scholarly journals Lack of brain insulin receptor substrate-1 causes growth retardation, with decreased expression of growth hormone-releasing hormone in the hypothalamus.

Diabetes ◽  
2021 ◽  
pp. db200482
Author(s):  
Takanori Hayashi ◽  
Tetsuya Kubota ◽  
Mariko Inoue ◽  
Iseki Takamoto ◽  
Masakazu Aihara ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Receptor ◽  
Growth Retardation ◽  
Insulin Receptor Substrate ◽  
Growth Hormone Releasing Hormone ◽  
Insulin Receptor Substrate 1 ◽  
Releasing Hormone ◽  
Brain Insulin

Lack of Brain Insulin Receptor Substrate-1 (IRS1) Causes Growth Retardation via Growth Hormone Releasing Hormone

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1795-P
Author(s):  
TAKANORI HAYASHI ◽  
NAOTO KUBOTA ◽  
TETSUYA KUBOTA ◽  
TAKASHI KADOWAKI
Keyword(s):  
Growth Hormone ◽  
Insulin Receptor ◽  
Growth Retardation ◽  
Insulin Receptor Substrate ◽  
Growth Hormone Releasing Hormone ◽  
Insulin Receptor Substrate 1 ◽  
Releasing Hormone ◽  
Brain Insulin

scholarly journals Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, with Decreased Expression of Growth Hormone-Releasing Hormone in the Hypothalamus

2021 ◽  
Author(s):  
Takanori Hayashi ◽  
Tetsuya Kubota ◽  
Inoue Mariko ◽  
Iseki Takamoto ◽  
Masakazu Aihara ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Receptor ◽  
Growth Retardation ◽  
Tyrosine Kinases ◽  
Insulin Receptor Substrate ◽  
Growth Hormone Releasing Hormone ◽  
Insulin Receptor Substrate 1 ◽  
Releasing Hormone ◽  
Expression Levels

Insulin receptor substrate-1 (Irs1) is one of the major substrates for insulin receptor and Insulin-like growth factor-1 (IGF-1) receptor tyrosine kinases. Systemic Irs1-deficient mice show growth retardation, with resistance to insulin and IGF-1, although the underlying mechanisms remain poorly understood. For this study, we generated mice with brain-specific deletion of Irs1 (NIrs1KO mice). The NIrs1KO mice exhibited lower body weights, shorter bodies and bone lengths, and decreased bone density. Moreover, the NIrs1KO mice exhibited increased insulin sensitivity and glucose utilization in the skeletal muscle. Although the ability of the pituitary to secrete growth hormone (GH) remained intact, the amount of hypothalamic growth hormone-releasing hormone (GHRH) was significantly decreased and accordingly, the pituitary GH mRNA expression levels were impaired in these mice. Plasma GH and IGF-1 levels were also lower in the NIrs1KO mice. The expression levels of GHRH protein in the median eminence, where Irs1 antibody staining is observed, were markedly decreased in the NIrs1KO mice. In vitro, neurite elongation after IGF-1 stimulation was significantly impaired by Irs1 downregulation in the cultured N-38 hypothalamic neurons. In conclusion, brain Irs1 plays important roles in the regulation of neurite outgrowth of GHRH neurons, somatic growth, and glucose homeostasis.

scholarly journals Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, with Decreased Expression of Growth Hormone-Releasing Hormone in the Hypothalamus

2021 ◽  
Author(s):  
Takanori Hayashi ◽  
Tetsuya Kubota ◽  
Inoue Mariko ◽  
Iseki Takamoto ◽  
Masakazu Aihara ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Receptor ◽  
Growth Retardation ◽  
Tyrosine Kinases ◽  
Insulin Receptor Substrate ◽  
Growth Hormone Releasing Hormone ◽  
Insulin Receptor Substrate 1 ◽  
Releasing Hormone ◽  
Expression Levels

