Background:
Polymorphonuclear neutrophils (PMNs) play a crucial role in the innate
immune system’s response to microbial pathogens through the release of reactive nitrogen species,
including Nitric Oxide (NO).
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Methods: In neutrophils, NO is produced by the inducible Nitric Oxide Synthase (iNOS), which is
regulated by various signaling pathways and transcription factors. N-nitrosodimethylamine
(NDMA), a potential human carcinogen, affects immune cells. NDMA plays a major part in the
growing incidence of cancers. Thanks to the increasing knowledge on the toxicological role of
NDMA, the environmental factors that condition the exposure to this compound, especially its precursors-
nitrates arouse wide concern.
Results:
In this article, we present a detailed summary of the molecular mechanisms of NDMA’s
effect on the iNOS-dependent NO production in human neutrophils.
Conclusion:
This research contributes to a more complete understanding of the mechanisms that
explain the changes that occur during nonspecific cellular responses to NDMA toxicity.
Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice: Potential Role of Tyrosine Nitration of Insulin Signaling Proteins
