260-LB: Continuous Glucose Monitoring Metrics in Islet Transplant Recipients with Long-Term Insulin Independence

Background: Although real-time continuous glucose monitoring (rtCGM) has been shown to improve glycemic control in patients with type 1 diabetes mellitus and type 2 diabetes mellitus treated with insulin, rates of adoption have been low. A novel approach, with the use of a long-term implantable continuous glucose monitoring (LTI CGM) has the potential to overcome barriers to rtCGM. The purpose of this review is to provide a background on the first LTI CGM technology to be approved, along with a review of contraindications, interference, safety, accuracy, and efficacy. Considerations for patient selection are discussed based on the available evidence. Methods: PubMed, EMBASE, and Cochrane Library were searched for keywords and subject headings to identify studies assessing LTI CGM. Results: Seven studies were identified which assessed LTI CGM. Mean absolute relative difference is similar to available CGM devices. Rates of adverse events were low. Change in hemoglobin A1c with LTI CGM may be comparable to rtCGM. Conclusions: Based on the available evidence, LTI CGM appears to be safe and accurate. Additional clinical trial investigation is warranted to evaluate the glycemic efficacy of LTI CGM.

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Resistance to Data Loss of Glycemic Variability Measurements in Long-Term Continuous Glucose Monitoring

Diabetes Technology & Therapeutics ◽

10.1089/dia.2018.0247 ◽

2018 ◽

Vol 20 (12) ◽

pp. 833-842 ◽

Cited By ~ 1

Author(s):

Przemysław Kucharski ◽

Konrad Pagacz ◽

Agnieszka Szadkowska ◽

Wojciech Młynarski ◽

Andrzej Romanowski ◽

...

Keyword(s):

Continuous Glucose Monitoring ◽

Glucose Monitoring ◽

Glycemic Variability ◽

Data Loss

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Continuous glucose monitoring: review of promising technologies

MATEC Web of Conferences ◽

10.1051/matecconf/201925202012 ◽

2019 ◽

Vol 252 ◽

pp. 02012

Author(s):

Monika Klimek ◽

Tytus Tulwin

Keyword(s):

Glycemic Control ◽

Continuous Glucose Monitoring ◽

New Technologies ◽

Glucose Monitoring ◽

Flash Glucose Monitoring ◽

Uncontrolled Diabetes ◽

Monitoring Technologies

Despite the progress we have made in the management of diabetes it is still incurable and aggravating disease affecting all domains of quality of life. Uncontrolled diabetes associated with hyperglycemia leads to serious microvascular and macrovascular long-term complications. The proper long-term glycemic control is a key strategy for preventing the development or slowing the progression of diabetes complications, thus there is a crucial role of new technologies in the diabetes care. New technologies in diabetology are developing dynamically in recent years and therefore this is a topical issue. In this paper we describe current and developing continuous glucose monitoring technologies and their usefulness in promoting optimal glycemic control, influence on personalized diabetes managements and the functioning of patients. Moreover we review knowledge about flash glucose monitoring and close-loop system. This review examines studies published before 31st August 2018.

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Electrochemically Activated Conductive Ni-Based MOFs for Non-enzymatic Sensors Toward Long-Term Glucose Monitoring

Frontiers in Chemistry ◽

10.3389/fchem.2020.602752 ◽

2020 ◽

Vol 8 ◽

Author(s):

Yating Chen ◽

Yulan Tian ◽

Ping Zhu ◽

Liping Du ◽

Wei Chen ◽

...

Keyword(s):

Continuous Glucose Monitoring ◽

Glucose Sensor ◽

Glucose Monitoring ◽

Glucose Sensors ◽

Blood Glucose Monitoring ◽

Diabetic Patients ◽

Potential Range ◽

Potential Applications ◽

Naoh Solution

Continuous intensive monitoring of glucose is one of the most important approaches in recovering the quality of life of diabetic patients. One challenge for electrochemical enzymatic glucose sensors is their short lifespan for continuous glucose monitoring. Therefore, it is of great significance to develop non-enzymatic glucose sensors as an alternative approach for long-term glucose monitoring. This study presented a highly sensitive and selective electrochemical non-enzymatic glucose sensor using the electrochemically activated conductive Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2 MOFs as sensing materials. The morphology and structure of the MOFs were investigated by scanning SEM and FTIR, respectively. The performance of the activated electrode toward the electrooxidation of glucose in alkaline solution was evaluated with cyclic voltammetry technology in the potential range from 0.2 V to 0.6 V. The electrochemical activated Ni-MOFs exhibited obvious anodic (0.46 V) and cathodic peaks (0.37 V) in the 0.1 M NaOH solution due to the Ni(II)/Ni(III) transfer. A linear relationship between the glucose concentrations (ranging from 0 to 10 mM) and anodic peak currents with R2 = 0.954 was obtained. It was found that the diffusion of glucose was the limiting step in the electrochemical reaction. The sensor exhibited good selectivity toward glucose in the presence of 10-folds uric acid and ascorbic acid. Moreover, this sensor showed good long-term stability for continuous glucose monitoring. The good selectivity, stability, and rapid response of this sensor suggests that it could have potential applications in long-term non-enzymatic blood glucose monitoring.

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