scholarly journals Distal Degenerative Sensory Neuropathy in a Long-Term Type 2 Diabetes Rat Model

Diabetes ◽  
2008 ◽  
Vol 57 (6) ◽  
pp. 1664-1673 ◽  
Author(s):  
V. Brussee ◽  
G. Guo ◽  
Y. Dong ◽  
C. Cheng ◽  
J. A. Martinez ◽  
...  
1998 ◽  
Vol 15 (12) ◽  
pp. 1022-1027 ◽  
Author(s):  
C. Weytjens ◽  
B. Keymeulen ◽  
C. Van Haleweyn ◽  
G. Somers ◽  
A. Bossuyt

2013 ◽  
Vol 60 (5) ◽  
pp. 249-253
Author(s):  
Irene Vinagre ◽  
Juan Sánchez-Hernández ◽  
José Luis Sánchez-Quesada ◽  
Miguel Ángel María ◽  
Alberto de Leiva ◽  
...  

2013 ◽  
Vol 27 (6) ◽  
pp. 609-617 ◽  
Author(s):  
Hanna Skärstrand ◽  
L.B. Dahlin ◽  
Å. Lernmark ◽  
F. Vaziri-Sani

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2074 ◽  
Author(s):  
Pedram Shokouh ◽  
Per B Jeppesen ◽  
Christine B Christiansen ◽  
Fredrik B Mellbye ◽  
Kjeld Hermansen ◽  
...  

The effects of chronic coffee exposure in models of type 2 diabetes mellitus (T2D) models is scarcely studied, and the efficacy of the main coffee species has never been compared. We tested the hypothesis that long-term consumption of arabica and robusta coffee may differentially delay and affect T2D development in Zucker diabetic fatty rats. Three study groups received either chow mixed with arabica or robusta instant coffee (1.8% w/w) or unsupplemented chow food for 10 weeks. Both coffee species reduced liver triglyceride content and area under the curve of fasting and postprandial insulin. At study end, plasma adiponectin, total cholesterol and high density lipoprotein levels were higher in the robust group compared with both arabica and control groups. The liver gene expression of Glucose-6-phosphatase, catalytic subunit (G6pc) and Mechanistic target of rapamycin (mTOR) in robusta and Cpt1a in both coffee groups was downregulated. In conclusion, long-term consumption of both coffee species reduced weight gain and liver steatosis and improved insulin sensitivity in a rat model of T2D. Robusta coffee was seemingly superior to arabica coffee with respect to effects on lipid profile, adiponectin level and hepatic gene expression.


Diabetes Care ◽  
2003 ◽  
Vol 26 (3) ◽  
pp. 625-630 ◽  
Author(s):  
L. J.C. van Loon ◽  
M. Kruijshoop ◽  
P. P.C.A. Menheere ◽  
A. J.M. Wagenmakers ◽  
W. H.M. Saris ◽  
...  

2018 ◽  
Vol 15 (12) ◽  
pp. 1678-1697 ◽  
Author(s):  
Maryam Masouminia ◽  
Robert Gelfand ◽  
Istvan Kovanecz ◽  
Dolores Vernet ◽  
James Tsao ◽  
...  

2014 ◽  
Vol 22 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Boshra Hatef ◽  
Farid Bahrpeyma ◽  
Poopak Moatamed Vaziri

2013 ◽  
Vol 60 (5) ◽  
pp. 249-253 ◽  
Author(s):  
Irene Vinagre ◽  
Juan Sánchez-Hernández ◽  
José Luis Sánchez-Quesada ◽  
Miguel Ángel María ◽  
Alberto de Leiva ◽  
...  

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