Insulin receptor substrate-1 (Irs1) is one of the major substrates for insulin receptor and Insulin-like growth factor-1 (IGF-1) receptor tyrosine kinases. Systemic Irs1-deficient mice show growth retardation, with resistance to insulin and IGF-1, although the underlying mechanisms remain poorly understood. For this study, we generated mice with brain-specific deletion of Irs1 (NIrs1KO mice). The NIrs1KO mice exhibited lower body weights, shorter bodies and bone lengths, and decreased bone density. Moreover, the NIrs1KO mice exhibited increased insulin sensitivity and glucose utilization in the skeletal muscle. Although the ability of the pituitary to secrete growth hormone (GH) remained intact, the amount of hypothalamic growth hormone-releasing hormone (GHRH) was significantly decreased and accordingly, the pituitary GH mRNA expression levels were impaired in these mice. Plasma GH and IGF-1 levels were also lower in the NIrs1KO mice. The expression levels of GHRH protein in the median eminence, where Irs1 antibody staining is observed, were markedly decreased in the NIrs1KO mice. In vitro, neurite elongation after IGF-1 stimulation was significantly impaired by Irs1 downregulation in the cultured N-38 hypothalamic neurons. In conclusion, brain Irs1 plays important roles in the regulation of neurite outgrowth of GHRH neurons, somatic growth, and glucose homeostasis.

Insulin Resistance and Growth Retardation in Mice Lacking Insulin Receptor Substrate-1 and Identification of Insulin Receptor Substrate-2

1996 ◽  
Vol 13 ◽  
pp. 103-108 ◽  
Author(s):  
T. Kadowaki ◽  
H. Tamemoto ◽  
K. Tobe ◽  
Y. Terauchi ◽  
K. Ueki ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Receptor ◽  
Growth Retardation ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1

scholarly journals Insulin Receptor Substrate-1 Enhances Growth Hormone-Induced Proliferation*

Endocrinology ◽  
1999 ◽  
Vol 140 (5) ◽  
pp. 1972-1983 ◽  
Author(s):  
Liang Liang ◽  
Tong Zhou ◽  
Jing Jiang ◽  
Jacalyn H. Pierce ◽  
Thomas A. Gustafson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Receptor ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1

NEONATAL CORTICOID ADMINISTRATION: EFFECTS UPON ADULT PITUITARY GROWTH HORMONE AND HYPOTHALAMIC GROWTH HORMONE-RELEASING HORMONE ACTIVITY

1969 ◽  
Vol 61 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Shinji Sawano ◽  
Akira Arimura ◽  
Andrew V. Schally ◽  
Tommie W. Redding ◽  
Shawn Schapiro
Keyword(s):  
Growth Hormone ◽  
Growth Retardation ◽  
Subcutaneous Injection ◽  
Growth Hormone Releasing Hormone ◽  
Hormone Activity ◽  
Single Subcutaneous Injection ◽  
Releasing Hormone ◽  
Pituitary Growth Hormone

ABSTRACT A single subcutaneous injection of 1 mg cortisone or cortisol acetate was given to rats during the first post-natal day. As others have reported, retardation of growth, detectable a week after birth, resulted. On reaching five to six weeks of age, treated rats had no detectable growth hormone (GH)-releasing activity in their hypothalami and little GH or thyrotrophin (TSH) activity in their pituitaries. These observations suggest that the growth retardation of rats treated neonatally with these steroids may be due, at least in part, to lack of pituitary GH resulting from impaired synthesis of GH-releasing hormone (GRH**) and also to lack of TSH.

scholarly journals Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 ◽  
Vol 270 (24) ◽  
pp. 14685-14692 ◽  
Author(s):  
Lawrence S. Argetsinger ◽  
Gene W. Hsu ◽  
Martin G. Myers ◽  
Nils Billestrup ◽  
Morris F. White ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Receptor ◽  
Leukemia Inhibitory Factor ◽  
Interferon Γ ◽  
Inhibitory Factor ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1 ◽  
Tyrosyl Phosphorylation
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