof ◽  
Noushin Mousavi
Keyword(s):  
Clinical Trial ◽  
Laparoscopic Surgery ◽  
Pain Intensity ◽  
Repeated Measures ◽  
Intervention Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Early Mobilisation ◽  
Repeated Measures Analysis ◽  
The Mean

BackgroundPain is a common complication after laparoscopic surgery. This study aimed to examine the effect of an early mobilisation programme on postoperative pain intensity after laparoscopic surgery.MethodsA randomised controlled clinical trial was conducted on 80 patients who underwent laparoscopic surgery in Shahid Beheshti Hospital in Kashan, Iran. The patients were randomly allocated to intervention (n=40) and a control (n=40) group. In the intervention group, an early mobilisation programme was implemented in two rounds. The patient’s perceived pain was assessed using a Visual Analogue Scale 15 min before and 30 min after each round of early mobilisation. Data were analysed through the independent samples t, χ2 and Fisher’s exact tests and the repeated measures analysis.ResultsThe repeated measures analysis showed that the mean pain scores have been decreased over time (F=98.88, p<0.001). Considering the observed interaction between time and the intervention, the t test was used for pairwise comparisons and showed that the mean pain score was not significantly different between the two groups in 15 min before the first round of early mobilisation (p=0.95). However, the mean pain in the intervention group was significantly less than the control group in all subsequent measurements (p<0.05).ConclusionEarly mobilisation programmes such as the one implemented in the current study are easy and inexpensive and can be implemented safely for the reduction of pain after laparoscopic surgeries.

Patient-Reported Fatigue Scores in Cancer Patients with Chemotherapy-Induced Anemia Treated with Erythropoietic-Stimulating Agents (ESAs).

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1304-1304
Author(s):  
Tanya Burton ◽  
David Hoaglin ◽  
Kay Larholt ◽  
Elizabeth Apgar ◽  
Chris Pashos ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Repeated Measures ◽  
Prospective Observational Study ◽  
Positive Trend ◽  
Significant Positive Trend ◽  
Repeated Measures Analysis ◽  
Patient Reported ◽  
Clinical Trial Evidence ◽  
Outcomes Study ◽  
Trial Evidence

Abstract Background: Clinical trial evidence has demonstrated greater anemia-related fatigue at lower hemoglobin (Hb) levels in ESA-treated patients with chemotherapy-induced anemia (CIA). To understand these patient-reported outcomes (PROs), during ESA treatment in a real-world setting, data were analyzed from the Dosing and Outcomes Study of Erythropoiesis-Stimulating Therapies (D.O.S.E.) Registry, an ongoing, prospective, observational study. Methods: Patients included for analysis were required to have a baseline Hb prior to ESA administration and at least two ESA administrations. PROs were measured using the Functional Assessment of Cancer Therapy: Fatigue subscale (FACT-F), a 13-question measure of anemia-associated fatigue with lower scores indicating greater fatigue in patients with CIA. Patients were to have completed up to three FACT-F questionnaires within seven days of a post-baseline Hb level. If multiple Hb values were identified, the Hb value closest to the FACT-F assessment was reported. The association between FACT-F scores and Hb levels was tested in a repeated-measures analysis. Mean FACT-F scores were calculated for specified Hb ranges. Results: 740 CIA patients from 63 sites were identified between 12/03 and 7/08. 1088 concurrent FACT-F and Hb level assessments were available during ESA treatment. Mean FACT-F scores were lower when patients had lower Hb levels (table). The association between FACT-F scores and Hb levels showed a significant positive trend (p&lt;.0001). Hb ≤ 8.0 g/dL 8.01–9.0 g/dL 9.01–10.0 g/dL 10.01–11.0 g/dL 11.01–12.0 g/dL n (concurrent FACT-F and Hb assessments) 19 63 212 336 458 Mean FACT-F score (SD) 21.26 (11.01) 22.95 (12.44) 25.64 (12.40) 26.84 (11.70) 29.34 (12.04) Conclusions: This analysis of FACT-F assessments in CIA patients suggests that lower Hb levels were associated with greater anemia-related fatigue. These findings are consistent with clinical trial evidence and provide observational PRO data to patients and providers regarding anemia-related fatigue during ESA treatment.

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