scholarly journals Negative Regulation of DsbA-L Gene Expression by the Transcription Factor Sp1

Diabetes ◽  
2014 ◽  
Vol 63 (12) ◽  
pp. 4165-4171 ◽  
Author(s):  
Q. Fang ◽  
W. Yang ◽  
H. Li ◽  
W. Hu ◽  
L. Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Negative Regulation ◽  
Transcription Factor Sp1

scholarly journals Overexpression of Transcription Factor Sp1 Leads to Gene Expression Perturbations and Cell Cycle Inhibition

PLoS ONE ◽  
2009 ◽  
Vol 4 (9) ◽  
pp. e7035 ◽  
Author(s):  
Emmanuelle Deniaud ◽  
Joël Baguet ◽  
Roxane Chalard ◽  
Bariza Blanquier ◽  
Lilia Brinza ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Transcription Factor ◽  
Transcription Factor Sp1 ◽  
Cell Cycle Inhibition

scholarly journals Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

2004 ◽  
Vol 24 (2) ◽  
pp. 865-874 ◽  
Author(s):  
Michelle A. Christensen ◽  
Weihui Zhou ◽  
Hong Qing ◽  
Anna Lehman ◽  
Sjaak Philipsen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Amyloid Precursor Protein ◽  
Proteolytic Processing ◽  
Precursor Protein ◽  
Transcriptional Level ◽  
Response Element ◽  
App Processing ◽  
Transcription Factor Sp1 ◽  
Β Amyloid

ABSTRACT Proteolytic processing of the β-amyloid precursor protein (APP) at the β site is essential to generate Aβ. BACE1, the major β-secretase involved in cleaving APP, has been identified as a type 1 membrane-associated aspartyl protease. We have cloned a 2.1-kb fragment upstream of the human BACE1 gene and identified key regions necessary for promoter activity. BACE1 gene expression is controlled by a TATA-less promoter. The region of bp −619 to +46 is the minimal promoter to control the transcription of the BACE1 gene. Several putative cis-acting elements, such as a GC box, HSF-1, a PU box, AP1, AP2, and lymphokine response element, are found in the 5′ flanking region of the BACE1 gene. Transcriptional activation and gel shift assays demonstrated that the BACE1 promoter contains a functional Sp1 response element, and overexpression of the transcription factor Sp1 potentiates BACE gene expression and APP processing to generate Aβ. Furthermore, Sp1 knockout reduced BACE1 expression. These results suggest that BACE1 gene expression is tightly regulated at the transcriptional level and that the transcription factor Sp1 plays an important role in regulation of BACE1 to process APP generating Aβ in Alzheimer's disease.

Characterization of the neuropilin-1 promoter; gene expression is mediated by the transcription factor Sp1

2002 ◽  
Vol 88 (4) ◽  
pp. 744-757 ◽  
Author(s):  
Mireille Rossignol ◽  
Jacques Pouysségur ◽  
Michael Klagsbrun
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Transcription Factor Sp1 ◽  
Neuropilin 1 ◽  
Promoter Gene

scholarly journals Transcription Factor Decoy to Study the Molecular Mechanism of Negative Regulation of Renin Gene Expression in the Liver In Vivo

1999 ◽  
Vol 84 (9) ◽  
pp. 1059-1066 ◽  
Author(s):  
Sawako Tomita ◽  
Naruya Tomita ◽  
Takehiko Yamada ◽  
Lunan Zhang ◽  
Yasufumi Kaneda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Molecular Mechanism ◽  
Negative Regulation ◽  
Transcription Factor Decoy ◽  
Renin Gene
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